TWI899197B - 編輯目標rna之方法 - Google Patents

編輯目標rna之方法

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Publication number
TWI899197B
TWI899197B TW110112005A TW110112005A TWI899197B TW I899197 B TWI899197 B TW I899197B TW 110112005 A TW110112005 A TW 110112005A TW 110112005 A TW110112005 A TW 110112005A TW I899197 B TWI899197 B TW I899197B
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TW
Taiwan
Prior art keywords
dyw
sequence
amino acids
rna
seq
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TW110112005A
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English (en)
Chinese (zh)
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TW202204382A (zh
Inventor
一瀬瑞穂
伯納德 古德曼
八木祐介
赤岩友美
島尻恭香
中村崇裕
Original Assignee
日商基因編輯力股份有限公司
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Publication of TW202204382A publication Critical patent/TW202204382A/zh
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW110112005A 2020-03-31 2021-03-31 編輯目標rna之方法 TWI899197B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020-065065 2020-03-31
JP2020065065 2020-03-31

Publications (2)

Publication Number Publication Date
TW202204382A TW202204382A (zh) 2022-02-01
TWI899197B true TWI899197B (zh) 2025-10-01

Family

ID=77930108

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110112005A TWI899197B (zh) 2020-03-31 2021-03-31 編輯目標rna之方法

Country Status (11)

Country Link
US (1) US20230125942A1 (https=)
EP (1) EP4130274A4 (https=)
JP (4) JP7668547B2 (https=)
KR (1) KR20220165747A (https=)
CN (1) CN115698296A (https=)
AU (1) AU2021248204A1 (https=)
BR (1) BR112022019571A2 (https=)
CA (1) CA3179365A1 (https=)
IL (1) IL296955A (https=)
TW (1) TWI899197B (https=)
WO (1) WO2021201198A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3216313A1 (en) * 2021-04-30 2022-11-03 Masayuki NAKAMORI Myotonic dystrophy type 1 therapeutic drug
US20250302993A1 (en) * 2021-12-24 2025-10-02 GeCoRT Co., Ltd. Enzyme, complex, recombinant vector, therapeutic agent for genetic disorder, and polynucleotide
WO2024249445A2 (en) * 2023-05-26 2024-12-05 The Trustees Of Columbia University In The City Of New York An rna recognition and editing code of pentatricopeptide repeat proteins
CN117384884B (zh) * 2023-11-30 2024-03-08 辉大(上海)生物科技有限公司 IscB多肽及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2336332A3 (en) * 2008-04-29 2011-11-09 Monsanto Technology LLC Genes and uses for plant enhancement
WO2013058404A1 (ja) * 2011-10-21 2013-04-25 国立大学法人九州大学 Pprモチーフを利用したrna結合性蛋白質の設計方法及びその利用
KR102893770B1 (ko) 2013-04-22 2025-11-28 고쿠리쓰다이가쿠호진 규슈다이가쿠 피피알 단백질을 이용하는 dna 결합성 단백질 및 그의 이용

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 Gerke Philipp ET AL: Towards a plant model for enigmatic U-to-C RNA editing: the organelle genomes, transcriptomes, editomes and candidate RNA editing factors in the hornwort Anthoceros agrestis, New Phytologist, vol. 225, no. 5, 2019-10-31, pages 1974-1992.

Also Published As

Publication number Publication date
CN115698296A (zh) 2023-02-03
JP7668547B2 (ja) 2025-04-25
US20230125942A1 (en) 2023-04-27
JP2025120313A (ja) 2025-08-15
CA3179365A1 (en) 2021-10-07
WO2021201198A1 (ja) 2021-10-07
JP7698351B2 (ja) 2025-06-25
BR112022019571A2 (pt) 2022-12-06
EP4130274A4 (en) 2024-05-22
IL296955A (en) 2022-12-01
EP4130274A1 (en) 2023-02-08
JP7698371B1 (ja) 2025-06-25
JP2025107239A (ja) 2025-07-17
TW202204382A (zh) 2022-02-01
JP2024096897A (ja) 2024-07-17
KR20220165747A (ko) 2022-12-15
JPWO2021201198A1 (https=) 2021-10-07
AU2021248204A1 (en) 2022-11-10

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