TWI925909B - 多特異性抗體及抗體組合 - Google Patents

多特異性抗體及抗體組合

Info

Publication number
TWI925909B
TWI925909B TW110145573A TW110145573A TWI925909B TW I925909 B TWI925909 B TW I925909B TW 110145573 A TW110145573 A TW 110145573A TW 110145573 A TW110145573 A TW 110145573A TW I925909 B TWI925909 B TW I925909B
Authority
TW
Taiwan
Prior art keywords
seq
antibody
cdr
binding domain
variable region
Prior art date
Application number
TW110145573A
Other languages
English (en)
Chinese (zh)
Other versions
TW202229340A (zh
Inventor
喬瑟夫麥克戴維 瑞絲翠克
約翰 保羅 西法
丹尼爾 約翰 萊特伍
羅夫 艾當斯
羅傑 湯瑪士 帕法曼
凱芮 路易斯 泰森
彼得 查理斯 埃利奧特
席馬 馬雅客
安德烈雅 朱莉 克羅斯比
艾米莉 瑪麗 凱莉斯坦 芭莉
塞普 弗蘭斯 羅曼 萊森
贊那巴 阿達斯
Original Assignee
比利時商Ｕｃｂ生物製藥公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 比利時商Ｕｃｂ生物製藥公司 filed Critical 比利時商Ｕｃｂ生物製藥公司
Publication of TW202229340A publication Critical patent/TW202229340A/zh
Application granted granted Critical
Publication of TWI925909B publication Critical patent/TWI925909B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW110145573A 2020-12-07 2021-12-07 多特異性抗體及抗體組合 TWI925909B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20212128.1 2020-12-07
EP20212128 2020-12-07

Publications (2)

Publication Number Publication Date
TW202229340A TW202229340A (zh) 2022-08-01
TWI925909B true TWI925909B (zh) 2026-05-21

Family

ID=73740239

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110145573A TWI925909B (zh) 2020-12-07 2021-12-07 多特異性抗體及抗體組合

Country Status (16)

Country Link
US (1) US20240067758A1 (enExample)
EP (1) EP4255926A1 (enExample)
JP (1) JP2023551981A (enExample)
KR (1) KR20230117588A (enExample)
CN (1) CN116670166A (enExample)
AR (1) AR125581A1 (enExample)
AU (1) AU2021395729A1 (enExample)
CA (1) CA3200847A1 (enExample)
CL (1) CL2023001509A1 (enExample)
CO (1) CO2023007097A2 (enExample)
IL (1) IL303295A (enExample)
MX (1) MX2023006650A (enExample)
PE (1) PE20231953A1 (enExample)
TW (1) TWI925909B (enExample)
WO (1) WO2022122654A1 (enExample)
ZA (1) ZA202305329B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017189805A1 (en) 2016-04-27 2017-11-02 Abbvie Inc. Methods of treatment of diseases in which il-13 activity is detrimental using anti-il-13 antibodies
US20250376535A1 (en) * 2022-06-28 2025-12-11 Beijing Starmab Biomed Technology Ltd Monospecific and multi-specific antibodies
TW202613165A (zh) 2024-05-17 2026-04-01 比利時商Ｕｃｂ生物製藥公司 具有il-11和il-17結合特異性的多特異性抗體

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007098170A1 (en) * 2006-02-21 2007-08-30 Wyeth Antibodies against human il-22 and uses therefor
CN104774266B (zh) * 2006-09-08 2020-03-03 艾伯维巴哈马有限公司 白介素-13结合蛋白

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Publication number Publication date
US20240067758A1 (en) 2024-02-29
EP4255926A1 (en) 2023-10-11
ZA202305329B (en) 2024-09-25
CL2023001509A1 (es) 2024-01-19
IL303295A (en) 2023-07-01
AU2021395729A9 (en) 2024-05-30
AR125581A1 (es) 2023-08-02
MX2023006650A (es) 2023-06-21
PE20231953A1 (es) 2023-12-06
JP2023551981A (ja) 2023-12-13
CN116670166A (zh) 2023-08-29
CA3200847A1 (en) 2022-06-16
TW202229340A (zh) 2022-08-01
WO2022122654A1 (en) 2022-06-16
KR20230117588A (ko) 2023-08-08
CO2023007097A2 (es) 2023-06-09
AU2021395729A1 (en) 2023-07-13

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