UA28103U - Комплексный противобактериальный сорбционный препарат сертасил с некролитическим действием для лечения гнойных ран, трофических язв и ожогов - Google Patents
Комплексный противобактериальный сорбционный препарат сертасил с некролитическим действием для лечения гнойных ран, трофических язв и ожогов Download PDFInfo
- Publication number
- UA28103U UA28103U UAU200707897U UAU200707897U UA28103U UA 28103 U UA28103 U UA 28103U UA U200707897 U UAU200707897 U UA U200707897U UA U200707897 U UAU200707897 U UA U200707897U UA 28103 U UA28103 U UA 28103U
- Authority
- UA
- Ukraine
- Prior art keywords
- wounds
- drug
- aerosil
- effect
- trophic ulcers
- Prior art date
Links
- 206010052428 Wound Diseases 0.000 title claims abstract description 27
- 208000027418 Wounds and injury Diseases 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 title claims abstract description 12
- 208000025865 Ulcer Diseases 0.000 title claims abstract description 9
- 231100000397 ulcer Toxicity 0.000 title claims abstract description 9
- 230000001228 trophic effect Effects 0.000 title claims abstract description 8
- 238000001179 sorption measurement Methods 0.000 title claims abstract description 5
- 230000003282 necrolytic effect Effects 0.000 title claims abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 title abstract description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229940079593 drug Drugs 0.000 claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 13
- 229910002012 Aerosil® Inorganic materials 0.000 claims abstract description 9
- 230000001338 necrotic effect Effects 0.000 claims abstract description 9
- 239000000377 silicon dioxide Substances 0.000 claims abstract 4
- 239000002594 sorbent Substances 0.000 claims abstract 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 230000000845 anti-microbial effect Effects 0.000 claims description 2
- 238000012876 topography Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 9
- 206010028851 Necrosis Diseases 0.000 description 5
- 230000017074 necrotic cell death Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229940000634 serratiopeptidase Drugs 0.000 description 4
- 108010038132 serratiopeptidase Proteins 0.000 description 4
- 229910021485 fumed silica Inorganic materials 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000013543 active substance Substances 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 230000000141 anti-hypoxic effect Effects 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
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- 230000002757 inflammatory effect Effects 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- XBCXJKGHPABGSD-UHFFFAOYSA-N methyluracil Natural products CN1C=CC(=O)NC1=O XBCXJKGHPABGSD-UHFFFAOYSA-N 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- OUFRIWNNMFWZTM-UHFFFAOYSA-M sodium arsanilate Chemical group [Na+].NC1=CC=C([As](O)([O-])=O)C=C1 OUFRIWNNMFWZTM-UHFFFAOYSA-M 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 238000011477 surgical intervention Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010006797 Burns first degree Diseases 0.000 description 1
- 206010006803 Burns third degree Diseases 0.000 description 1
- 206010061043 Clostridial infection Diseases 0.000 description 1
- 206010017711 Gangrene Diseases 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 206010062255 Soft tissue infection Diseases 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 210000003815 abdominal wall Anatomy 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004964 aerogel Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 230000003501 anti-edematous effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 description 1
- 229960004755 ceftriaxone Drugs 0.000 description 1
- 201000002816 chronic venous insufficiency Diseases 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229960001193 diclofenac sodium Drugs 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- -1 polymethylsiloxane Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000005067 remediation Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- FXSGDOZPBLGOIN-UHFFFAOYSA-N trihydroxy(methoxy)silane Chemical compound CO[Si](O)(O)O FXSGDOZPBLGOIN-UHFFFAOYSA-N 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 201000002282 venous insufficiency Diseases 0.000 description 1
Classifications
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
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- Health & Medical Sciences (AREA)
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Abstract
Комплексный противобактериальный сорбционный препарат с некролитическим действием для лечения гнойных ран, трофических язв и ожогов, инфильтратов с выраженным некротическим и экссудативным компонентами представляет собой кремнеземный сорбент с иммобилизованным на нем лекарственным средством. В качестве кремнеземного сорбент препарат содержит аэросил, а в качестве лекарственного средства – сератиопептидазу.
