JP7744358B2 - 急性骨髄性白血病の再発を処置または阻害するための化合物 - Google Patents
急性骨髄性白血病の再発を処置または阻害するための化合物Info
- Publication number
- JP7744358B2 JP7744358B2 JP2022555625A JP2022555625A JP7744358B2 JP 7744358 B2 JP7744358 B2 JP 7744358B2 JP 2022555625 A JP2022555625 A JP 2022555625A JP 2022555625 A JP2022555625 A JP 2022555625A JP 7744358 B2 JP7744358 B2 JP 7744358B2
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- pyrrolo
- pyrimidin
- amino
- phenoxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2020/079464 WO2021184154A1 (en) | 2020-03-16 | 2020-03-16 | Compounds for treating or inhibiting recurrence of acute myeloid leukemia |
| CNPCT/CN2020/079464 | 2020-03-16 | ||
| PCT/US2021/022322 WO2021188417A1 (en) | 2020-03-16 | 2021-03-15 | Compounds for treating or inhibiting recurrence of acute myeloid leukemia |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023518035A JP2023518035A (ja) | 2023-04-27 |
| JPWO2021188417A5 JPWO2021188417A5 (https=) | 2024-03-27 |
| JP2023518035A5 JP2023518035A5 (https=) | 2024-03-27 |
| JP7744358B2 true JP7744358B2 (ja) | 2025-09-25 |
Family
ID=77767943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022555625A Active JP7744358B2 (ja) | 2020-03-16 | 2021-03-15 | 急性骨髄性白血病の再発を処置または阻害するための化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11963960B2 (https=) |
| EP (1) | EP4121430A4 (https=) |
| JP (1) | JP7744358B2 (https=) |
| KR (1) | KR20220154164A (https=) |
| CN (1) | CN115298180B (https=) |
| AR (1) | AR121570A1 (https=) |
| AU (2) | AU2020436612A1 (https=) |
| BR (1) | BR112022018345A2 (https=) |
| CA (1) | CA3168988A1 (https=) |
| IL (1) | IL296296A (https=) |
| MX (1) | MX2022011407A (https=) |
| PE (1) | PE20230461A1 (https=) |
| PH (1) | PH12022552169A1 (https=) |
| TW (1) | TWI899184B (https=) |
| WO (2) | WO2021184154A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020436612A1 (en) | 2020-03-16 | 2022-09-01 | Flash Therapeutics, Llc | Compounds for treating or inhibiting recurrence of acute myeloid leukemia |
| ES2991366T3 (es) | 2020-05-08 | 2024-12-03 | Halia Therapeutics Inc | Inhibidores de NEK7 cinasa |
| MX2022015495A (es) * | 2020-06-08 | 2023-03-14 | Halia Therapeutics Inc | Inhibidores de cinasa relacionada con el gen a nunca en mitosis (nek7). |
| CN114075190A (zh) * | 2020-08-20 | 2022-02-22 | 北京诺诚健华医药科技有限公司 | 杂环类btk抑制剂 |
| CN113861179A (zh) * | 2021-10-22 | 2021-12-31 | 上海应用技术大学 | 一种新型flt3激酶抑制剂及其合成与应用 |
| WO2025124429A1 (zh) * | 2023-12-11 | 2025-06-19 | 北京康辰药业股份有限公司 | 芳香胺化合物及其药物组合物、应用 |
| CN121039131A (zh) * | 2024-01-11 | 2025-11-28 | 佩勒梅德有限公司 | 新型吡咯并三嗪衍生物及其用途 |
| KR20250157634A (ko) | 2024-04-29 | 2025-11-05 | 대한민국(질병관리청 국립보건연구원장) | Bax 활성제를 유효성분으로 포함하는 항-hiv-1 조성물 |
Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001516353A (ja) | 1997-03-19 | 2001-09-25 | ビーエーエスエフ アクチェンゲゼルシャフト | ピロロ［２，３ｄ］ピリミジンおよびチロシンキナーゼ阻害剤としてのこれらの使用 |
| JP2002526500A (ja) | 1998-09-18 | 2002-08-20 | ビーエーエスエフ アクチェンゲゼルシャフト | プロテインキナーゼ阻害剤としてのピロロピリミジン |
| JP2003509428A (ja) | 1999-09-17 | 2003-03-11 | アボツト・ゲー・エム・ベー・ハー・ウント・コンパニー・カーゲー | 治療薬としてのピラゾロピリミジン |
| JP2004531513A (ja) | 2001-03-22 | 2004-10-14 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 治療剤としてのピラゾールピリミジン |
