JP2023551981A - 多重特異性抗体及び抗体の組み合わせ - Google Patents

多重特異性抗体及び抗体の組み合わせ Download PDF

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Publication number
JP2023551981A
JP2023551981A JP2023534294A JP2023534294A JP2023551981A JP 2023551981 A JP2023551981 A JP 2023551981A JP 2023534294 A JP2023534294 A JP 2023534294A JP 2023534294 A JP2023534294 A JP 2023534294A JP 2023551981 A JP2023551981 A JP 2023551981A
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JP
Japan
Prior art keywords
seq
antibody
cdr
chain variable
variable region
Prior art date
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Pending
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JP2023534294A
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English (en)
Japanese (ja)
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JP2023551981A5 (enExample
Inventor
マイケル デイビッド ラストリック、ジョセフ
ポール シルバ、ジョン
ジョン ライトウッド、ダニエル
アダムス、ラルフ
トーマス パルフラマン、ロジャー
ルイーズ タイソン、ケリー
チャールズ エリオット、ペーター
マヤンカ、シーマ
ジュリー クロスビー、アンドレア
マリー カイリスティン バリー、エミリー
フランス ロマン レイゼン、セッペ
アーダッシュ、ザイナブ
Original Assignee
ユーシービー バイオファルマ エスアールエル
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Application filed by ユーシービー バイオファルマ エスアールエル filed Critical ユーシービー バイオファルマ エスアールエル
Publication of JP2023551981A publication Critical patent/JP2023551981A/ja
Publication of JP2023551981A5 publication Critical patent/JP2023551981A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2023534294A 2020-12-07 2021-12-06 多重特異性抗体及び抗体の組み合わせ Pending JP2023551981A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20212128.1 2020-12-07
EP20212128 2020-12-07
PCT/EP2021/084402 WO2022122654A1 (en) 2020-12-07 2021-12-06 Multi-specific antibodies and antibody combinations

Publications (2)

Publication Number Publication Date
JP2023551981A true JP2023551981A (ja) 2023-12-13
JP2023551981A5 JP2023551981A5 (enExample) 2024-12-09

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JP2023534294A Pending JP2023551981A (ja) 2020-12-07 2021-12-06 多重特異性抗体及び抗体の組み合わせ

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US (1) US20240067758A1 (enExample)
EP (1) EP4255926A1 (enExample)
JP (1) JP2023551981A (enExample)
KR (1) KR20230117588A (enExample)
CN (1) CN116670166A (enExample)
AR (1) AR125581A1 (enExample)
AU (1) AU2021395729A1 (enExample)
CA (1) CA3200847A1 (enExample)
CL (1) CL2023001509A1 (enExample)
CO (1) CO2023007097A2 (enExample)
IL (1) IL303295A (enExample)
MX (1) MX2023006650A (enExample)
PE (1) PE20231953A1 (enExample)
TW (1) TWI925909B (enExample)
WO (1) WO2022122654A1 (enExample)
ZA (1) ZA202305329B (enExample)

Families Citing this family (3)

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WO2017189805A1 (en) 2016-04-27 2017-11-02 Abbvie Inc. Methods of treatment of diseases in which il-13 activity is detrimental using anti-il-13 antibodies
US20250376535A1 (en) * 2022-06-28 2025-12-11 Beijing Starmab Biomed Technology Ltd Monospecific and multi-specific antibodies
TW202613165A (zh) 2024-05-17 2026-04-01 比利時商Ｕｃｂ生物製藥公司 具有il-11和il-17結合特異性的多特異性抗體

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US20240067758A1 (en) 2024-02-29
EP4255926A1 (en) 2023-10-11
ZA202305329B (en) 2024-09-25
TWI925909B (zh) 2026-05-21
CL2023001509A1 (es) 2024-01-19
IL303295A (en) 2023-07-01
AU2021395729A9 (en) 2024-05-30
AR125581A1 (es) 2023-08-02
MX2023006650A (es) 2023-06-21
PE20231953A1 (es) 2023-12-06
CN116670166A (zh) 2023-08-29
CA3200847A1 (en) 2022-06-16
TW202229340A (zh) 2022-08-01
WO2022122654A1 (en) 2022-06-16
KR20230117588A (ko) 2023-08-08
CO2023007097A2 (es) 2023-06-09
AU2021395729A1 (en) 2023-07-13

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