Priority Applications (27)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAU200707897U UA28103U (ru) | 2007-07-12 | 2007-07-12 | Комплексный противобактериальный сорбционный препарат сертасил с некролитическим действием для лечения гнойных ран, трофических язв и ожогов |
| PT08779534T PT2170415E (pt) | 2007-07-12 | 2008-07-11 | Composição antimicrobiana |
| PL08779534T PL2170415T3 (pl) | 2007-07-12 | 2008-07-11 | Kompozycja przeciwbakteryjna |
| AT08779534T ATE488255T1 (de) | 2007-07-12 | 2008-07-11 | Antimikrobielle zusammensetzung |
| EP08779534A EP2170415B1 (en) | 2007-07-12 | 2008-07-11 | Antimicrobial composition |
| EA201070130A EA016764B1 (ru) | 2007-07-12 | 2008-07-11 | Противомикробная композиция |
| PCT/UA2008/000041 WO2009008851A2 (en) | 2007-07-12 | 2008-07-11 | Antimicrobial composition |
| MX2010000367A MX2010000367A (es) | 2007-07-12 | 2008-07-11 | Composicion antimicrobiana. |
| BRPI0814549-0A BRPI0814549B1 (pt) | 2007-07-12 | 2008-07-11 | Composição antimicrobiana |
| SI200830123T SI2170415T1 (sl) | 2007-07-12 | 2008-07-11 | Antimikrobni sestavek |
| AU2008275852A AU2008275852B2 (en) | 2007-07-12 | 2008-07-11 | Antimicrobial composition |
| KR1020107003161A KR101482960B1 (ko) | 2007-07-12 | 2008-07-11 | 항균 조성물 |
| CA2693087A CA2693087C (en) | 2007-07-12 | 2008-07-11 | Antimicrobial composition |
| CN200880024342XA CN101772356B (zh) | 2007-07-12 | 2008-07-11 | 抗菌组合物 |
| JP2010516012A JP5464750B2 (ja) | 2007-07-12 | 2008-07-11 | 抗菌性組成物 |
| US12/668,827 US9302027B2 (en) | 2007-07-12 | 2008-07-11 | Antimicrobial composition comprising pyrogenic silica and serratiopeptidase |
| DE602008003584T DE602008003584D1 (de) | 2007-07-12 | 2008-07-11 | Antimikrobielle zusammensetzung |
| DK08779534.0T DK2170415T3 (da) | 2007-07-12 | 2008-07-11 | Antimikrobielt præparat |
| EP10191280A EP2277559A1 (en) | 2007-07-12 | 2008-07-11 | Antimicrobial composition |
| MYPI2010000038A MY148077A (en) | 2007-07-12 | 2008-07-11 | Antimicrobial composition |
| ES08779534T ES2353683T3 (es) | 2007-07-12 | 2008-07-11 | Composición antimicrobiana. |
| ZA2010/00126A ZA201000126B (en) | 2007-07-12 | 2010-01-07 | Antimicrobial composition |
| CY20111100153T CY1111652T1 (el) | 2007-07-12 | 2011-02-09 | Αντιμικροβiακη συνθεση |
| HR20110107T HRP20110107T1 (hr) | 2007-07-12 | 2011-02-15 | Antimikrobni sastav |
| US14/753,641 US9757436B2 (en) | 2007-07-12 | 2015-06-29 | Antimicrobial composition comprising pyrogenic silica and serrathiopeptidase and uses thereof |
| US15/086,724 US20160206709A1 (en) | 2007-07-12 | 2016-03-31 | Antimicrobial composition comprising pyrogenic silica and serrathopeptidase and uses thereof |
| US15/681,407 US10166275B2 (en) | 2007-07-12 | 2017-08-20 | Antimicrobial composition comprising pyrogenic silica and serrathiopeptidase and uses thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAU200707897U UA28103U (ru) | 2007-07-12 | 2007-07-12 | Комплексный противобактериальный сорбционный препарат сертасил с некролитическим действием для лечения гнойных ран, трофических язв и ожогов |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA28103U true UA28103U (ru) | 2007-11-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAU200707897U UA28103U (ru) | 2007-07-12 | 2007-07-12 | Комплексный противобактериальный сорбционный препарат сертасил с некролитическим действием для лечения гнойных ран, трофических язв и ожогов |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US9302027B2 (ru) |
| EP (2) | EP2277559A1 (ru) |
| JP (1) | JP5464750B2 (ru) |
| KR (1) | KR101482960B1 (ru) |
| CN (1) | CN101772356B (ru) |
| AT (1) | ATE488255T1 (ru) |
| AU (1) | AU2008275852B2 (ru) |
| BR (1) | BRPI0814549B1 (ru) |
| CA (1) | CA2693087C (ru) |
| CY (1) | CY1111652T1 (ru) |
| DE (1) | DE602008003584D1 (ru) |
| DK (1) | DK2170415T3 (ru) |
