IL151849A0 - Pyrido [2,3-d] pyrimidine and pyrimido [4,5-d] pyrimidine nucleosides - Google Patents
Pyrido [2,3-d] pyrimidine and pyrimido [4,5-d] pyrimidine nucleosidesInfo
- Publication number
- IL151849A0 IL151849A0 IL15184901A IL15184901A IL151849A0 IL 151849 A0 IL151849 A0 IL 151849A0 IL 15184901 A IL15184901 A IL 15184901A IL 15184901 A IL15184901 A IL 15184901A IL 151849 A0 IL151849 A0 IL 151849A0
- Authority
- IL
- Israel
- Prior art keywords
- pyrimidine
- pyrimido
- pyrido
- nucleosides
- pyrimidine nucleosides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21641800P | 2000-07-06 | 2000-07-06 | |
PCT/US2001/041242 WO2002003997A1 (en) | 2000-07-06 | 2001-07-03 | Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides |
Publications (1)
Publication Number | Publication Date |
---|---|
IL151849A0 true IL151849A0 (en) | 2003-04-10 |
Family
ID=22806989
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15184901A IL151849A0 (en) | 2000-07-06 | 2001-07-03 | Pyrido [2,3-d] pyrimidine and pyrimido [4,5-d] pyrimidine nucleosides |
Country Status (19)
Country | Link |
---|---|
US (1) | US7081449B2 (xx) |
EP (1) | EP1303282A4 (xx) |
JP (1) | JP2004522694A (xx) |
KR (1) | KR20030032944A (xx) |
CN (1) | CN1440292A (xx) |
AU (2) | AU2001273670B2 (xx) |
BR (1) | BR0111531A (xx) |
CA (1) | CA2405798A1 (xx) |
CZ (1) | CZ20024052A3 (xx) |
HU (1) | HUP0301614A3 (xx) |
IL (1) | IL151849A0 (xx) |
MX (1) | MXPA02012156A (xx) |
NO (1) | NO20030033D0 (xx) |
NZ (1) | NZ521457A (xx) |
PL (1) | PL359559A1 (xx) |
SK (1) | SK112003A3 (xx) |
UA (1) | UA72612C2 (xx) |
WO (1) | WO2002003997A1 (xx) |
ZA (1) | ZA200208010B (xx) |
Families Citing this family (71)
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BR0110023A (pt) | 2000-04-13 | 2003-12-30 | Pharmasset Ltd | Derivados de nucleosìdeo 3'-ou-2' substituìdos para tratamento de infecções por vìrus da hepatite |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
JP5230052B2 (ja) | 2000-05-26 | 2013-07-10 | イデニクス(ケイマン)リミテツド | フラビウイルスおよびペスチウイルス治療のための方法および組成物 |
BR0309557A (pt) | 2002-04-26 | 2005-03-01 | Gilead Sciences Inc | Inibidores da transcriptase reversa não nucleosìdeos |
CA2494340C (en) | 2002-08-01 | 2012-01-24 | Pharmasset Inc. | Compounds with the bicyclo[4.2.1]nonane system for the treatment of flaviviridae infections |
CA2506129C (en) | 2002-11-15 | 2015-02-17 | Idenix (Cayman) Limited | 2'-branched nucleosides and flaviviridae mutation |
WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
US7427636B2 (en) | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
EA014685B1 (ru) | 2003-04-25 | 2010-12-30 | Джилид Сайэнс, Инк. | Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе |
AU2004233897A1 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Kinase inhibitor phosphonate conjugates |
US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
WO2004096285A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
US7550442B2 (en) * | 2003-05-20 | 2009-06-23 | The Board Of Trustees Of The University Of Illinois | Nucleoside analog inhibitors of reverse transcriptase |
WO2005003147A2 (en) * | 2003-05-30 | 2005-01-13 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
WO2005009418A2 (en) | 2003-07-25 | 2005-02-03 | Idenix (Cayman) Limited | Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c |
EP1678321A1 (en) | 2003-10-24 | 2006-07-12 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds |
US7427624B2 (en) | 2003-10-24 | 2008-09-23 | Gilead Sciences, Inc. | Purine nucleoside phosphorylase inhibitory phosphonate compounds |
US7432273B2 (en) | 2003-10-24 | 2008-10-07 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
NZ547907A (en) | 2003-12-22 | 2010-07-30 | Gilead Sciences Inc | 4'-Substituted carbovir-and abacavir-derivatives as well as related compounds with HIV and HCV antiviral activity |
