UA103749C2 - ЕДИНИЧНЫЙ ВАРИАБЕЛЬНЫЙ ДОМЕН ИММУНОГЛОБУЛИНА ПРОТИВ РЕЦЕПТОРА TNFα ТИПА 1 - Google Patents

ЕДИНИЧНЫЙ ВАРИАБЕЛЬНЫЙ ДОМЕН ИММУНОГЛОБУЛИНА ПРОТИВ РЕЦЕПТОРА TNFα ТИПА 1

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Publication number
UA103749C2
UA103749C2 UAA200911791A UAA200911791A UA103749C2 UA 103749 C2 UA103749 C2 UA 103749C2 UA A200911791 A UAA200911791 A UA A200911791A UA A200911791 A UAA200911791 A UA A200911791A UA 103749 C2 UA103749 C2 UA 103749C2
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Ukraine
Prior art keywords
variable domain
single variable
immunoglobuline
receptor type
tnfα receptor
Prior art date
Application number
UAA200911791A
Other languages
English (en)
Ukrainian (uk)
Inventor
Лоран Жеспер
Мальгоржата Пупецка
Ян М. Томлинсон
Каролин ЭНЕВЕР
Original Assignee
Домантис Лимитед
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39941852&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA103749(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Домантис Лимитед filed Critical Домантис Лимитед
Priority claimed from PCT/GB2008/050405 external-priority patent/WO2008149148A2/en
Publication of UA103749C2 publication Critical patent/UA103749C2/ru

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к полипептиду и единичному вариабельному домену антитела иммуноглобулина против рецептора TNFα типа 1 (TNFR1; р55) (dAb), резистентного к разложению протеазы.
UAA200911791A 2007-06-06 2008-06-04 ЕДИНИЧНЫЙ ВАРИАБЕЛЬНЫЙ ДОМЕН ИММУНОГЛОБУЛИНА ПРОТИВ РЕЦЕПТОРА TNFα ТИПА 1 UA103749C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93363207P 2007-06-06 2007-06-06
PCT/GB2008/050405 WO2008149148A2 (en) 2007-06-06 2008-06-04 Polypeptides, antibody variable domains and antagonists

Publications (1)

Publication Number Publication Date
UA103749C2 true UA103749C2 (ru) 2013-11-25

Family

ID=39941852

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA200910273A UA102993C2 (ru) 2007-06-06 2008-06-03 Анти-vegf единичный вариабельный домен иммуноглобулина
UAA200911791A UA103749C2 (ru) 2007-06-06 2008-06-04 ЕДИНИЧНЫЙ ВАРИАБЕЛЬНЫЙ ДОМЕН ИММУНОГЛОБУЛИНА ПРОТИВ РЕЦЕПТОРА TNFα ТИПА 1

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UAA200910273A UA102993C2 (ru) 2007-06-06 2008-06-03 Анти-vegf единичный вариабельный домен иммуноглобулина

Country Status (24)

Country Link
US (1) US8877186B2 (ru)
EP (1) EP2158219A2 (ru)
JP (1) JP2010528647A (ru)
KR (1) KR20100040840A (ru)
CN (1) CN101679511A (ru)
AR (1) AR066849A1 (ru)
AU (1) AU2008259513B2 (ru)
BR (1) BRPI0812398A2 (ru)
CA (1) CA2683801A1 (ru)
CL (1) CL2008001675A1 (ru)
CO (1) CO6251320A2 (ru)
CR (1) CR11193A (ru)
DO (1) DOP2009000267A (ru)
EA (1) EA200901301A1 (ru)
IL (1) IL201399A0 (ru)
MA (1) MA31437B1 (ru)
MX (1) MX2009012968A (ru)
NZ (1) NZ580530A (ru)
PE (2) PE20130738A1 (ru)
SG (1) SG182170A1 (ru)
TW (1) TW200906853A (ru)
UA (2) UA102993C2 (ru)
WO (1) WO2008149147A2 (ru)
ZA (1) ZA200908454B (ru)

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CA2683801A1 (en) 2008-12-11
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