TWI858093B - 使用二氫吲哚啉酮衍生物之胰島素產生細胞之製作方法 - Google Patents
使用二氫吲哚啉酮衍生物之胰島素產生細胞之製作方法 Download PDFInfo
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- TWI858093B TWI858093B TW109122853A TW109122853A TWI858093B TW I858093 B TWI858093 B TW I858093B TW 109122853 A TW109122853 A TW 109122853A TW 109122853 A TW109122853 A TW 109122853A TW I858093 B TWI858093 B TW I858093B
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- 229910052717 sulfur Chemical group 0.000 description 1
- 239000011593 sulfur Chemical group 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- SIBLXDSFPQMIMR-UHFFFAOYSA-N tert-butyl 2-[4-[2-[(2-methylpropan-2-yl)oxycarbonylamino]-1,3-thiazol-5-yl]phenoxy]acetate Chemical compound C(C)(C)(C)OC(=O)NC=1SC(=CN=1)C1=CC=C(OCC(=O)OC(C)(C)C)C=C1 SIBLXDSFPQMIMR-UHFFFAOYSA-N 0.000 description 1
- OIZXJJIHVIYNKZ-UHFFFAOYSA-N tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dihydropyrrole-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CC=C1B1OC(C)(C)C(C)(C)O1 OIZXJJIHVIYNKZ-UHFFFAOYSA-N 0.000 description 1
- DETWROWJYGUHQS-UHFFFAOYSA-N tert-butyl N-[5-[4-(dimethylcarbamoyl)phenyl]-1,3-thiazol-2-yl]carbamate Chemical compound CN(C(=O)C1=CC=C(C=C1)C1=CN=C(S1)NC(OC(C)(C)C)=O)C DETWROWJYGUHQS-UHFFFAOYSA-N 0.000 description 1
- OIBKBVFFZYCBAQ-UHFFFAOYSA-N tert-butyl n-(5-bromo-1,3-thiazol-2-yl)carbamate Chemical compound CC(C)(C)OC(=O)NC1=NC=C(Br)S1 OIBKBVFFZYCBAQ-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 102000004217 thyroid hormone receptors Human genes 0.000 description 1
- 108090000721 thyroid hormone receptors Proteins 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C12N5/0602—Vertebrate cells
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- C12N2500/20—Transition metals
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- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- Cell Biology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
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- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
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- Microbiology (AREA)
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- Gastroenterology & Hepatology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019126861 | 2019-07-08 | ||
| JP2019-126861 | 2019-07-08 |
Publications (2)
| Publication Number | Publication Date |
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| TW202116311A TW202116311A (zh) | 2021-05-01 |
| TWI858093B true TWI858093B (zh) | 2024-10-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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| Country | Link |
|---|---|
| US (1) | US20220339260A1 (https=) |
| EP (1) | EP3998107A4 (https=) |
| JP (1) | JP7553030B2 (https=) |
| KR (1) | KR20220031620A (https=) |
| CN (1) | CN114040966A (https=) |
| AU (1) | AU2020309946A1 (https=) |
| CA (1) | CA3144360A1 (https=) |
| IL (1) | IL289501A (https=) |
| TW (1) | TWI858093B (https=) |
| WO (1) | WO2021006268A1 (https=) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015178397A1 (ja) * | 2014-05-20 | 2015-11-26 | 国立大学法人熊本大学 | インスリン産生細胞の分化誘導方法 |
| TW201802240A (zh) * | 2016-06-23 | 2018-01-16 | 泰森生物科技股份有限公司 | 表現副甲狀腺素1型受體之細胞及其用途 |
| TW201938156A (zh) * | 2018-01-18 | 2019-10-01 | 日商第一三共股份有限公司 | 二氫吲哚啉酮衍生物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039059A1 (es) | 2001-08-06 | 2005-02-09 | Sanofi Aventis | Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios |
| US8623648B2 (en) * | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| JPWO2012121168A1 (ja) | 2011-03-04 | 2014-07-17 | 国立大学法人京都大学 | キナーゼ阻害剤 |
| WO2015125662A1 (ja) | 2014-02-21 | 2015-08-27 | 国立大学法人熊本大学 | アミノ酸組成変更培地を用いた幹細胞の分化促進方法、及び該方法を用いて処理された幹細胞、並びに培地 |
| JP6094516B2 (ja) | 2014-03-19 | 2017-03-15 | 三菱電機株式会社 | エレベーター装置 |
| CN107001356B (zh) * | 2014-07-31 | 2019-09-03 | 默克专利有限公司 | 用于神经退化性疾病的中氮茚衍生物 |
| JP7035555B2 (ja) | 2018-01-23 | 2022-03-15 | セイコーエプソン株式会社 | 教示装置、及びシステム |
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2020
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- 2020-07-07 EP EP20836518.9A patent/EP3998107A4/en active Pending
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- 2020-07-07 JP JP2021530701A patent/JP7553030B2/ja active Active
- 2020-07-07 KR KR1020227001218A patent/KR20220031620A/ko active Pending
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015178397A1 (ja) * | 2014-05-20 | 2015-11-26 | 国立大学法人熊本大学 | インスリン産生細胞の分化誘導方法 |
| TW201802240A (zh) * | 2016-06-23 | 2018-01-16 | 泰森生物科技股份有限公司 | 表現副甲狀腺素1型受體之細胞及其用途 |
| TW201938156A (zh) * | 2018-01-18 | 2019-10-01 | 日商第一三共股份有限公司 | 二氫吲哚啉酮衍生物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7553030B2 (ja) | 2024-09-18 |
| TW202116311A (zh) | 2021-05-01 |
| CN114040966A (zh) | 2022-02-11 |
| KR20220031620A (ko) | 2022-03-11 |
| AU2020309946A1 (en) | 2022-03-03 |
| WO2021006268A1 (ja) | 2021-01-14 |
| IL289501A (en) | 2022-02-01 |
| US20220339260A1 (en) | 2022-10-27 |
| JPWO2021006268A1 (https=) | 2021-01-14 |
| CA3144360A1 (en) | 2021-01-14 |
| EP3998107A1 (en) | 2022-05-18 |
| EP3998107A4 (en) | 2023-07-26 |
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