BR112016013759A2 - Processo para a síntese de um composto, e, composto - Google Patents
Processo para a síntese de um composto, e, compostoInfo
- Publication number
- BR112016013759A2 BR112016013759A2 BR112016013759A BR112016013759A BR112016013759A2 BR 112016013759 A2 BR112016013759 A2 BR 112016013759A2 BR 112016013759 A BR112016013759 A BR 112016013759A BR 112016013759 A BR112016013759 A BR 112016013759A BR 112016013759 A2 BR112016013759 A2 BR 112016013759A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- synthesis
- gestonorone
- estr
- acetyl
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- 239000000543 intermediate Substances 0.000 abstract 2
- AOSZTAHDEDLTLQ-AZKQZHLXSA-N (1S,2S,4R,8S,9S,11S,12R,13S,19S)-6-[(3-chlorophenyl)methyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound C([C@@H]1C[C@H]2[C@H]3[C@]([C@]4(C=CC(=O)C=C4[C@@H](F)C3)C)(F)[C@@H](O)C[C@@]2([C@@]1(C1)C(=O)CO)C)N1CC1=CC=CC(Cl)=C1 AOSZTAHDEDLTLQ-AZKQZHLXSA-N 0.000 abstract 1
- -1 AND Chemical class 0.000 abstract 1
- 229940126657 Compound 17 Drugs 0.000 abstract 1
- XURCMZMFZXXQDJ-UKNJCJGYSA-N Gestonorone caproate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)CCCCC)[C@@]1(C)CC2 XURCMZMFZXXQDJ-UKNJCJGYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- GTFUITFQDGVJSK-XGXHKTLJSA-N gestonorone Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 GTFUITFQDGVJSK-XGXHKTLJSA-N 0.000 abstract 1
- 229960001902 gestonorone Drugs 0.000 abstract 1
- 229960003812 gestonorone caproate Drugs 0.000 abstract 1
- 229960004190 nomegestrol acetate Drugs 0.000 abstract 1
- IIVBFTNIGYRNQY-YQLZSBIMSA-N nomegestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 IIVBFTNIGYRNQY-YQLZSBIMSA-N 0.000 abstract 1
- 230000000757 progestagenic effect Effects 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
- C07J7/006—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a hydroxy group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCESSO PARA A SÍNTESE DE UM COMPOSTO, E, COMPOSTO. A presente invenção refere-se a um novo processo estereosseletivo para a síntese de 17(a)-17-acetil-17-hidroxi-estr-4- en-3-ona de fórmula (I), bem como aos novos intermediários do processo. O composto 17(a)-17-acetil-17-hidroxi-estr-4-en-3-ona (gestonorona) é um intermediário importante na síntese dos ingredientes ativos tendo atividade progestogênica - tal como capronato de gestonorona e acetato de nomegestrol. Fórmulas (I), (II) e (III).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1300722A HU230788B1 (en) | 2013-12-16 | 2013-12-16 | Norsteroid intermediates and process for their preparation |
| HUP1300722 | 2013-12-16 | ||
| PCT/IB2014/066907 WO2015092647A1 (en) | 2013-12-16 | 2014-12-15 | A process for the production of of 19-norpregn-4-en-3,20-dione-17.alpha.-ol (gestonorone) and intermediates therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112016013759A2 true BR112016013759A2 (pt) | 2017-08-08 |
| BR112016013759B1 BR112016013759B1 (pt) | 2021-11-30 |
Family
ID=89991356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016013759-0A BR112016013759B1 (pt) | 2013-12-16 | 2014-12-15 | Processo para a síntese de um composto, e, composto |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9562067B2 (pt) |
| EP (1) | EP3083655B1 (pt) |
| JP (1) | JP6453337B2 (pt) |
| CN (1) | CN105829335B (pt) |
| BR (1) | BR112016013759B1 (pt) |
| CA (1) | CA2932145C (pt) |
| CY (1) | CY1120153T1 (pt) |
| DK (1) | DK3083655T3 (pt) |
| EA (1) | EA030789B1 (pt) |
| ES (1) | ES2668461T3 (pt) |
| HR (1) | HRP20180681T1 (pt) |
| HU (2) | HU230788B1 (pt) |
| IL (1) | IL245812B (pt) |
| LT (1) | LT3083655T (pt) |
| MX (1) | MX366421B (pt) |
| NO (1) | NO3083655T3 (pt) |
| PL (1) | PL3083655T3 (pt) |
| PT (1) | PT3083655T (pt) |
| RS (1) | RS57156B1 (pt) |
| SI (1) | SI3083655T1 (pt) |
| UA (1) | UA118572C2 (pt) |
| WO (1) | WO2015092647A1 (pt) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB762308A (en) | 1953-04-25 | 1956-11-28 | Syntex Sa | New cyclopentanophenanthrene derivative and process for its preparation |
