TWI899184B - 治療或抑制急性骨髓性白血病復發之化合物 - Google Patents
治療或抑制急性骨髓性白血病復發之化合物Info
- Publication number
- TWI899184B TWI899184B TW110109254A TW110109254A TWI899184B TW I899184 B TWI899184 B TW I899184B TW 110109254 A TW110109254 A TW 110109254A TW 110109254 A TW110109254 A TW 110109254A TW I899184 B TWI899184 B TW I899184B
- Authority
- TW
- Taiwan
- Prior art keywords
- mmol
- pyrrolo
- pyrimidin
- amino
- phenoxyphenyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| WOPCT/CN2020/079464 | 2020-03-16 | ||
| PCT/CN2020/079464 WO2021184154A1 (en) | 2020-03-16 | 2020-03-16 | Compounds for treating or inhibiting recurrence of acute myeloid leukemia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202200583A TW202200583A (zh) | 2022-01-01 |
| TWI899184B true TWI899184B (zh) | 2025-10-01 |
Family
ID=77767943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110109254A TWI899184B (zh) | 2020-03-16 | 2021-03-16 | 治療或抑制急性骨髓性白血病復發之化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11963960B2 (https=) |
| EP (1) | EP4121430A4 (https=) |
| JP (1) | JP7744358B2 (https=) |
| KR (1) | KR20220154164A (https=) |
| CN (1) | CN115298180B (https=) |
| AR (1) | AR121570A1 (https=) |
| AU (2) | AU2020436612A1 (https=) |
| BR (1) | BR112022018345A2 (https=) |
| CA (1) | CA3168988A1 (https=) |
| IL (1) | IL296296A (https=) |
| MX (1) | MX2022011407A (https=) |
| PE (1) | PE20230461A1 (https=) |
| PH (1) | PH12022552169A1 (https=) |
| TW (1) | TWI899184B (https=) |
| WO (2) | WO2021184154A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020436612A1 (en) | 2020-03-16 | 2022-09-01 | Flash Therapeutics, Llc | Compounds for treating or inhibiting recurrence of acute myeloid leukemia |
| ES2991366T3 (es) | 2020-05-08 | 2024-12-03 | Halia Therapeutics Inc | Inhibidores de NEK7 cinasa |
| MX2022015495A (es) * | 2020-06-08 | 2023-03-14 | Halia Therapeutics Inc | Inhibidores de cinasa relacionada con el gen a nunca en mitosis (nek7). |
| CN114075190A (zh) * | 2020-08-20 | 2022-02-22 | 北京诺诚健华医药科技有限公司 | 杂环类btk抑制剂 |
| CN113861179A (zh) * | 2021-10-22 | 2021-12-31 | 上海应用技术大学 | 一种新型flt3激酶抑制剂及其合成与应用 |
| WO2025124429A1 (zh) * | 2023-12-11 | 2025-06-19 | 北京康辰药业股份有限公司 | 芳香胺化合物及其药物组合物、应用 |
| CN121039131A (zh) * | 2024-01-11 | 2025-11-28 | 佩勒梅德有限公司 | 新型吡咯并三嗪衍生物及其用途 |
| KR20250157634A (ko) | 2024-04-29 | 2025-11-05 | 대한민국(질병관리청 국립보건연구원장) | Bax 활성제를 유효성분으로 포함하는 항-hiv-1 조성물 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998041525A1 (en) * | 1997-03-19 | 1998-09-24 | Basf Aktiengesellschaft | Pyrrolo[2,3d]pyrimidines and their use as tyrosine kinase inhibitors |
| WO2002080926A1 (en) * | 2001-03-22 | 2002-10-17 | Abbott Gmbh & Co. Kg | Pyrazolopyrimidines as therapeutic agents |
| US20030153752A1 (en) * | 1998-09-18 | 2003-08-14 | Hirst Gavin C. | Pyrrolopyrimidines as therapeutic agents |
| WO2008121742A2 (en) * | 2007-03-28 | 2008-10-09 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| WO2014017659A1 (ja) * | 2012-07-27 | 2014-01-30 | 独立行政法人理化学研究所 | 急性骨髄性白血病の治療又は再発抑制剤 |
| CN105481862A (zh) * | 2015-01-21 | 2016-04-13 | 中国科学院合肥物质科学研究院 | Flt3激酶的新型抑制剂及其用途 |
| WO2018052120A1 (en) * | 2016-09-15 | 2018-03-22 | Riken | A hck inhibitor and a bcl-2 inhibitor for treating acute myeloid leukemia |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2344249A1 (en) * | 1998-09-18 | 2000-03-30 | Basf Aktiengesellschaft | Pyrrolopyrimidines as protein kinase inhibitors |
