HUE050964T2 - Heteroaril amidok mint protein aggregáció inhibitorai - Google Patents

Heteroaril amidok mint protein aggregáció inhibitorai

Info

Publication number
HUE050964T2
HUE050964T2 HUE18156929A HUE18156929A HUE050964T2 HU E050964 T2 HUE050964 T2 HU E050964T2 HU E18156929 A HUE18156929 A HU E18156929A HU E18156929 A HUE18156929 A HU E18156929A HU E050964 T2 HUE050964 T2 HU E050964T2
Authority
HU
Hungary
Prior art keywords
inhibitors
protein aggregation
heteroaryl amides
heteroaryl
amides
Prior art date
Application number
HUE18156929A
Other languages
English (en)
Hungarian (hu)
Inventor
Emily M Stocking
Wolfgang Wrasidlo
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52484559&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE050964(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of HUE050964T2 publication Critical patent/HUE050964T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HUE18156929A 2014-01-29 2015-01-28 Heteroaril amidok mint protein aggregáció inhibitorai HUE050964T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461933246P 2014-01-29 2014-01-29
US201462078895P 2014-11-12 2014-11-12

Publications (1)

Publication Number Publication Date
HUE050964T2 true HUE050964T2 (hu) 2021-01-28

Family

ID=52484559

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE18156929A HUE050964T2 (hu) 2014-01-29 2015-01-28 Heteroaril amidok mint protein aggregáció inhibitorai
HUE15705417A HUE040274T2 (hu) 2014-01-29 2015-01-28 Heteroarilamidok a proteinaggregáció inhibitoraiként

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE15705417A HUE040274T2 (hu) 2014-01-29 2015-01-28 Heteroarilamidok a proteinaggregáció inhibitoraiként

Country Status (38)

Country Link
US (3) US9738635B2 (OSRAM)
EP (2) EP3099684B8 (OSRAM)
JP (2) JP6619741B2 (OSRAM)
KR (1) KR102383038B1 (OSRAM)
CN (2) CN111039939B (OSRAM)
AP (1) AP2016009347A0 (OSRAM)
AU (1) AU2015211119B2 (OSRAM)
BR (2) BR122018001892B1 (OSRAM)
CA (1) CA2937967C (OSRAM)
CL (1) CL2016001918A1 (OSRAM)
CR (1) CR20160394A (OSRAM)
CY (2) CY1120348T1 (OSRAM)
DK (2) DK3099684T3 (OSRAM)
EA (1) EA032374B1 (OSRAM)
EC (1) ECSP16070327A (OSRAM)
ES (2) ES2808978T3 (OSRAM)
HK (1) HK1231470A1 (OSRAM)
HR (2) HRP20180813T1 (OSRAM)
HU (2) HUE050964T2 (OSRAM)
IL (1) IL246987B (OSRAM)
LT (2) LT3348556T (OSRAM)
ME (1) ME03800B (OSRAM)
MX (1) MX2016009896A (OSRAM)
MY (1) MY187450A (OSRAM)
NZ (1) NZ722487A (OSRAM)
PE (1) PE20161393A1 (OSRAM)
PH (1) PH12016501493B1 (OSRAM)
PL (2) PL3348556T3 (OSRAM)
PT (2) PT3099684T (OSRAM)
RS (2) RS60547B1 (OSRAM)
SA (1) SA516371579B1 (OSRAM)
SG (1) SG11201606108RA (OSRAM)
SI (2) SI3099684T1 (OSRAM)
SM (2) SMT201800318T1 (OSRAM)
TR (1) TR201809440T4 (OSRAM)
UA (1) UA118209C2 (OSRAM)
WO (1) WO2015116663A1 (OSRAM)
ZA (1) ZA201605246B (OSRAM)

