UA72913C2 - Remedy for treating rheumatoid arthritis - Google Patents
Remedy for treating rheumatoid arthritis Download PDFInfo
- Publication number
- UA72913C2 UA72913C2 UA2001096233A UA2001096233A UA72913C2 UA 72913 C2 UA72913 C2 UA 72913C2 UA 2001096233 A UA2001096233 A UA 2001096233A UA 2001096233 A UA2001096233 A UA 2001096233A UA 72913 C2 UA72913 C2 UA 72913C2
- Authority
- UA
- Ukraine
- Prior art keywords
- hyaluronic acid
- zinc
- rheumatoid arthritis
- synovial cells
- synovial
- Prior art date
Links
- 206010039073 rheumatoid arthritis Diseases 0.000 title abstract description 13
- 210000002437 synoviocyte Anatomy 0.000 abstract description 28
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract description 23
- 239000011701 zinc Substances 0.000 abstract description 22
- 229910052725 zinc Inorganic materials 0.000 abstract description 22
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract description 21
- 229920002674 hyaluronan Polymers 0.000 abstract description 21
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP06371899A JP2003089647A (ja) | 1999-03-10 | 1999-03-10 | 関節性疾患治療剤 |
| PCT/JP2000/001487 WO2000053194A1 (fr) | 1999-03-10 | 2000-03-10 | Medicaments contre les affections articulaires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA72913C2 true UA72913C2 (en) | 2005-05-16 |
Family
ID=13237463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2001096233A UA72913C2 (en) | 1999-03-10 | 2000-10-03 | Remedy for treating rheumatoid arthritis |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6608043B1 (ja) |
| EP (1) | EP1166788B8 (ja) |
| JP (1) | JP2003089647A (ja) |
| KR (1) | KR100728096B1 (ja) |
| CN (1) | CN1165315C (ja) |
| AT (1) | ATE466584T1 (ja) |
| AU (1) | AU2942500A (ja) |
| BG (1) | BG65681B1 (ja) |
| CA (1) | CA2364451C (ja) |
| CY (1) | CY1109773T1 (ja) |
| CZ (1) | CZ301736B6 (ja) |
| DE (1) | DE60044341D1 (ja) |
| DK (1) | DK1166788T3 (ja) |
| EA (1) | EA005010B1 (ja) |
| EE (1) | EE04660B1 (ja) |
| ES (1) | ES2344677T3 (ja) |
| PL (1) | PL200848B1 (ja) |
| PT (1) | PT1166788E (ja) |
| SK (1) | SK287223B6 (ja) |
| UA (1) | UA72913C2 (ja) |
| WO (1) | WO2000053194A1 (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0303779A2 (en) * | 2003-11-20 | 2006-02-28 | Richter Gedeon Vegyeszet | Pharmaceutical compositions containing hyaluronan complex for the treatment of sclerosis multiplex |
| ITRM20030590A1 (it) * | 2003-12-22 | 2005-06-23 | Univ Siena | Formulazione a base di polimetafosfati per la cura di artropatie microcristalline. |
| JPWO2005089800A1 (ja) * | 2004-03-17 | 2008-01-31 | 株式会社ロコモジェン | ｈｓＨＲＤ３を含む医薬組成物 |
| US20070099867A1 (en) * | 2005-05-24 | 2007-05-03 | Glycoscience Laboratories, Inc. | Pharmaceutical agent containing hyaluronan as an active ingredient |
| RU2342148C2 (ru) * | 2005-09-26 | 2008-12-27 | Гликосайенс Лабораториз, Инк. | Фармацевтическое средство, содержащее гиалуронан в качестве активного ингредиента |
| JP2009091248A (ja) * | 2006-01-17 | 2009-04-30 | Toshitsu Kagaku Kenkyusho:Kk | 外傷性神経障害および／または運動機能障害の治療薬 |
| WO2008068854A1 (ja) | 2006-12-05 | 2008-06-12 | Glycoscience Laboratories, Inc. | 変形性関節症の治療剤 |
| FR2927255B1 (fr) * | 2008-02-07 | 2011-08-12 | Keysan Consulting | Produits injectables biocompatibles a liberation de zinc et/ou de sel de saccharide sous forme de zinc et leurs utilisations. |
| US8462765B2 (en) * | 2008-08-20 | 2013-06-11 | Qualcomm Incorporated | Method and apparatus to perform ranging operations for wireless stations |
| JP5587637B2 (ja) * | 2009-04-10 | 2014-09-10 | 生化学工業株式会社 | マトリックスメタロプロテアーゼ阻害剤及びその用途 |
| HUP0900717A3 (en) | 2009-11-18 | 2012-02-28 | Richter Gedeon Nyrt | Pharmaceutical composition for urological use containing zinc hyaluronate |
| US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
| US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US8524662B2 (en) | 2010-12-28 | 2013-09-03 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
| ES2665254T3 (es) * | 2011-07-12 | 2018-04-25 | Holy Stone Healthcare Co., Ltd. | Composiciones que comprenden ácido hialurónico para tratamiento y prevención de enfermedades relacionadas con las mucosas |