| CA2385747A1 (en) * | 1999-09-17 | 2001-03-22 | Gavin C. Hirst | Pyrazolopyrimidines as therapeutic agents |
| MXPA03008560A (es) * | 2001-03-22 | 2004-06-30 | Abbot Gmbh & Co Kg | Pirazolopirimidinas como agentes terapeuticos. |
| JP2007520559A (ja) * | 2004-02-03 | 2007-07-26 | アボット・ラボラトリーズ | 治療薬としてのアミノベンゾオキサゾール類 |
| KR101461680B1 (ko) * | 2005-12-02 | 2014-11-19 | 바이엘 헬스케어 엘엘씨 | 과다-증식성 장애 및 맥관형성과 관련된 질환의 치료에유용한 치환된 4-아미노-피롤로트리아진 유도체 |
| TW200801008A (en) * | 2005-12-29 | 2008-01-01 | Abbott Lab | Protein kinase inhibitors |
| EP2283020B8 (en) * | 2008-05-19 | 2012-12-12 | OSI Pharmaceuticals, LLC | Substituted imidazopyr-and imidazotri-azines |
| US9758522B2 (en) * | 2012-10-19 | 2017-09-12 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
| CN105017256A (zh) * | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| WO2016019237A2 (en) * | 2014-07-31 | 2016-02-04 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| US10266535B2 (en) * | 2015-01-21 | 2019-04-23 | Hefei Institutes Of Physical Science, Chinese Academy Of Sciences | Inhibitor of FLT3 kinase and use thereof |
| GB201508747D0 (en) | 2015-05-21 | 2015-07-01 | Univ Edinburgh | Compounds |
| TWI762939B (zh) | 2019-05-31 | 2022-05-01 | 大陸商海思科醫藥集團股份有限公司 | Btk抑制劑環衍生物及其製備方法和藥學上的應用 |
| AU2020301399B2 (en) | 2019-06-24 | 2025-12-18 | Dana-Farber Cancer Institute, Inc. | HCK degraders and uses thereof |
| WO2021071922A1 (en) | 2019-10-08 | 2021-04-15 | Dana-Farber Cancer Institute, Inc. | A pyrazolopyrimidine derivative as a hck inhibitor for use in therapy, in particular myd88 mutated diseases |
| MX2022008148A (es) * | 2020-01-02 | 2022-07-21 | Dizal Jiangsu Pharmaceutical Co Ltd | Inhibidores de btk. |
| AU2020436612A1 (en) | 2020-03-16 | 2022-09-01 | Flash Therapeutics, Llc | Compounds for treating or inhibiting recurrence of acute myeloid leukemia |
-
2020
- 2020-03-16 AU AU2020436612A patent/AU2020436612A1/en active Pending
- 2020-03-16 WO PCT/CN2020/079464 patent/WO2021184154A1/en not_active Ceased
-
2021
- 2021-03-12 AR ARP210100645A patent/AR121570A1/es not_active Application Discontinuation
- 2021-03-15 JP JP2022555625A patent/JP7744358B2/ja active Active
- 2021-03-15 IL IL296296A patent/IL296296A/en unknown
- 2021-03-15 US US17/201,827 patent/US11963960B2/en active Active
- 2021-03-15 MX MX2022011407A patent/MX2022011407A/es unknown
- 2021-03-15 BR BR112022018345A patent/BR112022018345A2/pt not_active Application Discontinuation
- 2021-03-15 KR KR1020227035324A patent/KR20220154164A/ko active Pending
- 2021-03-15 CA CA3168988A patent/CA3168988A1/en active Pending
- 2021-03-15 EP EP21772015.0A patent/EP4121430A4/en active Pending
- 2021-03-15 WO PCT/US2021/022322 patent/WO2021188417A1/en not_active Ceased
- 2021-03-15 PH PH1/2022/552169A patent/PH12022552169A1/en unknown
- 2021-03-15 AU AU2021239828A patent/AU2021239828B2/en active Active
- 2021-03-15 PE PE2022001990A patent/PE20230461A1/es unknown
- 2021-03-15 CN CN202180016180.0A patent/CN115298180B/zh active Active
- 2021-03-16 TW TW110109254A patent/TWI899184B/zh active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998041525A1 (en) * | 1997-03-19 | 1998-09-24 | Basf Aktiengesellschaft | Pyrrolo[2,3d]pyrimidines and their use as tyrosine kinase inhibitors |
| US20030153752A1 (en) * | 1998-09-18 | 2003-08-14 | Hirst Gavin C. | Pyrrolopyrimidines as therapeutic agents |
