EA201101669A1 - Новая соль базедоксифена - Google Patents

Новая соль базедоксифена

Info

Publication number
EA201101669A1
EA201101669A1 EA201101669A EA201101669A EA201101669A1 EA 201101669 A1 EA201101669 A1 EA 201101669A1 EA 201101669 A EA201101669 A EA 201101669A EA 201101669 A EA201101669 A EA 201101669A EA 201101669 A1 EA201101669 A1 EA 201101669A1
Authority
EA
Eurasian Patent Office
Prior art keywords
basedoxyphene
new salt
new
salt
bazedoxifene
Prior art date
Application number
EA201101669A
Other languages
English (en)
Other versions
EA019682B1 (ru
Inventor
Йосеф Йирман
Йиндрих Рихтер
Original Assignee
Зентива К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива К.С. filed Critical Зентива К.С.
Publication of EA201101669A1 publication Critical patent/EA201101669A1/ru
Publication of EA019682B1 publication Critical patent/EA019682B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

Изобретение относится к новой соли, представляющей собой ацетат базедоксифена, предпочтительно, характеризующейся следующими отражениями на дифракционной рентгенограмме: 13,17; 15,97; 17,95; 19,62; 20,54; 22,08; 25,27.
EA201101669A 2007-07-25 2008-07-24 Новая соль базедоксифена EA019682B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ20070500A CZ302358B6 (cs) 2007-07-25 2007-07-25 Nové soli bazedoxifenu

Publications (2)

Publication Number Publication Date
EA201101669A1 true EA201101669A1 (ru) 2012-09-28
EA019682B1 EA019682B1 (ru) 2014-05-30

Family

ID=40281873

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201000250A EA017232B1 (ru) 2007-07-25 2008-07-24 Соль базедоксифена и фумаровой кислоты
EA201101669A EA019682B1 (ru) 2007-07-25 2008-07-24 Новая соль базедоксифена

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201000250A EA017232B1 (ru) 2007-07-25 2008-07-24 Соль базедоксифена и фумаровой кислоты

Country Status (13)

Country Link
US (1) US8034807B2 (ru)
EP (2) EP2185510B1 (ru)
AT (2) ATE504569T1 (ru)
CZ (1) CZ302358B6 (ru)
DE (1) DE602008006095D1 (ru)
EA (2) EA017232B1 (ru)
ES (1) ES2386953T3 (ru)
HR (1) HRP20120649T1 (ru)
PL (2) PL2311805T3 (ru)
PT (1) PT2311805E (ru)
SI (1) SI2311805T1 (ru)
UA (2) UA101590C2 (ru)
WO (1) WO2009012734A2 (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20091109A1 (it) * 2009-06-23 2010-12-24 Wyeth Corp Forma polimorfa d di bazedoxifene acetato e metodi per la sua preparazione
WO2011022596A2 (en) * 2009-08-21 2011-02-24 Dr. Reddy's Laboratories Ltd. Preparation of bazedoxifene and its salts
WO2012007453A1 (en) * 2010-07-14 2012-01-19 Sandoz Ag Crystalline compound of 1-[4-(2-azepan-1-ylethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1h-indol-5-ol
EP2407467A1 (de) 2010-07-14 2012-01-18 Sandoz Ag Kristalline Verbindung von 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol und Milchsäure
US9212172B2 (en) 2010-09-14 2015-12-15 Dr. Reddy's Laboratories Limited Preparation of crystalline bazedoxifene and its salts
EP2471770A1 (en) 2010-12-28 2012-07-04 Sandoz Ag Method of preparing polymorphic pure form A of bazedoxifene acetate
WO2013001511A1 (en) 2011-06-30 2013-01-03 Sandoz Ag Novel salt intermediates for the synthesis of bazedoxifene acetate and process thereof
CN102690231B (zh) * 2012-04-11 2014-07-09 南京友杰医药科技有限公司 治疗阿尔茨海默病潜在药物司马西特的合成方法
WO2013182169A1 (en) 2012-06-07 2013-12-12 Zentiva, K. S. Process of preparation of an antioxidant-free polymorphically and chemically stable formulation of bazedoxifene acetate
WO2013182170A1 (en) 2012-06-07 2013-12-12 Zentiva, K. S. Enhancement of dissolution rate from pharmaceutical composition comprising bazedoxifene acetate
US9751835B2 (en) 2013-05-15 2017-09-05 Indiana University Research And Technology Corporation Processes and intermediates for preparing indole pharmaceuticals
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN105085365B (zh) * 2014-05-12 2018-06-19 四川科伦药业股份有限公司 醋酸巴多昔芬及其中间体的制备方法
CN104311468A (zh) * 2014-09-24 2015-01-28 万特制药(海南)有限公司 巴多昔芬杂质的合成方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
IT201900001923A1 (it) 2019-02-11 2020-08-11 Erregierre Spa Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato
CN111004165A (zh) * 2019-12-03 2020-04-14 南京正济医药研究有限公司 一种醋酸巴多昔芬晶型a的制备方法
US11246874B1 (en) 2021-04-20 2022-02-15 Oxygen Biotech LLC Treatment of COVID-19

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998402A (en) * 1996-04-19 1999-12-07 American Home Products Corporation 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
KR20060135866A (ko) * 2004-04-07 2006-12-29 와이어쓰 바제독시펜 아세테이트의 결정질 다형체
PE20060173A1 (es) * 2004-04-07 2006-04-12 Wyeth Corp Polimorfo cristalino de acetato de bazedoxifeno
AR048534A1 (es) * 2004-04-08 2006-05-03 Wyeth Corp Formulaciones de acetato de bazedoxifeno
MXPA06011686A (es) * 2004-04-08 2006-12-14 Wyeth Corp Ascorbato de bazedoxifeno como modulador del receptor de estrogeno selectivo.
WO2006047791A2 (en) * 2004-10-27 2006-05-04 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library device and method for use
EP1863464B1 (en) * 2005-03-31 2009-11-11 Wyeth O-desmethylvenlafaxine and bazedoxifene combination product and uses thereof

Also Published As

Publication number Publication date
EP2311805B1 (en) 2012-05-09
DE602008006095D1 (de) 2011-05-19
ATE557001T1 (de) 2012-05-15
EA201000250A1 (ru) 2010-08-30
EA017232B1 (ru) 2012-10-30
CZ302358B6 (cs) 2011-03-30
SI2311805T1 (sl) 2012-10-30
WO2009012734A3 (en) 2009-07-23
US20100240888A1 (en) 2010-09-23
PL2311805T3 (pl) 2012-09-28
CZ2007500A3 (cs) 2009-03-04
US8034807B2 (en) 2011-10-11
HRP20120649T1 (hr) 2012-11-30
EA019682B1 (ru) 2014-05-30
UA101590C2 (en) 2013-04-10
ATE504569T1 (de) 2011-04-15
PL2185510T3 (pl) 2011-07-29
PT2311805E (pt) 2012-07-18
WO2009012734A2 (en) 2009-01-29
EP2311805A1 (en) 2011-04-20
UA100521C2 (en) 2013-01-10
EP2185510A2 (en) 2010-05-19
EP2185510B1 (en) 2011-04-06
ES2386953T3 (es) 2012-09-07

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU