UA106458C2 - Чутливий до сульфонілсечовини репресорний білок - Google Patents

Чутливий до сульфонілсечовини репресорний білок

Info

Publication number
UA106458C2
UA106458C2 UAA201312853A UAA201312853A UA106458C2 UA 106458 C2 UA106458 C2 UA 106458C2 UA A201312853 A UAA201312853 A UA A201312853A UA A201312853 A UAA201312853 A UA A201312853A UA 106458 C2 UA106458 C2 UA 106458C2
Authority
UA
Ukraine
Prior art keywords
sulfonylurea
polypeptide
repressor protein
responsive repressor
polynucleotide
Prior art date
Application number
UAA201312853A
Other languages
English (en)
Russian (ru)
Inventor
Майкл ЛАССНЕР
Лорен Л. Лугер
Кевін Е. Макбрайд
Брайан МакГонігл
Original Assignee
Піонер Хай-Бред Інтернешенл, Інк.
Е. І. Дюпон Де Немур Енд Компані
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Піонер Хай-Бред Інтернешенл, Інк., Е. І. Дюпон Де Немур Енд Компані filed Critical Піонер Хай-Бред Інтернешенл, Інк.
Publication of UA106458C2 publication Critical patent/UA106458C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8217—Gene switch
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8237—Externally regulated expression systems
    • C12N15/8238—Externally regulated expression systems chemically inducible, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
    • C12N15/8278—Sulfonylurea

Abstract

Винахід належить до ізольованого поліпептиду, який включає чутливий до сульфонілсечовини репресор, що специфічно зв'язується з полінуклеотидом, який включає послідовність оператора, де зв'язування регулюється сполукою сульфонілсечовини, і причому зазначений поліпептид включає амінокислотну послідовність, яка має принаймні 90 % ідентичності послідовності до SEQ ID NO: 1233. Винахід також належить до способу регуляції транскрипції полінуклеотиду, який представляє інтерес, у клітині-хазяїні із застосуванням зазначеного поліпептида.
UAA201312853A 2008-10-28 2009-10-22 Чутливий до сульфонілсечовини репресорний білок UA106458C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10891708P 2008-10-28 2008-10-28
UAA201106478A UA105017C2 (uk) 2008-10-28 2009-10-22 Чутливі до сульфонілсечовини репресорні білки

Publications (1)

Publication Number Publication Date
UA106458C2 true UA106458C2 (uk) 2014-08-26

Family

ID=42026787

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201106478A UA105017C2 (uk) 2008-10-28 2009-10-22 Чутливі до сульфонілсечовини репресорні білки
UAA201312853A UA106458C2 (uk) 2008-10-28 2009-10-22 Чутливий до сульфонілсечовини репресорний білок

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UAA201106478A UA105017C2 (uk) 2008-10-28 2009-10-22 Чутливі до сульфонілсечовини репресорні білки

Country Status (9)

Country Link
US (7) US8257956B2 (uk)
EP (1) EP2364322A1 (uk)
CN (1) CN102264758B (uk)
CA (1) CA2740147A1 (uk)
MX (1) MX2011003766A (uk)
RU (1) RU2532854C2 (uk)
UA (2) UA105017C2 (uk)
WO (1) WO2010062518A1 (uk)
ZA (1) ZA201102495B (uk)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8257956B2 (en) 2008-10-28 2012-09-04 E. I. Du Pont De Nemours And Company Sulfonylurea-responsive repressor proteins
WO2011133387A1 (en) * 2010-04-23 2011-10-27 Pioneer Hi-Bred International, Inc. Gene switch compositions and methods of use
US20140173781A1 (en) 2012-12-13 2014-06-19 Pioneer Hi-Bred International, Inc. Methods and compositions for producing and selecting transgenic wheat plants
US20160152995A1 (en) * 2013-03-11 2016-06-02 Pioneer Hi-Bred International, Inc. Methods and compositions to improve the spread of chemical signals in plants
CA2905399A1 (en) * 2013-03-11 2014-10-09 Pioneer Hi-Bred International, Inc. Methods and compositions employing a sulfonylurea-dependent stabilization domain
CN105829536A (zh) 2013-08-22 2016-08-03 纳幕尔杜邦公司 用于在不掺入选择性转基因标记的情况下，在植物基因组中产生基因修饰的方法，以及用于这种方法的组合物
CN108138155A (zh) 2015-10-20 2018-06-08 先锋国际良种公司 经由指导cas系统恢复非功能性基因产物的功能及使用方法
CN108292328B (zh) * 2015-11-10 2022-04-19 美国陶氏益农公司 用于预测转基因沉默风险的方法和系统
EP3497115A4 (en) * 2016-08-15 2020-07-29 enEvolv, Inc. MOLECULE SENSOR SYSTEMS
US20210002657A1 (en) 2018-03-02 2021-01-07 Pioneer Hi-Bred International, Inc. Plant health assay
WO2020005933A1 (en) 2018-06-28 2020-01-02 Pioneer Hi-Bred International, Inc. Methods for selecting transformed plants
JP2022512817A (ja) 2018-10-31 2022-02-07 パイオニア ハイ－ブレッド インターナショナル， インコーポレイテッド オクロバクテリウム（Ｏｃｈｒｏｂａｃｔｒｕｍ）媒介植物形質転換のための組成物及び方法
US20220154203A1 (en) 2019-03-11 2022-05-19 Pioneer Hi-Bred International, Inc. Methods for clonal plant production
US20220154193A1 (en) 2019-03-28 2022-05-19 Pioneer Hi-Bred International, Inc. Modified agrobacterium strains and use thereof for plant transformation

