TWI857043B - 用於治療kit及pdgfra介導之疾病的組合物及方法 - Google Patents

用於治療kit及pdgfra介導之疾病的組合物及方法 Download PDF

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Publication number
TWI857043B
TWI857043B TW109111858A TW109111858A TWI857043B TW I857043 B TWI857043 B TW I857043B TW 109111858 A TW109111858 A TW 109111858A TW 109111858 A TW109111858 A TW 109111858A TW I857043 B TWI857043 B TW I857043B
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Taiwan
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compound
mmol
compounds
pharmaceutically acceptable
kit
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TW109111858A
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Chinese (zh)
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TW202104231A (zh
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約瑟夫 L 金
湯瑪斯 A 迪寧
提摩西 古齊
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美商纜圖藥品公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW109111858A 2019-04-12 2020-04-08 用於治療kit及pdgfra介導之疾病的組合物及方法 TWI857043B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962833529P 2019-04-12 2019-04-12
US62/833,529 2019-04-12
US201962911016P 2019-10-04 2019-10-04
US62/911,016 2019-10-04
US201962930240P 2019-11-04 2019-11-04
US62/930,240 2019-11-04

Publications (2)

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TW202104231A TW202104231A (zh) 2021-02-01
TWI857043B true TWI857043B (zh) 2024-10-01

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TW109111858A TWI857043B (zh) 2019-04-12 2020-04-08 用於治療kit及pdgfra介導之疾病的組合物及方法

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US (2) US12552795B2 (https=)
EP (2) EP4424312A3 (https=)
JP (2) JP7600140B2 (https=)
KR (1) KR102875260B1 (https=)
CN (1) CN113939515B (https=)
AU (1) AU2020272743B2 (https=)
BR (1) BR112021020441A2 (https=)
CA (1) CA3136802A1 (https=)
CL (1) CL2021002656A1 (https=)
CO (1) CO2021015113A2 (https=)
DK (1) DK3953357T3 (https=)
EC (1) ECSP21080096A (https=)
ES (1) ES2980811T3 (https=)
FI (1) FI3953357T3 (https=)
HR (1) HRP20240702T1 (https=)
HU (1) HUE067299T2 (https=)
IL (1) IL287168B2 (https=)
LT (1) LT3953357T (https=)
MA (1) MA55604B1 (https=)
MD (1) MD3953357T2 (https=)
MX (1) MX2021012469A (https=)
MY (1) MY209048A (https=)
PE (1) PE20212331A1 (https=)
PH (1) PH12021552568A1 (https=)
PL (1) PL3953357T3 (https=)
PT (1) PT3953357T (https=)
RS (1) RS65644B1 (https=)
SG (1) SG11202111244XA (https=)
SI (1) SI3953357T1 (https=)
SM (1) SMT202400229T1 (https=)
TW (1) TWI857043B (https=)
WO (1) WO2020210293A1 (https=)
ZA (1) ZA202108104B (https=)

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CN117794935A (zh) * 2021-03-10 2024-03-29 缆图药品公司 激酶抑制剂的盐和固体形式
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CN113278023B (zh) * 2021-07-22 2021-10-15 上海睿跃生物科技有限公司 含氮杂环化合物及其制备方法和应用
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US20220153748A1 (en) 2022-05-19
ZA202108104B (en) 2024-02-28
US12552795B2 (en) 2026-02-17
US20200325141A1 (en) 2020-10-15
JP7600140B2 (ja) 2024-12-16
JP2025029094A (ja) 2025-03-05
IL287168A (en) 2021-12-01
WO2020210293A1 (en) 2020-10-15
CL2021002656A1 (es) 2022-08-26
CN113939515A (zh) 2022-01-14
PL3953357T3 (pl) 2024-09-02
CA3136802A1 (en) 2020-10-15
EP4424312A3 (en) 2025-01-08
FI3953357T3 (fi) 2024-07-15
EP3953357A1 (en) 2022-02-16
BR112021020441A2 (pt) 2021-12-14
CO2021015113A2 (es) 2022-02-28
EP3953357B1 (en) 2024-04-17
MY209048A (en) 2025-06-18
KR20220025704A (ko) 2022-03-03
SI3953357T1 (sl) 2024-08-30
ECSP21080096A (es) 2022-02-25
US10829493B2 (en) 2020-11-10
TW202104231A (zh) 2021-02-01
AU2020272743B2 (en) 2025-10-16
HRP20240702T1 (hr) 2024-08-16
DK3953357T3 (en) 2024-06-10
PH12021552568A1 (en) 2022-07-04
JP2022526850A (ja) 2022-05-26
PT3953357T (pt) 2024-07-24
MA55604A (fr) 2022-02-16
IL287168B1 (en) 2025-06-01
SMT202400229T1 (it) 2024-07-09
PE20212331A1 (es) 2021-12-14
RS65644B1 (sr) 2024-07-31
AU2020272743A1 (en) 2021-11-11
HUE067299T2 (hu) 2024-10-28
ES2980811T3 (es) 2024-10-03
MD3953357T2 (ro) 2024-09-30
SG11202111244XA (en) 2021-11-29
KR102875260B1 (ko) 2025-10-23
MA55604B1 (fr) 2024-08-30
CN113939515B (zh) 2024-06-18
EP4424312A2 (en) 2024-09-04
IL287168B2 (en) 2025-10-01
LT3953357T (lt) 2024-07-25
MX2021012469A (es) 2022-01-18

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