DK1453810T3 - Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as a drug containing the same - Google Patents
Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as a drug containing the sameInfo
- Publication number
- DK1453810T3 DK1453810T3 DK02804183T DK02804183T DK1453810T3 DK 1453810 T3 DK1453810 T3 DK 1453810T3 DK 02804183 T DK02804183 T DK 02804183T DK 02804183 T DK02804183 T DK 02804183T DK 1453810 T3 DK1453810 T3 DK 1453810T3
- Authority
- DK
- Denmark
- Prior art keywords
- phenyltetrahydroisoquinolines
- substituted
- preparation
- same
- drug containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10159714 | 2001-12-05 | ||
| PCT/EP2002/012990 WO2003048129A1 (en) | 2001-12-05 | 2002-11-20 | Substituted 4-phenyltetrahydroisoquinolines, method for the production thereof, the use thereof as medicaments, in addition to a medicament containing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1453810T3 true DK1453810T3 (en) | 2009-07-20 |
Family
ID=7708117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02804183T DK1453810T3 (en) | 2001-12-05 | 2002-11-20 | Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as a drug containing the same |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP1453810B1 (en) |
| JP (1) | JP4510457B2 (en) |
| KR (1) | KR20050044724A (en) |
| CN (1) | CN100497314C (en) |
| AR (1) | AR037620A1 (en) |
| AT (1) | ATE425968T1 (en) |
| AU (1) | AU2002356689B2 (en) |
| BR (1) | BR0214753A (en) |
| CA (1) | CA2469385A1 (en) |
| CO (1) | CO5580748A2 (en) |
| DE (1) | DE50213372D1 (en) |
| DK (1) | DK1453810T3 (en) |
| EC (1) | ECSP045138A (en) |
| ES (1) | ES2324528T3 (en) |
| HK (1) | HK1072597A1 (en) |
| HR (1) | HRP20040507A2 (en) |
| HU (1) | HUP0600854A2 (en) |
| IL (1) | IL162316A0 (en) |
| MA (1) | MA27147A1 (en) |
| MX (1) | MXPA04005343A (en) |
| MY (1) | MY157371A (en) |
| NO (1) | NO326650B1 (en) |
| NZ (1) | NZ533322A (en) |
| OA (1) | OA12740A (en) |
| PE (1) | PE20030726A1 (en) |
| PL (1) | PL369313A1 (en) |
| PT (1) | PT1453810E (en) |
| RS (1) | RS48004A (en) |
| RU (1) | RU2298003C2 (en) |
| TN (1) | TNSN04100A1 (en) |
| TW (1) | TWI281860B (en) |
| UA (1) | UA77042C2 (en) |
| WO (1) | WO2003048129A1 (en) |
| ZA (1) | ZA200403711B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10312963A1 (en) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as medicament, and medicament containing them |
| TW200526626A (en) | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
| DE102004046492A1 (en) * | 2004-09-23 | 2006-03-30 | Sanofi-Aventis Deutschland Gmbh | Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as medicament, and medicament containing them |
| US20060111393A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
| DE102005001411A1 (en) * | 2005-01-12 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as medicament, and medicament containing them |
| BRPI0607756A2 (en) | 2005-02-18 | 2010-05-18 | Astrazeneca Ab | compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, method for inhibiting bacterial DNA gyrase and / or topoisomerase iv in a warm-blooded animal, use of a compound or a pharmaceutically acceptable salt thereof, and process for preparing compounds or pharmaceutically acceptable salts thereof |
| US20080269214A1 (en) * | 2005-03-04 | 2008-10-30 | Astrazeneca Ab | Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors |
| DE102005044817A1 (en) * | 2005-09-20 | 2007-03-22 | Sanofi-Aventis Deutschland Gmbh | Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as medicament, and medicament containing them |
| DE102006012545A1 (en) | 2006-03-18 | 2007-09-27 | Sanofi-Aventis | Substituted 2-amino-4-phenyl-dihydroquinolines, process for their preparation, their use as medicament, and medicament containing them |
| WO2018129556A1 (en) * | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2010078449A2 (en) * | 2008-12-31 | 2010-07-08 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US10543207B2 (en) | 2008-12-31 | 2020-01-28 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| KR20120034644A (en) | 2009-05-12 | 2012-04-12 | 알바니 몰레큘라 리써치, 인크. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
| CA2880432C (en) * | 2012-08-21 | 2023-03-14 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| HUE044550T2 (en) | 2013-04-12 | 2019-11-28 | Ardelyx Inc | Nhe3-binding compounds and methods for inhibiting phosphate transport |
