UA72436C2 - A method for achieving site specific integration of a desired dna at a target site in a mammalian cell via homologous recombination and vectors for realizing this method - Google Patents
A method for achieving site specific integration of a desired dna at a target site in a mammalian cell via homologous recombination and vectors for realizing this method Download PDFInfo
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- UA72436C2 UA72436C2 UA99095073A UA99095073A UA72436C2 UA 72436 C2 UA72436 C2 UA 72436C2 UA 99095073 A UA99095073 A UA 99095073A UA 99095073 A UA99095073 A UA 99095073A UA 72436 C2 UA72436 C2 UA 72436C2
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- dna
- plasmid
- selectable marker
- vector system
- cell
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
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- Biophysics (AREA)
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- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
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- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/819,866 US5830698A (en) | 1997-03-14 | 1997-03-14 | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
| PCT/US1998/003935 WO1998041645A1 (en) | 1997-03-14 | 1998-03-09 | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA72436C2 true UA72436C2 (en) | 2005-03-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA99095073A UA72436C2 (en) | 1997-03-14 | 1998-09-03 | A method for achieving site specific integration of a desired dna at a target site in a mammalian cell via homologous recombination and vectors for realizing this method |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5830698A (ko) |
| EP (2) | EP1605054A1 (ko) |
| KR (1) | KR100571105B1 (ko) |
| HK (1) | HK1026000A1 (ko) |
| MY (1) | MY137837A (ko) |
| NZ (1) | NZ337676A (ko) |
| RU (1) | RU2233334C2 (ko) |
| UA (1) | UA72436C2 (ko) |
| ZA (1) | ZA982152B (ko) |
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| DE69432901T2 (de) * | 1993-12-23 | 2004-05-27 | Merck & Co., Inc. | Expressionssystem von antikörpern bei homologischer rekombinierung in murinezellen |
| US5830698A (en) * | 1997-03-14 | 1998-11-03 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
| PL191251B1 (pl) * | 1997-03-14 | 2006-04-28 | Idec Pharma Corp | Sposób wprowadzania żądanego DNA w docelowe miejsce w genomie ssaka i układ wektorów |
| US20040009166A1 (en) * | 1997-04-30 | 2004-01-15 | Filpula David R. | Single chain antigen-binding polypeptides for polymer conjugation |
| EP0979102A4 (en) | 1997-04-30 | 2005-11-23 | Enzon Inc | DETAILED POLYPEPTIDE MODIFIED BY POLYALKYLENE OXIDE |
| US7316923B1 (en) | 1997-09-26 | 2008-01-08 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
| US6897066B1 (en) | 1997-09-26 | 2005-05-24 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
| WO2000011155A1 (en) * | 1998-08-19 | 2000-03-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for genomic modification |
| EP0998945A1 (en) * | 1998-09-30 | 2000-05-10 | Transgene S.A. | Use of magnesium (Mg2+) for the enhancement of gene delivery in gene therapy |
| US6333396B1 (en) | 1998-10-20 | 2001-12-25 | Enzon, Inc. | Method for targeted delivery of nucleic acids |
| US20070065838A1 (en) * | 1999-01-19 | 2007-03-22 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US6897044B1 (en) | 1999-01-28 | 2005-05-24 | Biogen Idec, Inc. | Production of tetravalent antibodies |
| US6890726B1 (en) | 1999-04-06 | 2005-05-10 | Oklahoma Medical Research Foundation | Method for selecting recombinase variants with altered specificity |
| WO2001035735A1 (en) * | 1999-11-19 | 2001-05-25 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
| US7820878B2 (en) * | 1999-11-19 | 2010-10-26 | Kyowa Hakko Kirin Co., Ltd. | Production of ungulates, preferably bovines that produce human immunoglobulins |
| US7414170B2 (en) * | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
| US7074983B2 (en) * | 1999-11-19 | 2006-07-11 | Kirin Beer Kabushiki Kaisha | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
