UA115228C2 - Інгібітори протеїнкіназ (варіанти), їх застосування для лікування онкологічних захворювань та фармацевтична композиція на їх основі - Google Patents
Інгібітори протеїнкіназ (варіанти), їх застосування для лікування онкологічних захворювань та фармацевтична композиція на їх основіInfo
- Publication number
- UA115228C2 UA115228C2 UAA201404861A UAA201404861A UA115228C2 UA 115228 C2 UA115228 C2 UA 115228C2 UA A201404861 A UAA201404861 A UA A201404861A UA A201404861 A UAA201404861 A UA A201404861A UA 115228 C2 UA115228 C2 UA 115228C2
- Authority
- UA
- Ukraine
- Prior art keywords
- protein kinase
- kinase inhibitors
- variants
- pharmaceutical composition
- composition based
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Даний винахід стосується терапії онкологічних, хронічних запальних та інших захворювань за допомогою нових сімейств хімічних сполук, що мають підвищену ефективність в інгібуванні Ab1-кінази і її мутантних форм, а також інших терапевтично значимих кіназ. Описано інгібітори протеїнкіназ, що являють собою сполуку загальної формули І, їх таутомери, їх фармацевтично прийнятна сіль. EMBED ISISServer
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2011124304/04A RU2477723C2 (ru) | 2011-06-16 | 2011-06-16 | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе |
PCT/RU2012/000423 WO2012173521A2 (ru) | 2011-06-16 | 2012-05-29 | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе |
Publications (1)
Publication Number | Publication Date |
---|---|
UA115228C2 true UA115228C2 (uk) | 2017-10-10 |
Family
ID=47357651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201404861A UA115228C2 (uk) | 2011-06-16 | 2012-05-29 | Інгібітори протеїнкіназ (варіанти), їх застосування для лікування онкологічних захворювань та фармацевтична композиція на їх основі |
Country Status (22)
Country | Link |
---|---|
US (1) | US9522910B2 (uk) |
EP (1) | EP2743266B8 (uk) |
AU (1) | AU2012269818B2 (uk) |
CA (1) | CA2850137C (uk) |
CY (1) | CY1118513T1 (uk) |
DK (1) | DK2743266T3 (uk) |
EA (1) | EA026704B1 (uk) |
ES (1) | ES2602797T3 (uk) |
HK (1) | HK1195771A1 (uk) |
HR (1) | HRP20161478T1 (uk) |
HU (1) | HUE031837T2 (uk) |
IL (1) | IL232357A (uk) |
IN (1) | IN2014MN00635A (uk) |
LT (1) | LT2743266T (uk) |
PL (1) | PL2743266T3 (uk) |
PT (1) | PT2743266T (uk) |
RS (1) | RS55380B1 (uk) |
RU (1) | RU2477723C2 (uk) |
SI (1) | SI2743266T1 (uk) |
SM (1) | SMT201600398B (uk) |
UA (1) | UA115228C2 (uk) |
WO (1) | WO2012173521A2 (uk) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101852169B1 (ko) | 2010-05-20 | 2018-04-26 | 어레이 바이오파마 인크. | Trk 키나제 저해제로서의 매크로시클릭 화합물 |
WO2013170770A1 (zh) * | 2012-05-16 | 2013-11-21 | 上海医药集团股份有限公司 | 具有抗肿瘤活性的乙炔衍生物 |
US8859553B2 (en) * | 2012-07-30 | 2014-10-14 | Astar Biotech Llc | Protein kinase inhibitors |
CN103664787B (zh) * | 2012-09-17 | 2015-09-09 | 南京圣和药业股份有限公司 | 炔杂芳环化合物及其应用 |
CN104341416B (zh) * | 2013-07-31 | 2017-03-29 | 南京圣和药业股份有限公司 | 蛋白酪氨酸激酶抑制剂及其应用 |
