UA66867C2 - 19-норстероїди, галогеновані в положенні 17, спосіб їх отримання, фармацевтична композиція та лікарський засіб, проміжні продукти - Google Patents

19-норстероїди, галогеновані в положенні 17, спосіб їх отримання, фармацевтична композиція та лікарський засіб, проміжні продукти

Info

Publication number
UA66867C2
UA66867C2 UA2001010468A UA01010468A UA66867C2 UA 66867 C2 UA66867 C2 UA 66867C2 UA 2001010468 A UA2001010468 A UA 2001010468A UA 01010468 A UA01010468 A UA 01010468A UA 66867 C2 UA66867 C2 UA 66867C2
Authority
UA
Ukraine
Prior art keywords
norsteroids
halogenated
medicament
preparation
pharmaceutical composition
Prior art date
Application number
UA2001010468A
Other languages
English (en)
Russian (ru)
Inventor
Йасміна Буалі
Жак Може
Франсуа НІК
Де Вельд Патрік Ван
Original Assignee
Хехст Маріон Руссель
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст Маріон Руссель filed Critical Хехст Маріон Руссель
Publication of UA66867C2 publication Critical patent/UA66867C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Предметом винаходу є сполуки загальної формули (I), в якій, зокрема, Х = галоген, Y = простий зв'язок, О, NH, S, SO або SO2; Z = водень або галоген; n, R1, R2, R3 і R4 такі, як визначені в описі, спосіб їх отримання і проміжні продукти, їх застосування як ліків і фармацевтичні композиції, що їх містять.
UA2001010468A 1998-06-23 1999-06-22 19-норстероїди, галогеновані в положенні 17, спосіб їх отримання, фармацевтична композиція та лікарський засіб, проміжні продукти UA66867C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9807898A FR2780060B1 (fr) 1998-06-23 1998-06-23 Nouveaux 19-nor steroides 17-halogenes, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant
PCT/FR1999/001491 WO1999067274A1 (fr) 1998-06-23 1999-06-22 Nouveaux 19-nor steroides 17-halogenes, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
UA66867C2 true UA66867C2 (uk) 2004-06-15

Family

ID=9527717

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2001010468A UA66867C2 (uk) 1998-06-23 1999-06-22 19-норстероїди, галогеновані в положенні 17, спосіб їх отримання, фармацевтична композиція та лікарський засіб, проміжні продукти

Country Status (37)

Country Link
US (2) US6423700B1 (uk)
EP (1) EP1090027B1 (uk)
JP (1) JP4509380B2 (uk)
KR (1) KR20010034919A (uk)
CN (1) CN1313862A (uk)
AP (1) AP1579A (uk)
AR (1) AR018916A1 (uk)
AT (1) ATE237628T1 (uk)
AU (1) AU771369B2 (uk)
BR (1) BR9912206A (uk)
CA (1) CA2336167A1 (uk)
CZ (1) CZ296246B6 (uk)
DE (1) DE69906972T2 (uk)
DK (1) DK1090027T3 (uk)
DZ (1) DZ2827A1 (uk)
EA (1) EA003325B1 (uk)
ES (1) ES2196879T3 (uk)
FR (1) FR2780060B1 (uk)
HK (1) HK1039945A1 (uk)
HR (1) HRP20000893A2 (uk)
HU (1) HUP0103194A3 (uk)
ID (1) ID27410A (uk)
IL (1) IL140416A (uk)
MA (1) MA26656A1 (uk)
MY (1) MY118101A (uk)
NO (1) NO318381B1 (uk)
NZ (1) NZ508535A (uk)
PL (1) PL345073A1 (uk)
PT (1) PT1090027E (uk)
SK (1) SK19492000A3 (uk)
TN (1) TNSN99130A1 (uk)
TR (1) TR200003857T2 (uk)
TW (1) TW550077B (uk)
UA (1) UA66867C2 (uk)
WO (1) WO1999067274A1 (uk)
YU (1) YU80700A (uk)
ZA (1) ZA200007355B (uk)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3922104B2 (ja) * 2002-06-07 2007-05-30 富士通株式会社 ポイント管理装置、ポイント管理システム、ポイント管理方法、およびポイント管理プログラム
FR2854402B1 (fr) * 2003-04-29 2008-07-04 Aventis Pharma Sa Nouveau procede et intermediaires de preparation de composes 19-nor-steroides
FR2854403B1 (fr) 2003-04-29 2008-07-11 Aventis Pharma Sa Nouveau procede et intermediaires de preparation de composes 19-nor-steroides 17-halogenes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3079408A (en) * 1963-02-26 Ig-bisoxygenated iy-haloestra-
US3264327A (en) * 1962-07-27 1966-08-02 Syntex Corp 17alpha-fluoro-, 17beta-chlorofluoroacetoxy- and 17beta-methyl-delta4-and delta5-androstene derivatives
US3413321A (en) * 1966-06-03 1968-11-26 Du Pont Selected 17-fluoro-delta16 steroids
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
FR2640977A2 (en) * 1982-06-11 1990-06-29 Roussel Uclaf New position-11 substituted 19-norsteroids and their application as medicinal products.
FR2685332A1 (fr) * 1991-12-20 1993-06-25 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.
FR2757519B1 (fr) * 1996-12-23 1999-06-11 Hoechst Marion Roussel Inc Steroides substitues en position 11, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant
FR2761992B1 (fr) * 1997-04-09 1999-06-11 Hoechst Marion Roussel Inc Nouveaux steroides 4-halogenes, leur procede et intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2771096B1 (fr) * 1997-11-17 2000-08-11 Hoechst Marion Roussel Inc Nouveaux 19-nor steroides, substitues en position 11beta, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
US6566542B2 (en) 2003-05-20
ID27410A (id) 2001-04-05
PT1090027E (pt) 2003-09-30
HUP0103194A3 (en) 2002-09-30
CN1313862A (zh) 2001-09-19
SK19492000A3 (sk) 2001-09-11
MY118101A (en) 2004-08-30
AP1579A (en) 2006-02-22
BR9912206A (pt) 2001-04-10
US20030022874A1 (en) 2003-01-30
YU80700A (sh) 2003-10-31
FR2780060B1 (fr) 2000-08-04
AR018916A1 (es) 2001-12-12
DE69906972T2 (de) 2004-02-05
CZ20004834A3 (en) 2001-06-13
NO318381B1 (no) 2005-03-14
NO20006573L (no) 2001-02-22
PL345073A1 (en) 2001-12-03
WO1999067274A1 (fr) 1999-12-29
JP4509380B2 (ja) 2010-07-21
AU771369B2 (en) 2004-03-18
IL140416A (en) 2005-07-25
MA26656A1 (fr) 2004-12-20
DK1090027T3 (da) 2003-08-04
EP1090027A1 (fr) 2001-04-11
DE69906972D1 (de) 2003-05-22
HRP20000893A2 (en) 2001-10-31
HUP0103194A2 (hu) 2002-01-28
KR20010034919A (ko) 2001-04-25
AU4270599A (en) 2000-01-10
ES2196879T3 (es) 2003-12-16
HK1039945A1 (zh) 2002-05-17
TR200003857T2 (tr) 2001-06-21
ZA200007355B (en) 2001-12-11
JP2002518516A (ja) 2002-06-25
EA200100069A1 (ru) 2001-06-25
IL140416A0 (en) 2002-02-10
ATE237628T1 (de) 2003-05-15
TW550077B (en) 2003-09-01
DZ2827A1 (fr) 2003-12-01
AP2000002007A0 (en) 2000-12-31
FR2780060A1 (fr) 1999-12-24
NO20006573D0 (no) 2000-12-21
NZ508535A (en) 2002-08-28
CA2336167A1 (fr) 1999-12-29
TNSN99130A1 (fr) 2005-11-10
EP1090027B1 (fr) 2003-04-16
EA003325B1 (ru) 2003-04-24
CZ296246B6 (cs) 2006-02-15
US6423700B1 (en) 2002-07-23

