DOP2022000057A - Derivados de piridazin-3(2h)-ona fusionados con azol - Google Patents
Derivados de piridazin-3(2h)-ona fusionados con azolInfo
- Publication number
- DOP2022000057A DOP2022000057A DO2022000057A DO2022000057A DOP2022000057A DO P2022000057 A DOP2022000057 A DO P2022000057A DO 2022000057 A DO2022000057 A DO 2022000057A DO 2022000057 A DO2022000057 A DO 2022000057A DO P2022000057 A DOP2022000057 A DO P2022000057A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- azole
- derivatives
- fused pyridazine
- compounds
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962901052P | 2019-09-16 | 2019-09-16 | |
| PCT/US2020/050823 WO2021055326A1 (en) | 2019-09-16 | 2020-09-15 | Azole-fused pyridazin-3(2h)-one derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2022000057A true DOP2022000057A (es) | 2022-06-30 |
Family
ID=72670806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2022000057A DOP2022000057A (es) | 2019-09-16 | 2022-03-15 | Derivados de piridazin-3(2h)-ona fusionados con azol |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US12370192B2 (https=) |
| EP (1) | EP4031552B1 (https=) |
| JP (1) | JP7566888B2 (https=) |
| KR (1) | KR102924294B1 (https=) |
| CN (1) | CN114728975A (https=) |
| AR (1) | AR119971A1 (https=) |
| AU (1) | AU2020348675B2 (https=) |
| BR (1) | BR112022004819A2 (https=) |
| CA (1) | CA3150508A1 (https=) |
| CO (1) | CO2022004684A2 (https=) |
| CR (1) | CR20220160A (https=) |
| DO (1) | DOP2022000057A (https=) |
| EC (1) | ECSP22020159A (https=) |
| ES (1) | ES2997267T3 (https=) |
| HR (1) | HRP20250088T1 (https=) |
| HU (1) | HUE069908T2 (https=) |
| IL (1) | IL291181B2 (https=) |
| JO (1) | JOP20220063A1 (https=) |
| MX (1) | MX2022003177A (https=) |
| PE (1) | PE20221341A1 (https=) |
| PH (1) | PH12022550597A1 (https=) |
| PL (1) | PL4031552T3 (https=) |
| RS (1) | RS66463B1 (https=) |
| TW (1) | TWI873185B (https=) |
| WO (1) | WO2021055326A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| CR20220160A (es) | 2019-09-16 | 2022-06-16 | Takeda Pharmaceuticals Co | Derivados de piridazin-3(2h)-ona fusionados con azol |
| WO2021224680A1 (en) | 2020-05-08 | 2021-11-11 | Takeda Pharmaceutical Company Limited | Substituted benzotriazinone metabolites of a gpr139 agonist |
| GB202106872D0 (en) * | 2021-05-13 | 2021-06-30 | Addex Pharmaceuticals Sa | Novel compounds |
| CN114149371B (zh) * | 2021-11-26 | 2023-08-22 | 首都医科大学 | 四取代吡唑类化合物及其应用 |
| CN116693545A (zh) * | 2022-03-01 | 2023-09-05 | 上海科技大学 | 噻吩并含氮杂环类化合物、含其的药物组合物、其制备方法及其应用 |
| CN116693536A (zh) * | 2022-03-01 | 2023-09-05 | 上海科技大学 | 吡咯并三嗪酮类化合物、含其的药物组合物、其制备方法及其应用 |
| IT202200024948A1 (it) * | 2022-12-05 | 2024-06-05 | Angelini Pharma S P A | Composti attivatori dei canali potassio KV7.2/KV7.3 |
| CN116063179A (zh) * | 2023-02-20 | 2023-05-05 | 南京杰运医药科技有限公司 | 一种4-甲氧基乙酰乙酸甲酯的合成方法 |
| WO2025119351A1 (zh) * | 2023-12-08 | 2025-06-12 | 深圳湾实验室 | Gpr139激动剂 |
| WO2025124544A1 (zh) * | 2023-12-14 | 2025-06-19 | 华润医药研究院（深圳）有限公司 | 3,4-二氢-2H-苯并[b][1,4]二氧杂环庚烷类化合物及其制备方法和医药用途 |
| WO2025162441A1 (zh) * | 2024-02-02 | 2025-08-07 | 上海科技大学 | 稠杂环类化合物与其制备方法、药物组合物及应用 |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3794726A (en) | 1972-08-21 | 1974-02-26 | Uniroyal Inc | Inhibiting aggressive behavior with 1,2,3-benzotriazin-(3h)-one |