| US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4746504A (en) * | 1986-03-14 | 1988-05-24 | Bio-Technology General Corp. | Heavy metal salts of hyaluronic acid and their use as antimicrobial agents |
| EP0259485A4 (en) * | 1986-03-14 | 1988-07-29 | Bio Technology General Corp | HEAVY METAL SALTS OF HYALURONIC ACID FOR USE AS AN ANTIMICROBIAL AGENT. |
| CA1327354C (en) * | 1987-03-19 | 1994-03-01 | David Cullis-Hill | Anti-inflamatory compounds and compositions |
| AU616502B2 (en) * | 1988-04-22 | 1991-10-31 | Medvet Science Pty. Ltd. | Treatment of inflammatory disorders in humans |
| HU203372B (en) * | 1989-02-24 | 1991-07-29 | Richter Gedeon Vegyeszet | Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient |
| CZ202591A3 (cs) * | 1991-07-02 | 1993-01-13 | Hypro Vyzkum | Prostředek pro prevenci dekubitft a topickou terapii kožních lézt |
| US5744442A (en) * | 1992-08-26 | 1998-04-28 | Bristol Meyers Squibb Company | Regulation of cellular invasiveness |
| IT1281877B1 (it) * | 1995-05-10 | 1998-03-03 | Fidia Advanced Biopolymers Srl | Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici |
| IT1288290B1 (it) * | 1996-06-21 | 1998-09-11 | Fidia Spa In Amministrazione S | Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie |
| EP0834319A1 (en) * | 1996-10-07 | 1998-04-08 | Kartar Dr. Lalvani | Mineral and vitamin combinations in arthritic pain |
-
1999
- 1999-03-10 JP JP06371899A patent/JP2003089647A/ja active Pending
-
2000
- 2000-03-10 EA EA200100963A patent/EA005010B1/ru not_active IP Right Cessation
- 2000-03-10 AU AU29425/00A patent/AU2942500A/en not_active Abandoned
- 2000-03-10 DE DE60044341T patent/DE60044341D1/de not_active Expired - Lifetime
- 2000-03-10 EP EP00908017A patent/EP1166788B8/en not_active Expired - Lifetime
- 2000-03-10 KR KR1020017011505A patent/KR100728096B1/ko active IP Right Grant
- 2000-03-10 CA CA2364451A patent/CA2364451C/en not_active Expired - Lifetime
- 2000-03-10 PL PL350289A patent/PL200848B1/pl unknown
- 2000-03-10 DK DK00908017.7T patent/DK1166788T3/da active
- 2000-03-10 WO PCT/JP2000/001487 patent/WO2000053194A1/ja not_active Application Discontinuation
- 2000-03-10 US US09/936,245 patent/US6608043B1/en not_active Expired - Lifetime
- 2000-03-10 PT PT00908017T patent/PT1166788E/pt unknown
- 2000-03-10 AT AT00908017T patent/ATE466584T1/de active
- 2000-03-10 SK SK1250-2001A patent/SK287223B6/sk not_active IP Right Cessation
- 2000-03-10 CN CNB008047391A patent/CN1165315C/zh not_active Expired - Lifetime
- 2000-03-10 CZ CZ20013110A patent/CZ301736B6/cs not_active IP Right Cessation
- 2000-03-10 ES ES00908017T patent/ES2344677T3/es not_active Expired - Lifetime
- 2000-03-10 EE EEP200100478A patent/EE04660B1/xx unknown
- 2000-10-03 UA UA2001096233A patent/UA72913C2/uk unknown
-
2001
- 2001-09-10 BG BG105885A patent/BG65681B1/bg unknown
-
2010
- 2010-06-08 CY CY20101100507T patent/CY1109773T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK287223B6 (sk) | 2010-03-08 |
| WO2000053194A1 (fr) | 2000-09-14 |
| EP1166788B1 (en) | 2010-05-05 |
| BG65681B1 (bg) | 2009-06-30 |
| DE60044341D1 (de) | 2010-06-17 |
| EP1166788B8 (en) | 2010-06-16 |
| CA2364451A1 (en) | 2000-09-14 |
| PL350289A1 (en) | 2002-12-02 |
| CZ20013110A3 (cs) | 2002-01-16 |
| EA005010B1 (ru) | 2004-10-28 |
| CN1343122A (zh) | 2002-04-03 |
| PT1166788E (pt) | 2010-06-25 |
| EE04660B1 (et) | 2006-08-15 |
| CA2364451C (en) | 2011-08-02 |
| ATE466584T1 (de) | 2010-05-15 |
| AU2942500A (en) | 2000-09-28 |
| SK12502001A3 (sk) | 2002-02-05 |
| KR20010108343A (ko) | 2001-12-07 |
| ES2344677T3 (es) | 2010-09-03 |
| EP1166788A4 (en) | 2007-10-10 |
| PL200848B1 (pl) | 2009-02-27 |
| EA200100963A1 (ru) | 2002-02-28 |
| CZ301736B6 (cs) | 2010-06-09 |
| CY1109773T1 (el) | 2014-09-10 |
| CN1165315C (zh) | 2004-09-08 |
| KR100728096B1 (ko) | 2007-06-14 |
| BG105885A (en) | 2002-06-28 |
| US6608043B1 (en) | 2003-08-19 |
| DK1166788T3 (da) | 2010-08-23 |
| JP2003089647A (ja) | 2003-03-28 |
| EP1166788A1 (en) | 2002-01-02 |
| EE200100478A (et) | 2003-02-17 |
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