Similar Documents

Publication Publication Date Title
GB9104890D0 (en) Compositions
GEP20074208B (en) Substituted amides active at the cannabinoid-1 receptor
MY130157A (en) Method of use for inhibiting bone loss and lowering serum cholesterol
CA2392973A1 (en) Benzoimidazole derivatives useful as antiproliferative agents
GEP20043324B (en) Purine Derivatives
MY127126A (en) Imidazolo-5-yl-2-anilino-pyrimidines as agents for the inhibition of the cell proliferation
CA2183972A1 (en) Oxazolidinone derivatives and pharmaceutical compositions containing them
AU2003225617A1 (en) Thiadiazolylpiperazine derivatives useful for treating or preventing pain
RU94044436A (ru) Способы подавления атрофии кожи и влагалища
GEP20022654B (en) Indazole Amide Compounds As Serotoninergic Agents
AU3850600A (en) Dalda analogs and their use
TW327601B (en) Compositions for use in inhibiting uterine fibrosis
HU229443B1 (en) Betha-carboline particulate form, pharmaceutical compositions containing it, their preparations and their use
GB0109122D0 (en) Novel compounds
IL101358A0 (en) Crystalline tiagabine hydrochloride monohydrate,its preparation and pharmaceutical compositions containing it
HK1045464A1 (en) Use of sulfodehydroabietic acid for the treatment of inflammatory bowel disease
HUT50334A (en) Process for producing arylpiperazinyl-alkilenephenyl-p-heterocycluc compounds, pharmaceutically acceptable acid addition salts thereof and pharmaceutical compositions comprising the compounds as active ingredient
HUT70531A (en) Arylmorpholine derivatives, pharmaceutical compositions containing them as active agent and process for preparing them
UA66867C2 (uk) 19-норстероїди, галогеновані в положенні 17, спосіб їх отримання, фармацевтична композиція та лікарський засіб, проміжні продукти
WO2000066550A8 (en) New compounds
CA2382654A1 (en) Novel a-500359 derivatives
HUP0200412A2 (en) New morpholinobenzamide salts, process for their preparation and pharmaceutical compositions containing them and their use
ZA935045B (en) Pharmacologically active alfa-(tertiary-aminomethyl)-ben-zenemethanol derivatives
HUP0001712A3 (en) 2,3-methano-amino acid derivatives, a process for their preparation and pharmaceutical compositions containing them
HUT61017A (en) Process for producing 4-/3-(4-oxothiazolidinyl)/-butinylamine derivatives and pharmaceutical compositions comprising same as active ingredient