UA72612C2 - Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells - Google Patents
Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells Download PDFInfo
- Publication number
- UA72612C2 UA72612C2 UA2002119182A UA2002119182A UA72612C2 UA 72612 C2 UA72612 C2 UA 72612C2 UA 2002119182 A UA2002119182 A UA 2002119182A UA 2002119182 A UA2002119182 A UA 2002119182A UA 72612 C2 UA72612 C2 UA 72612C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compounds
- pyrido
- cancer cells
- prodrugs
- ribofuranose
- Prior art date
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- 239000000651 prodrug Substances 0.000 title claims abstract description 20
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- 230000002401 inhibitory effect Effects 0.000 title claims description 6
- 230000012010 growth Effects 0.000 title abstract description 4
- UDJFFSGCRRMVFH-UHFFFAOYSA-N pyrido[2,3-d]pyrimidine Chemical compound N1=CN=CC2=CC=CN=C21 UDJFFSGCRRMVFH-UHFFFAOYSA-N 0.000 title abstract description 3
- 210000005170 neoplastic cell Anatomy 0.000 title abstract 2
- QGDYVSSVBYMOJN-UHFFFAOYSA-N pyrimido[4,5-d]pyrimidine Chemical compound C1=NC=NC2=NC=NC=C21 QGDYVSSVBYMOJN-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002718 pyrimidine nucleoside Substances 0.000 title description 4
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- 125000003342 alkenyl group Chemical group 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 125000000304 alkynyl group Chemical group 0.000 claims description 11
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- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21641800P | 2000-07-06 | 2000-07-06 | |
| PCT/US2001/041242 WO2002003997A1 (en) | 2000-07-06 | 2001-07-03 | Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA72612C2 true UA72612C2 (en) | 2005-03-15 |
Family
ID=22806989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002119182A UA72612C2 (en) | 2000-07-06 | 2001-03-07 | Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7081449B2 (zh) |
| EP (1) | EP1303282A4 (zh) |
| JP (1) | JP2004522694A (zh) |
| KR (1) | KR20030032944A (zh) |
| CN (1) | CN1440292A (zh) |
| AU (2) | AU2001273670B2 (zh) |
| BR (1) | BR0111531A (zh) |
| CA (1) | CA2405798A1 (zh) |
| CZ (1) | CZ20024052A3 (zh) |
| HU (1) | HUP0301614A3 (zh) |
| IL (1) | IL151849A0 (zh) |
| MX (1) | MXPA02012156A (zh) |
| NO (1) | NO20030033D0 (zh) |
| NZ (1) | NZ521457A (zh) |
| PL (1) | PL359559A1 (zh) |
| SK (1) | SK112003A3 (zh) |
| UA (1) | UA72612C2 (zh) |
| WO (1) | WO2002003997A1 (zh) |
| ZA (1) | ZA200208010B (zh) |
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| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| NZ547204A (en) | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
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| BR0313164A (pt) | 2002-08-01 | 2007-07-17 | Pharmasset Inc | compostos com o sistema biciclo[4.2.1] nonano para o tratamento de infecções por flaviviridae |
| HUE033832T2 (en) | 2002-11-15 | 2018-01-29 | Idenix Pharmaceuticals Llc | 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation |
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| CN101743007B (zh) | 2007-07-12 | 2015-04-08 | 南佛罗里达大学 | 具有抗肿瘤活性的akt/pkb抑制剂 |
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| BRPI0915878A2 (pt) | 2008-07-08 | 2015-11-03 | Gilead Sciences Inc | sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende |
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| NZ593648A (en) | 2008-12-23 | 2013-09-27 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
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| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
| KR101715981B1 (ko) | 2010-03-31 | 2017-03-13 | 길리애드 파마셋 엘엘씨 | 뉴클레오사이드 포스포르아미데이트 |
| EA025341B1 (ru) | 2010-09-22 | 2016-12-30 | Алиос Биофарма, Инк. | Замещенные аналоги нуклеотидов |
| WO2012158197A2 (en) * | 2010-11-11 | 2012-11-22 | Lyndor Biosciences L.L.C. | Compounds useful as akt/pkb modulators and uses thereof |
