UA118209C2 - Гетероариламіди як інгібітори агрегації білків - Google Patents

Гетероариламіди як інгібітори агрегації білків

Info

Publication number
UA118209C2
UA118209C2 UAA201609003A UAA201609003A UA118209C2 UA 118209 C2 UA118209 C2 UA 118209C2 UA A201609003 A UAA201609003 A UA A201609003A UA A201609003 A UAA201609003 A UA A201609003A UA 118209 C2 UA118209 C2 UA 118209C2
Authority
UA
Ukraine
Prior art keywords
disease
protein aggregation
methods
parkinson
heteroarylamides
Prior art date
Application number
UAA201609003A
Other languages
English (en)
Ukrainian (uk)
Inventor
Емілі М. Стокін
Вольфган Расідло
Original Assignee
Неуропор Терапіс, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52484559&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA118209(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Неуропор Терапіс, Інк. filed Critical Неуропор Терапіс, Інк.
Publication of UA118209C2 publication Critical patent/UA118209C2/uk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
UAA201609003A 2014-01-29 2015-01-28 Гетероариламіди як інгібітори агрегації білків UA118209C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461933246P 2014-01-29 2014-01-29
US201462078895P 2014-11-12 2014-11-12
PCT/US2015/013263 WO2015116663A1 (en) 2014-01-29 2015-01-28 Heteroarly amides as inhibitors of protein aggregation

Publications (1)

Publication Number Publication Date
UA118209C2 true UA118209C2 (uk) 2018-12-10

Family

ID=52484559

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201609003A UA118209C2 (uk) 2014-01-29 2015-01-28 Гетероариламіди як інгібітори агрегації білків

Country Status (38)

Country Link
US (3) US9738635B2 (OSRAM)
EP (2) EP3099684B8 (OSRAM)
JP (2) JP6619741B2 (OSRAM)
KR (1) KR102383038B1 (OSRAM)
CN (2) CN106132960B (OSRAM)
AP (1) AP2016009347A0 (OSRAM)
AU (1) AU2015211119B2 (OSRAM)
BR (2) BR122018001892B1 (OSRAM)
CA (1) CA2937967C (OSRAM)
CL (1) CL2016001918A1 (OSRAM)
CR (1) CR20160394A (OSRAM)
CY (2) CY1120348T1 (OSRAM)
DK (2) DK3099684T3 (OSRAM)
EA (1) EA032374B1 (OSRAM)
EC (1) ECSP16070327A (OSRAM)
ES (2) ES2808978T3 (OSRAM)
HK (1) HK1231470A1 (OSRAM)
HR (2) HRP20180813T1 (OSRAM)
HU (2) HUE050964T2 (OSRAM)
IL (1) IL246987B (OSRAM)
LT (2) LT3348556T (OSRAM)
ME (1) ME03800B (OSRAM)
MX (1) MX2016009896A (OSRAM)
MY (1) MY187450A (OSRAM)
NZ (1) NZ722487A (OSRAM)
PE (1) PE20161393A1 (OSRAM)
PH (1) PH12016501493B1 (OSRAM)
PL (2) PL3099684T3 (OSRAM)
PT (2) PT3099684T (OSRAM)
RS (2) RS60547B1 (OSRAM)
SA (1) SA516371579B1 (OSRAM)
SG (1) SG11201606108RA (OSRAM)
SI (2) SI3348556T1 (OSRAM)
SM (2) SMT201800318T1 (OSRAM)
TR (1) TR201809440T4 (OSRAM)
UA (1) UA118209C2 (OSRAM)
WO (1) WO2015116663A1 (OSRAM)
ZA (1) ZA201605246B (OSRAM)