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US564168A (en) * 1896-07-14 George armes tower
US4476227A (en) * 1982-10-06 1984-10-09 Smithkline Beckman Corporation Cosmid cloning vectors
US5605011A (en) * 1986-08-26 1997-02-25 E. I. Du Pont De Nemours And Company Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase
DE4100594A1 (de) 1991-01-08 1992-07-09 Inst Genbiologische Forschung Neue plasmide zur zeitlichen und oertlichen kontrollierten expression eines heterologen produktes in pflanzen
CA2143326A1 (en) * 1992-08-26 1994-03-03 Guerard Byrne Tetracycline repressor-mediated binary regulation system for control of gene expression in transgenic animals
US5589362A (en) 1993-06-14 1996-12-31 Basf Aktiengesellschaft Tetracycline regulated transcriptional modulators with altered DNA binding specificities
US5814618A (en) 1993-06-14 1998-09-29 Basf Aktiengesellschaft Methods for regulating gene expression
US5866755A (en) 1993-06-14 1999-02-02 Basf Aktiengellschaft Animals transgenic for a tetracycline-regulated transcriptional inhibitor
US5912411A (en) 1993-06-14 1999-06-15 University Of Heidelberg Mice transgenic for a tetracycline-inducible transcriptional activator
US5888981A (en) 1993-06-14 1999-03-30 Basf Aktiengesellschaft Methods for regulating gene expression
DE705334T1 (de) 1993-06-14 1999-12-30 Basf Ag Strenge kontrolle der genexpression in eukaryotischen zellen durch auf tetrazyklin ansprechende promotoren
US5859310A (en) 1993-06-14 1999-01-12 Basf Aktiengesellschaft Mice transgenic for a tetracycline-controlled transcriptional activator
US5654168A (en) 1994-07-01 1997-08-05 Basf Aktiengesellschaft Tetracycline-inducible transcriptional activator and tetracycline-regulated transcription units
US6004941A (en) 1993-06-14 1999-12-21 Basf Aktiengesellschaft Methods for regulating gene expression
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5789156A (en) 1993-06-14 1998-08-04 Basf Ag Tetracycline-regulated transcriptional inhibitors
US5723765A (en) 1994-08-01 1998-03-03 Delta And Pine Land Co. Control of plant gene expression
EG23907A (en) 1994-08-01 2007-12-30 Delta & Pine Land Co Control of plant gene expression
US5851796A (en) 1995-06-07 1998-12-22 Yale University Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes
US6087166A (en) 1997-07-03 2000-07-11 Basf Aktiengesellschaft Transcriptional activators with graded transactivation potential
WO1999027108A1 (en) 1997-11-20 1999-06-03 William Marsh Rice University Lactose repressor proteins with altered ligand responsivity
DE60043889D1 (en) 1999-06-07 2010-04-08 Tet Systems Holding Gmbh & Co Tet repressor basierte transkriptionale regulatorische proteine
AU2001293798B2 (en) * 2000-09-09 2006-12-21 Basf Plant Science Gmbh Modified tet-inducible system for regulation of gene expression in plants
MXPA03005039A (es) * 2000-12-07 2004-08-02 Gencell Sa Secuencias anteriores al gen prac, vectores que las contienen y usos de las mismas.
GB0123401D0 (en) 2001-09-28 2001-11-21 Novartis Forschungsstiftung Methods of inducing gene expression
US20030186281A1 (en) 2001-12-21 2003-10-02 Wolfgang Hillen Modified tetracycline repressor protein compositions and methods of use
CN1385527A (zh) 2002-02-08 2002-12-18 复旦大学 一种受化学除草剂诱导的启动子及其应用
DK1532260T3 (da) 2002-08-28 2009-03-09 Tet Systems Holding Gmbh & Co Kromosomale lod til stringent regulering af genaktiviteter via transkriptionsaktiveringssystemer
CA2442521A1 (en) 2002-10-03 2004-04-03 Derek Lydiate Repressor-mediated selection strategies
US20040133944A1 (en) 2003-01-08 2004-07-08 Delta And Pine Land Company Seed oil suppression to enhance yield of commercially important macromolecules
GB2404382B (en) 2003-07-28 2008-01-30 Oxitec Ltd Pest control
US7491811B2 (en) 2004-01-15 2009-02-17 University Of Georgia Research Foundation, Inc. Repressor-mediated tissue-specific gene expression in plants
US7674621B2 (en) * 2004-05-21 2010-03-09 The United States Of America As Represented By The Department Of Health And Human Services Plasmids and phages for homologous recombination and methods of use
WO2005123923A2 (en) 2004-06-17 2005-12-29 Wolfgang Hillen Inducer specific tetracycline repressor proteins and methods of use thereof
WO2006124502A2 (en) 2005-05-12 2006-11-23 Delta And Pine Land Company An inducible genetic cascade for triggering protein expression in subsequent generations of plants
CA2652347A1 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
US8080647B2 (en) * 2006-11-22 2011-12-20 Pioneer Hi Bred International Inc Tetracycline repressor and uses thereof
US8257956B2 (en) 2008-10-28 2012-09-04 E. I. Du Pont De Nemours And Company Sulfonylurea-responsive repressor proteins

