TWI873185B - 唑稠合之嗒-3(2h)-酮衍生物 - Google Patents

唑稠合之嗒-3(2h)-酮衍生物 Download PDF

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Publication number
TWI873185B
TWI873185B TW109131750A TW109131750A TWI873185B TW I873185 B TWI873185 B TW I873185B TW 109131750 A TW109131750 A TW 109131750A TW 109131750 A TW109131750 A TW 109131750A TW I873185 B TWI873185 B TW I873185B
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Taiwan
Prior art keywords
dihydro
ethyl
acetamide
oxo
pyrazolo
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TW109131750A
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English (en)
Chinese (zh)
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TW202124386A (zh
Inventor
豪格 默尼斯錢
西恩 默菲
史考特 歐森
娜塔莎 歐洛克
荷莉 芮查德
梅林達 戴維斯
貝蒂 蘭姆
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日商武田藥品工業股份有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW109131750A 2019-09-16 2020-09-15 唑稠合之嗒-3(2h)-酮衍生物 TWI873185B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962901052P 2019-09-16 2019-09-16
US62/901,052 2019-09-16

Publications (2)

Publication Number Publication Date
TW202124386A TW202124386A (zh) 2021-07-01
TWI873185B true TWI873185B (zh) 2025-02-21

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TW109131750A TWI873185B (zh) 2019-09-16 2020-09-15 唑稠合之嗒-3(2h)-酮衍生物

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EP (1) EP4031552B1 (https=)
JP (1) JP7566888B2 (https=)
KR (1) KR102924294B1 (https=)
CN (1) CN114728975A (https=)
AR (1) AR119971A1 (https=)
AU (1) AU2020348675B2 (https=)
BR (1) BR112022004819A2 (https=)
CA (1) CA3150508A1 (https=)
CO (1) CO2022004684A2 (https=)
CR (1) CR20220160A (https=)
DO (1) DOP2022000057A (https=)
EC (1) ECSP22020159A (https=)
ES (1) ES2997267T3 (https=)
HR (1) HRP20250088T1 (https=)
HU (1) HUE069908T2 (https=)
IL (1) IL291181B2 (https=)
JO (1) JOP20220063A1 (https=)
MX (1) MX2022003177A (https=)
PE (1) PE20221341A1 (https=)
PH (1) PH12022550597A1 (https=)
PL (1) PL4031552T3 (https=)
RS (1) RS66463B1 (https=)
TW (1) TWI873185B (https=)
WO (1) WO2021055326A1 (https=)

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WO2021224680A1 (en) 2020-05-08 2021-11-11 Takeda Pharmaceutical Company Limited Substituted benzotriazinone metabolites of a gpr139 agonist
GB202106872D0 (en) * 2021-05-13 2021-06-30 Addex Pharmaceuticals Sa Novel compounds
CN114149371B (zh) * 2021-11-26 2023-08-22 首都医科大学 四取代吡唑类化合物及其应用
CN116693545A (zh) * 2022-03-01 2023-09-05 上海科技大学 噻吩并含氮杂环类化合物、含其的药物组合物、其制备方法及其应用
CN116693536A (zh) * 2022-03-01 2023-09-05 上海科技大学 吡咯并三嗪酮类化合物、含其的药物组合物、其制备方法及其应用
IT202200024948A1 (it) * 2022-12-05 2024-06-05 Angelini Pharma S P A Composti attivatori dei canali potassio KV7.2/KV7.3
CN116063179A (zh) * 2023-02-20 2023-05-05 南京杰运医药科技有限公司 一种4-甲氧基乙酰乙酸甲酯的合成方法
WO2025119351A1 (zh) * 2023-12-08 2025-06-12 深圳湾实验室 Gpr139激动剂
WO2025124544A1 (zh) * 2023-12-14 2025-06-19 华润医药研究院（深圳）有限公司 3,4-二氢-2H-苯并[b][1,4]二氧杂环庚烷类化合物及其制备方法和医药用途
WO2025162441A1 (zh) * 2024-02-02 2025-08-07 上海科技大学 稠杂环类化合物与其制备方法、药物组合物及应用

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CR20220160A (es) 2022-06-16
IL291181A (en) 2022-05-01
WO2021055326A1 (en) 2021-03-25
CO2022004684A2 (es) 2022-07-08
EP4031552A1 (en) 2022-07-27
CN114728975A (zh) 2022-07-08
MX2022003177A (es) 2022-04-06
US12370192B2 (en) 2025-07-29
PH12022550597A1 (en) 2024-03-04
EP4031552C0 (en) 2024-11-06
CA3150508A1 (en) 2021-03-25
IL291181B1 (en) 2025-05-01
DOP2022000057A (es) 2022-06-30
AU2020348675B2 (en) 2025-11-20
BR112022004819A2 (pt) 2022-06-07
AR119971A1 (es) 2022-01-26
AU2020348675A1 (en) 2022-04-14
HUE069908T2 (hu) 2025-04-28
PL4031552T3 (pl) 2025-03-17
JOP20220063A1 (ar) 2023-01-30
RS66463B1 (sr) 2025-02-28
JP7566888B2 (ja) 2024-10-15
IL291181B2 (en) 2025-09-01
KR20220063228A (ko) 2022-05-17
US20230028114A1 (en) 2023-01-26
ECSP22020159A (es) 2022-05-31
EP4031552B1 (en) 2024-11-06
KR102924294B1 (ko) 2026-02-09
ES2997267T3 (en) 2025-02-14
JP2022548602A (ja) 2022-11-21
PE20221341A1 (es) 2022-09-13
HRP20250088T1 (hr) 2025-03-28
TW202124386A (zh) 2021-07-01

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