UA104187C2 - Полимерные конъюгаты паклитакселя и доцетакселя с рн-контролируемым высвобождением средства, которое оказывает статическое действие на злокачественные новообразования - Google Patents
Полимерные конъюгаты паклитакселя и доцетакселя с рн-контролируемым высвобождением средства, которое оказывает статическое действие на злокачественные новообразованияInfo
- Publication number
- UA104187C2 UA104187C2 UAA201115172A UAA201115172A UA104187C2 UA 104187 C2 UA104187 C2 UA 104187C2 UA A201115172 A UAA201115172 A UA A201115172A UA A201115172 A UAA201115172 A UA A201115172A UA 104187 C2 UA104187 C2 UA 104187C2
- Authority
- UA
- Ukraine
- Prior art keywords
- polymeric
- docetaxel
- paclitaxel
- carrier
- preparation
- Prior art date
Links
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title abstract 3
- 229930012538 Paclitaxel Natural products 0.000 title abstract 3
- 229960003668 docetaxel Drugs 0.000 title abstract 3
- 229960001592 paclitaxel Drugs 0.000 title abstract 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 3
- 230000003327 cancerostatic effect Effects 0.000 title 1
- 229920001577 copolymer Polymers 0.000 abstract 2
- 239000000824 cytostatic agent Substances 0.000 abstract 2
- 229950005692 larotaxel Drugs 0.000 abstract 2
- SEFGUGYLLVNFIJ-QDRLFVHASA-N larotaxel dihydrate Chemical compound O.O.O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@@]23[C@H]1[C@@]1(CO[C@@H]1C[C@@H]2C3)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 SEFGUGYLLVNFIJ-QDRLFVHASA-N 0.000 abstract 2
- VHSHLMUCYSAUQU-UHFFFAOYSA-N 2-hydroxypropyl methacrylate Chemical compound CC(O)COC(=O)C(C)=C VHSHLMUCYSAUQU-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000015636 Oligopeptides Human genes 0.000 abstract 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 1
- 229940123237 Taxane Drugs 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000007857 hydrazones Chemical class 0.000 abstract 1
- 150000004715 keto acids Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20090085A CZ303072B6 (cs) | 2009-02-13 | 2009-02-13 | Polymerní konjugáty paclitaxelu a docetaxelu s pH rízeným uvolnováním kancerostatika |
| PCT/CZ2010/000014 WO2010091650A1 (en) | 2009-02-13 | 2010-02-09 | Polymeric conjugates of paclitaxel and docetaxel with ph-controlled releasing of the cancerostatic agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA104187C2 true UA104187C2 (ru) | 2014-01-10 |
Family
ID=42309667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201115172A UA104187C2 (ru) | 2009-02-13 | 2010-02-09 | Полимерные конъюгаты паклитакселя и доцетакселя с рн-контролируемым высвобождением средства, которое оказывает статическое действие на злокачественные новообразования |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2413973A1 (cs) |
| CZ (1) | CZ303072B6 (cs) |
| EA (1) | EA022803B1 (cs) |
| UA (1) | UA104187C2 (cs) |
| WO (1) | WO2010091650A1 (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3239139B1 (en) | 2010-05-27 | 2020-10-28 | Ningbo Combireg Pharmaceutical Technology Co. Ltd | Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate |
| CN112807299B (zh) | 2015-05-15 | 2022-06-24 | 珠海贝海生物技术有限公司 | 包含多西他赛和人血清白蛋白的固体组合物及其制备方法和应用 |
| GB2551979A (en) * | 2016-06-30 | 2018-01-10 | Rs Arastirma Egitim Danismanlik Llac Sanayi Ticaret Ltd | Cleavable polymer drug conjugates |
| CN110062622B (zh) | 2016-10-27 | 2022-10-14 | 珠海贝海生物技术有限公司 | 多西他赛和人血清白蛋白的中性pH组合物 |
| WO2021158632A1 (en) | 2020-02-04 | 2021-08-12 | Zhuhai Beihai Biotech Co., Ltd. | Formulations of docetaxel |
| RU2753479C1 (ru) * | 2020-10-14 | 2021-08-17 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации | 2-Амино-1-бензамидо-5-[2-(нафталин-1-ил)-2-оксоэтилиден]-4-оксо-4,5-дигидро-1Н-пиррол-3-карбоксамид, обладающий цитотоксическими и проапоптогенными свойствами в отношении клеток солидных опухолей человека, в том числе резистентных к химиопрепаратам |
| KR20240154544A (ko) | 2022-02-25 | 2024-10-25 | 주하이 베이하이 바이오테크 컴퍼니 리미티드 | 도세탁셀 조성물 및 방법 |
| CN114588272B (zh) * | 2022-04-08 | 2023-05-26 | 皖西学院 | 一种负载no的多西紫杉醇纳米药物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9213077D0 (en) * | 1992-06-19 | 1992-08-05 | Erba Carlo Spa | Polymerbound taxol derivatives |
| US20030003048A1 (en) * | 2001-04-26 | 2003-01-02 | Chun Li | Diagnostic imaging compositions, their methods of synthesis and use |
| CZ2006207A3 (cs) * | 2006-03-28 | 2008-01-16 | Zentiva, A. S. | Micelární nosiče léčiv s protinádorovou aktivitou |
| CZ2006505A3 (cs) * | 2006-08-09 | 2008-04-09 | Zentiva, A. S. | Polymerní konjugáty doxorubicinu s pH-rízeným uvolnováním léciva a zpusob jejich prípravy |
| CZ2006592A3 (cs) * | 2006-09-18 | 2008-03-19 | Zentiva, A. S. | Polymerní lécivo a zpusob jeho výroby |
| US8017141B2 (en) * | 2006-12-15 | 2011-09-13 | Advanced Cardiovascular Systems, Inc. | Coatings of acrylamide-based copolymers |
| JP2010516675A (ja) * | 2007-01-17 | 2010-05-20 | イミューノメディクス、インコーポレイテッド | 治療薬剤のポリマー担体および疾病部位の抗体に基づく標的化のための認識部分 |
| CZ301004B6 (cs) * | 2007-06-27 | 2009-10-07 | Ústav experimentální botaniky AV CR v. v. i. | Cílené deriváty paclitaxelu, jejich zpusob výroby a jejich použití |
-
2009
- 2009-02-13 CZ CZ20090085A patent/CZ303072B6/cs not_active IP Right Cessation
-
2010
- 2010-02-09 EA EA201190315A patent/EA022803B1/ru not_active IP Right Cessation
- 2010-02-09 EP EP10716267A patent/EP2413973A1/en not_active Withdrawn
- 2010-02-09 WO PCT/CZ2010/000014 patent/WO2010091650A1/en active Application Filing
- 2010-02-09 UA UAA201115172A patent/UA104187C2/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201190315A1 (ru) | 2012-05-30 |
| EA022803B1 (ru) | 2016-03-31 |
| WO2010091650A1 (en) | 2010-08-19 |
| CZ200985A3 (cs) | 2010-08-25 |
| EP2413973A1 (en) | 2012-02-08 |
| CZ303072B6 (cs) | 2012-03-21 |
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