UA123534C2 - Кристалічні тверді форми n-{4-[(6,7-диметоксихінолін-4-іл)окси]феніл}-n'-(4-флуорофеніл)циклопропан-1,1-дикарбоксаміду, способи отримання і способи застосування - Google Patents

Кристалічні тверді форми n-{4-[(6,7-диметоксихінолін-4-іл)окси]феніл}-n'-(4-флуорофеніл)циклопропан-1,1-дикарбоксаміду, способи отримання і способи застосування Download PDF

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Publication number
UA123534C2
UA123534C2 UAA201609472A UAA201609472A UA123534C2 UA 123534 C2 UA123534 C2 UA 123534C2 UA A201609472 A UAA201609472 A UA A201609472A UA A201609472 A UAA201609472 A UA A201609472A UA 123534 C2 UA123534 C2 UA 123534C2
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Ukraine
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compound
shk
still
xxx
shi
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UAA201609472A
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English (en)
Ukrainian (uk)
Inventor
Дена Т. Афтеб
Дэна Т. Афтэб
Нейтан Ґаз
Нэйтан Газ
Стивен Лау
Ноел Геміл
Ноел Гэмил
Трейсі Вокер
Трэйси Вокер
Джена Ґелбрейт
Джэна Гелбрэйт
Саймон Йау
Галід Ша
Галид Ша
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Екселіксис, Інк.
Экселиксис, Инк.
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Publication of UA123534C2 publication Critical patent/UA123534C2/uk

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
UAA201609472A 2014-02-14 2015-02-16 Кристалічні тверді форми n-{4-[(6,7-диметоксихінолін-4-іл)окси]феніл}-n'-(4-флуорофеніл)циклопропан-1,1-дикарбоксаміду, способи отримання і способи застосування UA123534C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461939985P 2014-02-14 2014-02-14
PCT/US2015/016052 WO2015123639A1 (en) 2014-02-14 2015-02-16 Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1, 1-dicarboxamide, processes for making, and methods of use

Publications (1)

Publication Number Publication Date
UA123534C2 true UA123534C2 (uk) 2021-04-21

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US (5) US10501418B2 (cg-RX-API-DMAC7.html)
EP (2) EP3738952A1 (cg-RX-API-DMAC7.html)
JP (2) JP6756617B2 (cg-RX-API-DMAC7.html)
KR (1) KR102354963B1 (cg-RX-API-DMAC7.html)
CN (1) CN106068255A (cg-RX-API-DMAC7.html)
AU (3) AU2015218236B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016018450A2 (cg-RX-API-DMAC7.html)
CA (2) CA3181899A1 (cg-RX-API-DMAC7.html)
EA (1) EA032757B1 (cg-RX-API-DMAC7.html)
IL (1) IL247035B2 (cg-RX-API-DMAC7.html)
MX (2) MX384828B (cg-RX-API-DMAC7.html)
UA (1) UA123534C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015123639A1 (cg-RX-API-DMAC7.html)
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ZA201605424B (en) 2022-12-21
US20170044106A1 (en) 2017-02-16
MX2021001583A (es) 2023-02-08
US12486233B2 (en) 2025-12-02
JP2017505796A (ja) 2017-02-23
NZ723714A (en) 2021-03-26
MX2016010266A (es) 2017-02-08
US20210198205A1 (en) 2021-07-01
CA2939546A1 (en) 2015-08-20
US11760726B2 (en) 2023-09-19
CN106068255A (zh) 2016-11-02
CA2939546C (en) 2023-01-17
AU2021204278A1 (en) 2021-07-22
BR112016018450A2 (pt) 2018-09-18
CA3181899A1 (en) 2015-08-20
US10501418B2 (en) 2019-12-10
AU2019226302B2 (en) 2021-04-01
US20230382867A1 (en) 2023-11-30
IL247035B2 (en) 2023-03-01
EP3738952A1 (en) 2020-11-18
US20200190033A1 (en) 2020-06-18
EA032757B1 (ru) 2019-07-31
AU2019226302A1 (en) 2019-09-26
AU2015218236B2 (en) 2019-06-13
AU2015218236A1 (en) 2016-09-15
IL247035B (en) 2022-11-01
US20210206722A1 (en) 2021-07-08
AU2021204278B2 (en) 2023-10-26
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