UA74625C2 - 4-[4-(2-pyrrolylcarbonyl)-l-piperazinyl]-3-trifluoromethyl-benzoylguanidine hydrochloride, and a pharmaceutical composition - Google Patents
4-[4-(2-pyrrolylcarbonyl)-l-piperazinyl]-3-trifluoromethyl-benzoylguanidine hydrochloride, and a pharmaceutical composition Download PDFInfo
- Publication number
- UA74625C2 UA74625C2 UA2003098454A UA2003098454A UA74625C2 UA 74625 C2 UA74625 C2 UA 74625C2 UA 2003098454 A UA2003098454 A UA 2003098454A UA 2003098454 A UA2003098454 A UA 2003098454A UA 74625 C2 UA74625 C2 UA 74625C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pyrrolylcarbonyl
- formula
- piperazinyl
- trifluoromethyl
- benzoylguanidine
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- UFVMVHAWZDUFMJ-UHFFFAOYSA-N n-(diaminomethylidene)-4-[4-(1h-pyrrole-2-carbonyl)piperazin-1-yl]-3-(trifluoromethyl)benzamide;hydrochloride Chemical compound Cl.FC(F)(F)C1=CC(C(=O)NC(=N)N)=CC=C1N1CCN(C(=O)C=2NC=CC=2)CC1 UFVMVHAWZDUFMJ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims description 27
- 239000013543 active substance Substances 0.000 claims description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 claims description 5
- 230000001413 cellular effect Effects 0.000 claims description 3
- 150000004677 hydrates Chemical class 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 150000004682 monohydrates Chemical class 0.000 claims description 2
- 239000012535 impurity Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 13
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Surgery (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10106970A DE10106970A1 (de) | 2001-02-15 | 2001-02-15 | Neues Benzoylguanidinsalz |
| PCT/EP2002/001535 WO2002064563A1 (de) | 2001-02-15 | 2002-02-14 | Neues benzoylguanidinsalz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA74625C2 true UA74625C2 (en) | 2006-01-16 |
Family
ID=7674094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2003098454A UA74625C2 (en) | 2001-02-15 | 2002-02-14 | 4-[4-(2-pyrrolylcarbonyl)-l-piperazinyl]-3-trifluoromethyl-benzoylguanidine hydrochloride, and a pharmaceutical composition |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US20080025919A1 (ja) |
| EP (1) | EP1362030B1 (ja) |
| JP (3) | JP4408626B2 (ja) |
| KR (1) | KR100862176B1 (ja) |
| CN (1) | CN1222510C (ja) |
| AT (1) | ATE553078T1 (ja) |
| AU (1) | AU2002250939B2 (ja) |
| BG (1) | BG66330B1 (ja) |
| BR (1) | BR0207867A (ja) |
| CA (1) | CA2434829C (ja) |
| CY (1) | CY1112878T1 (ja) |
| CZ (1) | CZ303277B6 (ja) |
| DE (1) | DE10106970A1 (ja) |
| DK (1) | DK1362030T3 (ja) |
| EA (1) | EA006245B1 (ja) |
| EC (1) | ECSP034708A (ja) |
| EE (1) | EE200300393A (ja) |
| ES (1) | ES2385472T3 (ja) |
| HK (1) | HK1064093A1 (ja) |
| HR (1) | HRP20030653B1 (ja) |
| HU (1) | HU230035B1 (ja) |
| IL (1) | IL156934A (ja) |
| NO (1) | NO20033299L (ja) |
| NZ (1) | NZ528081A (ja) |
| PL (1) | PL213300B1 (ja) |
| PT (1) | PT1362030E (ja) |
| RS (1) | RS52014B (ja) |
| SI (1) | SI1362030T1 (ja) |
| SK (1) | SK287830B6 (ja) |
| UA (1) | UA74625C2 (ja) |
| WO (1) | WO2002064563A1 (ja) |
| ZA (1) | ZA200305365B (ja) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10106970A1 (de) * | 2001-02-15 | 2002-08-29 | Boehringer Ingelheim Pharma | Neues Benzoylguanidinsalz |
| DE10144030A1 (de) * | 2001-09-07 | 2003-03-27 | Boehringer Ingelheim Pharma | Verbesserung der lokalen Verträglichkeit bei intravenöser Verabreichung von 4-(4-(2-Pyrrolylcarbonyl-1-piperazinyl)-3-trifluormethyl-benzoylguanidin |