| WO1987004928A1 (fr) | 1986-02-24 | 1987-08-27 | Mitsui Petrochemical Industries, Ltd. | Agents therapeutiques de la neuropathie |
| EP0315390B1 (en) | 1987-11-04 | 1994-07-20 | Beecham Group Plc | Novel 4-oxobenzotriazines and 4-oxoquinazolines |
| JPH0285851A (ja) | 1988-09-22 | 1990-03-27 | Konica Corp | 新規な写真用カプラー |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| JP2874960B2 (ja) | 1990-06-03 | 1999-03-24 | コニカ株式会社 | 新規な染料を含有するハロゲン化銀写真感光材料 |
| JPH04119890A (ja) | 1990-09-11 | 1992-04-21 | Konica Corp | ピラゾロチアジアジン系色素 |
| JP3430375B2 (ja) | 1993-11-12 | 2003-07-28 | コニカ株式会社 | 感熱転写材料及び該材料に好適な色素 |
| DE4339868A1 (de) * | 1993-11-23 | 1995-05-24 | Merck Patent Gmbh | Imidazopyridazine |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| DE19704923A1 (de) | 1997-02-10 | 1998-08-13 | Hoechst Schering Agrevo Gmbh | Klebstoffhaltige Schädlingsbekämpfungsmittel |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| CN1293665A (zh) | 1998-02-18 | 2001-05-02 | 神经研究公司 | 新化合物及其用作阳性ampa受体调节剂 |
| AU1153601A (en) | 1999-10-29 | 2001-05-08 | Merck Sharp & Dohme Limited | Method to treat pain utilizing benzimidazole NMDA NR2B antagonists |
| JP2003526341A (ja) | 1999-11-04 | 2003-09-09 | コロラド ステート ユニバーシティー リサーチ ファウンデーション | 昆虫を誘引するための装置および方法 |
| FR2801587B1 (fr) | 1999-11-30 | 2002-01-11 | Adir | Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP2002085851A (ja) | 2000-09-19 | 2002-03-26 | Totan Information Technology Kk | 経済指標予想ゲームシステム |
| MXPA04003297A (es) | 2001-10-10 | 2004-07-23 | Neurosearch As | Derivados novedosos de benzotiacina su preparacion y uso. |
| FR2833955B1 (fr) | 2001-12-21 | 2004-01-30 | Servier Lab | Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2003235121A1 (en) | 2002-04-26 | 2003-11-10 | Takeda Pharmaceutical Company Limited | Novel thiol derivative, process for producing the same and use thereof |
| JP4079727B2 (ja) | 2002-09-06 | 2008-04-23 | セントラル硝子株式会社 | 光学活性１−（フルオロ、トリフルオロメチルまたはトリフルオロメトキシ置換フェニル）アルキルアミンｎ−モノアルキル誘導体とその製造方法 |
| JP3981316B2 (ja) | 2002-09-27 | 2007-09-26 | 京セラ株式会社 | 半導体素子収納用パッケージ |
| FR2854634B1 (fr) | 2003-05-05 | 2005-07-08 | Servier Lab | Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2526506A1 (en) | 2003-06-09 | 2004-12-16 | Boehringer Ingelheim International Gmbh | Inhibitors of papilloma virus |
| AU2004261283B2 (en) | 2003-07-31 | 2008-05-01 | Irm, Llc | Bicyclic compounds and compositions as PDF inhibitors |
| FR2865474B1 (fr) | 2004-01-26 | 2008-06-13 | Servier Lab | Nouveaux derives de benzothiazines fluorees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2875805B1 (fr) | 2004-09-27 | 2006-12-29 | Genfit S A | Composes derives de n-(benzyl) phenylacetamide substitues, preparation et utilisations |
| FR2879201B1 (fr) | 2004-12-10 | 2007-02-16 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP4738988B2 (ja) | 2005-11-17 | 2011-08-03 | 花王株式会社 | ２連式吐出器 |
| TWI403320B (zh) | 2005-12-16 | 2013-08-01 | Infinity Discovery Inc | 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法 |
| TW200736227A (en) | 2005-12-23 | 2007-10-01 | Astrazeneca Ab | New compounds III |
| AU2007262661A1 (en) | 2006-06-23 | 2007-12-27 | Nufarm Australia Limited | Phenoxy alkanoate herbicidal composition and method of preparation and use |
| TWI433839B (zh) | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
