UA104438C2 - Спосіб одержання дабігатрану і його проміжних сполук - Google Patents
Спосіб одержання дабігатрану і його проміжних сполукInfo
- Publication number
- UA104438C2 UA104438C2 UAA201106447A UAA201106447A UA104438C2 UA 104438 C2 UA104438 C2 UA 104438C2 UA A201106447 A UAA201106447 A UA A201106447A UA A201106447 A UAA201106447 A UA A201106447A UA 104438 C2 UA104438 C2 UA 104438C2
- Authority
- UA
- Ukraine
- Prior art keywords
- preparation
- dabigatran
- intermediates
- vii
- 2hcl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
Описуються проміжні сполуки для одержання дабігатрану формул VIІ-2НСl і VII-НСl, способи їх одержання і спосіб одержання дабігатрану формули VIII, використовуючи ці проміжні сполуки. EMBED ISISServer VII-2HCl EMBED ISISServer VII-HCl EMBED ISISServer VIII
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ20080669A CZ2008669A3 (cs) | 2008-10-24 | 2008-10-24 | Zpusob prípravy dabigatranu a jeho meziprodukty |
PCT/CZ2009/000127 WO2010045900A1 (en) | 2008-10-24 | 2009-10-26 | A method for the preparation of dabigatran and its intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
UA104438C2 true UA104438C2 (uk) | 2014-02-10 |
Family
ID=41557568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201106447A UA104438C2 (uk) | 2008-10-24 | 2009-10-26 | Спосіб одержання дабігатрану і його проміжних сполук |
Country Status (8)
Country | Link |
---|---|
US (1) | US8394962B2 (uk) |
EP (1) | EP2346850B1 (uk) |
CZ (1) | CZ2008669A3 (uk) |
EA (1) | EA018227B1 (uk) |
ES (1) | ES2393692T3 (uk) |
SI (1) | SI2346850T1 (uk) |
UA (1) | UA104438C2 (uk) |
WO (1) | WO2010045900A1 (uk) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2013000295A (es) | 2010-07-09 | 2013-05-28 | Esteve Quimica Sa | Procedimiento de preparacion de un inhibidor especifico de la trombina. |
US9006448B2 (en) | 2010-12-06 | 2015-04-14 | Msn Laboratories Private Limited | Process for the preparation of benzimidazole derivatives and its salts |
HUP1100244A2 (hu) | 2011-05-11 | 2012-11-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Gyógyszeripari intermedierek és eljárás elõállításukra |
EP2522662A1 (en) | 2011-05-11 | 2012-11-14 | Medichem, S.A. | Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers |
WO2013024394A1 (en) * | 2011-08-12 | 2013-02-21 | Alembic Pharmaceuticals Limited | Novel reference markers of dabigatran etexilate |
WO2013024384A1 (en) * | 2011-08-12 | 2013-02-21 | Alembic Pharmaceuticals Limited | Improved process for preparation of dabigatran etexilate and its novel intermediate |
CN102633713B (zh) * | 2012-03-22 | 2013-12-11 | 南京工业大学 | 达比加群酯中间体及其制备方法、以及制备达比加群酯的方法 |
US9273030B2 (en) | 2012-04-02 | 2016-03-01 | Msn Laboratories Private Limited | Process for the preparation of benzimidazole derivatives and salts thereof |
CN103420983B (zh) * | 2012-05-24 | 2015-07-08 | 天津药物研究院 | 达比加群酯衍生物及其制备方法和用途 |
CN102911160B (zh) * | 2012-06-29 | 2014-10-22 | 上海奥博生物医药技术有限公司 | 一种制备和纯化达比加群酯中间体的方法 |
WO2014012880A1 (en) | 2012-07-16 | 2014-01-23 | Interquim, S.A. | Process for the preparation of intermediates for the synthesis of dabigatran etexilate, and crystalline forms of said intermediates |
WO2014041559A2 (en) * | 2012-08-27 | 2014-03-20 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for the preparation of dabigatran etexilate and intermediates thereof |
EP2835370A1 (en) | 2013-08-08 | 2015-02-11 | Medichem, S.A. | New crystals of dabigatran etexilate mesylate |
IN2014MU00675A (uk) | 2014-02-26 | 2015-10-23 | Megafine Pharma P Ltd | |
CN110339193B (zh) * | 2018-04-04 | 2022-04-29 | 上海汉都医药科技有限公司 | 含达比加群酯的药物组合物及其制备方法 |
WO2022198361A1 (zh) * | 2021-03-22 | 2022-09-29 | 天津睿创康泰生物技术有限公司 | 一种达比加群酯乙酯盐酸盐新晶型及其制备方法和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6087380A (en) | 1949-11-24 | 2000-07-11 | Boehringer Ingelheim Pharma Kg | Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions |
PE121699A1 (es) * | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
EP1609784A1 (de) | 2004-06-25 | 2005-12-28 | Boehringer Ingelheim Pharma GmbH & Co.KG | Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen |
DE102005061623A1 (de) | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen |
CZ305085B6 (cs) * | 2008-03-14 | 2015-04-29 | Zentiva, K.S. | Způsob přípravy dabigatranu |
-
2008
- 2008-10-24 CZ CZ20080669A patent/CZ2008669A3/cs unknown
-
2009
- 2009-10-26 UA UAA201106447A patent/UA104438C2/uk unknown
- 2009-10-26 EP EP09752269A patent/EP2346850B1/en not_active Not-in-force
- 2009-10-26 ES ES09752269T patent/ES2393692T3/es active Active
- 2009-10-26 SI SI200930400T patent/SI2346850T1/sl unknown
- 2009-10-26 EA EA201100517A patent/EA018227B1/ru not_active IP Right Cessation
- 2009-10-26 US US13/124,034 patent/US8394962B2/en active Active
- 2009-10-26 WO PCT/CZ2009/000127 patent/WO2010045900A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20110224441A1 (en) | 2011-09-15 |
ES2393692T3 (es) | 2012-12-27 |
CZ2008669A3 (cs) | 2010-05-05 |
EA018227B1 (ru) | 2013-06-28 |
EP2346850B1 (en) | 2012-09-05 |
EP2346850A1 (en) | 2011-07-27 |
SI2346850T1 (sl) | 2013-01-31 |
US8394962B2 (en) | 2013-03-12 |
EA201100517A1 (ru) | 2011-10-31 |
WO2010045900A1 (en) | 2010-04-29 |
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