PL2185510T3 - Nowe sole bazedoksyfenu - Google Patents
Nowe sole bazedoksyfenuInfo
- Publication number
- PL2185510T3 PL2185510T3 PL08784167T PL08784167T PL2185510T3 PL 2185510 T3 PL2185510 T3 PL 2185510T3 PL 08784167 T PL08784167 T PL 08784167T PL 08784167 T PL08784167 T PL 08784167T PL 2185510 T3 PL2185510 T3 PL 2185510T3
- Authority
- PL
- Poland
- Prior art keywords
- bazedoxifene
- new salts
- new
- salts
- ray diffraction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ20070500A CZ302358B6 (cs) | 2007-07-25 | 2007-07-25 | Nové soli bazedoxifenu |
EP08784167A EP2185510B1 (en) | 2007-07-25 | 2008-07-24 | New salts of bazedoxifene |
PCT/CZ2008/000089 WO2009012734A2 (en) | 2007-07-25 | 2008-07-24 | New salts of bazedoxifene |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2185510T3 true PL2185510T3 (pl) | 2011-07-29 |
Family
ID=40281873
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL08784167T PL2185510T3 (pl) | 2007-07-25 | 2008-07-24 | Nowe sole bazedoksyfenu |
PL10013501T PL2311805T3 (pl) | 2007-07-25 | 2008-07-24 | Nowa postać polimorficzna octanu bazedoksyfenu |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL10013501T PL2311805T3 (pl) | 2007-07-25 | 2008-07-24 | Nowa postać polimorficzna octanu bazedoksyfenu |
Country Status (13)
Country | Link |
---|---|
US (1) | US8034807B2 (pl) |
EP (2) | EP2185510B1 (pl) |
AT (2) | ATE504569T1 (pl) |
CZ (1) | CZ302358B6 (pl) |
DE (1) | DE602008006095D1 (pl) |
EA (2) | EA017232B1 (pl) |
ES (1) | ES2386953T3 (pl) |
HR (1) | HRP20120649T1 (pl) |
PL (2) | PL2185510T3 (pl) |
PT (1) | PT2311805E (pl) |
SI (1) | SI2311805T1 (pl) |
UA (2) | UA101590C2 (pl) |
WO (1) | WO2009012734A2 (pl) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20091109A1 (it) * | 2009-06-23 | 2010-12-24 | Wyeth Corp | Forma polimorfa d di bazedoxifene acetato e metodi per la sua preparazione |
WO2011022596A2 (en) * | 2009-08-21 | 2011-02-24 | Dr. Reddy's Laboratories Ltd. | Preparation of bazedoxifene and its salts |
WO2012007453A1 (en) | 2010-07-14 | 2012-01-19 | Sandoz Ag | Crystalline compound of 1-[4-(2-azepan-1-ylethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1h-indol-5-ol |
EP2407467A1 (de) | 2010-07-14 | 2012-01-18 | Sandoz Ag | Kristalline Verbindung von 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol und Milchsäure |
EP2616463A4 (en) | 2010-09-14 | 2014-01-08 | Reddys Lab Ltd Dr | PREPARATION OF CRYSTALLINE BAZEDOXIFES AND THEIR SALTS |
EP2471770A1 (en) | 2010-12-28 | 2012-07-04 | Sandoz Ag | Method of preparing polymorphic pure form A of bazedoxifene acetate |
WO2013001511A1 (en) | 2011-06-30 | 2013-01-03 | Sandoz Ag | Novel salt intermediates for the synthesis of bazedoxifene acetate and process thereof |
CN102690231B (zh) * | 2012-04-11 | 2014-07-09 | 南京友杰医药科技有限公司 | 治疗阿尔茨海默病潜在药物司马西特的合成方法 |
WO2013182169A1 (en) | 2012-06-07 | 2013-12-12 | Zentiva, K. S. | Process of preparation of an antioxidant-free polymorphically and chemically stable formulation of bazedoxifene acetate |
WO2013182170A1 (en) | 2012-06-07 | 2013-12-12 | Zentiva, K. S. | Enhancement of dissolution rate from pharmaceutical composition comprising bazedoxifene acetate |
WO2014186325A1 (en) | 2013-05-15 | 2014-11-20 | Indiana University Research And Technology Corporation | Processes and intermediates for preparing indole pharmaceuticals |
CN103709090A (zh) * | 2014-01-16 | 2014-04-09 | 江苏万特制药有限公司 | 醋酸巴多昔芬的制备方法及其关键中间体 |
CN105085365B (zh) * | 2014-05-12 | 2018-06-19 | 四川科伦药业股份有限公司 | 醋酸巴多昔芬及其中间体的制备方法 |
CN104311468A (zh) * | 2014-09-24 | 2015-01-28 | 万特制药(海南)有限公司 | 巴多昔芬杂质的合成方法 |
CN105669518B (zh) * | 2014-12-04 | 2019-06-04 | 上海医药集团股份有限公司 | 醋酸巴多昔芬及其a晶型的制备方法 |
