CA3181899A1 - Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use - Google Patents

Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use

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Publication number
CA3181899A1
CA3181899A1 CA3181899A CA3181899A CA3181899A1 CA 3181899 A1 CA3181899 A1 CA 3181899A1 CA 3181899 A CA3181899 A CA 3181899A CA 3181899 A CA3181899 A CA 3181899A CA 3181899 A1 CA3181899 A1 CA 3181899A1
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CA
Canada
Prior art keywords
compound
cancer
xxx
iii
xxxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3181899A
Other languages
English (en)
French (fr)
Inventor
Dana T. Aftab
Nathan GUZ
Stephen Lau
Noel Hamill
Tracy Walker
Jana GALBRAITH
Simon Yau
Khalid Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exelixis Inc
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of CA3181899A1 publication Critical patent/CA3181899A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CA3181899A 2014-02-14 2015-02-16 Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use Pending CA3181899A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461939985P 2014-02-14 2014-02-14
US61/939,985 2014-02-14
CA2939546A CA2939546C (en) 2014-02-14 2015-02-16 Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2939546A Division CA2939546C (en) 2014-02-14 2015-02-16 Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use

Publications (1)

Publication Number Publication Date
CA3181899A1 true CA3181899A1 (en) 2015-08-20

Family

ID=52684662

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3181899A Pending CA3181899A1 (en) 2014-02-14 2015-02-16 Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use
CA2939546A Active CA2939546C (en) 2014-02-14 2015-02-16 Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2939546A Active CA2939546C (en) 2014-02-14 2015-02-16 Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use

Country Status (14)

Country Link
US (5) US10501418B2 (cg-RX-API-DMAC7.html)
EP (2) EP3738952A1 (cg-RX-API-DMAC7.html)
JP (2) JP6756617B2 (cg-RX-API-DMAC7.html)
KR (1) KR102354963B1 (cg-RX-API-DMAC7.html)
CN (1) CN106068255A (cg-RX-API-DMAC7.html)
AU (3) AU2015218236B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016018450A2 (cg-RX-API-DMAC7.html)
CA (2) CA3181899A1 (cg-RX-API-DMAC7.html)
EA (1) EA032757B1 (cg-RX-API-DMAC7.html)
IL (1) IL247035B2 (cg-RX-API-DMAC7.html)
MX (2) MX384828B (cg-RX-API-DMAC7.html)
UA (1) UA123534C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015123639A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201605424B (cg-RX-API-DMAC7.html)

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ZA201605424B (en) 2022-12-21
US20170044106A1 (en) 2017-02-16
MX2021001583A (es) 2023-02-08
US12486233B2 (en) 2025-12-02
JP2017505796A (ja) 2017-02-23
NZ723714A (en) 2021-03-26
MX2016010266A (es) 2017-02-08
US20210198205A1 (en) 2021-07-01
CA2939546A1 (en) 2015-08-20
US11760726B2 (en) 2023-09-19
CN106068255A (zh) 2016-11-02
CA2939546C (en) 2023-01-17
UA123534C2 (uk) 2021-04-21
AU2021204278A1 (en) 2021-07-22
BR112016018450A2 (pt) 2018-09-18
US10501418B2 (en) 2019-12-10
AU2019226302B2 (en) 2021-04-01
US20230382867A1 (en) 2023-11-30
IL247035B2 (en) 2023-03-01
EP3738952A1 (en) 2020-11-18
US20200190033A1 (en) 2020-06-18
EA032757B1 (ru) 2019-07-31
AU2019226302A1 (en) 2019-09-26
AU2015218236B2 (en) 2019-06-13
AU2015218236A1 (en) 2016-09-15
IL247035B (en) 2022-11-01
US20210206722A1 (en) 2021-07-08
AU2021204278B2 (en) 2023-10-26
IL247035A0 (en) 2016-09-29
KR20160121544A (ko) 2016-10-19
EP3105204A1 (en) 2016-12-21
JP2019163337A (ja) 2019-09-26
EA201691629A1 (ru) 2016-11-30
US11724986B2 (en) 2023-08-15
KR102354963B1 (ko) 2022-01-21
WO2015123639A1 (en) 2015-08-20
MX384828B (es) 2025-03-14
JP6756617B2 (ja) 2020-09-16
US10851061B2 (en) 2020-12-01

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