| WO2002080926A1 (en) * | 2001-03-22 | 2002-10-17 | Abbott Gmbh & Co. Kg | Pyrazolopyrimidines as therapeutic agents |
| WO2008121742A2 (en) * | 2007-03-28 | 2008-10-09 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| WO2014017659A1 (ja) * | 2012-07-27 | 2014-01-30 | 独立行政法人理化学研究所 | 急性骨髄性白血病の治療又は再発抑制剤 |
| CN105481862A (zh) * | 2015-01-21 | 2016-04-13 | 中国科学院合肥物质科学研究院 | Flt3激酶的新型抑制剂及其用途 |
| WO2018052120A1 (en) * | 2016-09-15 | 2018-03-22 | Riken | A hck inhibitor and a bcl-2 inhibitor for treating acute myeloid leukemia |
Non-Patent Citations (2)
| Title |
|---|
| 期刊 Koda Y, et al. "Identification of pyrrolo [2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors" Bioorganic & medicinal chemistry letters 27(22): Elsevier 2017; 4994-4998;期刊 Yuki H, et al. "Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen" Bioorganic & medicinal chemistry 25(16): Elsevier 2017; 4259-4264 * |
| 期刊 Yuki H, et al. "Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen" Bioorganic & medicinal chemistry 25(16): Elsevier 2017; 4259-4264 |
Also Published As
| Publication number | Publication date |
|---|---|
| US11963960B2 (en) | 2024-04-23 |
| AR121570A1 (es) | 2022-06-15 |
| IL296296A (en) | 2022-11-01 |
| KR20220154164A (ko) | 2022-11-21 |
| WO2021188417A1 (en) | 2021-09-23 |
| BR112022018345A2 (pt) | 2022-11-08 |
| US20210299128A1 (en) | 2021-09-30 |
| CN115298180A (zh) | 2022-11-04 |
| AU2020436612A1 (en) | 2022-09-01 |
| EP4121430A4 (en) | 2024-04-17 |
| WO2021184154A1 (en) | 2021-09-23 |
| CN115298180B (zh) | 2025-06-10 |
| TW202200583A (zh) | 2022-01-01 |
| MX2022011407A (es) | 2022-10-13 |
| PE20230461A1 (es) | 2023-03-14 |
| AU2021239828A1 (en) | 2025-04-03 |
| JP2023518035A (ja) | 2023-04-27 |
| PH12022552169A1 (en) | 2024-01-29 |
| EP4121430A1 (en) | 2023-01-25 |
| CA3168988A1 (en) | 2021-09-23 |
| AU2021239828B2 (en) | 2025-06-26 |
| JP7744358B2 (ja) | 2025-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI899184B (zh) | 治療或抑制急性骨髓性白血病復發之化合物 | |
| TWI811353B (zh) | 作為parp7抑制劑的嗒酮 | |
| CN102548557B (zh) | 用于降低β-淀粉状蛋白生成的化合物 | |
| CN106061973B (zh) | 吡咯并[2,3-d]嘧啶基、吡咯并[2,3-b]吡嗪基和吡咯并[2,3-d]吡啶基丙烯酰胺 | |
| TWI498325B (zh) | ３－取代吡唑及其用途 | |
| CN104470925B (zh) | 作为激酶抑制剂的咪唑并三嗪甲腈 | |
| CN105732636A (zh) | 杂芳化合物及其在药物中的应用 | |
| KR20180015160A (ko) | Brk 저해 화합물 | |
| TWI596095B (zh) | Dihydropyridazine-3,5-dione derivatives | |
| CN105164114A (zh) | C-连接的杂环烷基取代的嘧啶类和它们的用途 | |
| CN105939997A (zh) | 作为dlk抑制剂的吡唑衍生物及其用途 | |
| CN102827170A (zh) | 治疗活性组合物和它们的使用方法 | |
| CN103328451B (zh) | 降低β-淀粉样物质生成的化合物 | |
| US20240092761A1 (en) | Quinazoline compounds and methods of use | |
| JP2019501971A (ja) | 縮合四環式の化合物、組成物及びその使用 | |
| CN120981466A (zh) | 作为egfr抑制剂的大环氨基吡啶化合物 | |
| HK40083594A (en) | Compounds for treating or inhibiting recurrence of acute myeloid leukemia | |
| WO2025153712A1 (en) | Tricyclic compounds, preparation thereof and therapeutic uses as erk5 inhibitors | |
| HK40117941A (zh) | 包含抗癌剂和对前列腺素e2受体具有抑制活性的新化合物的用於治疗癌症的药物组合物 | |
| HK1242689A1 (en) | Heterocyclic acrylamides | |
| HK1209114B (en) | 3-substituted pyrazoles and use as dlk inhibitors | |
| HK40006173B (zh) | 稠合四环化合物、其组合物和用途 | |
| HK1228913A1 (en) | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides | |
| HK1124603A (en) | Pyridazinone derivatives used for the treatment of pain | |
| HK1244486A1 (zh) | 三环dlk抑制剂及其用途 |