| EA (1) | EA016764B1 (ru) |
| ES (1) | ES2353683T3 (ru) |
| HR (1) | HRP20110107T1 (ru) |
| MX (1) | MX2010000367A (ru) |
| MY (1) | MY148077A (ru) |
| PL (1) | PL2170415T3 (ru) |
| PT (1) | PT2170415E (ru) |
| SI (1) | SI2170415T1 (ru) |
| UA (1) | UA28103U (ru) |
| WO (1) | WO2009008851A2 (ru) |
| ZA (1) | ZA201000126B (ru) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010079209A3 (en) * | 2009-01-08 | 2010-09-02 | Golub Alexandr A | Compositions for treating wounds and skin conditions |
| MD4197C1 (ru) * | 2012-10-22 | 2013-09-30 | Мария ДАНУ | Метод лечения трофических язв |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961336B (zh) * | 2012-12-13 | 2014-08-13 | 清华大学深圳研究生院 | 纳米级铂类药物及其制备方法 |
| WO2016071405A2 (en) * | 2014-11-04 | 2016-05-12 | Invenres Gmbh | Pharmaceutical preparation and method of its production and use |
| US10226425B2 (en) * | 2013-11-06 | 2019-03-12 | Invenres Gmbh | Pharmaceutical preparation and method of its production and use |
| CN106558599B (zh) * | 2015-09-29 | 2020-04-07 | 中芯国际集成电路制造(上海)有限公司 | 电阻随机存取存储器及其形成方法 |
| CN108309941B (zh) * | 2018-03-20 | 2023-08-11 | 南京工业大学 | 一种舍雷肽酶外用粉剂及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3792160A (en) | 1972-01-18 | 1974-02-12 | Takeda Chemical Industries Ltd | Method of treating inflammation and composition therefor |
| JPS5826822A (ja) * | 1981-08-10 | 1983-02-17 | Kaken Pharmaceut Co Ltd | 慢性腎炎治療剤 |
| NZ529957A (en) | 2001-07-24 | 2005-11-25 | Advanced Biotechnologies | Topical pharmaceutical formulation |
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2007
- 2007-07-12 UA UAU200707897U patent/UA28103U/ru unknown
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2008
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- 2008-07-11 SI SI200830123T patent/SI2170415T1/sl unknown
- 2008-07-11 JP JP2010516012A patent/JP5464750B2/ja active Active
- 2008-07-11 AU AU2008275852A patent/AU2008275852B2/en not_active Ceased
- 2008-07-11 AT AT08779534T patent/ATE488255T1/de active
- 2008-07-11 DE DE602008003584T patent/DE602008003584D1/de active Active
- 2008-07-11 EA EA201070130A patent/EA016764B1/ru not_active IP Right Cessation
- 2008-07-11 ES ES08779534T patent/ES2353683T3/es active Active
- 2008-07-11 CA CA2693087A patent/CA2693087C/en active Active
- 2008-07-11 EP EP10191280A patent/EP2277559A1/en not_active Withdrawn
- 2008-07-11 BR BRPI0814549-0A patent/BRPI0814549B1/pt not_active IP Right Cessation
- 2008-07-11 PT PT08779534T patent/PT2170415E/pt unknown
- 2008-07-11 MX MX2010000367A patent/MX2010000367A/es active IP Right Grant
- 2008-07-11 CN CN200880024342XA patent/CN101772356B/zh active Active
- 2008-07-11 MY MYPI2010000038A patent/MY148077A/en unknown
- 2008-07-11 PL PL08779534T patent/PL2170415T3/pl unknown
- 2008-07-11 EP EP08779534A patent/EP2170415B1/en active Active
- 2008-07-11 WO PCT/UA2008/000041 patent/WO2009008851A2/en active Application Filing
- 2008-07-11 DK DK08779534.0T patent/DK2170415T3/da active
- 2008-07-11 KR KR1020107003161A patent/KR101482960B1/ko active IP Right Grant
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2010
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2011
- 2011-02-09 CY CY20111100153T patent/CY1111652T1/el unknown
- 2011-02-15 HR HR20110107T patent/HRP20110107T1/hr unknown
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2015
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2016
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2017
- 2017-08-20 US US15/681,407 patent/US10166275B2/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010079209A3 (en) * | 2009-01-08 | 2010-09-02 | Golub Alexandr A | Compositions for treating wounds and skin conditions |
| MD4197C1 (ru) * | 2012-10-22 | 2013-09-30 | Мария ДАНУ | Метод лечения трофических язв |
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