| US2781365A (en) * | 1953-04-25 | 1957-02-12 | Syntex Sa | 17alpha-hydroxy-19-norprogesterone, process therefor and intermediates obtained thereby |
| US3381003A (en) | 1965-06-01 | 1968-04-30 | Merck & Co Inc | 3-keto-13beta-alkyl-17beta-acetyl-gona-4-ene-17alpha-ol compounds and processes of preparing them |
| US3423435A (en) * | 1965-06-30 | 1969-01-21 | Searle & Co | Process and intermediates for manufacture of 3-hydroxy-17-keto steroids |
| BE787242A (fr) * | 1971-08-06 | 1973-02-05 | Schering Ag | Procede de preparation de derives du pregnane, et produits obtenus |
| DD289540A5 (de) * | 1985-09-20 | 1991-05-02 | Veb Jenapharm,De | Verfahren zur herstellung von steroid-c17-cyanhydrinsilylethern |
| US5929262A (en) * | 1995-03-30 | 1999-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Method for preparing 17α-acetoxy-11β-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates |
| HUP0501132A2 (en) * | 2005-12-05 | 2007-06-28 | Richter Gedeon Nyrt | 17-alpha-cyanomethyl-17betha-hydroxyestra-4,9-diene-3-one of high purity and process for its production |
| CN101993468A (zh) * | 2009-08-27 | 2011-03-30 | 杭州容立医药科技有限公司 | 一种改进地诺孕素的合成方法 |
| CN103130862B (zh) * | 2011-11-30 | 2016-04-13 | 成都伊诺达博医药科技有限公司 | 醋酸乌利司他关键中间体3,20-双(亚乙二氧基)-19-去甲孕甾-5,9-二烯-17-醇的合成方法 |
-
2013
- 2013-12-16 HU HU1300722A patent/HU230788B1/hu not_active IP Right Cessation
-
2014
- 2014-12-15 CN CN201480068436.2A patent/CN105829335B/zh active Active
- 2014-12-15 WO PCT/IB2014/066907 patent/WO2015092647A1/en active Application Filing
- 2014-12-15 EA EA201691241A patent/EA030789B1/ru unknown
- 2014-12-15 CA CA2932145A patent/CA2932145C/en active Active
- 2014-12-15 SI SI201430696T patent/SI3083655T1/en unknown
- 2014-12-15 DK DK14833541.7T patent/DK3083655T3/en active
- 2014-12-15 EP EP14833541.7A patent/EP3083655B1/en active Active
- 2014-12-15 LT LTEP14833541.7T patent/LT3083655T/lt unknown
- 2014-12-15 JP JP2016539916A patent/JP6453337B2/ja active Active
- 2014-12-15 MX MX2016007990A patent/MX366421B/es active IP Right Grant
- 2014-12-15 BR BR112016013759-0A patent/BR112016013759B1/pt active IP Right Grant
- 2014-12-15 PL PL14833541T patent/PL3083655T3/pl unknown
- 2014-12-15 NO NO14833541A patent/NO3083655T3/no unknown
- 2014-12-15 HU HUE14833541A patent/HUE036726T2/hu unknown
- 2014-12-15 ES ES14833541.7T patent/ES2668461T3/es active Active
- 2014-12-15 US US15/038,299 patent/US9562067B2/en active Active
- 2014-12-15 RS RS20180514A patent/RS57156B1/sr unknown
- 2014-12-15 PT PT148335417T patent/PT3083655T/pt unknown
- 2014-12-15 UA UAA201607942A patent/UA118572C2/uk unknown
-
2016
- 2016-05-24 IL IL245812A patent/IL245812B/en active IP Right Grant
-
2018
- 2018-04-27 CY CY20181100446T patent/CY1120153T1/el unknown
- 2018-04-30 HR HRP20180681TT patent/HRP20180681T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1120153T1 (el) | 2018-12-12 |
| DK3083655T3 (en) | 2018-05-28 |
| BR112016013759B1 (pt) | 2021-11-30 |
| SI3083655T1 (en) | 2018-06-29 |
| LT3083655T (lt) | 2018-06-25 |
| MX366421B (es) | 2019-07-08 |
| HRP20180681T1 (hr) | 2018-06-01 |
| CA2932145C (en) | 2021-12-07 |
| CN105829335A (zh) | 2016-08-03 |
| HUE036726T2 (hu) | 2018-07-30 |
| PL3083655T3 (pl) | 2018-07-31 |
| HU230788B1 (en) | 2018-05-02 |
| JP6453337B2 (ja) | 2019-01-16 |
| EP3083655A1 (en) | 2016-10-26 |
| IL245812B (en) | 2018-10-31 |
| NO3083655T3 (pt) | 2018-07-07 |
| JP2017501159A (ja) | 2017-01-12 |
| US9562067B2 (en) | 2017-02-07 |
| CA2932145A1 (en) | 2015-06-25 |
| WO2015092647A1 (en) | 2015-06-25 |
| EP3083655B1 (en) | 2018-02-07 |
| EA030789B1 (ru) | 2018-09-28 |
| IL245812A0 (en) | 2016-08-02 |
| MX2016007990A (es) | 2017-03-08 |
| US20160297848A1 (en) | 2016-10-13 |
| PT3083655T (pt) | 2018-05-09 |
| UA118572C2 (uk) | 2019-02-11 |
| EA201691241A1 (ru) | 2016-10-31 |
| HUP1300722A2 (en) | 2015-06-29 |
| ES2668461T3 (es) | 2018-05-18 |
| RS57156B1 (sr) | 2018-07-31 |
| CN105829335B (zh) | 2018-05-29 |
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| BR112016013759A2 (pt) | Processo para a síntese de um composto, e, composto |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/12/2014, OBSERVADAS AS CONDICOES LEGAIS. |