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ES2884145T3 (es) * 2017-01-26 2021-12-10 UCB Biopharma SRL Derivados bicíclicos de bis-heteroarilo como moduladores de la agregación de proteínas
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TR201809440T4 (tr) 2014-01-29 2018-07-23 Ucb Biopharma Sprl Protein agregasyonunun inhibitörleri olarak heteroaril amidler.
ES2885049T3 (es) 2015-07-29 2021-12-13 UCB Biopharma SRL Derivados de bis-heteroarilo como moduladores de la agregación de proteínas
ES2884145T3 (es) 2017-01-26 2021-12-10 UCB Biopharma SRL Derivados bicíclicos de bis-heteroarilo como moduladores de la agregación de proteínas
KR20190111080A (ko) 2017-01-26 2019-10-01 유씨비 바이오파마 에스피알엘 단백질 응집의 조절제로서의 비스-헤테로아릴 유도체

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EA032374B1 (ru) 2019-05-31
PL3348556T3 (pl) 2020-11-02
BR112016017344B1 (pt) 2023-05-16
EP3348556A1 (en) 2018-07-18
SMT201800318T1 (it) 2018-07-17
ES2808978T3 (es) 2021-03-02
HRP20201107T8 (hr) 2020-12-11
US9738635B2 (en) 2017-08-22
US11078196B2 (en) 2021-08-03
JP2019163321A (ja) 2019-09-26
DK3099684T3 (en) 2018-07-16
HK1231470A1 (zh) 2017-12-22
MY187450A (en) 2021-09-22
KR20160113287A (ko) 2016-09-28
MX2016009896A (es) 2017-01-11
HRP20201107T1 (hr) 2020-10-30
BR112016017344A2 (pt) 2017-10-03
EP3099684B1 (en) 2018-04-04
US20190308965A1 (en) 2019-10-10
AP2016009347A0 (en) 2016-07-31
CR20160394A (es) 2016-11-01
PL3099684T3 (pl) 2018-09-28
WO2015116663A8 (en) 2016-09-15
CN106132960A (zh) 2016-11-16
SG11201606108RA (en) 2016-08-30
BR122018001892B1 (pt) 2023-05-02
AU2015211119A8 (en) 2016-12-15
SMT202000376T1 (it) 2020-09-10
CN106132960B (zh) 2019-12-17
CN111039939B (zh) 2023-09-19
US20160207912A1 (en) 2016-07-21
EP3099684A1 (en) 2016-12-07
LT3348556T (lt) 2020-08-10
EA201691529A1 (ru) 2017-01-30
CL2016001918A1 (es) 2017-01-13
PH12016501493A1 (en) 2017-02-06
PE20161393A1 (es) 2017-01-08
EP3348556B1 (en) 2020-04-29
CY1120348T1 (el) 2019-07-10
CA2937967A1 (en) 2015-08-06
SI3348556T1 (sl) 2020-10-30
AU2015211119B2 (en) 2019-05-30
RS57533B1 (sr) 2018-10-31
AU2015211119A1 (en) 2016-08-11
EP3099684B8 (en) 2018-07-04
ZA201605246B (en) 2022-05-25
LT3099684T (lt) 2018-06-25
NZ722487A (en) 2022-04-29
IL246987B (en) 2021-12-01
HUE040274T2 (hu) 2019-03-28
RS60547B1 (sr) 2020-08-31
HRP20180813T1 (hr) 2018-07-27
CN111039939A (zh) 2020-04-21
SI3099684T1 (en) 2018-08-31
PT3099684T (pt) 2018-10-22
CA2937967C (en) 2022-07-26
ES2675301T3 (es) 2018-07-10
TR201809440T4 (tr) 2018-07-23
DK3348556T3 (da) 2020-08-03
ECSP16070327A (es) 2018-05-31
JP2017505779A (ja) 2017-02-23
ME03800B (me) 2021-04-20
US20180093979A1 (en) 2018-04-05
IL246987A0 (en) 2016-09-29
ES2808978T8 (es) 2021-03-22
KR102383038B1 (ko) 2022-04-05
UA118209C2 (uk) 2018-12-10
WO2015116663A1 (en) 2015-08-06
SA516371579B1 (ar) 2019-07-16
US10358443B2 (en) 2019-07-23
CY1123374T1 (el) 2021-12-31
JP6619741B2 (ja) 2019-12-11
PH12016501493B1 (en) 2017-02-06
PT3348556T (pt) 2020-07-27
JP6783900B2 (ja) 2020-11-11

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