| JP2009518303A (ja) | 2005-12-02 | 2009-05-07 | バイエル・ヘルスケア・エルエルシー | 過剰増殖性疾患および血管新生と関連する疾患を処置するために有用な置換された４−アミノ−ピロロトリアジン誘導体 |
| JP2009522284A (ja) | 2005-12-29 | 2009-06-11 | アボット・ラボラトリーズ | タンパク質キナーゼ阻害薬 |
| JP2010526768A (ja) | 2007-03-28 | 2010-08-05 | ファーマサイクリックス，インク． | ブルトンチロシンキナーゼインヒビター |
| JP2011520970A (ja) | 2008-05-19 | 2011-07-21 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換されたイミダゾピラジン類およびイミダゾトリアジン類 |
| WO2014017659A1 (ja) | 2012-07-27 | 2014-01-30 | 独立行政法人理化学研究所 | 急性骨髄性白血病の治療又は再発抑制剤 |
| WO2016019237A2 (en) | 2014-07-31 | 2016-02-04 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| JP2017518276A (ja) | 2014-04-29 | 2017-07-06 | チョーチアン ディーティーアールエム バイオファーマ コーポレーション リミテッド | ブルトン型チロシンキナーゼ（ｂｔｋ）インヒビターとしての多フルオロ置換化合物 |
| US20180030054A1 (en) | 2015-01-21 | 2018-02-01 | Hefei Institutes Of Physical Science, Chinese Academy Of Sciences | Novel inhibitor of flt3 kinase and use thereof |
| JP2019529423A (ja) | 2016-09-15 | 2019-10-17 | 国立研究開発法人理化学研究所 | 急性骨髄性白血病を処置するためのＨＣＫ阻害剤及びＢｃｌ−２阻害剤 |
| WO2020239103A1 (zh) | 2019-05-31 | 2020-12-03 | 四川海思科制药有限公司 | 一种btk抑制剂环衍生物及其制备方法和药学上的应用 |
| WO2020263935A1 (en) | 2019-06-24 | 2020-12-30 | Dana-Farber Cancer Institute, Inc. | Hck degraders and uses thereof |
| JP2022551502A (ja) | 2019-10-08 | 2022-12-09 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 治療、特にｍｙｄ８８変異疾患における使用のためのｈｃｋ阻害剤としてのピラゾロピリミジン誘導体 |
| JP2023510212A (ja) | 2020-01-02 | 2023-03-13 | ディザル（ジァンスー）ファーマシューティカル・カンパニー・リミテッド | Ｂｔｋ阻害薬 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713474B2 (en) * | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| MXPA03008560A (es) * | 2001-03-22 | 2004-06-30 | Abbot Gmbh & Co Kg | Pirazolopirimidinas como agentes terapeuticos. |
| JP2007520559A (ja) * | 2004-02-03 | 2007-07-26 | アボット・ラボラトリーズ | 治療薬としてのアミノベンゾオキサゾール類 |
| US9758522B2 (en) * | 2012-10-19 | 2017-09-12 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
| CN105481862B (zh) * | 2015-01-21 | 2018-08-21 | 中国科学院合肥物质科学研究院 | Flt3激酶的新型抑制剂及其用途 |
| GB201508747D0 (en) | 2015-05-21 | 2015-07-01 | Univ Edinburgh | Compounds |
| AU2020436612A1 (en) | 2020-03-16 | 2022-09-01 | Flash Therapeutics, Llc | Compounds for treating or inhibiting recurrence of acute myeloid leukemia |
-
2020
- 2020-03-16 AU AU2020436612A patent/AU2020436612A1/en active Pending
- 2020-03-16 WO PCT/CN2020/079464 patent/WO2021184154A1/en not_active Ceased
-
2021
- 2021-03-12 AR ARP210100645A patent/AR121570A1/es not_active Application Discontinuation
- 2021-03-15 JP JP2022555625A patent/JP7744358B2/ja active Active
- 2021-03-15 IL IL296296A patent/IL296296A/en unknown
- 2021-03-15 US US17/201,827 patent/US11963960B2/en active Active
- 2021-03-15 MX MX2022011407A patent/MX2022011407A/es unknown
- 2021-03-15 BR BR112022018345A patent/BR112022018345A2/pt not_active Application Discontinuation
- 2021-03-15 KR KR1020227035324A patent/KR20220154164A/ko active Pending
- 2021-03-15 CA CA3168988A patent/CA3168988A1/en active Pending
- 2021-03-15 EP EP21772015.0A patent/EP4121430A4/en active Pending
- 2021-03-15 WO PCT/US2021/022322 patent/WO2021188417A1/en not_active Ceased
- 2021-03-15 PH PH1/2022/552169A patent/PH12022552169A1/en unknown
