UA102993C2 - Анти-vegf единичный вариабельный домен иммуноглобулина - Google Patents

Анти-vegf единичный вариабельный домен иммуноглобулина

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Publication number
UA102993C2
UA102993C2 UAA200910273A UAA200910273A UA102993C2 UA 102993 C2 UA102993 C2 UA 102993C2 UA A200910273 A UAA200910273 A UA A200910273A UA A200910273 A UAA200910273 A UA A200910273A UA 102993 C2 UA102993 C2 UA 102993C2
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Prior art keywords
amino acid
variable domain
single variable
immunoglobulin single
vegf
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UAA200910273A
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English (en)
Ukrainian (uk)
Inventor
Майкл Стюард
Мальгоржата Пупецка
Ян Томлинсон
Каролин Инивер
Лоран Жеспер
Тил Динук Батувангала
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Домантис Лимитед
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Application filed by Домантис Лимитед filed Critical Домантис Лимитед
Publication of UA102993C2 publication Critical patent/UA102993C2/ru

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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Изобретение относится к анти-VEGF единичному вариабельному домену иммуноглобулина, который включает аминокислотную последовательность, которая является идентичной аминокислотной последовательности DOM15-26-593, как представлено на Фигуре 5, или отличается от аминокислотной последовательности DOM15-26-593 в 1 или 2 аминокислотных положениях. Указанный домен является устойчивым к протеазе, применяется в фармацевтических композициях, а также в производстве лекарственного средства для лечения или профилактики рака, воспаления, аутоиммунного заболевания или возрастной макулярной дегенерации, опосредованного VEGF заболевания, хронического обструктивного заболевания легких или пневмонии. Изобретение также относится к нуклеиновой кислоте, которая кодирует анти-VEGF единичный вариабельный домен иммуноглобулина, к вектору,
UAA200910273A 2007-06-06 2008-06-03 Анти-vegf единичный вариабельный домен иммуноглобулина UA102993C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93363207P 2007-06-06 2007-06-06
PCT/GB2008/050404 WO2008149147A2 (en) 2007-06-06 2008-06-03 Polypeptides, antibody variable domains and antagonists

Publications (1)

Publication Number Publication Date
UA102993C2 true UA102993C2 (ru) 2013-09-10

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ID=39941852

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA200910273A UA102993C2 (ru) 2007-06-06 2008-06-03 Анти-vegf единичный вариабельный домен иммуноглобулина
UAA200911791A UA103749C2 (ru) 2007-06-06 2008-06-04 ЕДИНИЧНЫЙ ВАРИАБЕЛЬНЫЙ ДОМЕН ИММУНОГЛОБУЛИНА ПРОТИВ РЕЦЕПТОРА TNFα ТИПА 1

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA200911791A UA103749C2 (ru) 2007-06-06 2008-06-04 ЕДИНИЧНЫЙ ВАРИАБЕЛЬНЫЙ ДОМЕН ИММУНОГЛОБУЛИНА ПРОТИВ РЕЦЕПТОРА TNFα ТИПА 1

Country Status (24)

Country Link
US (1) US8877186B2 (ru)
EP (1) EP2158219A2 (ru)
JP (1) JP2010528647A (ru)
KR (1) KR20100040840A (ru)
CN (1) CN101679511A (ru)
AR (1) AR066849A1 (ru)
AU (1) AU2008259513B2 (ru)
BR (1) BRPI0812398A2 (ru)
CA (1) CA2683801A1 (ru)
CL (1) CL2008001675A1 (ru)
CO (1) CO6251320A2 (ru)
CR (1) CR11193A (ru)
DO (1) DOP2009000267A (ru)
EA (1) EA200901301A1 (ru)
IL (1) IL201399A0 (ru)
MA (1) MA31437B1 (ru)
MX (1) MX2009012968A (ru)
NZ (1) NZ580530A (ru)
PE (2) PE20130738A1 (ru)
SG (1) SG182170A1 (ru)
TW (1) TW200906853A (ru)
UA (2) UA102993C2 (ru)
WO (1) WO2008149147A2 (ru)
ZA (1) ZA200908454B (ru)

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JP6907188B2 (ja) * 2015-08-13 2021-07-21 ダイアックス コーポレーション 接触系活性化の評価のためのプロテアーゼ阻害剤を含む真空採血管
JP6893928B2 (ja) 2015-09-01 2021-06-23 イルドン ファーマスーティカル カンパニー リミテッド 腫瘍透過性ペプチドと抗新生血管生成製剤が融合した融合蛋白質の有効成分を含む癌又は血管新生関連疾患の予防及び治療用薬学的組成物
KR20160130366A (ko) 2016-11-02 2016-11-11 에스케이플래닛 주식회사 어플리케이션 제공 시스템, 이를 위한 방법, 이를 위한 장치 및 이를 위한 단말기
KR20210091147A (ko) * 2018-10-09 2021-07-21 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 수용체 길항제로서의 조작된 섬유아세포 성장 인자 변이체
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