UA118572C2 - СПОСІБ ОДЕРЖАННЯ 19-НОРПРЕГН-4-ЕН-3,20-ДІОН-17(α)-ОЛУ (ГЕСТОНОРОНУ) І ПРОМІЖНІ ПРОДУКТИ ДЛЯ НЬОГО - Google Patents

СПОСІБ ОДЕРЖАННЯ 19-НОРПРЕГН-4-ЕН-3,20-ДІОН-17(α)-ОЛУ (ГЕСТОНОРОНУ) І ПРОМІЖНІ ПРОДУКТИ ДЛЯ НЬОГО

Info

Publication number
UA118572C2
UA118572C2 UAA201607942A UAA201607942A UA118572C2 UA 118572 C2 UA118572 C2 UA 118572C2 UA A201607942 A UAA201607942 A UA A201607942A UA A201607942 A UAA201607942 A UA A201607942A UA 118572 C2 UA118572 C2 UA 118572C2
Authority
UA
Ukraine
Prior art keywords
gestonorone
norpregn
dione
alpha
production
Prior art date
Application number
UAA201607942A
Other languages
English (en)
Inventor
Янош Чоргей
Аніта Хорват
Чаба Шанта
Шандор Махо
Золтан Бені
Янош Хорват
Original Assignee
Ріхтер Гедеон Нірт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ріхтер Гедеон Нірт. filed Critical Ріхтер Гедеон Нірт.
Publication of UA118572C2 publication Critical patent/UA118572C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/006—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a hydroxy group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Винахід стосується нового стереоселективного способу синтезу 17(()-17-ацетил-17-гідроксіестр-4-ен-3-ону, що має формулу (І), а також нових проміжних продуктів для цього способу, причому 17(()-17-ацетил-17-гідроксіестр-4-ен-3-он (гестонорон) є важливим проміжним продуктом для синтезу активних інгредієнтів, що мають прогестогенну активність, таких як гестонорону капронат і номегестролу ацетат. , (І) , (II) (III).
UAA201607942A 2013-12-16 2014-12-15 СПОСІБ ОДЕРЖАННЯ 19-НОРПРЕГН-4-ЕН-3,20-ДІОН-17(α)-ОЛУ (ГЕСТОНОРОНУ) І ПРОМІЖНІ ПРОДУКТИ ДЛЯ НЬОГО UA118572C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1300722A HU230788B1 (en) 2013-12-16 2013-12-16 Norsteroid intermediates and process for their preparation
PCT/IB2014/066907 WO2015092647A1 (en) 2013-12-16 2014-12-15 A process for the production of of 19-norpregn-4-en-3,20-dione-17.alpha.-ol (gestonorone) and intermediates therefor

Publications (1)

Publication Number Publication Date
UA118572C2 true UA118572C2 (uk) 2019-02-11

Family

ID=89991356

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201607942A UA118572C2 (uk) 2013-12-16 2014-12-15 СПОСІБ ОДЕРЖАННЯ 19-НОРПРЕГН-4-ЕН-3,20-ДІОН-17(α)-ОЛУ (ГЕСТОНОРОНУ) І ПРОМІЖНІ ПРОДУКТИ ДЛЯ НЬОГО

Country Status (22)

Country Link
US (1) US9562067B2 (uk)
EP (1) EP3083655B1 (uk)
JP (1) JP6453337B2 (uk)
CN (1) CN105829335B (uk)
BR (1) BR112016013759B1 (uk)
CA (1) CA2932145C (uk)
CY (1) CY1120153T1 (uk)
DK (1) DK3083655T3 (uk)
EA (1) EA030789B1 (uk)
ES (1) ES2668461T3 (uk)
HR (1) HRP20180681T1 (uk)
HU (2) HU230788B1 (uk)
IL (1) IL245812B (uk)
LT (1) LT3083655T (uk)
MX (1) MX366421B (uk)
NO (1) NO3083655T3 (uk)
PL (1) PL3083655T3 (uk)
PT (1) PT3083655T (uk)
RS (1) RS57156B1 (uk)
SI (1) SI3083655T1 (uk)
UA (1) UA118572C2 (uk)
WO (1) WO2015092647A1 (uk)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB762308A (en) 1953-04-25 1956-11-28 Syntex Sa New cyclopentanophenanthrene derivative and process for its preparation
US2781365A (en) * 1953-04-25 1957-02-12 Syntex Sa 17alpha-hydroxy-19-norprogesterone, process therefor and intermediates obtained thereby
US3381003A (en) 1965-06-01 1968-04-30 Merck & Co Inc 3-keto-13beta-alkyl-17beta-acetyl-gona-4-ene-17alpha-ol compounds and processes of preparing them
US3423435A (en) * 1965-06-30 1969-01-21 Searle & Co Process and intermediates for manufacture of 3-hydroxy-17-keto steroids
BE787242A (fr) * 1971-08-06 1973-02-05 Schering Ag Procede de preparation de derives du pregnane, et produits obtenus
DD289540A5 (de) * 1985-09-20 1991-05-02 Veb Jenapharm,De Verfahren zur herstellung von steroid-c17-cyanhydrinsilylethern
US5929262A (en) * 1995-03-30 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method for preparing 17α-acetoxy-11β-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates
HUP0501132A2 (en) * 2005-12-05 2007-06-28 Richter Gedeon Nyrt 17-alpha-cyanomethyl-17betha-hydroxyestra-4,9-diene-3-one of high purity and process for its production
CN101993468A (zh) * 2009-08-27 2011-03-30 杭州容立医药科技有限公司 一种改进地诺孕素的合成方法
CN103130862B (zh) * 2011-11-30 2016-04-13 成都伊诺达博医药科技有限公司 醋酸乌利司他关键中间体3,20-双(亚乙二氧基)-19-去甲孕甾-5,9-二烯-17-醇的合成方法

Also Published As

Publication number Publication date
CY1120153T1 (el) 2018-12-12
DK3083655T3 (en) 2018-05-28
BR112016013759B1 (pt) 2021-11-30
SI3083655T1 (en) 2018-06-29
LT3083655T (lt) 2018-06-25
MX366421B (es) 2019-07-08
HRP20180681T1 (hr) 2018-06-01
CA2932145C (en) 2021-12-07
CN105829335A (zh) 2016-08-03
HUE036726T2 (hu) 2018-07-30
PL3083655T3 (pl) 2018-07-31
HU230788B1 (en) 2018-05-02
JP6453337B2 (ja) 2019-01-16
EP3083655A1 (en) 2016-10-26
IL245812B (en) 2018-10-31
NO3083655T3 (uk) 2018-07-07
JP2017501159A (ja) 2017-01-12
US9562067B2 (en) 2017-02-07
CA2932145A1 (en) 2015-06-25
WO2015092647A1 (en) 2015-06-25
EP3083655B1 (en) 2018-02-07
EA030789B1 (ru) 2018-09-28
IL245812A0 (en) 2016-08-02
MX2016007990A (es) 2017-03-08
BR112016013759A2 (pt) 2017-08-08
US20160297848A1 (en) 2016-10-13
PT3083655T (pt) 2018-05-09
EA201691241A1 (ru) 2016-10-31
HUP1300722A2 (en) 2015-06-29
ES2668461T3 (es) 2018-05-18
RS57156B1 (sr) 2018-07-31
CN105829335B (zh) 2018-05-29

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