UA115228C2 - Інгібітори протеїнкіназ (варіанти), їх застосування для лікування онкологічних захворювань та фармацевтична композиція на їх основі - Google Patents
Інгібітори протеїнкіназ (варіанти), їх застосування для лікування онкологічних захворювань та фармацевтична композиція на їх основіInfo
- Publication number
- UA115228C2 UA115228C2 UAA201404861A UAA201404861A UA115228C2 UA 115228 C2 UA115228 C2 UA 115228C2 UA A201404861 A UAA201404861 A UA A201404861A UA A201404861 A UAA201404861 A UA A201404861A UA 115228 C2 UA115228 C2 UA 115228C2
- Authority
- UA
- Ukraine
- Prior art keywords
- protein kinase
- kinase inhibitors
- variants
- pharmaceutical composition
- composition based
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Даний винахід стосується терапії онкологічних, хронічних запальних та інших захворювань за допомогою нових сімейств хімічних сполук, що мають підвищену ефективність в інгібуванні Ab1-кінази і її мутантних форм, а також інших терапевтично значимих кіназ. Описано інгібітори протеїнкіназ, що являють собою сполуку загальної формули І, їх таутомери, їх фармацевтично прийнятна сіль. EMBED ISISServer
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2011124304/04A RU2477723C2 (ru) | 2011-06-16 | 2011-06-16 | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе |
PCT/RU2012/000423 WO2012173521A2 (ru) | 2011-06-16 | 2012-05-29 | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе |
Publications (1)
Publication Number | Publication Date |
---|---|
UA115228C2 true UA115228C2 (uk) | 2017-10-10 |
Family
ID=47357651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201404861A UA115228C2 (uk) | 2011-06-16 | 2012-05-29 | Інгібітори протеїнкіназ (варіанти), їх застосування для лікування онкологічних захворювань та фармацевтична композиція на їх основі |
Country Status (22)
Country | Link |
---|---|
US (1) | US9522910B2 (uk) |
EP (1) | EP2743266B8 (uk) |
AU (1) | AU2012269818B2 (uk) |
CA (1) | CA2850137C (uk) |
CY (1) | CY1118513T1 (uk) |
DK (1) | DK2743266T3 (uk) |
EA (1) | EA026704B1 (uk) |
ES (1) | ES2602797T3 (uk) |
HK (1) | HK1195771A1 (uk) |
HR (1) | HRP20161478T1 (uk) |
HU (1) | HUE031837T2 (uk) |
IL (1) | IL232357A (uk) |
IN (1) | IN2014MN00635A (uk) |
LT (1) | LT2743266T (uk) |
PL (1) | PL2743266T3 (uk) |
PT (1) | PT2743266T (uk) |
RS (1) | RS55380B1 (uk) |
RU (1) | RU2477723C2 (uk) |
SI (1) | SI2743266T1 (uk) |
SM (1) | SMT201600398B (uk) |
UA (1) | UA115228C2 (uk) |
WO (1) | WO2012173521A2 (uk) |
Families Citing this family (26)
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ES2534335T3 (es) | 2010-05-20 | 2015-04-21 | Array Biopharma, Inc. | Compuestos macrocíclicos como inhibidores de la Trk cinasa |
WO2013170770A1 (zh) * | 2012-05-16 | 2013-11-21 | 上海医药集团股份有限公司 | 具有抗肿瘤活性的乙炔衍生物 |
US8859553B2 (en) * | 2012-07-30 | 2014-10-14 | Astar Biotech Llc | Protein kinase inhibitors |
CN103664787B (zh) * | 2012-09-17 | 2015-09-09 | 南京圣和药业股份有限公司 | 炔杂芳环化合物及其应用 |
CN104341416B (zh) * | 2013-07-31 | 2017-03-29 | 南京圣和药业股份有限公司 | 蛋白酪氨酸激酶抑制剂及其应用 |
RU2697480C2 (ru) * | 2014-03-06 | 2019-08-14 | Юниверсити Оф Саутерн Калифорния | Применение режима краткосрочного голодания в сочетании с ингибиторами киназ для усовершенствования традиционной химио-лекарственной эффективности и пригодности и обращения вспять побочных эффектов от киназ в нормальных клетках и тканях |
