UA48150C2 - Производные аминокислот или аминоспиртов, олигонуклеотид - Google Patents
Производные аминокислот или аминоспиртов, олигонуклеотид Download PDFInfo
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- UA48150C2 UA48150C2 UA97041995A UA97041995A UA48150C2 UA 48150 C2 UA48150 C2 UA 48150C2 UA 97041995 A UA97041995 A UA 97041995A UA 97041995 A UA97041995 A UA 97041995A UA 48150 C2 UA48150 C2 UA 48150C2
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- oligomers
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- 150000002739 metals Chemical class 0.000 description 1
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- IZAGSTRIDUNNOY-UHFFFAOYSA-N methyl 2-[(2,4-dioxo-1h-pyrimidin-5-yl)oxy]acetate Chemical compound COC(=O)COC1=CNC(=O)NC1=O IZAGSTRIDUNNOY-UHFFFAOYSA-N 0.000 description 1
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- 238000002156 mixing Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- NTYICSDTCGMBQM-UHFFFAOYSA-N n,n-bis(2-methylpropyl)formamide Chemical compound CC(C)CN(C=O)CC(C)C NTYICSDTCGMBQM-UHFFFAOYSA-N 0.000 description 1
- PVLBXGOAMWLNFQ-UHFFFAOYSA-N n,n-bis(2-methylpropyl)methanimidamide Chemical compound CC(C)CN(C=N)CC(C)C PVLBXGOAMWLNFQ-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
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- 108700020942 nucleic acid binding protein Proteins 0.000 description 1
- HYDZPXNVHXJHBG-UHFFFAOYSA-N o-benzylhydroxylamine;hydron;chloride Chemical compound Cl.NOCC1=CC=CC=C1 HYDZPXNVHXJHBG-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
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- 239000011886 peripheral blood Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
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- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
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- 230000000717 retained effect Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 108010066481 ribonuclease F Proteins 0.000 description 1
- 239000002342 ribonucleoside Substances 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
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- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229910000679 solder Inorganic materials 0.000 description 1
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- 229940063675 spermine Drugs 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 102000055501 telomere Human genes 0.000 description 1
- 108091035539 telomere Proteins 0.000 description 1
- 210000003411 telomere Anatomy 0.000 description 1
- 238000011191 terminal modification Methods 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000037 tert-butyldiphenylsilyl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1[Si]([H])([*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
- 238000002076 thermal analysis method Methods 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 239000005450 thionucleoside Substances 0.000 description 1
- ZEMGGZBWXRYJHK-UHFFFAOYSA-N thiouracil Chemical compound O=C1C=CNC(=S)N1 ZEMGGZBWXRYJHK-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
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- 210000005253 yeast cell Anatomy 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
Настоящим изобретением предложены различные новые аналоги олигонуклеотидов, обладающие одним или несколькими свойствами, дающими им преимущества перед олигонуклеотидами, традиционно используемыми в процессах, где требуются олигонуклеотиды. Соединения, предложенные настоящим изобретением, - это аналоги олигонуклеотидов, в которых фуранозное кольцо, присутствующее в природной нуклеиновой кислоте, замещено аминокислотой или модифицированным аминоспиртовым остатком. Некоторые из этих новых веществ, предложенных настоящим изобретением, особенно полезны для антисмыслового управления экспрессией генов. Соединения, соответствующие настоящему изобретению, могут быть использованы как гибридизационные зонды или затравки.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33389594A | 1994-11-02 | 1994-11-02 | |