US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
CN101912400B (zh) | 2004-06-11 | 2013-06-26 | 日本烟草产业株式会社 | 用于治疗癌症的5-氨基-2,4,7-三氧代-3,4,7,8-四氢-2H-吡啶并[2,3-d]嘧啶衍生物和相关化合物 |
US7378423B2 (en) | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
CN101023094B (zh) * | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
UA88313C2 (ru) | 2004-07-27 | 2009-10-12 | Гилиад Сайенсиз, Инк. | Фосфонатные аналоги соединений ингибиторов вич |
SI3109244T1 (sl) * | 2004-09-14 | 2019-06-28 | Gilead Pharmasset Llc | Priprava 2'fluoro-2'-alkil-substituiranih ali drugih neobvezno substituiranih ribofuranozil pirimidinov in purinov in njihovih derivatov |
AU2006222563A1 (en) * | 2005-03-08 | 2006-09-14 | Biota Scientific Management Pty Ltd. | Bicyclic nucleosides and nucleotides as therapeutic agents |
US7951789B2 (en) * | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
KR101618037B1 (ko) | 2007-07-12 | 2016-05-04 | 유니버시티 오브 사우스 플로리다 | 항종양 활성이 있는 Akt/PKB 저해제 |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
EA018308B1 (ru) | 2008-07-08 | 2013-07-30 | Джилид Сайэнс, Инк. | Соли соединений ингибиторов вич |
WO2010075517A2 (en) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Nucleoside analogs |
CL2009002207A1 (es) | 2008-12-23 | 2011-02-18 | Gilead Pharmasset Llc | Compuestos derivados de 3-hidroxi-5-(9h-purin-9-il)tetrahidrofuran-2-il, inhibidor de la replicacion de arn viral dependiente de arn; composicion farmaceutica; uso para el tratamiento de hepatitis c. |
SG172363A1 (en) | 2008-12-23 | 2011-07-28 | Pharmasset Inc | Synthesis of purine nucleosides |
EA201190178A1 (ru) | 2009-03-20 | 2012-06-29 | Алиос Биофарма, Инк. | Замещённые нуклеозидные и нуклеотидные аналоги |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
US8563530B2 (en) | 2010-03-31 | 2013-10-22 | Gilead Pharmassel LLC | Purine nucleoside phosphoramidate |
AP3515A (en) | 2010-03-31 | 2016-01-11 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
CN103209987B (zh) | 2010-09-22 | 2017-06-06 | 艾丽奥斯生物制药有限公司 | 取代的核苷酸类似物 |
WO2012158197A2 (en) * | 2010-11-11 | 2012-11-22 | Lyndor Biosciences L.L.C. | Compounds useful as akt/pkb modulators and uses thereof |
JP6069215B2 (ja) | 2010-11-30 | 2017-02-01 | ギリアド ファーマセット エルエルシー | 化合物 |
UA116087C2 (uk) | 2011-09-16 | 2018-02-12 | Гіліад Фармассет Елелсі | Композиція для лікування вірусу гепатиту c |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
SG11201402826YA (en) | 2011-12-22 | 2014-12-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
AU2012358804B2 (en) | 2011-12-22 | 2018-04-19 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
WO2013136254A1 (en) * | 2012-03-14 | 2013-09-19 | Lupin Limited | Heterocyclyl compounds |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
WO2013142124A1 (en) | 2012-03-21 | 2013-09-26 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US9012427B2 (en) | 2012-03-22 | 2015-04-21 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
EA027929B1 (ru) | 2012-05-25 | 2017-09-29 | Янссен Сайенсиз Айрлэнд Юси | Нуклеозиды на основе урацила и спирооксетана |
CN102816197B (zh) * | 2012-08-24 | 2015-04-29 | 四川大学华西医院 | 一种新的嘧啶并嘧啶类核苷类似物、制备方法及其形成的超分子结构和应用 |
SG11201504554UA (en) | 2012-12-21 | 2015-07-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
KR20140119012A (ko) | 2013-01-31 | 2014-10-08 | 길리어드 파마셋 엘엘씨 | 두 항바이러스 화합물의 병용 제형물 |
ES2900570T3 (es) | 2013-08-27 | 2022-03-17 | Gilead Pharmasset Llc | Formulación de combinación de dos compuestos antivirales |
SG10201804835VA (en) | 2013-10-11 | 2018-07-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
EP3105238A4 (en) | 2014-02-13 | 2017-11-08 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