US10172839B2 (en) | 2014-03-06 | 2019-01-08 | University Of Southern California | Use of short term starvation regimen in combination with kinase inhibitors to enhance traditional chemo-drug efficacy and feasibility and reverse side effects of kinases in normal cells and tissues |
AR104259A1 (es) * | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
CN106146391A (zh) | 2015-04-15 | 2016-11-23 | 中国科学院上海药物研究所 | 5-芳香炔基取代的苯甲酰胺类化合物及其制备方法、药物组合物和用途 |
PT3322706T (pt) | 2015-07-16 | 2021-03-08 | Array Biopharma Inc | Compostos de pirazolo[1,5-a]piridina substituídos como inibidores da quinase do ret |
RU2652992C2 (ru) * | 2016-04-18 | 2018-05-04 | Общество С Ограниченной Ответственностью "Фьюжн Фарма" | Новая кристаллическая солевая форма 3-(1,2,4-триазоло[4,3-а]пиридин-3-илэтинил)-4-метил-n-(4-((4-метилпиперазин-1-ил)метил)-3-трифторметилфенил)бензамида для медицинского применения |
TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
CN110267960B (zh) | 2017-01-18 | 2022-04-26 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物 |
WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
RU2664420C1 (ru) * | 2017-10-31 | 2018-08-17 | Общество С Ограниченной Ответственностью "Фьюжн Фарма" | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ДОЗИРОВКА И СПОСОБ ЛЕЧЕНИЯ Ph+ ЛЕЙКЕМИЙ |
EP3740486A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
WO2019143977A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
CN111630054B (zh) | 2018-01-18 | 2023-05-09 | 奥瑞生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物 |
CN112996794A (zh) | 2018-09-10 | 2021-06-18 | 阿雷生物药品公司 | 作为ret激酶抑制剂的稠合杂环化合物 |
EP3873893A1 (en) * | 2018-11-02 | 2021-09-08 | Merck Sharp & Dohme Corp. | 2-amino-n-heteroaryl-nicotinamides as nav1.8 inhibitors |
WO2022015051A1 (ko) * | 2020-07-14 | 2022-01-20 | 주식회사 보로노이바이오 | 아릴 또는 헤테로아릴 유도체, 및 이를 유효성분으로 포함하는 키나아제 관련 질환 예방 또는 치료용 약학적 조성물 |
GB202209210D0 (en) * | 2022-06-23 | 2022-08-10 | Univ Strathclyde | Cycloaddition reactions |
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RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
EP1318997B1 (en) | 2000-09-15 | 2006-05-31 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US7709520B2 (en) | 2000-10-06 | 2010-05-04 | The Texas A&M University System | Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers |
CN1933839A (zh) | 2004-01-23 | 2007-03-21 | 安进公司 | 化合物和使用方法 |
EP1758892B1 (en) | 2004-06-10 | 2012-10-17 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
JP2008546793A (ja) | 2005-06-24 | 2008-12-25 | メルク エンド カムパニー インコーポレーテッド | 修飾マロン酸誘導体 |
EP3747441A1 (en) * | 2005-12-23 | 2020-12-09 | ARIAD Pharmaceuticals, Inc. | Bicyclic heteroaryl compounds |
JP2009526855A (ja) | 2006-02-16 | 2009-07-23 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | アルファカルボリンおよびその使用 |
MX2008014289A (es) * | 2006-05-08 | 2008-11-26 | Ariad Pharma Inc | Compuestos heteroarilicos acetilenicos. |
US7919092B2 (en) | 2006-06-13 | 2011-04-05 | Oncomed Pharmaceuticals, Inc. | Antibodies to notch receptors |
US7612085B2 (en) | 2006-07-11 | 2009-11-03 | Washington University | Sigma 2 receptor ligands and therapeutic uses therefor |
ES2446269T3 (es) | 2006-12-19 | 2014-03-06 | The Board Of Trustees Of The University Of Illinois | 3-Benzofuranil-4-indolil-maleimidas como potentes inhibidores de GSK-3 para trastornos neurodegenerativos |
WO2008156783A2 (en) | 2007-06-18 | 2008-12-24 | University Of Louisville Research Foundation, Inc. | Family of pfkfb3 inhibitors with anti-neoplastic activities |