IT201900001923A1 (it) | 2019-02-11 | 2020-08-11 | Erregierre Spa | Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato |
CN111004165A (zh) * | 2019-12-03 | 2020-04-14 | 南京正济医药研究有限公司 | 一种醋酸巴多昔芬晶型a的制备方法 |
US11246874B1 (en) | 2021-04-20 | 2022-02-15 | Oxygen Biotech LLC | Treatment of COVID-19 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5998402A (en) * | 1996-04-19 | 1999-12-07 | American Home Products Corporation | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents |
US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
BRPI0509257A (pt) * | 2004-04-07 | 2007-09-11 | Wyeth Corp | polimorfo cristalino de acetato de bazedoxifeno, composição, processo para preparar um polimorfo e para aumentar a proporção de acetato de bazedoxifeno forma b em uma composição, métodos de tratar um mamìfero, cáncer de mama e uma mulher em pós-menopausa para um ou mais distúrbios vasomotores, de abaixar colesterol e de inibir perda óssea em um mamìfero e uso de um polimorfo |
AU2005233133A1 (en) * | 2004-04-07 | 2005-10-27 | Wyeth | Crystalline polymorph of a bazedoxifene acetate |
WO2005100315A1 (en) | 2004-04-08 | 2005-10-27 | Wyeth | Bazedoxifene ascorbate as selective estrogen receptor modulator |
GT200500083A (es) * | 2004-04-08 | 2005-10-31 | Formulaciones de acetato de bazedoxifeno | |
WO2006047791A2 (en) * | 2004-10-27 | 2006-05-04 | The Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library device and method for use |
JP2008534592A (ja) | 2005-03-31 | 2008-08-28 | ワイス | O−デスメチルベンラファキシンおよびバゼドキシフェンの組み合わせ生成物およびその使用 |
-
2007
- 2007-07-25 CZ CZ20070500A patent/CZ302358B6/cs not_active IP Right Cessation
-
2008
- 2008-07-24 PL PL08784167T patent/PL2185510T3/pl unknown
- 2008-07-24 EA EA201000250A patent/EA017232B1/ru not_active IP Right Cessation
- 2008-07-24 WO PCT/CZ2008/000089 patent/WO2009012734A2/en active Application Filing
- 2008-07-24 AT AT08784167T patent/ATE504569T1/de not_active IP Right Cessation
- 2008-07-24 US US12/670,574 patent/US8034807B2/en active Active
- 2008-07-24 EA EA201101669A patent/EA019682B1/ru not_active IP Right Cessation
- 2008-07-24 EP EP08784167A patent/EP2185510B1/en not_active Not-in-force
- 2008-07-24 PT PT10013501T patent/PT2311805E/pt unknown
- 2008-07-24 ES ES10013501T patent/ES2386953T3/es active Active
- 2008-07-24 PL PL10013501T patent/PL2311805T3/pl unknown
- 2008-07-24 UA UAA201206688A patent/UA101590C2/ru unknown
- 2008-07-24 AT AT10013501T patent/ATE557001T1/de active
- 2008-07-24 UA UAA201002032A patent/UA100521C2/ru unknown
- 2008-07-24 DE DE602008006095T patent/DE602008006095D1/de active Active
- 2008-07-24 SI SI200830689T patent/SI2311805T1/sl unknown
- 2008-07-24 EP EP10013501A patent/EP2311805B1/en not_active Not-in-force
-
2012
- 2012-08-09 HR HRP20120649AT patent/HRP20120649T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
ES2386953T3 (es) | 2012-09-07 |
HRP20120649T1 (hr) | 2012-11-30 |
US20100240888A1 (en) | 2010-09-23 |
WO2009012734A2 (en) | 2009-01-29 |
EA017232B1 (ru) | 2012-10-30 |
DE602008006095D1 (de) | 2011-05-19 |
EP2311805A1 (en) | 2011-04-20 |
UA101590C2 (en) | 2013-04-10 |
EA201101669A1 (ru) | 2012-09-28 |
UA100521C2 (en) | 2013-01-10 |
ATE557001T1 (de) | 2012-05-15 |
EP2185510A2 (en) | 2010-05-19 |
EP2185510B1 (en) | 2011-04-06 |
EP2311805B1 (en) | 2012-05-09 |
CZ2007500A3 (cs) | 2009-03-04 |
CZ302358B6 (cs) | 2011-03-30 |
EA019682B1 (ru) | 2014-05-30 |
WO2009012734A3 (en) | 2009-07-23 |
EA201000250A1 (ru) | 2010-08-30 |
US8034807B2 (en) | 2011-10-11 |
PT2311805E (pt) | 2012-07-18 |
ATE504569T1 (de) | 2011-04-15 |
SI2311805T1 (sl) | 2012-10-30 |
PL2311805T3 (pl) | 2012-09-28 |
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