WO2016003812A1 (en) | 2014-07-02 | 2016-01-07 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
CN107073002B (zh) * | 2014-09-26 | 2019-10-15 | 里博科学有限责任公司 | 作为呼吸道合胞体病毒rna复制抑制剂的4’-乙烯基取代的核苷衍生物 |
PL3661937T3 (pl) | 2017-08-01 | 2021-12-20 | Gilead Sciences, Inc. | Formy krystaliczne ((s)-((((2r,5r)-5-(6-amino-9h-puryn-9-ylo)-4-fluoro-2,5-dihydrofuran-2-ylo)oksy)metylo)(fenoksy)fosforylo)-l-alaninianu etylu (gs-9131) do leczenia zakażeń wirusowych |
CN111788196A (zh) | 2018-01-09 | 2020-10-16 | 配体药物公司 | 缩醛化合物及其治疗用途 |
FI3794012T3 (fi) * | 2018-05-15 | 2024-01-08 | Illumina Inc | Koostumuksia ja menetelmiä pintaan sitoutuneiden oligonukleotidien kemiallista pilkkomista ja suojauksen poistoa varten |
MX2021011606A (es) | 2019-04-02 | 2021-12-10 | Aligos Therapeutics Inc | Compuestos dirigidos a prmt5. |
CN111995649A (zh) * | 2020-04-09 | 2020-11-27 | 瀚海新拓(杭州)生物医药有限公司 | 一种蝶啶酮核苷酸类似物及其药物组合物、制备方法和医药用途 |
JP2024506909A (ja) * | 2021-02-12 | 2024-02-15 | ニンバス サターン, インコーポレイテッド | Hpk1アンタゴニスト及びその使用 |
WO2022187856A1 (en) | 2021-03-05 | 2022-09-09 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
JP2024513011A (ja) | 2021-03-29 | 2024-03-21 | ニンバス サターン, インコーポレイテッド | Hpk1アンタゴニスト及びその使用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3423398A (en) * | 1965-05-10 | 1969-01-21 | Pfizer & Co C | Sangivamycin and derivatives thereof |
EP0235301B1 (en) * | 1985-09-09 | 1992-07-22 | Teijin Limited | Pyridopyrimidine nucleotide derivatives |
US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
-
2001
- 2001-03-07 UA UA2002119182A patent/UA72612C2/uk unknown
- 2001-07-03 MX MXPA02012156A patent/MXPA02012156A/es unknown
- 2001-07-03 SK SK11-2003A patent/SK112003A3/sk unknown
- 2001-07-03 CZ CZ20024052A patent/CZ20024052A3/cs unknown
- 2001-07-03 CA CA002405798A patent/CA2405798A1/en not_active Abandoned
- 2001-07-03 BR BR0111531-6A patent/BR0111531A/pt not_active IP Right Cessation
- 2001-07-03 PL PL01359559A patent/PL359559A1/xx not_active Application Discontinuation
- 2001-07-03 EP EP01952967A patent/EP1303282A4/en not_active Withdrawn
- 2001-07-03 HU HU0301614A patent/HUP0301614A3/hu unknown
- 2001-07-03 AU AU2001273670A patent/AU2001273670B2/en not_active Expired - Fee Related
- 2001-07-03 IL IL15184901A patent/IL151849A0/xx unknown
- 2001-07-03 JP JP2002508451A patent/JP2004522694A/ja not_active Withdrawn
- 2001-07-03 CN CN01812327A patent/CN1440292A/zh active Pending
- 2001-07-03 AU AU7367001A patent/AU7367001A/xx active Pending
- 2001-07-03 KR KR1020027014601A patent/KR20030032944A/ko active IP Right Grant
- 2001-07-03 WO PCT/US2001/041242 patent/WO2002003997A1/en not_active Application Discontinuation
- 2001-07-03 NZ NZ521457A patent/NZ521457A/en unknown
- 2001-07-03 US US10/221,397 patent/US7081449B2/en not_active Expired - Fee Related
-
2002
- 2002-10-04 ZA ZA200208010A patent/ZA200208010B/en unknown
-
2003
- 2003-01-03 NO NO20030033A patent/NO20030033D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
UA72612C2 (en) | 2005-03-15 |
NO20030033L (no) | 2003-01-03 |
US7081449B2 (en) | 2006-07-25 |
NZ521457A (en) | 2005-03-24 |
ZA200208010B (en) | 2004-04-28 |
KR20030032944A (ko) | 2003-04-26 |
NO20030033D0 (no) | 2003-01-03 |
CZ20024052A3 (cs) | 2003-03-12 |
JP2004522694A (ja) | 2004-07-29 |
BR0111531A (pt) | 2004-07-06 |
AU7367001A (en) | 2002-01-21 |
HUP0301614A3 (en) | 2005-02-28 |
PL359559A1 (en) | 2004-08-23 |
CA2405798A1 (en) | 2002-01-17 |
SK112003A3 (en) | 2003-04-01 |
HUP0301614A2 (hu) | 2003-09-29 |
AU2001273670B2 (en) | 2005-07-14 |
WO2002003997A1 (en) | 2002-01-17 |
US20030144502A1 (en) | 2003-07-31 |
CN1440292A (zh) | 2003-09-03 |
MXPA02012156A (es) | 2004-08-19 |
EP1303282A1 (en) | 2003-04-23 |
EP1303282A4 (en) | 2004-04-07 |
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