| US6982256B2 (en) | 2001-09-07 | 2006-01-03 | Boehringer Ingelheim Pharma Kg | Tolerance of 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine in intravenous administration |
| JP2011527677A (ja) * | 2008-07-08 | 2011-11-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｎｈｅ−１阻害剤として有用なピロリジニル及びピペリジニル化合物 |
| WO2015160820A1 (en) * | 2014-04-14 | 2015-10-22 | The University Of Memphis | Wireless analog passive sensors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19601303A1 (de) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
| US6323207B1 (en) * | 1998-09-22 | 2001-11-27 | Boehringer Ingelheim Pharma Kg | Benzoylguanidine derivatives |
| DE19843489B4 (de) * | 1998-09-22 | 2006-12-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Benzoylguanidin-Abkömmlinge mit vorteilhaften Eigenschaften, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln, sowie diese enthaltende pharmazeutische Zubereitung |
| DE10106970A1 (de) * | 2001-02-15 | 2002-08-29 | Boehringer Ingelheim Pharma | Neues Benzoylguanidinsalz |
| US6730678B2 (en) * | 2001-02-15 | 2004-05-04 | Boehringer Ingelheim Pharma Kg | Benzoylguanidine salt and hydrates thereof |
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2001
- 2001-02-15 DE DE10106970A patent/DE10106970A1/de not_active Ceased
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2002
- 2002-02-14 BR BR0207867-8A patent/BR0207867A/pt active Pending
- 2002-02-14 PT PT02719831T patent/PT1362030E/pt unknown
- 2002-02-14 JP JP2002564496A patent/JP4408626B2/ja not_active Expired - Fee Related
- 2002-02-14 HU HU0303027A patent/HU230035B1/hu not_active IP Right Cessation
- 2002-02-14 ES ES02719831T patent/ES2385472T3/es not_active Expired - Lifetime
- 2002-02-14 UA UA2003098454A patent/UA74625C2/uk unknown
- 2002-02-14 AU AU2002250939A patent/AU2002250939B2/en not_active Ceased
- 2002-02-14 AT AT02719831T patent/ATE553078T1/de active
- 2002-02-14 DK DK02719831.6T patent/DK1362030T3/da active
- 2002-02-14 WO PCT/EP2002/001535 patent/WO2002064563A1/de active IP Right Grant
- 2002-02-14 EP EP02719831A patent/EP1362030B1/de not_active Expired - Lifetime
- 2002-02-14 CZ CZ20032210A patent/CZ303277B6/cs not_active IP Right Cessation
- 2002-02-14 KR KR1020037010723A patent/KR100862176B1/ko not_active IP Right Cessation
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- 2002-02-14 EE EEP200300393A patent/EE200300393A/xx unknown
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- 2002-02-14 SK SK1020-2003A patent/SK287830B6/sk not_active IP Right Cessation
- 2002-02-14 SI SI200230982T patent/SI1362030T1/sl unknown
- 2002-02-14 CN CNB028049926A patent/CN1222510C/zh not_active Expired - Fee Related
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2003
- 2003-07-11 ZA ZA200305365A patent/ZA200305365B/en unknown
- 2003-07-22 NO NO20033299A patent/NO20033299L/no not_active Application Discontinuation
- 2003-07-29 EC EC2003004708A patent/ECSP034708A/es unknown
- 2003-08-06 BG BG108065A patent/BG66330B1/bg active Active
- 2003-08-13 HR HRP20030653AA patent/HRP20030653B1/xx not_active IP Right Cessation
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2004
- 2004-09-08 HK HK04106807A patent/HK1064093A1/xx not_active IP Right Cessation
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2007
- 2007-08-21 US US11/842,941 patent/US20080025919A1/en not_active Abandoned
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2008
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2009
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