RU2697480C2 (ru) * | 2014-03-06 | 2019-08-14 | Юниверсити Оф Саутерн Калифорния | Применение режима краткосрочного голодания в сочетании с ингибиторами киназ для усовершенствования традиционной химио-лекарственной эффективности и пригодности и обращения вспять побочных эффектов от киназ в нормальных клетках и тканях |
US10172839B2 (en) | 2014-03-06 | 2019-01-08 | University Of Southern California | Use of short term starvation regimen in combination with kinase inhibitors to enhance traditional chemo-drug efficacy and feasibility and reverse side effects of kinases in normal cells and tissues |
AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
CN106146391A (zh) * | 2015-04-15 | 2016-11-23 | 中国科学院上海药物研究所 | 5-芳香炔基取代的苯甲酰胺类化合物及其制备方法、药物组合物和用途 |
SI3322706T1 (sl) | 2015-07-16 | 2021-04-30 | Array Biopharma, Inc. | Substituirane pirazolo(1,5-A)piridinske spojine kot zaviralci ret-kinaze |
RU2652992C2 (ru) * | 2016-04-18 | 2018-05-04 | Общество С Ограниченной Ответственностью "Фьюжн Фарма" | Новая кристаллическая солевая форма 3-(1,2,4-триазоло[4,3-а]пиридин-3-илэтинил)-4-метил-n-(4-((4-метилпиперазин-1-ил)метил)-3-трифторметилфенил)бензамида для медицинского применения |
JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
ES2948194T3 (es) | 2017-01-18 | 2023-09-01 | Array Biopharma Inc | Compuestos de pirazolo[1,5-a]pirazina sustituida como inhibidores de la cinasa RET |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
RU2664420C1 (ru) * | 2017-10-31 | 2018-08-17 | Общество С Ограниченной Ответственностью "Фьюжн Фарма" | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ДОЗИРОВКА И СПОСОБ ЛЕЧЕНИЯ Ph+ ЛЕЙКЕМИЙ |
WO2019143994A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
CN111971286B (zh) | 2018-01-18 | 2023-04-14 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物 |
CN111630054B (zh) | 2018-01-18 | 2023-05-09 | 奥瑞生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物 |
US11964988B2 (en) | 2018-09-10 | 2024-04-23 | Array Biopharma Inc. | Fused heterocyclic compounds as RET kinase inhibitors |
US11377438B2 (en) * | 2018-11-02 | 2022-07-05 | Merck Sharp & Dohme Llc | 2-amino-n-heteroaryl-nicotinamides as Nav1.8 inhibitors |
WO2022015051A1 (ko) * | 2020-07-14 | 2022-01-20 | 주식회사 보로노이바이오 | 아릴 또는 헤테로아릴 유도체, 및 이를 유효성분으로 포함하는 키나아제 관련 질환 예방 또는 치료용 약학적 조성물 |
GB202209210D0 (en) * | 2022-06-23 | 2022-08-10 | Univ Strathclyde | Cycloaddition reactions |
CN116217571A (zh) * | 2023-03-28 | 2023-06-06 | 上海锐谱医药科技有限公司 | 一种制备药物砌块1,2,4-三唑并[4,3-a]吡啶-3-胺的方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6638926B2 (en) | 2000-09-15 | 2003-10-28 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
US7709520B2 (en) | 2000-10-06 | 2010-05-04 | The Texas A&M University System | Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers |
KR20070026390A (ko) | 2004-01-23 | 2007-03-08 | 암젠 인코포레이션 | 화합물 및 사용방법 |
JP4688876B2 (ja) | 2004-06-10 | 2011-05-25 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
AU2006262166A1 (en) | 2005-06-24 | 2007-01-04 | Merck Sharp & Dohme Corp. | Modified malonate derivatives |
PL2495016T3 (pl) * | 2005-12-23 | 2020-06-01 | Ariad Pharmaceuticals, Inc. | Bicykliczne związki heteroarylowe |
