UA123111C2 - Антитіло до cd40 та його застосування - Google Patents

Антитіло до cd40 та його застосування Download PDF

Info

Publication number
UA123111C2
UA123111C2 UAA201812784A UAA201812784A UA123111C2 UA 123111 C2 UA123111 C2 UA 123111C2 UA A201812784 A UAA201812784 A UA A201812784A UA A201812784 A UAA201812784 A UA A201812784A UA 123111 C2 UA123111 C2 UA 123111C2
Authority
UA
Ukraine
Prior art keywords
antibody
antibodies
zeo
che
chain
Prior art date
Application number
UAA201812784A
Other languages
English (en)
Ukrainian (uk)
Inventor
Діана Холленбо
Диана ХОЛЛЕНБО
Шимін Є
Шимин Е
Діана Сау Мун Коен
Диана Сау Мун Коен
Original Assignee
Еббві Байотерапьютікс Інк.
Эббви Байотерапьютикс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Еббві Байотерапьютікс Інк., Эббви Байотерапьютикс Инк. filed Critical Еббві Байотерапьютікс Інк.
Publication of UA123111C2 publication Critical patent/UA123111C2/uk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/524CH2 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
UAA201812784A 2016-05-27 2017-05-26 Антитіло до cd40 та його застосування UA123111C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662342417P 2016-05-27 2016-05-27
PCT/US2017/034681 WO2017205742A1 (en) 2016-05-27 2017-05-26 Anti-cd40 antibodies and their uses

Publications (1)

Publication Number Publication Date
UA123111C2 true UA123111C2 (uk) 2021-02-17

Family

ID=59014833

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201812784A UA123111C2 (uk) 2016-05-27 2017-05-26 Антитіло до cd40 та його застосування

Country Status (35)

