UA100521C2 - Salts of bazedoxifene - Google Patents

Salts of bazedoxifene

Info

Publication number
UA100521C2
UA100521C2 UAA201002032A UAA201002032A UA100521C2 UA 100521 C2 UA100521 C2 UA 100521C2 UA A201002032 A UAA201002032 A UA A201002032A UA A201002032 A UAA201002032 A UA A201002032A UA 100521 C2 UA100521 C2 UA 100521C2
Authority
UA
Ukraine
Prior art keywords
bazedoxifene
salts
invention deals
new crystalline
crystalline salts
Prior art date
Application number
UAA201002032A
Other languages
English (en)
Russian (ru)
Inventor
Йосеф Ирман
Индржих Рихтер
Original Assignee
Зентива, К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива, К.С. filed Critical Зентива, К.С.
Publication of UA100521C2 publication Critical patent/UA100521C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

Винахід стосується нових кристалічних солей базедоксифену, завдяки яким можна забезпечити високу АРІ якість при високому виході.
UAA201002032A 2007-07-25 2008-07-24 Salts of bazedoxifene UA100521C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20070500A CZ302358B6 (cs) 2007-07-25 2007-07-25 Nové soli bazedoxifenu
PCT/CZ2008/000089 WO2009012734A2 (en) 2007-07-25 2008-07-24 New salts of bazedoxifene

Publications (1)

Publication Number Publication Date
UA100521C2 true UA100521C2 (en) 2013-01-10

Family

ID=40281873

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201002032A UA100521C2 (en) 2007-07-25 2008-07-24 Salts of bazedoxifene
UAA201206688A UA101590C2 (en) 2007-07-25 2008-07-24 Bazedoxifene salt

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA201206688A UA101590C2 (en) 2007-07-25 2008-07-24 Bazedoxifene salt

Country Status (13)

Country Link
US (1) US8034807B2 (uk)
EP (2) EP2311805B1 (uk)
AT (2) ATE504569T1 (uk)
CZ (1) CZ302358B6 (uk)
DE (1) DE602008006095D1 (uk)
EA (2) EA019682B1 (uk)
ES (1) ES2386953T3 (uk)
HR (1) HRP20120649T1 (uk)
PL (2) PL2311805T3 (uk)
PT (1) PT2311805E (uk)
SI (1) SI2311805T1 (uk)
UA (2) UA100521C2 (uk)
WO (1) WO2009012734A2 (uk)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20091109A1 (it) * 2009-06-23 2010-12-24 Wyeth Corp Forma polimorfa d di bazedoxifene acetato e metodi per la sua preparazione
WO2011022596A2 (en) * 2009-08-21 2011-02-24 Dr. Reddy's Laboratories Ltd. Preparation of bazedoxifene and its salts
WO2012007453A1 (en) * 2010-07-14 2012-01-19 Sandoz Ag Crystalline compound of 1-[4-(2-azepan-1-ylethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1h-indol-5-ol
EP2407467A1 (de) 2010-07-14 2012-01-18 Sandoz Ag Kristalline Verbindung von 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol und Milchsäure
WO2012037187A2 (en) 2010-09-14 2012-03-22 Dr. Reddy's Laboratories Ltd. Preparation of crystalline bazedoxifene and its salts
EP2471770A1 (en) 2010-12-28 2012-07-04 Sandoz Ag Method of preparing polymorphic pure form A of bazedoxifene acetate
WO2013001511A1 (en) 2011-06-30 2013-01-03 Sandoz Ag Novel salt intermediates for the synthesis of bazedoxifene acetate and process thereof
CN102690231B (zh) * 2012-04-11 2014-07-09 南京友杰医药科技有限公司 治疗阿尔茨海默病潜在药物司马西特的合成方法
WO2013182169A1 (en) 2012-06-07 2013-12-12 Zentiva, K. S. Process of preparation of an antioxidant-free polymorphically and chemically stable formulation of bazedoxifene acetate
WO2013182170A1 (en) 2012-06-07 2013-12-12 Zentiva, K. S. Enhancement of dissolution rate from pharmaceutical composition comprising bazedoxifene acetate
WO2014186325A1 (en) 2013-05-15 2014-11-20 Indiana University Research And Technology Corporation Processes and intermediates for preparing indole pharmaceuticals
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN105085365B (zh) * 2014-05-12 2018-06-19 四川科伦药业股份有限公司 醋酸巴多昔芬及其中间体的制备方法
CN104311468A (zh) * 2014-09-24 2015-01-28 万特制药(海南)有限公司 巴多昔芬杂质的合成方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
IT201900001923A1 (it) 2019-02-11 2020-08-11 Erregierre Spa Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato
CN111004165A (zh) * 2019-12-03 2020-04-14 南京正济医药研究有限公司 一种醋酸巴多昔芬晶型a的制备方法
US11246874B1 (en) 2021-04-20 2022-02-15 Oxygen Biotech LLC Treatment of COVID-19

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998402A (en) * 1996-04-19 1999-12-07 American Home Products Corporation 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
US6479535B1 (en) * 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
TW200536845A (en) * 2004-04-07 2005-11-16 Wyeth Corp Crystalline polymorph of bazedoxifene acetate
RU2006132180A (ru) * 2004-04-07 2008-05-20 Вайет (Us) Кристаллический полиморф базедоксифен ацетата
BRPI0509381A (pt) * 2004-04-08 2007-09-18 Wyeth Corp dispersão sólida, métodos de preparar a dispersão sólida, de tratar um mamìfero tendo uma doença ou sìndrome associadas com a deficiência ou o excesso de estrogênio, uma doença ou distúrbio associados com a proliferação ou desenvolvimento anormal de tecidos endometrais, de tratar cáncer de mamas de um mamìfero, e uma mulher pós-menopáusica quanto a um ou mais distúrbios vasomotores, de reduzir colesterol, e de inibir perda óssea em um mamìfero, composição, forma de dosagem, e, uso de uma dispersão sólida
AU2005233128A1 (en) * 2004-04-08 2005-10-27 Wyeth Bazedoxifene ascorbate as selective estrogen receptor modulator
US20060099626A1 (en) * 2004-10-27 2006-05-11 Harbury Pehr B DNA-templated combinatorial library device and method for use
RU2007132852A (ru) 2005-03-31 2009-05-10 Вайет (Us) Продукт комбинации о-десметилвенлафаксина и базедоксифена и его применение

Also Published As

Publication number Publication date
CZ302358B6 (cs) 2011-03-30
WO2009012734A2 (en) 2009-01-29
ATE504569T1 (de) 2011-04-15
EA017232B1 (ru) 2012-10-30
ES2386953T3 (es) 2012-09-07
EP2311805A1 (en) 2011-04-20
WO2009012734A3 (en) 2009-07-23
ATE557001T1 (de) 2012-05-15
PL2185510T3 (pl) 2011-07-29
EP2185510A2 (en) 2010-05-19
PT2311805E (pt) 2012-07-18
DE602008006095D1 (de) 2011-05-19
EP2311805B1 (en) 2012-05-09
EA019682B1 (ru) 2014-05-30
EA201101669A1 (ru) 2012-09-28
SI2311805T1 (sl) 2012-10-30
EP2185510B1 (en) 2011-04-06
US8034807B2 (en) 2011-10-11
US20100240888A1 (en) 2010-09-23
EA201000250A1 (ru) 2010-08-30
CZ2007500A3 (cs) 2009-03-04
UA101590C2 (en) 2013-04-10
PL2311805T3 (pl) 2012-09-28
HRP20120649T1 (hr) 2012-11-30

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