- 2021-03-15 AU AU2021239828A patent/AU2021239828B2/en active Active
- 2021-03-15 PE PE2022001990A patent/PE20230461A1/es unknown
- 2021-03-15 CN CN202180016180.0A patent/CN115298180B/zh active Active
- 2021-03-16 TW TW110109254A patent/TWI899184B/zh active
Patent Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001516353A (ja) | 1997-03-19 | 2001-09-25 | ビーエーエスエフ アクチェンゲゼルシャフト | ピロロ［２，３ｄ］ピリミジンおよびチロシンキナーゼ阻害剤としてのこれらの使用 |
| JP2002526500A (ja) | 1998-09-18 | 2002-08-20 | ビーエーエスエフ アクチェンゲゼルシャフト | プロテインキナーゼ阻害剤としてのピロロピリミジン |
| JP2003509428A (ja) | 1999-09-17 | 2003-03-11 | アボツト・ゲー・エム・ベー・ハー・ウント・コンパニー・カーゲー | 治療薬としてのピラゾロピリミジン |
| JP2004531513A (ja) | 2001-03-22 | 2004-10-14 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 治療剤としてのピラゾールピリミジン |
| JP2009518303A (ja) | 2005-12-02 | 2009-05-07 | バイエル・ヘルスケア・エルエルシー | 過剰増殖性疾患および血管新生と関連する疾患を処置するために有用な置換された４−アミノ−ピロロトリアジン誘導体 |
| JP2009522284A (ja) | 2005-12-29 | 2009-06-11 | アボット・ラボラトリーズ | タンパク質キナーゼ阻害薬 |
| JP2010526768A (ja) | 2007-03-28 | 2010-08-05 | ファーマサイクリックス，インク． | ブルトンチロシンキナーゼインヒビター |
| JP2011520970A (ja) | 2008-05-19 | 2011-07-21 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換されたイミダゾピラジン類およびイミダゾトリアジン類 |
| WO2014017659A1 (ja) | 2012-07-27 | 2014-01-30 | 独立行政法人理化学研究所 | 急性骨髄性白血病の治療又は再発抑制剤 |
| JP2017518276A (ja) | 2014-04-29 | 2017-07-06 | チョーチアン ディーティーアールエム バイオファーマ コーポレーション リミテッド | ブルトン型チロシンキナーゼ（ｂｔｋ）インヒビターとしての多フルオロ置換化合物 |
| WO2016019237A2 (en) | 2014-07-31 | 2016-02-04 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| US20180030054A1 (en) | 2015-01-21 | 2018-02-01 | Hefei Institutes Of Physical Science, Chinese Academy Of Sciences | Novel inhibitor of flt3 kinase and use thereof |
| JP2019529423A (ja) | 2016-09-15 | 2019-10-17 | 国立研究開発法人理化学研究所 | 急性骨髄性白血病を処置するためのＨＣＫ阻害剤及びＢｃｌ−２阻害剤 |
| WO2020239103A1 (zh) | 2019-05-31 | 2020-12-03 | 四川海思科制药有限公司 | 一种btk抑制剂环衍生物及其制备方法和药学上的应用 |
| WO2020263935A1 (en) | 2019-06-24 | 2020-12-30 | Dana-Farber Cancer Institute, Inc. | Hck degraders and uses thereof |
| JP2022551502A (ja) | 2019-10-08 | 2022-12-09 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 治療、特にｍｙｄ８８変異疾患における使用のためのｈｃｋ阻害剤としてのピラゾロピリミジン誘導体 |
| JP2023510212A (ja) | 2020-01-02 | 2023-03-13 | ディザル（ジァンスー）ファーマシューティカル・カンパニー・リミテッド | Ｂｔｋ阻害薬 |
Also Published As
| Publication number | Publication date |
|---|---|
| US11963960B2 (en) | 2024-04-23 |
| AR121570A1 (es) | 2022-06-15 |
| IL296296A (en) | 2022-11-01 |
| KR20220154164A (ko) | 2022-11-21 |
| WO2021188417A1 (en) | 2021-09-23 |
| BR112022018345A2 (pt) | 2022-11-08 |
| US20210299128A1 (en) | 2021-09-30 |
| CN115298180A (zh) | 2022-11-04 |
| AU2020436612A1 (en) | 2022-09-01 |
| EP4121430A4 (en) | 2024-04-17 |
| WO2021184154A1 (en) | 2021-09-23 |
| CN115298180B (zh) | 2025-06-10 |
| TW202200583A (zh) | 2022-01-01 |
| MX2022011407A (es) | 2022-10-13 |
| PE20230461A1 (es) | 2023-03-14 |
| AU2021239828A1 (en) | 2025-04-03 |
| JP2023518035A (ja) | 2023-04-27 |
| PH12022552169A1 (en) | 2024-01-29 |
| EP4121430A1 (en) | 2023-01-25 |
| CA3168988A1 (en) | 2021-09-23 |
| AU2021239828B2 (en) | 2025-06-26 |
| TWI899184B (zh) | 2025-10-01 |
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