UA115357C2 - Похідні піридин-4-ілу - Google Patents

Похідні піридин-4-ілу

Info

Publication number
UA115357C2
UA115357C2 UAA201510003A UAA201510003A UA115357C2 UA 115357 C2 UA115357 C2 UA 115357C2 UA A201510003 A UAA201510003 A UA A201510003A UA A201510003 A UAA201510003 A UA A201510003A UA 115357 C2 UA115357 C2 UA 115357C2
Authority
UA
Ukraine
Prior art keywords
pyridin
derivatives
compounds
formula
preparation
Prior art date
Application number
UAA201510003A
Other languages
English (en)
Ukrainian (uk)
Inventor
Мартін Боллі
Сірілл Лескоп
Олівер Найлер
Беат ШТАЙНЕР
Original Assignee
Ідорсія Фармасьютікалз Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ідорсія Фармасьютікалз Лтд filed Critical Ідорсія Фармасьютікалз Лтд
Publication of UA115357C2 publication Critical patent/UA115357C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
UAA201510003A 2013-03-15 2014-03-14 Похідні піридин-4-ілу UA115357C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13159482 2013-03-15
PCT/IB2014/059794 WO2014141171A1 (en) 2013-03-15 2014-03-14 Pyridin-4-yl derivatives

Publications (1)

Publication Number Publication Date
UA115357C2 true UA115357C2 (uk) 2017-10-25

Family

ID=47877933

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201510003A UA115357C2 (uk) 2013-03-15 2014-03-14 Похідні піридин-4-ілу

Country Status (33)

Country Link
US (1) US9617250B2 (cg-RX-API-DMAC7.html)
EP (1) EP2970236B1 (cg-RX-API-DMAC7.html)
JP (1) JP6387361B2 (cg-RX-API-DMAC7.html)
KR (1) KR102212975B1 (cg-RX-API-DMAC7.html)
CN (1) CN105189487B (cg-RX-API-DMAC7.html)
AR (1) AR095523A1 (cg-RX-API-DMAC7.html)
AU (1) AU2014229217B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015023161B1 (cg-RX-API-DMAC7.html)
CA (1) CA2900910C (cg-RX-API-DMAC7.html)
CL (1) CL2015002620A1 (cg-RX-API-DMAC7.html)
CY (1) CY1119619T1 (cg-RX-API-DMAC7.html)
DK (1) DK2970236T3 (cg-RX-API-DMAC7.html)
EA (1) EA029309B1 (cg-RX-API-DMAC7.html)
ES (1) ES2649475T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20171763T1 (cg-RX-API-DMAC7.html)
HU (1) HUE035154T2 (cg-RX-API-DMAC7.html)
IL (1) IL241363B (cg-RX-API-DMAC7.html)
LT (1) LT2970236T (cg-RX-API-DMAC7.html)
MA (1) MA38482B1 (cg-RX-API-DMAC7.html)
MX (1) MX363545B (cg-RX-API-DMAC7.html)
MY (1) MY173573A (cg-RX-API-DMAC7.html)
NO (1) NO2970236T3 (cg-RX-API-DMAC7.html)
NZ (1) NZ713080A (cg-RX-API-DMAC7.html)
PH (1) PH12015502118A1 (cg-RX-API-DMAC7.html)
PL (1) PL2970236T3 (cg-RX-API-DMAC7.html)
PT (1) PT2970236T (cg-RX-API-DMAC7.html)
SA (1) SA515361104B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201507227UA (cg-RX-API-DMAC7.html)
SI (1) SI2970236T1 (cg-RX-API-DMAC7.html)
TW (1) TWI623534B (cg-RX-API-DMAC7.html)
UA (1) UA115357C2 (cg-RX-API-DMAC7.html)
WO (1) WO2014141171A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201507657B (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014110574A1 (en) 2013-01-14 2014-07-17 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
UA121098C2 (uk) 2013-01-15 2020-04-10 Інсайт Холдинґс Корпорейшн Тіазолкарбоксаміди і піридинкарбоксаміди, які використовуються як інгібітори рім-кінази
WO2015027124A1 (en) 2013-08-23 2015-02-26 Incyte Corporation Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
ES2770348T3 (es) 2015-05-20 2020-07-01 Idorsia Pharmaceuticals Ltd Forma cristalina del compuesto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4]oxadiazol-3-il]-2-etil-6-metil-fenoxi}-propano-1,2-diol
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
WO2017004610A1 (en) * 2015-07-02 2017-01-05 Exelixis, Inc. Tercyclic s1p3-sparing, s1p1 receptor agonists
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
AR113922A1 (es) 2017-12-08 2020-07-01 Incyte Corp Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7686891A (en) 1990-04-05 1991-10-30 American National Red Cross, The A protein family related to immediate-early protein expressed by human endothelial cells during differentiation
WO1999046277A1 (en) 1998-03-09 1999-09-16 Smithkline Beecham Corporation HUMAN EDG-1c POLYNUCLEOTIDES AND POLYPEPTIDES AND METHODS OF USE
AU2003279915A1 (en) 2002-10-15 2004-05-04 Merck And Co., Inc. Process for making azetidine-3-carboxylic acid
SI2069336T1 (sl) * 2006-09-07 2013-03-29 Actelion Pharmaceuticals Ltd. Derivati piridin-4-ila kot imunomodulirna sredstva
CL2007002594A1 (es) 2006-09-08 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de piridin-3-il, agentes inmunomoduladores; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades asociadas con un sistema inmunologico activado. .
KR20090051774A (ko) 2006-09-21 2009-05-22 액테리온 파마슈티칼 리미티드 페닐 유도체 및 면역조절제로서 이들의 용도
AU2008227979B2 (en) 2007-03-16 2014-02-06 Actelion Pharmaceuticals Ltd Amino- pyridine derivatives as S1P1 /EDG1 receptor agonists
MX2010001881A (es) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de piridina como moduladores del receptor s1p1/edg1.
KR20100075608A (ko) 2007-10-04 2010-07-02 메르크 세로노 에스. 에이. 옥사다이졸 유도체
ES2449749T3 (es) 2007-11-01 2014-03-21 Actelion Pharmaceuticals Ltd. Nuevos derivados de pirimidina
JP5411877B2 (ja) 2008-03-06 2014-02-12 アクテリオン ファーマシューティカルズ リミテッド ピリジン化合物
US20110046170A1 (en) 2008-03-06 2011-02-24 Martin Bolli Novel pyrimidine-pyridine derivatives
HRP20130641T1 (en) 2008-03-07 2013-08-31 Actelion Pharmaceuticals Ltd. Pyridin-2-yl derivatives as immunomodulating agents
RU2010140847A (ru) 2008-03-07 2012-04-20 Актелион Фармасьютиклз Лтд (Ch) Новые производные аминометилбензола
MY156381A (en) * 2008-05-14 2016-02-15 Scripps Research Inst Novel modulators of sphingosine phosphate receptors
CA2752804C (en) 2009-03-03 2017-04-04 Anna Quattropani Oxazole pyridine derivatives useful as s1p1 receptor agonists
MY153617A (en) 2009-07-16 2015-02-27 Actelion Pharmaceuticals Ltd Pyridin-4-yl derivatives
TW201120016A (en) 2009-12-08 2011-06-16 Abbott Lab Novel oxadiazole compounds
MX350009B (es) 2011-01-19 2017-08-23 Idorsia Pharmaceuticals Ltd Derivados de 2-metoxi-piridin-4-ilo.