| CN103788084A (en) * | 2014-03-02 | 2014-05-14 | 湖南华腾制药有限公司 | Tetrahydroisoquinoline derivative and synthesis method thereof |
| CN106536502B (en) * | 2014-07-25 | 2019-03-05 | 大正制药株式会社 | The phenyl tetrahydro isoquinoline compound being substituted by heteroaryl |
| JP6903923B2 (en) * | 2016-01-22 | 2021-07-14 | 大正製薬株式会社 | A drug containing a phenyltetrahydroisoquinoline compound substituted with a heteroaryl as an active ingredient. |
| CN110267944B (en) | 2017-01-09 | 2024-03-08 | 阿德利克斯股份有限公司 | Compounds useful for the treatment of gastrointestinal disorders |
| JP2020505333A (en) | 2017-01-09 | 2020-02-20 | アルデリックス， インコーポレイテッド | Inhibitors of NHE-mediated antiport |
| IL303799A (en) * | 2020-12-18 | 2023-08-01 | Shanghai Jemincare Pharmaceutical Co Ltd | Benzoheterocycle substituted tetrahydroisoquinoline compound |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19951702A1 (en) * | 1999-10-27 | 2001-05-03 | Aventis Pharma Gmbh | Use of 2-amino-3,4-dihydroquinazolines for the manufacture of a medicament for the treatment or prophylaxis of diseases caused by ischemic conditions |
| ES2304984T3 (en) * | 1999-11-03 | 2008-11-01 | Amr Technology, Inc. | TETRA-HYDROISOQUINOLINAS OF ARILICA AND HETEROARILICA SUBSTITUTION AND ITS USE TO BLOCK THE RECOVERY OF NOREPINEFRINE, DOPAMINE AND SEROTONINE. |
| AU784280B2 (en) * | 1999-11-03 | 2006-03-02 | Albany Molecular Research, Inc. | 4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
| EP1113007A1 (en) * | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists |
| DE10019062A1 (en) * | 2000-04-18 | 2001-10-25 | Merck Patent Gmbh | Use of known and new 2-guanidino-4-aryl-quinazoline derivatives as NHE-3 inhibitors useful for the treatment of e.g. hypertension, thrombosis, cardiac ischemia, peripheral and CNS ischemia |
-
2002
- 2002-11-20 PL PL02369313A patent/PL369313A1/en not_active Application Discontinuation
- 2002-11-20 RS YU48004A patent/RS48004A/en unknown
- 2002-11-20 KR KR1020047008697A patent/KR20050044724A/en active IP Right Grant
- 2002-11-20 BR BR0214753-0A patent/BR0214753A/en not_active IP Right Cessation
- 2002-11-20 IL IL16231602A patent/IL162316A0/en unknown
- 2002-11-20 CN CNB028278879A patent/CN100497314C/en not_active Expired - Fee Related
- 2002-11-20 AT AT02804183T patent/ATE425968T1/en not_active IP Right Cessation
- 2002-11-20 PT PT02804183T patent/PT1453810E/en unknown
- 2002-11-20 EP EP02804183A patent/EP1453810B1/en not_active Expired - Lifetime
- 2002-11-20 HU HU0600854A patent/HUP0600854A2/en unknown
- 2002-11-20 OA OA1200400166A patent/OA12740A/en unknown
- 2002-11-20 CA CA002469385A patent/CA2469385A1/en not_active Abandoned
- 2002-11-20 AU AU2002356689A patent/AU2002356689B2/en not_active Ceased
- 2002-11-20 DE DE50213372T patent/DE50213372D1/en not_active Expired - Lifetime
- 2002-11-20 UA UA20040705310A patent/UA77042C2/en unknown
- 2002-11-20 WO PCT/EP2002/012990 patent/WO2003048129A1/en active Application Filing
- 2002-11-20 RU RU2004120295/04A patent/RU2298003C2/en not_active IP Right Cessation
- 2002-11-20 ES ES02804183T patent/ES2324528T3/en not_active Expired - Lifetime
- 2002-11-20 DK DK02804183T patent/DK1453810T3/en active
- 2002-11-20 MX MXPA04005343A patent/MXPA04005343A/en active IP Right Grant
- 2002-11-20 NZ NZ533322A patent/NZ533322A/en unknown
- 2002-11-20 JP JP2003549321A patent/JP4510457B2/en not_active Expired - Fee Related
- 2002-11-26 PE PE2002001138A patent/PE20030726A1/en not_active Application Discontinuation
- 2002-12-03 TW TW091134977A patent/TWI281860B/en not_active IP Right Cessation
- 2002-12-03 AR ARP020104667A patent/AR037620A1/en unknown
- 2002-12-04 MY MYPI20024565A patent/MY157371A/en unknown
-
2004
- 2004-05-14 ZA ZA200403711A patent/ZA200403711B/en unknown
- 2004-05-21 MA MA27693A patent/MA27147A1/en unknown
- 2004-05-25 NO NO20042158A patent/NO326650B1/en not_active IP Right Cessation
- 2004-06-03 CO CO04052088A patent/CO5580748A2/en not_active Application Discontinuation
- 2004-06-04 EC EC2004005138A patent/ECSP045138A/en unknown
- 2004-06-04 TN TNP2004000100A patent/TNSN04100A1/en unknown
- 2004-06-04 HR HR20040507A patent/HRP20040507A2/en not_active Application Discontinuation
-
2005
- 2005-06-22 HK HK05105174.2A patent/HK1072597A1/en not_active IP Right Cessation
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