| FR2909090B1 (fr) | 2006-11-23 | 2009-01-09 | Sanofi Aventis Sa | Derives de 2,5-dihydro-3h-pyrazolo[4,3-c]pyridazin-3-one substitues,leur preparation et leur application en therapeutique. |
| WO2008073789A1 (en) | 2006-12-11 | 2008-06-19 | Eli Lilly And Company | Ampa receptor potentiators |
| US20080167374A1 (en) | 2007-01-09 | 2008-07-10 | Loveland Products, Inc. | Pesticide composition and method of use |
| US8148367B2 (en) | 2007-01-12 | 2012-04-03 | Takeda Pharmaceutical Company Limited | Renin inhibitors |
| WO2008094556A2 (en) | 2007-01-30 | 2008-08-07 | Biogen Idec Ma Inc. | Imidazolone compounds as tgf-beta family type i receptors, alk5 and/or alk4 antagonists |
| WO2009004430A1 (en) | 2007-06-29 | 2009-01-08 | Pfizer Inc. | N-benzyl oxazolidinones and related heterocycleic compounds as potentiators of glutamate receptors |
| MX2010005028A (es) | 2007-11-05 | 2010-05-27 | Schering Corp | Moduladores de gamma secretasa. |
| JP2009119088A (ja) | 2007-11-16 | 2009-06-04 | Hoya Corp | 内視鏡用バイポーラ高周波処置具 |
| WO2009086303A2 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2009097970A1 (de) | 2008-02-05 | 2009-08-13 | Sanofi-Aventis | Triazolopyridazine als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel |
| WO2009119088A1 (ja) | 2008-03-25 | 2009-10-01 | 武田薬品工業株式会社 | 複素環化合物 |
| JP2009248543A (ja) | 2008-04-11 | 2009-10-29 | Fujifilm Corp | 光情報記録媒体および情報記録方法 |
| TW201012803A (en) | 2008-06-06 | 2010-04-01 | Organon Nv | Heterocyclic derivatives |
| FR2933698A1 (fr) | 2008-07-09 | 2010-01-15 | Servier Lab | Nouveaux derives de benzothiadiazines cycloalkylees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| CN102149407A (zh) * | 2008-09-10 | 2011-08-10 | 贝林格尔.英格海姆国际有限公司 | 治疗糖尿病和相关病症的组合疗法 |
| AU2009313527A1 (en) | 2008-11-06 | 2010-05-14 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| FR2943342B1 (fr) | 2009-03-20 | 2011-03-04 | Servier Lab | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO2010140339A1 (ja) | 2009-06-01 | 2010-12-09 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2011007756A1 (ja) | 2009-07-13 | 2011-01-20 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| WO2011036885A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2011036889A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2011138265A2 (en) | 2010-05-03 | 2011-11-10 | Evotec Ag | Indole and indazole derivatives as orexin receptor antagonists |
| US9150591B2 (en) | 2010-08-10 | 2015-10-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| WO2014152917A2 (en) | 2013-03-14 | 2014-09-25 | Janssen Pharmaceutica Nv | Physiological ligands for gpr139 |
| MD20170011A2 (ro) | 2014-08-06 | 2017-08-31 | Pfizer Inc. | Compuşi imidazopiridazinici |
| JO3719B1 (ar) | 2014-11-20 | 2021-01-31 | Takeda Pharmaceuticals Co | 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139 |
| WO2020081999A1 (en) | 2018-10-18 | 2020-04-23 | Essa Pharma, Inc. | Androgen receptor modulators and methods for their use |
| WO2020097609A1 (en) | 2018-11-09 | 2020-05-14 | Blackthorn Therapeutics, Inc. | Gpr139 receptor modulators |
| CA3134545A1 (en) | 2019-03-28 | 2020-10-01 | Essa Pharma, Inc. | Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof |
| JP2022547952A (ja) | 2019-09-16 | 2022-11-16 | ノバルティス アーゲー | Ｂｒｄ９二機能性分解誘導薬及びその使用方法 |