Country Link
US (8) US10519243B2 (enExample)
EP (2) EP3464361B1 (enExample)
JP (2) JP2019523221A (enExample)
KR (2) KR20220028143A (enExample)
CN (1) CN109476750B (enExample)
AR (2) AR108611A1 (enExample)
AU (1) AU2017271602A1 (enExample)
BR (1) BR112018074468A2 (enExample)
CA (1) CA3025347A1 (enExample)
CL (1) CL2018003366A1 (enExample)
CO (1) CO2018012699A2 (enExample)
CR (1) CR20180605A (enExample)
CY (1) CY1124806T1 (enExample)
DO (1) DOP2018000258A (enExample)
EC (1) ECSP18094829A (enExample)
ES (1) ES2901722T3 (enExample)
HR (1) HRP20211882T1 (enExample)
HU (1) HUE056670T2 (enExample)
IL (1) IL263223B2 (enExample)
LT (1) LT3464361T (enExample)
MX (1) MX393455B (enExample)
MY (1) MY195442A (enExample)
NZ (1) NZ748644A (enExample)
PE (1) PE20190970A1 (enExample)
PH (1) PH12018502456A1 (enExample)
PL (1) PL3464361T3 (enExample)
PT (1) PT3464361T (enExample)
RS (1) RS62726B1 (enExample)
RU (1) RU2752049C2 (enExample)
SG (2) SG11201810522UA (enExample)
SI (1) SI3464361T1 (enExample)
SM (1) SMT202100721T1 (enExample)
TW (2) TWI814279B (enExample)
UA (1) UA123111C2 (enExample)
WO (1) WO2017205742A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ601880A (en) * 2007-11-01 2013-12-20 Univ Arkansas Compositions and methods of enhancing immune responses to eimeria
WO2017205742A1 (en) 2016-05-27 2017-11-30 Abbvie Biotherapeutics Inc. Anti-cd40 antibodies and their uses
US11976123B2 (en) 2018-04-20 2024-05-07 Lyvgen Biopharma Holdings Limited Anti-CD40 antibodies and uses thereof
AU2019383548A1 (en) 2018-11-23 2021-06-24 Strike Pharma Ab Bi-specific conjugates
MX2021005823A (es) * 2018-11-30 2021-07-15 Jiangsu Hengrui Medicine Co Anticuerpo anti-cd40, fragmento de union a antigeno y uso farmaceutico del mismo.
CN111548415B (zh) * 2019-03-04 2021-04-20 北京天广实生物技术股份有限公司 与cd40特异结合的抗体及其用途
US10570210B1 (en) * 2019-03-04 2020-02-25 Beijing Mabworks Biotech Co.Ltd Antibodies binding CD40 and uses thereof
JP7640466B2 (ja) 2019-03-27 2025-03-05 アンスティチュート、ナシオナル、ドゥ、ラ、サンテ、エ、ドゥ、ラ、ルシェルシュ、メディカル Cd40活性化特性を有する組換えタンパク質
JP7535060B2 (ja) * 2019-04-10 2024-08-15 ナンカイ ユニバーシティ 抗cd40抗体およびその使用
GB201910900D0 (en) * 2019-07-31 2019-09-11 Scancell Ltd Modified fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof
WO2021048135A1 (en) 2019-09-09 2021-03-18 Basilea Pharmaceutica International AG Pharmaceutical combinations comprising a furazanobenzimidazoles and a cd40 agonist for use in the treatment of neoplastic diseases
MX2022003009A (es) * 2019-09-11 2022-06-14 Novartis Ag Metodo para prevenir trastornos asociados a virus humanos en pacientes.
US20220372155A1 (en) * 2019-10-23 2022-11-24 Lyvgen Biopharma Holdings Limited Anti-cd40 binding molecules and bi-specific antibodies comprising such
JP2023500156A (ja) * 2019-11-08 2023-01-04 チャンスー シムサー ファーマシューティカル カンパニー リミテッド 抗-ヒトプログラム細胞死リガンド-1(pd-l1)の抗体及びその用途
IL293450A (en) * 2019-12-03 2022-07-01 Evotec Int Gmbh Interferon-associated antigen binding proteins and uses thereof
GB202008003D0 (en) 2020-05-28 2020-07-15 Quine Medical Ab Anti-CD40 antibody
US20230346966A1 (en) * 2020-07-23 2023-11-02 Dyne Therapeutics, Inc. Muscle-targeting complexes and uses thereof in treating muscle atrophy
CN115403670A (zh) * 2021-05-26 2022-11-29 安徽瀚海博兴生物技术有限公司 抗cd40抗体及其用途
CA3257929A1 (en) * 2022-05-31 2025-04-22 Futuregen Biopharmaceutical (Beijing) Co., Ltd. Anti-CD40 antibodies, bispecific anti-PD-L1×CD40 antibodies, and their use
CN120035611A (zh) * 2022-09-20 2025-05-23 科锐生物制品私人有限公司 双特异性多肽及其用途
TW202500587A (zh) * 2023-02-16 2025-01-01 法商賽諾菲公司 Cd40結合蛋白