| PCT/US1995/014599 WO1996014330A1 (en) | 1994-11-02 | 1995-11-02 | Amino acid nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA48150C2 true UA48150C2 (ru) | 2002-08-15 |
Family
ID=23304698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA97041995A UA48150C2 (ru) | 1994-11-02 | 1995-02-11 | Производные аминокислот или аминоспиртов, олигонуклеотид |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0789707A4 (ru) |
| JP (1) | JPH10508312A (ru) |
| KR (1) | KR100393336B1 (ru) |
| CN (1) | CN1171112A (ru) |
| AU (1) | AU693622B2 (ru) |
| CA (1) | CA2202274A1 (ru) |
| HU (1) | HU218086B (ru) |
| MX (1) | MX9703188A (ru) |
| PL (1) | PL185852B1 (ru) |
| RU (1) | RU2154638C2 (ru) |
| SI (1) | SI9520112A (ru) |
| UA (1) | UA48150C2 (ru) |
| WO (1) | WO1996014330A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840879A (en) * | 1996-12-06 | 1998-11-24 | Wang; Edge R. | Reagents and solid supports for improved synthesis and labeling of polynucleotides |
| JP4594588B2 (ja) * | 2001-04-10 | 2010-12-08 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニヴァーシティ | 抗体特異的プロファイルの治療的および診断的使用方法 |
| WO2009064471A1 (en) * | 2007-11-15 | 2009-05-22 | Avi Biopharma, Inc. | Method of synthesis of morpholino oligomers |
| JP5199519B2 (ja) | 2010-11-30 | 2013-05-15 | 独立行政法人科学技術振興機構 | ヌクレオシド類縁体又はその塩、オリゴヌクレオチド類縁体、遺伝子発現抑制剤、及び遺伝子検出用核酸プローブ |
| RU2460721C1 (ru) * | 2011-02-25 | 2012-09-10 | Учреждение Российской академии наук Институт химической биологии и фундаментальной медицины Сибирского отделения РАН (ИХБФМ СО РАН) | Способ получения амидофосфитного мономера ахиральной ненуклеотидной вставки для модификации олигонуклеотидов |
| DE102014007158A1 (de) * | 2014-05-16 | 2015-11-19 | Ugichem Gmbh | Neue Peptid-Nukleinsäuren-Monomere und -Oligomere |
| EP3643706B1 (en) * | 2017-06-16 | 2023-11-15 | Eisai R&D Management Co., Ltd. | Modified nucleic acid monomers and oligonucleic acid analogues, with high biological stability and target gene silencing activity, for use in therapy and diagnosis of cancer and viral diseases |
| CN113956183B (zh) * | 2021-10-28 | 2023-06-20 | 成都市科隆化学品有限公司 | 一种Boc-Ser(Bzl)-OH及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0215942B1 (en) * | 1985-03-15 | 1995-07-12 | Antivirals Inc. | Polynucleotide assay reagent and method |
| DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
-
1995
- 1995-02-11 UA UA97041995A patent/UA48150C2/ru unknown
- 1995-11-02 KR KR1019970702925A patent/KR100393336B1/ko not_active IP Right Cessation
- 1995-11-02 WO PCT/US1995/014599 patent/WO1996014330A1/en not_active Application Discontinuation
- 1995-11-02 RU RU97108680/04A patent/RU2154638C2/ru not_active IP Right Cessation
- 1995-11-02 MX MX9703188A patent/MX9703188A/es not_active Application Discontinuation
- 1995-11-02 HU HU9702053A patent/HU218086B/hu not_active IP Right Cessation
- 1995-11-02 EP EP95940671A patent/EP0789707A4/en not_active Withdrawn
- 1995-11-02 SI SI9520112A patent/SI9520112A/sl unknown
- 1995-11-02 PL PL95320084A patent/PL185852B1/pl not_active IP Right Cessation
- 1995-11-02 CA CA002202274A patent/CA2202274A1/en not_active Abandoned
- 1995-11-02 AU AU42341/96A patent/AU693622B2/en not_active Ceased
- 1995-11-02 JP JP8515518A patent/JPH10508312A/ja active Pending
- 1995-11-02 CN CN95196989A patent/CN1171112A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0789707A4 (en) | 1999-02-24 |
| MX9703188A (es) | 1997-12-31 |
| RU2154638C2 (ru) | 2000-08-20 |
| JPH10508312A (ja) | 1998-08-18 |
| EP0789707A1 (en) | 1997-08-20 |
| KR970707144A (ko) | 1997-12-01 |
| KR100393336B1 (ko) | 2003-12-24 |
| PL320084A1 (en) | 1997-09-15 |
| CA2202274A1 (en) | 1996-05-17 |
| CN1171112A (zh) | 1998-01-21 |
| SI9520112A (sl) | 1998-08-31 |
| HUT77435A (hu) | 1998-04-28 |
| AU693622B2 (en) | 1998-07-02 |
| WO1996014330A1 (en) | 1996-05-17 |
| PL185852B1 (pl) | 2003-08-29 |
| AU4234196A (en) | 1996-05-31 |
| HU218086B (hu) | 2000-05-28 |
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