| CR20220160A (es) | 2019-09-16 | 2022-06-16 | Takeda Pharmaceuticals Co | Derivados de piridazin-3(2h)-ona fusionados con azol |
| JP2021080177A (ja) | 2019-11-14 | 2021-05-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| WO2021224680A1 (en) | 2020-05-08 | 2021-11-11 | Takeda Pharmaceutical Company Limited | Substituted benzotriazinone metabolites of a gpr139 agonist |
| US20230310441A1 (en) | 2020-09-21 | 2023-10-05 | Takeda Pharmaceutical Company | Treatment for schizophrenia |
-
2020
- 2020-09-15 CR CR20220160A patent/CR20220160A/es unknown
- 2020-09-15 PH PH1/2022/550597A patent/PH12022550597A1/en unknown
- 2020-09-15 CN CN202080079367.0A patent/CN114728975A/zh active Pending
- 2020-09-15 JP JP2022516328A patent/JP7566888B2/ja active Active
- 2020-09-15 HR HRP20250088TT patent/HRP20250088T1/hr unknown
- 2020-09-15 US US17/753,803 patent/US12370192B2/en active Active
- 2020-09-15 IL IL291181A patent/IL291181B2/en unknown
- 2020-09-15 KR KR1020227012292A patent/KR102924294B1/ko active Active
- 2020-09-15 PL PL20781670.3T patent/PL4031552T3/pl unknown
- 2020-09-15 WO PCT/US2020/050823 patent/WO2021055326A1/en not_active Ceased
- 2020-09-15 ES ES20781670T patent/ES2997267T3/es active Active
- 2020-09-15 TW TW109131750A patent/TWI873185B/zh active
- 2020-09-15 JO JOP/2022/0063A patent/JOP20220063A1/ar unknown
- 2020-09-15 HU HUE20781670A patent/HUE069908T2/hu unknown
- 2020-09-15 EP EP20781670.3A patent/EP4031552B1/en active Active
- 2020-09-15 BR BR112022004819A patent/BR112022004819A2/pt unknown
- 2020-09-15 MX MX2022003177A patent/MX2022003177A/es unknown
- 2020-09-15 RS RS20250125A patent/RS66463B1/sr unknown
- 2020-09-15 CA CA3150508A patent/CA3150508A1/en active Pending
- 2020-09-15 AU AU2020348675A patent/AU2020348675B2/en active Active
- 2020-09-15 AR ARP200102558A patent/AR119971A1/es unknown
- 2020-09-15 PE PE2022000427A patent/PE20221341A1/es unknown
-
2022
- 2022-03-15 DO DO2022000057A patent/DOP2022000057A/es unknown
- 2022-03-16 EC ECSENADI202220159A patent/ECSP22020159A/es unknown
- 2022-04-12 CO CONC2022/0004684A patent/CO2022004684A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI873185B (zh) | 2025-02-21 |
| CR20220160A (es) | 2022-06-16 |
| IL291181A (en) | 2022-05-01 |
| WO2021055326A1 (en) | 2021-03-25 |
| CO2022004684A2 (es) | 2022-07-08 |
| EP4031552A1 (en) | 2022-07-27 |
| CN114728975A (zh) | 2022-07-08 |
| MX2022003177A (es) | 2022-04-06 |
| US12370192B2 (en) | 2025-07-29 |
| PH12022550597A1 (en) | 2024-03-04 |
| EP4031552C0 (en) | 2024-11-06 |
| CA3150508A1 (en) | 2021-03-25 |
| IL291181B1 (en) | 2025-05-01 |
| AU2020348675B2 (en) | 2025-11-20 |
| BR112022004819A2 (pt) | 2022-06-07 |
| AR119971A1 (es) | 2022-01-26 |
| AU2020348675A1 (en) | 2022-04-14 |
| HUE069908T2 (hu) | 2025-04-28 |
| PL4031552T3 (pl) | 2025-03-17 |
| JOP20220063A1 (ar) | 2023-01-30 |
| RS66463B1 (sr) | 2025-02-28 |
| JP7566888B2 (ja) | 2024-10-15 |
| IL291181B2 (en) | 2025-09-01 |
| KR20220063228A (ko) | 2022-05-17 |
| US20230028114A1 (en) | 2023-01-26 |
| ECSP22020159A (es) | 2022-05-31 |
| EP4031552B1 (en) | 2024-11-06 |
| KR102924294B1 (ko) | 2026-02-09 |
| ES2997267T3 (en) | 2025-02-14 |
| JP2022548602A (ja) | 2022-11-21 |
| PE20221341A1 (es) | 2022-09-13 |
| HRP20250088T1 (hr) | 2025-03-28 |
| TW202124386A (zh) | 2021-07-01 |
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