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4716111A (en) 1982-08-11 1987-12-29 Trustees Of Boston University Process for producing human antibodies
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
DK0546073T3 (da) 1990-08-29 1998-02-02 Genpharm Int Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
IE922437A1 (en) 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
DE69637481T2 (de) 1995-04-27 2009-04-09 Amgen Fremont Inc. Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
US5834597A (en) 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
CA2616914C (en) 1996-12-03 2012-05-29 Abgenix, Inc. Egfr-binding antibody
ATE200679T1 (de) 1997-04-14 2001-05-15 Micromet Ag Neues verfahren zur herstellung von anti-humanen antigenrezeptoren und deren verwendungen
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
JP2002530081A (ja) 1998-11-18 2002-09-17 ジェネンテック・インコーポレーテッド 親抗体より高度な結合親和性を持つ抗体変異体
US6946129B1 (en) * 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
US7172759B2 (en) 2000-02-01 2007-02-06 Pangenetics Bv Induction of cytotoxic T lymphocyte responses using anti-CD40 antibodies
US20030059427A1 (en) * 2000-04-28 2003-03-27 Force Walker R. Isolation and characterization of highly active anti-CD40 antibody
AR039067A1 (es) 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
ES2397631T3 (es) * 2003-12-25 2013-03-08 Kyowa Hakko Kirin Co., Ltd. Mutante antagonista de anticuerpos ANTI-CD40
WO2005123780A2 (en) 2004-04-09 2005-12-29 Protein Design Labs, Inc. Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
CA2573293A1 (en) * 2004-07-10 2006-02-16 Alexion Pharmaceuticals, Inc. Methods for discovering antibodies specific to cancer cells and antibodies discovered thereby
CA2587766A1 (en) 2004-11-10 2007-03-01 Macrogenics, Inc. Engineering fc antibody regions to confer effector function
US20090074711A1 (en) * 2006-09-07 2009-03-19 University Of Southhampton Human therapies using chimeric agonistic anti-human cd40 antibody
ES2383710T3 (es) * 2006-09-08 2012-06-25 Medimmune, Llc Anticuerpos anti-CD19 humanizados y su uso en el tratamiento de tumores, trasplantes y enfermedades autoinmunes
NZ601858A (en) * 2007-10-05 2014-03-28 Genentech Inc Methods and compositions for diagnosis and treatment of amyloidosis
PE20130159A1 (es) * 2010-03-31 2013-03-10 Boehringer Ingelheim Int Anticuerpos anti-cd40
AU2012249454B2 (en) 2011-04-29 2016-03-24 Apexigen, Inc. Anti-CD40 antibodies and methods of use
GB201115280D0 (en) * 2011-09-05 2011-10-19 Alligator Bioscience Ab Antibodies, uses and methods
EP2889377B1 (en) 2012-08-24 2020-01-08 Chugai Seiyaku Kabushiki Kaisha Fcyriib-specific fc region variant
JP6693745B2 (ja) * 2012-10-30 2020-05-13 アペクシジェン, インコーポレイテッド 抗cd40抗体および使用方法
AU2014233528B2 (en) 2013-03-15 2019-02-28 Abbvie Biotherapeutics Inc. Fc variants
GB201322583D0 (en) * 2013-12-19 2014-02-05 Alligator Bioscience Ab Antibodies
KR20240073140A (ko) 2014-10-29 2024-05-24 씨젠 인크. 비-푸코실화된 항-cd40 항체의 용량 및 투여
JP6518917B2 (ja) * 2015-05-29 2019-05-29 アッヴィ・インコーポレイテッド 抗cd40抗体およびその使用
SG11201810591VA (en) * 2016-05-27 2018-12-28 Abbvie Biotherapeutics Inc Bispecific binding proteins binding an immunomodulatory protein and a tumor antigen
WO2017205742A1 (en) * 2016-05-27 2017-11-30 Abbvie Biotherapeutics Inc. Anti-cd40 antibodies and their uses