| AU2001284703B2 (en) * | 2000-08-03 | 2007-03-22 | Therapeutic Human Polyclonals Inc. | Production of humanized antibodies in transgenic animals |
| EP1356035B1 (en) | 2000-12-22 | 2011-03-16 | Kyowa Hakko Kirin Co., Ltd. | Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells |
| US20020142397A1 (en) * | 2000-12-22 | 2002-10-03 | Philippe Collas | Methods for altering cell fate |
| US7491534B2 (en) | 2000-12-22 | 2009-02-17 | Kirin Holdings Kabushiki Kaisha | Methods for altering cell fate to generate T-cells specific for an antigen of interest |
| ZA200508985B (en) * | 2001-07-10 | 2006-07-26 | Biogen Idec Inc | Inhibition of apotosis process and improvement of cell performance |
| CA2467363A1 (en) | 2001-11-16 | 2003-06-12 | Idec Pharmaceuticals Corporation | Polycistronic expression of antibodies |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| CA2965865C (en) * | 2002-07-18 | 2021-10-19 | Merus N.V. | Recombinant production of mixtures of antibodies |
| WO2007116408A2 (en) * | 2006-04-11 | 2007-10-18 | Nanodiagnostics Israel Ltd. | Pluripotent stem cells characterized by expression of germline specific genes |
| AU2003247135A1 (en) * | 2002-07-23 | 2004-02-09 | Nanodiagnostics, Inc. | Embryonic stem cell markers and uses thereof |
| AU2003290689A1 (en) | 2002-11-08 | 2004-06-03 | Kyowa Hakko Kirin Co., Ltd. | Transgenic ungulates having reduced prion protein activity and uses thereof |
| EP2266628A3 (en) | 2003-05-13 | 2012-01-18 | Novartis Vaccines and Diagnostics, Inc. | Method of determining the susceptibility to bone meatastases by EPhA2 expression |
| US7335496B2 (en) * | 2003-06-05 | 2008-02-26 | Ajinomoto Co., Inc. | Method for producing target substance |
| US20070098718A1 (en) | 2003-11-04 | 2007-05-03 | Chiron | Methods of therapy for b cell-related cancers |
| DE602004028643D1 (de) | 2003-11-04 | 2010-09-23 | Novartis Vaccines & Diagnostic | Verfahren zur behandlung von soliden tumoren mit expression des cd40-zelloberflächen-antigens |
| AU2004287480B2 (en) | 2003-11-04 | 2011-09-15 | Novartis Vaccines And Diagnostics, Inc. | Use of antagonist anti-CD40 antibodies for treatment of chronic lymphocytic leukemia |
| WO2005044854A2 (en) | 2003-11-04 | 2005-05-19 | Chiron Corporation | Antagonist anti-cd40 monoclonal antibodies and methods for their use |
| WO2005044855A2 (en) | 2003-11-04 | 2005-05-19 | Chiron Corporation | Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| WO1993024642A1 (en) * | 1992-06-04 | 1993-12-09 | Exemplar Corporation | Insertion of heterologous dna outside of known chromosomal genes |
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| US5648267A (en) * | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
| US5830698A (en) * | 1997-03-14 | 1998-11-03 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
| PL191251B1 (pl) * | 1997-03-14 | 2006-04-28 | Idec Pharma Corp | Sposób wprowadzania żądanego DNA w docelowe miejsce w genomie ssaka i układ wektorów |
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1998
- 1998-02-13 US US09/023,715 patent/US5998144A/en not_active Expired - Fee Related
- 1998-03-09 KR KR1019997008366A patent/KR100571105B1/ko not_active IP Right Cessation
- 1998-03-09 EP EP05075757A patent/EP1605054A1/en not_active Withdrawn
- 1998-03-09 RU RU99121660/13A patent/RU2233334C2/ru not_active IP Right Cessation
- 1998-03-09 EP EP05076212A patent/EP1605055A1/en not_active Withdrawn
- 1998-03-09 NZ NZ337676A patent/NZ337676A/xx unknown
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- 1998-03-14 MY MYPI98001130A patent/MY137837A/en unknown
- 1998-09-03 UA UA99095073A patent/UA72436C2/uk unknown
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2000
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| MY137837A (en) | 2009-03-31 |
| KR100571105B1 (ko) | 2006-04-14 |
| ZA982152B (en) | 1998-10-09 |
| RU2233334C2 (ru) | 2004-07-27 |
| KR20000076270A (ko) | 2000-12-26 |
| US20090047668A1 (en) | 2009-02-19 |
| EP1605054A1 (en) | 2005-12-14 |
| HK1026000A1 (en) | 2000-12-01 |
| EP1605055A1 (en) | 2005-12-14 |
| US5998144A (en) | 1999-12-07 |
| US5830698A (en) | 1998-11-03 |
| NZ337676A (en) | 2001-01-26 |
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