UA68350C2 - Dosage forms of encapsulated sertraline - Google Patents
Dosage forms of encapsulated sertraline Download PDFInfo
- Publication number
- UA68350C2 UA68350C2 UA99116393A UA99116393A UA68350C2 UA 68350 C2 UA68350 C2 UA 68350C2 UA 99116393 A UA99116393 A UA 99116393A UA 99116393 A UA99116393 A UA 99116393A UA 68350 C2 UA68350 C2 UA 68350C2
- Authority
- UA
- Ukraine
- Prior art keywords
- sertraline
- dosage form
- form according
- mga
- solution
- Prior art date
Links
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 title claims abstract description 214
- 229960002073 sertraline Drugs 0.000 title claims abstract description 212
- 239000002552 dosage form Substances 0.000 title claims abstract description 62
- 238000001556 precipitation Methods 0.000 claims abstract description 22
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims abstract description 21
- 239000002904 solvent Substances 0.000 claims description 61
- 150000003839 salts Chemical class 0.000 claims description 21
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 18
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 18
- 229940068968 polysorbate 80 Drugs 0.000 claims description 18
- 229920000053 polysorbate 80 Polymers 0.000 claims description 18
- 235000019486 Sunflower oil Nutrition 0.000 claims description 16
- 239000002600 sunflower oil Substances 0.000 claims description 16
- 150000003626 triacylglycerols Chemical class 0.000 claims description 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 9
- 239000004006 olive oil Substances 0.000 claims description 8
- 235000008390 olive oil Nutrition 0.000 claims description 8
- 238000011282 treatment Methods 0.000 claims description 8
- 239000004094 surface-active agent Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 235000005687 corn oil Nutrition 0.000 claims description 6
- 239000002285 corn oil Substances 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- 150000004665 fatty acids Chemical class 0.000 claims description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 6
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 5
- 239000008159 sesame oil Substances 0.000 claims description 5
- 235000011803 sesame oil Nutrition 0.000 claims description 5
- 230000009471 action Effects 0.000 claims description 4
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- 244000000231 Sesamum indicum Species 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 3
- 125000002252 acyl group Chemical group 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- -1 propylene glycol ethers Chemical class 0.000 claims description 3
- 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
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- 239000003240 coconut oil Substances 0.000 claims description 2
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- 235000012343 cottonseed oil Nutrition 0.000 claims description 2
- 239000002385 cottonseed oil Substances 0.000 claims description 2
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 2
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 235000020778 linoleic acid Nutrition 0.000 claims description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N linoleic acid group Chemical group C(CCCCCCC\C=C/C\C=C/CCCCC)(=O)O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 244000105624 Arachis hypogaea Species 0.000 claims 1
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- 235000019483 Peanut oil Nutrition 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 240000008042 Zea mays Species 0.000 claims 1
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid ester group Chemical group C(CCCCCCCCCCC)(=O)O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
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- 210000000813 small intestine Anatomy 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- GLQPTZAAUROJMO-UHFFFAOYSA-N 4-(3,4-dimethoxyphenyl)benzaldehyde Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC=C(C=O)C=C1 GLQPTZAAUROJMO-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 239000007853 buffer solution Substances 0.000 description 6