Also Published As

Publication number Publication date
EP2364322A1 (en) 2011-09-14
RU2011121542A (ru) 2012-12-10
US20110212838A1 (en) 2011-09-01
US8877503B2 (en) 2014-11-04
US8580556B2 (en) 2013-11-12
RU2532854C2 (ru) 2014-11-10
CN102264758A (zh) 2011-11-30
US20150184169A1 (en) 2015-07-02
MX2011003766A (es) 2011-04-27
US20110294216A1 (en) 2011-12-01
US8257956B2 (en) 2012-09-04
US20120295354A1 (en) 2012-11-22
ZA201102495B (en) 2012-06-27
UA105017C2 (uk) 2014-04-10
US20160060304A1 (en) 2016-03-03
WO2010062518A1 (en) 2010-06-03
US9206432B2 (en) 2015-12-08
CN102264758B (zh) 2015-04-22
US20100105141A1 (en) 2010-04-29
US8993315B2 (en) 2015-03-31
CA2740147A1 (en) 2010-06-03
US20140033371A1 (en) 2014-01-30
WO2010062518A4 (en) 2010-08-05

Similar Documents

Publication Publication Date Title
UA106458C2 (uk) Чутливий до сульфонілсечовини репресорний білок
PH12018501250A1 (en) Chimeric factor viii polypeptides and uses thereof
MX346731B (es) Producción de proteínas heteromultiméricas.
MY153751A (en) Antibodies directed to her-3 and uses thereof
MX355255B (es) Variantes de fc y métodos para su producción.
IN2012DN01652A (uk)
MX2012005527A (es) Preparaciones que contienen el factor de von willebrand (fvw) procedimientos, kits y aplicaciones relacionados con las mismas.
WO2012160563A3 (en) Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
NZ587506A (en) Selective exosite inhibition of papp-a activity against igfbp-4
EA200801531A1 (ru) Способы регулирования содержания маннозы в рекомбинантных белках
EP3053931A3 (en) Chromatography matrices including novel staphylococcus aureus protein a based ligands
MX348071B (es) Variantes de fc.
EA200970909A1 (ru) Новый антиген, ассоциированный с новообразованными сосудами опухолевых метастазов
NZ628625A (en) Polypeptides binding to human complement c5
EA201300048A1 (ru) Система экспрессии гетерологичных и гомологичных целлюлаз
WO2011056954A8 (en) Haemophilus parasuis polypeptides and methods of use
MX346117B (es) Metodo para produccion mejorada de proteinas en hongo filamentoso.
MX2021001418A (es) Produccion de proteinas heteromultimericas usando celulas de mamifero.
NZ605640A (en) Signal biomarkers
MX2018003445A (es) Expresion de proteinas que contienen fc.
FI20105634A0 (fi) Proteiinien parannettu tuotto rihmamaisilla sienillä
WO2009137837A3 (en) Neuregulin/erbb signaling and integrin
WO2013178809A3 (en) Oral preparation
WO2009149083A3 (en) Non-hemolytic clya for excretion of proteins
AU2011350442B2 (en) Modified tamavidin