US7812018B2 (en) | 2006-02-16 | 2010-10-12 | Millennium Pharmaceuticals, Inc. | Alpha carbolines and uses thereof |
MX2008014289A (es) * | 2006-05-08 | 2008-11-26 | Ariad Pharma Inc | Compuestos heteroarilicos acetilenicos. |
PL2032166T3 (pl) | 2006-06-13 | 2013-09-30 | Oncomed Pharm Inc | Kompozycje i sposoby diagnozowania i leczenia nowotworów |
US7612085B2 (en) | 2006-07-11 | 2009-11-03 | Washington University | Sigma 2 receptor ligands and therapeutic uses therefor |
WO2008077138A1 (en) | 2006-12-19 | 2008-06-26 | The Board Of Trustees Of The University Of Illinois | 3-benzofuranyl-4-indolyl maleimides as potent gsk3 inhibitors for neurogenerative disorders |
WO2008156783A2 (en) | 2007-06-18 | 2008-12-24 | University Of Louisville Research Foundation, Inc. | Family of pfkfb3 inhibitors with anti-neoplastic activities |
DK2235002T3 (da) | 2008-01-23 | 2013-03-11 | Bristol Myers Squibb Co | 4-pyridinonforbindelser og anvendelse heraf til behandling af cancer |
US8211911B2 (en) | 2008-08-19 | 2012-07-03 | Guoqing Paul Chen | Compounds as kinase inhibitors |
US8188109B2 (en) | 2009-07-20 | 2012-05-29 | Naxospharma S.R.L. | Benzoquinolizinium salt derivatives as anticancer agents |
US8242282B2 (en) | 2010-05-18 | 2012-08-14 | Taipei Medical University | Histone deacetylase inhibitors |
RU2011113236A (ru) | 2011-04-07 | 2012-10-20 | Общество с ограниченной ответственностью "Фьюжн Фарма" (RU) | Новые химические соединения для лечения онкологических заболеваний |
WO2013170770A1 (zh) * | 2012-05-16 | 2013-11-21 | 上海医药集团股份有限公司 | 具有抗肿瘤活性的乙炔衍生物 |
US8859553B2 (en) | 2012-07-30 | 2014-10-14 | Astar Biotech Llc | Protein kinase inhibitors |
-
2011
- 2011-06-16 RU RU2011124304/04A patent/RU2477723C2/ru active IP Right Revival
-
2012
- 2012-05-29 AU AU2012269818A patent/AU2012269818B2/en active Active
- 2012-05-29 LT LTEP12801171.5T patent/LT2743266T/lt unknown
- 2012-05-29 PT PT128011715T patent/PT2743266T/pt unknown
- 2012-05-29 ES ES12801171.5T patent/ES2602797T3/es active Active
- 2012-05-29 DK DK12801171.5T patent/DK2743266T3/en active
- 2012-05-29 CA CA2850137A patent/CA2850137C/en active Active
- 2012-05-29 IN IN635MUN2014 patent/IN2014MN00635A/en unknown
- 2012-05-29 EA EA201491356A patent/EA026704B1/ru unknown
- 2012-05-29 UA UAA201404861A patent/UA115228C2/uk unknown
- 2012-05-29 PL PL12801171T patent/PL2743266T3/pl unknown
- 2012-05-29 EP EP12801171.5A patent/EP2743266B8/en active Active
- 2012-05-29 HU HUE12801171A patent/HUE031837T2/en unknown
- 2012-05-29 RS RS20160956A patent/RS55380B1/sr unknown
- 2012-05-29 SI SI201230763A patent/SI2743266T1/en unknown
- 2012-05-29 WO PCT/RU2012/000423 patent/WO2012173521A2/ru active Application Filing
-
2014
- 2014-04-01 US US14/242,241 patent/US9522910B2/en active Active
- 2014-04-29 IL IL232357A patent/IL232357A/en active IP Right Grant
- 2014-09-12 HK HK14109243.0A patent/HK1195771A1/zh unknown
-
2016
- 2016-11-07 SM SM201600398T patent/SMT201600398B/it unknown
- 2016-11-08 HR HRP20161478TT patent/HRP20161478T1/hr unknown