- 210000004013 groin Anatomy 0.000 description 6
- 239000010452 phosphate Substances 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 5
- 230000002183 duodenal effect Effects 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 239000007935 oral tablet Substances 0.000 description 5
- 239000008363 phosphate buffer Substances 0.000 description 5
- 229960003660 sertraline hydrochloride Drugs 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 4
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 4
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 4
- 239000005642 Oleic acid Substances 0.000 description 4
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 4
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- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 4
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- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
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- GHVNFZFCNZKVNT-UHFFFAOYSA-M decanoate Chemical compound CCCCCCCCCC([O-])=O GHVNFZFCNZKVNT-UHFFFAOYSA-M 0.000 description 3
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
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- OVYMWJFNQQOJBU-UHFFFAOYSA-N 1-octanoyloxypropan-2-yl octanoate Chemical compound CCCCCCCC(=O)OCC(C)OC(=O)CCCCCCC OVYMWJFNQQOJBU-UHFFFAOYSA-N 0.000 description 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 2
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- 229940037959 monooctanoin Drugs 0.000 description 1
- 229940074096 monoolein Drugs 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 208000019906 panic disease Diseases 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 208000028173 post-traumatic stress disease Diseases 0.000 description 1
- 238000000079 presaturation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 210000003384 transverse colon Anatomy 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 229940117972 triolein Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000003799 water insoluble solvent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5140197P | 1997-07-01 | 1997-07-01 | |
| PCT/IB1998/000936 WO1999001113A1 (en) | 1997-07-01 | 1998-06-16 | Gelatine encapsulated solution dosage forms of sertraline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA68350C2 true UA68350C2 (en) | 2004-08-16 |
Family
ID=21971076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA99116393A UA68350C2 (en) | 1997-07-01 | 1998-06-16 | Dosage forms of encapsulated sertraline |
Country Status (40)
| Country | Link |
|---|---|
| EP (1) | EP0980241B1 (zh) |
| JP (1) | JP3585245B2 (zh) |
| KR (1) | KR100371730B1 (zh) |
| CN (1) | CN1261792A (zh) |
| AP (1) | AP945A (zh) |
| AR (1) | AR015916A1 (zh) |
| AT (1) | ATE256457T1 (zh) |
| AU (1) | AU724635B2 (zh) |
| BG (1) | BG103917A (zh) |
| BR (1) | BR9809712A (zh) |
| CA (1) | CA2290973C (zh) |
| CO (1) | CO4940405A1 (zh) |
| DE (1) | DE69820608T2 (zh) |
| DK (1) | DK0980241T3 (zh) |
| DZ (1) | DZ2544A1 (zh) |
| EA (1) | EA001905B1 (zh) |
| ES (1) | ES2210760T3 (zh) |
| GT (1) | GT199800090A (zh) |
| HR (1) | HRP980378B1 (zh) |
| HU (1) | HUP0002250A3 (zh) |
| ID (1) | ID24673A (zh) |
| IL (1) | IL133075A0 (zh) |
| IS (1) | IS5266A (zh) |
| MA (1) | MA24586A1 (zh) |
| MY (1) | MY119728A (zh) |
| NO (1) | NO996492L (zh) |
| NZ (1) | NZ501252A (zh) |
| OA (1) | OA11246A (zh) |
| PA (1) | PA8454001A1 (zh) |
| PE (1) | PE97299A1 (zh) |
| PL (1) | PL337807A1 (zh) |
| PT (1) | PT980241E (zh) |
| SK (1) | SK282914B6 (zh) |
| TN (1) | TNSN98123A1 (zh) |
| TR (1) | TR199903282T2 (zh) |
| TW (1) | TW382597B (zh) |
| UA (1) | UA68350C2 (zh) |
| UY (1) | UY25070A1 (zh) |
| WO (1) | WO1999001113A1 (zh) |
| ZA (1) | ZA985709B (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL348119A1 (en) * | 1998-10-13 | 2002-05-06 | Pfizer Prod Inc | Sertraline oral concentrate |