| US8841275B2 (en) | 2010-11-30 | 2014-09-23 | Gilead Pharmasset Llc | 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections |
| DE202012013074U1 (de) | 2011-09-16 | 2014-10-29 | Gilead Pharmasset Lcc | Zusammensetzungen zur Behandlung von HCV |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
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| KR20140138910A (ko) * | 2012-03-14 | 2014-12-04 | 루핀 리미티드 | 헤테로사이클릴 화합물 |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
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| CN102816197B (zh) * | 2012-08-24 | 2015-04-29 | 四川大学华西医院 | 一种新的嘧啶并嘧啶类核苷类似物、制备方法及其形成的超分子结构和应用 |
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| JP2021509907A (ja) | 2018-01-09 | 2021-04-08 | リガンド・ファーマシューティカルズ・インコーポレイテッド | アセタール化合物およびその治療的使用 |
| EP3794012B1 (en) | 2018-05-15 | 2023-10-18 | Illumina Inc. | Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotides |
| KR20210145787A (ko) | 2019-04-02 | 2021-12-02 | 알리고스 테라퓨틱스 인코포레이티드 | Prmt5를 표적으로 하는 화합물 |
| CN111995649A (zh) * | 2020-04-09 | 2020-11-27 | 瀚海新拓(杭州)生物医药有限公司 | 一种蝶啶酮核苷酸类似物及其药物组合物、制备方法和医药用途 |
| WO2022174253A1 (en) * | 2021-02-12 | 2022-08-18 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
| CN117295737A (zh) | 2021-03-05 | 2023-12-26 | 林伯士萨顿公司 | Hpk1拮抗剂和其用途 |
| EP4313989A1 (en) | 2021-03-29 | 2024-02-07 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3423398A (en) | 1965-05-10 | 1969-01-21 | Pfizer & Co C | Sangivamycin and derivatives thereof |
| JPH0725788B1 (zh) * | 1985-09-09 | 1995-03-22 | Teijin Ltd | |
| US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
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2001
- 2001-03-07 UA UA2002119182A patent/UA72612C2/uk unknown
- 2001-07-03 KR KR1020027014601A patent/KR20030032944A/ko active IP Right Grant
- 2001-07-03 PL PL01359559A patent/PL359559A1/xx not_active Application Discontinuation
- 2001-07-03 MX MXPA02012156A patent/MXPA02012156A/es unknown
- 2001-07-03 US US10/221,397 patent/US7081449B2/en not_active Expired - Fee Related
- 2001-07-03 EP EP01952967A patent/EP1303282A4/en not_active Withdrawn
- 2001-07-03 BR BR0111531-6A patent/BR0111531A/pt not_active IP Right Cessation
- 2001-07-03 AU AU2001273670A patent/AU2001273670B2/en not_active Expired - Fee Related
- 2001-07-03 SK SK11-2003A patent/SK112003A3/sk unknown
- 2001-07-03 CA CA002405798A patent/CA2405798A1/en not_active Abandoned
- 2001-07-03 HU HU0301614A patent/HUP0301614A3/hu unknown
- 2001-07-03 JP JP2002508451A patent/JP2004522694A/ja not_active Withdrawn
- 2001-07-03 CN CN01812327A patent/CN1440292A/zh active Pending
- 2001-07-03 AU AU7367001A patent/AU7367001A/xx active Pending
- 2001-07-03 NZ NZ521457A patent/NZ521457A/en unknown
- 2001-07-03 CZ CZ20024052A patent/CZ20024052A3/cs unknown
- 2001-07-03 WO PCT/US2001/041242 patent/WO2002003997A1/en not_active Application Discontinuation
- 2001-07-03 IL IL15184901A patent/IL151849A0/xx unknown
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2002
- 2002-10-04 ZA ZA200208010A patent/ZA200208010B/en unknown
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2003
- 2003-01-03 NO NO20030033A patent/NO20030033D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
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| NO20030033L (no) | 2003-01-03 |
| HUP0301614A3 (en) | 2005-02-28 |
| AU2001273670B2 (en) | 2005-07-14 |
| CA2405798A1 (en) | 2002-01-17 |
| SK112003A3 (en) | 2003-04-01 |
| IL151849A0 (en) | 2003-04-10 |
| US20030144502A1 (en) | 2003-07-31 |
| JP2004522694A (ja) | 2004-07-29 |
| CZ20024052A3 (cs) | 2003-03-12 |
| BR0111531A (pt) | 2004-07-06 |
| PL359559A1 (en) | 2004-08-23 |
| HUP0301614A2 (hu) | 2003-09-29 |
| EP1303282A4 (en) | 2004-04-07 |
| NZ521457A (en) | 2005-03-24 |
| MXPA02012156A (es) | 2004-08-19 |
| NO20030033D0 (no) | 2003-01-03 |
| AU7367001A (en) | 2002-01-21 |
| ZA200208010B (en) | 2004-04-28 |
| KR20030032944A (ko) | 2003-04-26 |
| WO2002003997A1 (en) | 2002-01-17 |
| US7081449B2 (en) | 2006-07-25 |
| EP1303282A1 (en) | 2003-04-23 |
| CN1440292A (zh) | 2003-09-03 |
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