Also Published As

Publication number Publication date
JP7331179B2 (ja) 2023-08-22
WO2017205742A1 (en) 2017-11-30
US20200040090A1 (en) 2020-02-06
TW202229356A (zh) 2022-08-01
CR20180605A (es) 2020-01-13
RU2752049C2 (ru) 2021-07-22
MY195442A (en) 2023-01-21
LT3464361T (lt) 2022-01-10
EP3464361A1 (en) 2019-04-10
HUE056670T2 (hu) 2022-02-28
PT3464361T (pt) 2021-12-27
BR112018074468A2 (pt) 2019-03-06
DOP2018000258A (es) 2019-02-15
EP3464361B1 (en) 2021-11-10
IL263223B2 (en) 2023-03-01
US20180186889A1 (en) 2018-07-05
CN109476750B (zh) 2022-02-01
US10400041B2 (en) 2019-09-03
ECSP18094829A (es) 2019-03-29
MX393455B (es) 2025-03-24
US20170342159A1 (en) 2017-11-30
CO2018012699A2 (es) 2019-08-20
US10023645B1 (en) 2018-07-17
EP3995511A1 (en) 2022-05-11
MX2018014630A (es) 2019-06-10
IL263223A (en) 2018-12-31
RS62726B1 (sr) 2022-01-31
AR108611A1 (es) 2018-09-05
NZ748644A (en) 2023-05-26
RU2018146533A (ru) 2020-06-29
SI3464361T1 (sl) 2022-01-31
US20190071509A1 (en) 2019-03-07
RU2018146533A3 (enExample) 2020-06-29
PL3464361T3 (pl) 2022-01-31
CL2018003366A1 (es) 2019-03-15
TW201806971A (zh) 2018-03-01
US10597460B2 (en) 2020-03-24
AR124692A2 (es) 2023-04-26
TWI761348B (zh) 2022-04-21
AU2017271602A1 (en) 2018-12-13
US10519243B2 (en) 2019-12-31
US20200010558A1 (en) 2020-01-09
CA3025347A1 (en) 2017-11-30
SMT202100721T1 (it) 2022-01-10
JP2022068294A (ja) 2022-05-09
CY1124806T1 (el) 2022-11-25
US20220119542A1 (en) 2022-04-21
SG11201810522UA (en) 2018-12-28
IL263223B (en) 2022-11-01
SG10201914132RA (en) 2020-03-30
US20210277137A1 (en) 2021-09-09
KR102366355B1 (ko) 2022-02-24
ES2901722T3 (es) 2022-03-23
KR20190014524A (ko) 2019-02-12
TWI814279B (zh) 2023-09-01
JP2019523221A (ja) 2019-08-22
PE20190970A1 (es) 2019-07-09
CN109476750A (zh) 2019-03-15
PH12018502456A1 (en) 2019-10-21
US20210024642A1 (en) 2021-01-28
US10844131B2 (en) 2020-11-24
KR20220028143A (ko) 2022-03-08
HRP20211882T1 (hr) 2022-03-04

Similar Documents

Publication Publication Date Title
UA123111C2 (uk) Антитіло до cd40 та його застосування
EP4186926A1 (en) Ccr8 antibody and application thereof
JP5068270B2 (ja) 癌を処置するためのil−17アンタゴニスト抗体
JP7030689B2 (ja) 抗il-2抗体ならびにその組成物及び使用
JP6938383B2 (ja) イヌインターロイキン4受容体アルファに対する抗体
US20240117044A1 (en) Tim-3 antagonists for the treatment and diagnosis of cancers
US20220041748A1 (en) Antibodies specific to muc18
UA128387C2 (uk) Антитіло до lag3
BR112021000397A2 (pt) Fragmentos de ligação fc que compreendem um sítio de ligação a antígeno cd137
JP2022523710A (ja) Cd44に特異的な抗体
CN101014386A (zh) 拮抗性抗-cd40单克隆抗体及其使用方法
CN112512571B (zh) 抗il-27抗体及其用途
EP4292611A1 (en) Anti-cd112r antibody and use thereof
JP2022514786A (ja) Muc18に特異的な抗体
JP2023520587A (ja) 癌及び感染症の治療のためのNKp46に対する抗体及びそのコンストラクト
KR20190034238A (ko) 종양 관련 대식세포를 표적화하는 항체 및 이의 용도
EP3904383A1 (en) Anti-ox40 monoclonal antibody and application thereof
US20230293680A1 (en) A composition of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma
RU2777573C2 (ru) Антитела против 4-1bb человека и их применение
JP2025532758A (ja) 癌の治療における使用のためのbtn3a活性化抗体、bcl2阻害剤及び低メチル化剤の併用
CN117946270A (zh) 抗cd93抗体及其用途
CN121108347A (zh) 抗ly6g6d抗体或其抗原结合片段及其用途
HK40061374A (en) Antibodies specific to cd44
HK40006958B (en) Anti-cd40 antibodies and their uses
NZ793343A (en) Anti- LAG-3 antibodies and compositions