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US8211911B2 (en) | 2008-08-19 | 2012-07-03 | Guoqing Paul Chen | Compounds as kinase inhibitors |
US8188109B2 (en) | 2009-07-20 | 2012-05-29 | Naxospharma S.R.L. | Benzoquinolizinium salt derivatives as anticancer agents |
US8242282B2 (en) | 2010-05-18 | 2012-08-14 | Taipei Medical University | Histone deacetylase inhibitors |
RU2011113236A (ru) | 2011-04-07 | 2012-10-20 | Общество с ограниченной ответственностью "Фьюжн Фарма" (RU) | Новые химические соединения для лечения онкологических заболеваний |
WO2013170770A1 (zh) * | 2012-05-16 | 2013-11-21 | 上海医药集团股份有限公司 | 具有抗肿瘤活性的乙炔衍生物 |
US8859553B2 (en) | 2012-07-30 | 2014-10-14 | Astar Biotech Llc | Protein kinase inhibitors |
-
2011
- 2011-06-16 RU RU2011124304/04A patent/RU2477723C2/ru active IP Right Revival
-
2012
- 2012-05-29 RS RS20160956A patent/RS55380B1/sr unknown
- 2012-05-29 PT PT128011715T patent/PT2743266T/pt unknown
- 2012-05-29 LT LTEP12801171.5T patent/LT2743266T/lt unknown
- 2012-05-29 ES ES12801171.5T patent/ES2602797T3/es active Active
- 2012-05-29 CA CA2850137A patent/CA2850137C/en active Active
- 2012-05-29 DK DK12801171.5T patent/DK2743266T3/en active
- 2012-05-29 EP EP12801171.5A patent/EP2743266B8/en active Active
- 2012-05-29 UA UAA201404861A patent/UA115228C2/uk unknown
- 2012-05-29 IN IN635MUN2014 patent/IN2014MN00635A/en unknown
- 2012-05-29 SI SI201230763A patent/SI2743266T1/en unknown
- 2012-05-29 WO PCT/RU2012/000423 patent/WO2012173521A2/ru active Application Filing
- 2012-05-29 AU AU2012269818A patent/AU2012269818B2/en active Active
- 2012-05-29 EA EA201491356A patent/EA026704B1/ru unknown
- 2012-05-29 PL PL12801171T patent/PL2743266T3/pl unknown
- 2012-05-29 HU HUE12801171A patent/HUE031837T2/en unknown
-
2014
- 2014-04-01 US US14/242,241 patent/US9522910B2/en active Active
- 2014-04-29 IL IL232357A patent/IL232357A/en active IP Right Grant
- 2014-09-12 HK HK14109243.0A patent/HK1195771A1/zh unknown
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2016
- 2016-11-07 SM SM201600398T patent/SMT201600398B/it unknown
- 2016-11-08 HR HRP20161478TT patent/HRP20161478T1/hr unknown
- 2016-11-16 CY CY20161101178T patent/CY1118513T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2012269818A1 (en) | 2014-06-26 |
EA201491356A1 (ru) | 2015-01-30 |
IN2014MN00635A (uk) | 2015-07-03 |
HUE031837T2 (en) | 2017-08-28 |
RS55380B1 (sr) | 2017-03-31 |
LT2743266T (lt) | 2016-12-12 |
US20140213592A1 (en) | 2014-07-31 |
WO2012173521A2 (ru) | 2012-12-20 |
SMT201600398B (it) | 2017-01-10 |
WO2012173521A3 (ru) | 2013-03-28 |
EP2743266B1 (en) | 2016-08-17 |
SI2743266T1 (en) | 2017-02-28 |
IL232357A0 (en) | 2014-07-01 |
RU2477723C2 (ru) | 2013-03-20 |
DK2743266T3 (en) | 2016-12-05 |
HRP20161478T1 (hr) | 2016-12-16 |
US9522910B2 (en) | 2016-12-20 |
PL2743266T3 (pl) | 2017-02-28 |
EP2743266A2 (en) | 2014-06-18 |
HK1195771A1 (zh) | 2014-11-21 |
EP2743266B8 (en) | 2016-09-28 |
PT2743266T (pt) | 2016-10-14 |
CA2850137C (en) | 2016-10-25 |
AU2012269818B2 (en) | 2016-05-19 |
IL232357A (en) | 2017-05-29 |
EA026704B1 (ru) | 2017-05-31 |
CY1118513T1 (el) | 2017-07-12 |
CA2850137A1 (en) | 2012-12-20 |
EP2743266A4 (en) | 2015-03-11 |
RU2011124304A (ru) | 2012-12-27 |
ES2602797T3 (es) | 2017-02-22 |
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