| US6727283B2 (en) | 1998-10-13 | 2004-04-27 | Pfizer Inc. | Sertraline oral concentrate |
| EP1889614A3 (en) | 1999-09-03 | 2010-09-22 | APBI Holdings, LLC | Methods of using rapid-onset selective serotonin reuptake inhibitors for treating sexual dysfunction |
| AU2001276608A1 (en) | 2000-08-30 | 2002-03-13 | Pfizer Products Inc. | Sustained release formulations for growth hormone secretagogues |
| EP1375659A1 (en) * | 2002-06-18 | 2004-01-02 | Laboratorio di Diagnostica Moleculare | Soluble capsules containing stock mixtures for easy preparation of chemical or biological solutions |
| CN1728982A (zh) * | 2002-10-31 | 2006-02-01 | 阿尔扎公司 | 可增加疏水性药物生物利用度的药物制剂 |
| WO2016020936A2 (en) * | 2014-07-21 | 2016-02-11 | Patel Jayendrakumar Dasharathlal | A novel oral gastroretentive pharmaceutical dosage form |
| CN108014087A (zh) * | 2017-12-27 | 2018-05-11 | 江苏联环药业股份有限公司 | 一种盐酸舍曲林胶囊的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE214276T1 (de) * | 1994-09-19 | 2002-03-15 | Du Pont Pharm Co | Zusammensetzungen von opioid antagonisten mit selektiven serotonin-aufnahme inhibitoren, zur behandlung von alkoholismus und alkohoabhängigkeit |
| PT768083E (pt) * | 1995-07-17 | 2003-08-29 | Pfizer | Sertralina para o tratamento de doentes pos-enfarte miocardico |
-
1998
- 1998-06-16 KR KR10-1999-7011596A patent/KR100371730B1/ko not_active IP Right Cessation
- 1998-06-16 DK DK98923021T patent/DK0980241T3/da active
- 1998-06-16 CA CA002290973A patent/CA2290973C/en not_active Expired - Fee Related
- 1998-06-16 ID IDW991697A patent/ID24673A/id unknown
- 1998-06-16 BR BR9809712-1A patent/BR9809712A/pt not_active Application Discontinuation
- 1998-06-16 UA UA99116393A patent/UA68350C2/uk unknown
- 1998-06-16 IL IL13307598A patent/IL133075A0/xx unknown
- 1998-06-16 HU HU0002250A patent/HUP0002250A3/hu unknown
- 1998-06-16 WO PCT/IB1998/000936 patent/WO1999001113A1/en not_active Application Discontinuation
- 1998-06-16 AU AU75450/98A patent/AU724635B2/en not_active Ceased
- 1998-06-16 PT PT98923021T patent/PT980241E/pt unknown
- 1998-06-16 PL PL98337807A patent/PL337807A1/xx unknown
- 1998-06-16 EP EP98923021A patent/EP0980241B1/en not_active Expired - Lifetime
- 1998-06-16 JP JP50677699A patent/JP3585245B2/ja not_active Expired - Fee Related
- 1998-06-16 EA EA199900963A patent/EA001905B1/ru not_active IP Right Cessation
- 1998-06-16 DE DE69820608T patent/DE69820608T2/de not_active Expired - Fee Related
- 1998-06-16 TR TR1999/03282T patent/TR199903282T2/xx unknown
- 1998-06-16 SK SK1805-99A patent/SK282914B6/sk unknown
- 1998-06-16 AT AT98923021T patent/ATE256457T1/de not_active IP Right Cessation
- 1998-06-16 CN CN98806765A patent/CN1261792A/zh active Pending
- 1998-06-16 ES ES98923021T patent/ES2210760T3/es not_active Expired - Lifetime
- 1998-06-16 NZ NZ501252A patent/NZ501252A/en unknown
- 1998-06-19 PA PA19988454001A patent/PA8454001A1/es unknown
- 1998-06-25 AP APAP/P/1998/001279A patent/AP945A/en active
- 1998-06-25 TW TW087110254A patent/TW382597B/zh not_active IP Right Cessation
- 1998-06-26 PE PE1998000575A patent/PE97299A1/es not_active Application Discontinuation
- 1998-06-29 AR ARP980103145A patent/AR015916A1/es not_active Application Discontinuation
- 1998-06-29 UY UY25070A patent/UY25070A1/es not_active IP Right Cessation
- 1998-06-29 GT GT199800090A patent/GT199800090A/es unknown
- 1998-06-29 MY MYPI98002949A patent/MY119728A/en unknown
- 1998-06-30 DZ DZ980154A patent/DZ2544A1/xx active
- 1998-06-30 TN TNTNSN98123A patent/TNSN98123A1/fr unknown
- 1998-06-30 ZA ZA9805709A patent/ZA985709B/xx unknown
- 1998-06-30 MA MA25145A patent/MA24586A1/fr unknown
- 1998-07-01 CO CO98037136A patent/CO4940405A1/es unknown
- 1998-07-01 HR HR980378A patent/HRP980378B1/xx not_active IP Right Cessation
-
1999
- 1999-11-23 BG BG103917A patent/BG103917A/bg unknown
- 1999-11-23 IS IS5266A patent/IS5266A/is unknown
- 1999-12-23 OA OA9900306A patent/OA11246A/en unknown
- 1999-12-27 NO NO996492A patent/NO996492L/no not_active Application Discontinuation
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