TWI873263B - 胜肽化合物的合成法 - Google Patents

胜肽化合物的合成法 Download PDF

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Publication number
TWI873263B
TWI873263B TW109146180A TW109146180A TWI873263B TW I873263 B TWI873263 B TW I873263B TW 109146180 A TW109146180 A TW 109146180A TW 109146180 A TW109146180 A TW 109146180A TW I873263 B TWI873263 B TW I873263B
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Taiwan
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terminal active
mmol
group
area
reaction
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TW109146180A
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English (en)
Chinese (zh)
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TW202138382A (zh
Inventor
近藤泰博
瀬戸健太郎
小宮志央
侯増燁
村形政利
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日商中外製藥股份有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW109146180A 2019-12-27 2020-12-25 胜肽化合物的合成法 TWI873263B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019-238793 2019-12-27
JP2019238793 2019-12-27

Publications (2)

Publication Number Publication Date
TW202138382A TW202138382A (zh) 2021-10-16
TWI873263B true TWI873263B (zh) 2025-02-21

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ID=76575534

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TW109146180A TWI873263B (zh) 2019-12-27 2020-12-25 胜肽化合物的合成法

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US (1) US20230056969A1 (https=)
EP (1) EP4083051A4 (https=)
JP (2) JP7709920B2 (https=)
KR (1) KR20220119421A (https=)
CN (1) CN114867734B (https=)
TW (1) TWI873263B (https=)
WO (1) WO2021132545A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI787670B (zh) 2011-12-28 2022-12-21 日商中外製藥股份有限公司 具有環狀部之胜肽化合物及其醫藥組成物
WO2018225851A1 (ja) 2017-06-09 2018-12-13 中外製薬株式会社 Ｎ－置換アミノ酸を含むペプチドの合成方法
EP3878836B1 (en) 2018-11-07 2025-07-23 Chugai Seiyaku Kabushiki Kaisha O-substituted serine derivative production method
KR20210139366A (ko) 2019-03-15 2021-11-22 추가이 세이야쿠 가부시키가이샤 방향족 아미노산 유도체의 제조 방법
US12404299B2 (en) 2019-11-07 2025-09-02 Chugai Seiyaku Kabushiki Kaisha Method for producing peptide compound comprising highly sterically hindered amino acid
PE20221323A1 (es) 2019-11-07 2022-09-09 Chugai Pharmaceutical Co Ltd Compuesto de peptidos ciclicos que tiene accion inhibidora de kras
TW202309065A (zh) 2021-05-07 2023-03-01 日商中外製藥股份有限公司 包含n-取代胺基酸殘基之環狀化合物的製造方法
CA3256645A1 (en) 2022-05-06 2025-04-23 Chugai Seiyaku Kabushiki Kaisha CYCLIC COMPOUND HAVING A SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS
CN114920669A (zh) * 2022-06-28 2022-08-19 吉尔多肽生物制药(大连市)有限公司 一种n-甲基-n-苄氧羰基-l-天门冬氨酸（4-叔丁酯）二环己胺盐的合成方法
WO2024024965A1 (ja) 2022-07-29 2024-02-01 中外製薬株式会社 Ｏ－置換セリン誘導体の製造方法
EP4596567A1 (en) 2022-11-01 2025-08-06 Chugai Seiyaku Kabushiki Kaisha Method for removing dibenzofulvene or dibenzofulvene derivative
JPWO2024143514A1 (https=) 2022-12-28 2024-07-04
WO2025070753A1 (ja) 2023-09-28 2025-04-03 中外製薬株式会社 混合酸無水物法を用いたペプチド化合物の製造方法
CN121889409A (zh) 2023-12-27 2026-04-17 中外制药株式会社 用于使用独立型缩合剂生产肽化合物的方法
CN119613485B (zh) * 2024-12-16 2025-10-28 中原食品实验室 一种二肽-2的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW401421B (en) * 1994-03-07 2000-08-11 Syn Tech Chem & Pharm Co Ltd A method of asymmeric synthezing of optically active peptides
TW200626611A (en) * 2004-09-20 2006-08-01 Lonza Ag Peptide cyclisation
EP1995254B1 (en) * 2006-03-01 2019-04-03 Kaneka Corporation Method of producing peptides

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JPS5212371B2 (https=) 1973-07-18 1977-04-06
JP2862167B2 (ja) * 1995-03-02 1999-02-24 株式会社島津製作所 光学活性アミノ酸誘導体の回収方法
TWI247012B (en) * 2001-07-19 2006-01-11 Akzo Nobel Nv Process for rapid solution synthesis of peptides
CN101018803A (zh) * 2004-07-16 2007-08-15 隆萨股份公司 肽合成法
JP5212371B2 (ja) 2007-07-25 2013-06-19 味の素株式会社 ペプチドの製造方法
WO2012087307A1 (en) * 2010-12-22 2012-06-28 Empire Technology Development Llc Economical, food-safe extraction of bisphenols
EP3266792B1 (en) * 2015-03-04 2020-12-30 Jitsubo Co., Ltd. Peptide synthesis method
WO2018225851A1 (ja) * 2017-06-09 2018-12-13 中外製薬株式会社 Ｎ－置換アミノ酸を含むペプチドの合成方法
EP3725796A4 (en) * 2017-12-15 2021-09-15 Chugai Seiyaku Kabushiki Kaisha METHOD FOR MANUFACTURING PEPTIDE AND METHOD FOR PROCESSING BASES
EP3778621B1 (en) * 2018-04-13 2023-08-23 Jitsubo Co., Ltd. Peptide synthesis method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW401421B (en) * 1994-03-07 2000-08-11 Syn Tech Chem & Pharm Co Ltd A method of asymmeric synthezing of optically active peptides
TW200626611A (en) * 2004-09-20 2006-08-01 Lonza Ag Peptide cyclisation
EP1995254B1 (en) * 2006-03-01 2019-04-03 Kaneka Corporation Method of producing peptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 Shiina et al 4-(Dimethylamino)pyridine N-oxide(DMAPO): an effective nucleophilic catalyst in the peptide coupling reaction with 2-methyl-6-nitrobenzoic anhydride Chem. Asian J. 3. InterScience 2008 p454-461 *

Also Published As

Publication number Publication date
JP2025148420A (ja) 2025-10-07
CN114867734A (zh) 2022-08-05
KR20220119421A (ko) 2022-08-29
EP4083051A4 (en) 2024-01-17
US20230056969A1 (en) 2023-02-23
CN114867734B (zh) 2025-07-01
JPWO2021132545A1 (https=) 2021-07-01
WO2021132545A1 (ja) 2021-07-01
TW202138382A (zh) 2021-10-16
JP7709920B2 (ja) 2025-07-17
EP4083051A1 (en) 2022-11-02

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