UA118278C2 - Гідроксиформамідні похідні та їх застосування - Google Patents

Гідроксиформамідні похідні та їх застосування

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Publication number
UA118278C2
UA118278C2 UAA201608690A UAA201608690A UA118278C2 UA 118278 C2 UA118278 C2 UA 118278C2 UA A201608690 A UAA201608690 A UA A201608690A UA A201608690 A UAA201608690 A UA A201608690A UA 118278 C2 UA118278 C2 UA 118278C2
Authority
UA
Ukraine
Prior art keywords
formamide derivatives
hydroxy formamide
tll1
hydroxy
tll2
Prior art date
Application number
UAA201608690A
Other languages
English (en)
Inventor
Сара Е. Дауделл
Хіларі Шенк Ейдем
Марк Елбен
Райян Майкл Фокс
Мерліз Хеммонд
Марк А. Хілфайкер
Трем Х. Хоанг
Лара С. Келлендер
Брайан Гріффін Лоухорн
Шарада Меннз
Джоанн Філп
Дейвід Г. Уошберн
Госень Йе
Original Assignee
Глаксосмітклайн Інтеллектьюел Проперті (№ 2) Лімітед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксосмітклайн Інтеллектьюел Проперті (№ 2) Лімітед filed Critical Глаксосмітклайн Інтеллектьюел Проперті (№ 2) Лімітед
Publication of UA118278C2 publication Critical patent/UA118278C2/uk

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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07F9/02—Phosphorus compounds
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Abstract

Розкриті сполуки, що мають формулу: , де R1, R2 і R3 мають значення, визначені в даній заявці, і способи отримання і застосування таких сполук, включаючи застосування як інгібіторів ВМР1, TLL1 та/або TLL2 і для лікування захворювань, пов'язаних з активністю ВМР1, TLL1 та/або TLL2.
UAA201608690A 2014-01-10 2015-01-09 Гідроксиформамідні похідні та їх застосування UA118278C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461925848P 2014-01-10 2014-01-10
PCT/IB2015/050179 WO2015104684A1 (en) 2014-01-10 2015-01-09 Hydroxy formamide derivatives and their use

Publications (1)

Publication Number Publication Date
UA118278C2 true UA118278C2 (uk) 2018-12-26

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US (2) US10450288B2 (uk)
EP (1) EP3092233A1 (uk)
JP (2) JP2017507915A (uk)
KR (1) KR20160106684A (uk)
CN (2) CN109970797A (uk)
AU (1) AU2015205370B2 (uk)
BR (1) BR112016016130A2 (uk)
CA (1) CA2936467A1 (uk)
CL (1) CL2016001746A1 (uk)
CR (1) CR20160316A (uk)
DO (1) DOP2016000170A (uk)
EA (1) EA031654B1 (uk)
IL (1) IL246653A0 (uk)
MA (1) MA39171A1 (uk)
MX (1) MX2016009064A (uk)
PE (1) PE20160998A1 (uk)
PH (1) PH12016501349A1 (uk)
SG (1) SG11201605539SA (uk)
TW (1) TW201620887A (uk)
UA (1) UA118278C2 (uk)
WO (1) WO2015104684A1 (uk)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
KR20160106684A (ko) * 2014-01-10 2016-09-12 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 히드록시포름아미드 유도체 및 그의 용도
WO2017006295A1 (en) * 2015-07-08 2017-01-12 Glaxosmithkline Intellectual Property (No.2) Limited Hydroxy formamide derivatives and their use
EP3319961A1 (en) 2015-07-09 2018-05-16 Glaxosmithkline Intellectual Property (No. 2) Limited N-hydroxyformamide compounds and compositions comprising them for use as bmp1, tll1 and/or tll2 inhibitors
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