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JP7073385B2 (ja) * 2017-01-26 2022-05-23 ユーシービー バイオファルマ エスアールエル タンパク質凝集のモジュレーターとしての二環式ビス-ヘテロアリール誘導体
EP3573981B1 (en) * 2017-01-26 2022-03-16 UCB Biopharma SRL Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation
EP3634403B1 (en) * 2017-05-12 2025-06-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma
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EP4458824A4 (en) 2021-12-27 2025-12-24 Shanghai Jingxin Biomedical Co Ltd Fused bicyclic heteroarylamide compound useful as a protein aggregation inhibitor
GB202213796D0 (en) * 2022-09-21 2022-11-02 Wista Lab Ltd Tau aggregation inhibitors
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WO2024184179A1 (en) 2023-03-06 2024-09-12 UCB Biopharma SRL Minzasolmin for use in the treatment of parkinson's disease
WO2024184180A1 (en) 2023-03-06 2024-09-12 UCB Biopharma SRL Minzasolmin for use in the treatment of parkinson's disease
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NZ722487A (en) 2014-01-29 2022-04-29 Ucb Biopharma Sprl Heteroaryl amides as inhibitors of protein aggregation
EP3328379B1 (en) 2015-07-29 2021-07-28 UCB Biopharma SRL Bis-heteroaryl derivatives as modulators of protein aggregation
RU2019126170A (ru) 2017-01-26 2021-02-26 Юсб Байофарма Спрл Бисгетероарильные производные в качестве модуляторов агрегации белков
JP7073385B2 (ja) 2017-01-26 2022-05-23 ユーシービー バイオファルマ エスアールエル タンパク質凝集のモジュレーターとしての二環式ビス-ヘテロアリール誘導体

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Publication number Publication date
SMT201800318T1 (it) 2018-07-17
SMT202000376T1 (it) 2020-09-10
US9738635B2 (en) 2017-08-22
EP3348556B1 (en) 2020-04-29
PL3099684T3 (pl) 2018-09-28
CY1120348T1 (el) 2019-07-10
EP3099684A1 (en) 2016-12-07
HUE040274T2 (hu) 2019-03-28
HRP20180813T1 (hr) 2018-07-27
HK1231470A1 (zh) 2017-12-22
BR112016017344A2 (pt) 2017-10-03
AU2015211119A1 (en) 2016-08-11
HUE050964T2 (hu) 2021-01-28
US20160207912A1 (en) 2016-07-21
PH12016501493A1 (en) 2017-02-06
BR112016017344B1 (pt) 2023-05-16
NZ722487A (en) 2022-04-29
CN106132960B (zh) 2019-12-17
EP3099684B1 (en) 2018-04-04
EP3099684B8 (en) 2018-07-04
IL246987A0 (en) 2016-09-29
EA201691529A1 (ru) 2017-01-30
CR20160394A (es) 2016-11-01
CN106132960A (zh) 2016-11-16
ES2808978T3 (es) 2021-03-02
AP2016009347A0 (en) 2016-07-31
ES2808978T8 (es) 2021-03-22
SI3099684T1 (en) 2018-08-31
JP6783900B2 (ja) 2020-11-11
WO2015116663A1 (en) 2015-08-06
DK3348556T3 (da) 2020-08-03
JP2019163321A (ja) 2019-09-26
RS57533B1 (sr) 2018-10-31
IL246987B (en) 2021-12-01
ZA201605246B (en) 2022-05-25
US20180093979A1 (en) 2018-04-05
DK3099684T3 (en) 2018-07-16
SA516371579B1 (ar) 2019-07-16
CA2937967C (en) 2022-07-26
AU2015211119A8 (en) 2016-12-15
WO2015116663A8 (en) 2016-09-15
EA032374B1 (ru) 2019-05-31
US20190308965A1 (en) 2019-10-10
LT3348556T (lt) 2020-08-10
AU2015211119B2 (en) 2019-05-30
PT3348556T (pt) 2020-07-27
TR201809440T4 (tr) 2018-07-23
PL3348556T3 (pl) 2020-11-02
PT3099684T (pt) 2018-10-22
KR102383038B1 (ko) 2022-04-05
EP3348556A1 (en) 2018-07-18
PE20161393A1 (es) 2017-01-08
CN111039939A (zh) 2020-04-21
CN111039939B (zh) 2023-09-19
CL2016001918A1 (es) 2017-01-13
US11078196B2 (en) 2021-08-03
CY1123374T1 (el) 2021-12-31
ME03800B (me) 2021-04-20
CA2937967A1 (en) 2015-08-06
MY187450A (en) 2021-09-22
JP6619741B2 (ja) 2019-12-11
ECSP16070327A (es) 2018-05-31
HRP20201107T8 (hr) 2020-12-11
JP2017505779A (ja) 2017-02-23
RS60547B1 (sr) 2020-08-31
SG11201606108RA (en) 2016-08-30
LT3099684T (lt) 2018-06-25
BR122018001892B1 (pt) 2023-05-02
MX2016009896A (es) 2017-01-11
KR20160113287A (ko) 2016-09-28
US10358443B2 (en) 2019-07-23
PH12016501493B1 (en) 2017-02-06
HRP20201107T1 (hr) 2020-10-30
SI3348556T1 (sl) 2020-10-30
ES2675301T3 (es) 2018-07-10

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