Also Published As

Publication number Publication date
CY1119619T1 (el) 2018-04-04
DK2970236T3 (en) 2017-10-16
PL2970236T3 (pl) 2018-01-31
ES2649475T3 (es) 2018-01-12
KR102212975B1 (ko) 2021-02-05
PH12015502118B1 (en) 2016-01-25
US20160031866A1 (en) 2016-02-04
JP2016512227A (ja) 2016-04-25
HUE035154T2 (en) 2018-05-02
EA201500931A1 (ru) 2016-03-31
MY173573A (en) 2020-02-04
IL241363A0 (en) 2015-11-30
BR112015023161A8 (pt) 2021-06-22
CA2900910A1 (en) 2014-09-18
US9617250B2 (en) 2017-04-11
NO2970236T3 (cg-RX-API-DMAC7.html) 2018-01-27
AU2014229217A1 (en) 2015-11-05
AU2014229217B2 (en) 2017-12-14
CL2015002620A1 (es) 2016-03-18
EA029309B1 (ru) 2018-03-30
MX2015012293A (es) 2015-12-16
PH12015502118A1 (en) 2016-01-25
AR095523A1 (es) 2015-10-21
EP2970236A1 (en) 2016-01-20
CN105189487A (zh) 2015-12-23
IL241363B (en) 2018-11-29
LT2970236T (lt) 2017-11-10
HK1220454A1 (en) 2017-05-05
SA515361104B1 (ar) 2016-06-28
CN105189487B (zh) 2017-12-26
TW201443044A (zh) 2014-11-16
MA38482A1 (fr) 2017-12-29
EP2970236B1 (en) 2017-08-30
WO2014141171A1 (en) 2014-09-18
MX363545B (es) 2019-03-27
NZ713080A (en) 2020-06-26
CA2900910C (en) 2021-03-30
BR112015023161B1 (pt) 2022-11-16
JP6387361B2 (ja) 2018-09-05
KR20150128947A (ko) 2015-11-18
ZA201507657B (en) 2022-08-31
BR112015023161A2 (pt) 2017-07-18
HRP20171763T1 (hr) 2017-12-29
SG11201507227UA (en) 2015-10-29
TWI623534B (zh) 2018-05-11
MA38482B1 (fr) 2018-11-30
SI2970236T1 (sl) 2017-11-30
PT2970236T (pt) 2017-11-30

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