- 2016-11-16 CY CY20161101178T patent/CY1118513T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP2743266A2 (en) | 2014-06-18 |
PT2743266T (pt) | 2016-10-14 |
HK1195771A1 (zh) | 2014-11-21 |
WO2012173521A2 (ru) | 2012-12-20 |
CY1118513T1 (el) | 2017-07-12 |
WO2012173521A3 (ru) | 2013-03-28 |
PL2743266T3 (pl) | 2017-02-28 |
CA2850137A1 (en) | 2012-12-20 |
LT2743266T (lt) | 2016-12-12 |
US9522910B2 (en) | 2016-12-20 |
EA026704B1 (ru) | 2017-05-31 |
US20140213592A1 (en) | 2014-07-31 |
AU2012269818A1 (en) | 2014-06-26 |
EA201491356A1 (ru) | 2015-01-30 |
EP2743266B8 (en) | 2016-09-28 |
DK2743266T3 (en) | 2016-12-05 |
AU2012269818B2 (en) | 2016-05-19 |
SMT201600398B (it) | 2017-01-10 |
IN2014MN00635A (uk) | 2015-07-03 |
RU2477723C2 (ru) | 2013-03-20 |
HUE031837T2 (en) | 2017-08-28 |
ES2602797T3 (es) | 2017-02-22 |
IL232357A0 (en) | 2014-07-01 |
IL232357A (en) | 2017-05-29 |
SI2743266T1 (en) | 2017-02-28 |
HRP20161478T1 (hr) | 2016-12-16 |
EP2743266A4 (en) | 2015-03-11 |
RS55380B1 (sr) | 2017-03-31 |
EP2743266B1 (en) | 2016-08-17 |
CA2850137C (en) | 2016-10-25 |
RU2011124304A (ru) | 2012-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA115228C2 (uk) | Інгібітори протеїнкіназ (варіанти), їх застосування для лікування онкологічних захворювань та фармацевтична композиція на їх основі | |
JO2885B1 (en) | Protein kinase inhibitors | |
PH12018502125A1 (en) | Bipyrazole derivatives as jak inhibitors | |
TN2014000128A1 (en) | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh | |
MX2015012822A (es) | 3-pirimidin-4-il-oxazolidin-2-onas- como inhibidores del idh mutante. | |
UA115320C2 (uk) | Інгібітори кінази | |
EA201171213A1 (ru) | Ингибитор р38 мар киназы | |
UA111382C2 (uk) | Інгібітори протеїнкінази | |
MX2013008296A (es) | Diarilacetileno hidracido que contiene inhibidores de tirosina quinasa. | |
EA201100580A1 (ru) | Имидазопиридазинкарбонитрилы, используемые в качестве ингибиторов киназы | |
PL415078A1 (pl) | Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków | |
AU2012214029A8 (en) | Rorgammat inhibitors | |
PH12014501355A1 (en) | Disubstituted benzothienyl-pyrrolotriazines and their use as fgfr kinase inhibitors | |
MX344335B (es) | Derivados de benzonitrilo como inhibidores de cinasa. | |
MX2009011810A (es) | Tiazoles y pirazoles utiles como inhibidores de cinasa. | |
MX346186B (es) | Inhibidores de proteina cinasas. | |
MX2009012719A (es) | Tiazoles y pirazoles utiles como inhibidores de cinasa. | |
WO2009033033A3 (en) | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases | |
WO2012135697A3 (en) | Novel rho kinase inhibitors and methods of use | |
PH12014501278A1 (en) | Kinase inhibitors | |
MX2010007948A (es) | Inhibidores de proteinas de apoptosis. | |
MA32183B1 (fr) | Pyrimidylcyclopentanes hydroxylés utilisés comme inhibiteurs de protéine kinase akt | |
NZ598144A (en) | Kinase inhibitors, prodrug forms thereof and their use in therapy | |
ATE502935T1 (de) | C-met-proteinkinasehemmer | |
MX2011012522A (es) | Inhibidores de pirazol sustituido de proteina cinasa c-met. |