TWI856945B - 用抗tslp抗體治療氣喘 - Google Patents
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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| RS61763B1 (sr) * | 2015-09-09 | 2021-05-31 | Novartis Ag | Antitela koja vezuju timusni stromalni limfopoetin (tslp) i metode za korišćenje antitela |
| JOP20190243A1 (ar) * | 2017-04-12 | 2019-10-13 | Medimmune Llc | علاج الربو بجسم مضاد لـ tslp |
| WO2020244544A1 (zh) * | 2019-06-04 | 2020-12-10 | 江苏恒瑞医药股份有限公司 | 能结合胸腺基质淋巴细胞生成素的抗体及其应用 |
| US12435131B2 (en) | 2019-07-11 | 2025-10-07 | Tavotek Biotherapeutics (Hong Kong) Limited | Agents that interfere with thymic stromal lymphopoietin (TSLP)-receptor signaling |
| CN117467007A (zh) * | 2019-09-04 | 2024-01-30 | 正大天晴药业集团股份有限公司 | 结合tslp的抗体及其用途 |
| UA129038C2 (uk) * | 2019-10-28 | 2024-12-25 | Медіммуне Лімітед | Сухий порошкоподібний склад антитіла, що зв'язує тимічний стромальний лімфопоетин (tslp) |
| CN112876564B (zh) * | 2019-11-29 | 2022-07-15 | 康诺亚生物医药科技（成都）有限公司 | 一种tslp相关病症治疗剂的开发和应用 |
| KR20220113673A (ko) * | 2019-12-13 | 2022-08-16 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 항-tslp 항체 및 그 용도 |
| TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法 |
| US20230073888A1 (en) * | 2020-02-13 | 2023-03-09 | Amgen Inc. | Treatment of atopic dermatitis with anti-tslp antibody |
| IL295042A (en) * | 2020-02-13 | 2022-09-01 | Amgen Inc | Formulations of human anti-tslp antibodies and methods of treating inflammatory disease |
| AR121368A1 (es) * | 2020-02-18 | 2022-06-01 | Amgen Inc | Formulaciones de anticuerpos anti-tslp humanos y métodos de uso de los mismos |
| CN113388035A (zh) * | 2020-03-13 | 2021-09-14 | 迈威(上海)生物科技股份有限公司 | 特异性针对人tslp的抗体及其应用 |
| WO2022117079A1 (zh) * | 2020-12-03 | 2022-06-09 | 江苏恒瑞医药股份有限公司 | 结合胸腺基质淋巴细胞生成素的抗体及其应用 |
| CN113501878B (zh) * | 2021-02-03 | 2022-12-02 | 北京智仁美博生物科技有限公司 | 针对人tslp的多种抗体及其用途 |
| CN114853888B (zh) * | 2021-02-05 | 2023-11-03 | 上海洛启生物医药技术有限公司 | 抗tslp纳米抗体及其应用 |
| WO2022184074A1 (zh) * | 2021-03-03 | 2022-09-09 | 正大天晴药业集团股份有限公司 | 含抗tslp抗体的药物组合物 |
| PH12023552762A1 (en) * | 2021-04-19 | 2024-04-15 | Medimmune Ltd | An anti-tslp fab with improved stability |
| KR20230175245A (ko) | 2021-04-23 | 2023-12-29 | 암젠 인크 | 변형된 항-tslp 항체 |
| MX2023012363A (es) | 2021-04-23 | 2023-11-01 | Amgen Inc | Composiciones de anticuerpos anti-tslp y usos de las mismas. |
| CN113683694B (zh) | 2021-09-03 | 2022-05-13 | 江苏荃信生物医药股份有限公司 | 一种抗人tslp单克隆抗体及其应用 |
| CN117209604B (zh) * | 2021-12-02 | 2024-03-22 | 北京东方百泰生物科技股份有限公司 | 一种抗tslp的单克隆抗体、其抗原结合片段及其应用 |
| CN117327176A (zh) * | 2022-06-24 | 2024-01-02 | 南京融捷康生物科技有限公司 | 一种抗tslp的单域抗体及其用途 |
| US12110324B2 (en) | 2022-07-22 | 2024-10-08 | Flagship Pioneering Innovations Vi, Llc | Antigen binding molecules targeting thymic stromal lymphopoietin (TSLP) |
| UY40500A (es) | 2022-10-26 | 2024-04-30 | Amgen Inc | Composiciones de anticuerpos anti-tslp y usos de las mismas |
| AR133647A1 (es) | 2023-08-25 | 2025-10-22 | Proteologix Us Inc | Constructos de anticuerpos multiespecíficos anti-il-13 y usos de los mismos |
| AR133648A1 (es) * | 2023-08-25 | 2025-10-22 | Proteologix Us Inc | Constructos de anticuerpos anti-tslp y sus usos |
| CN117551195B (zh) * | 2024-01-12 | 2024-04-09 | 杭州畅溪制药有限公司 | 靶向tslp的vhh纳米抗体及其应用 |
| WO2025179220A1 (en) * | 2024-02-22 | 2025-08-28 | Flagship Pioneering Innovations Vi, Llc | Dosing of antigen binding molecules targeting thymic stromal lymphopoietin (tslp) |
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| DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
| WO1994002602A1 (en) | 1992-07-24 | 1994-02-03 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
| JP4312259B2 (ja) | 1995-04-27 | 2009-08-12 | アムジェン フレモント インク． | 免疫したゼノマウス（ＸｅｎｏＭｏｕｓｅ）に由来するヒト抗体 |
| US7982016B2 (en) | 2007-09-10 | 2011-07-19 | Amgen Inc. | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
| US8359965B2 (en) | 2007-09-17 | 2013-01-29 | Oxford J Craig | Apparatus and method for broad spectrum radiation attenuation |
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| WO2011056772A1 (en) | 2009-11-04 | 2011-05-12 | Schering Corporation | Engineered anti-tslp antibody |
| WO2012007495A1 (en) | 2010-07-15 | 2012-01-19 | F. Hoffmann-La Roche Ag | Antibodies specifically binding to human tslpr and methods of use |
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| US9306926B2 (en) | 2013-03-15 | 2016-04-05 | Brian A. Truong | User authentication using unique hidden identifiers |
| AR098155A1 (es) * | 2013-10-23 | 2016-05-04 | Genentech Inc | Métodos para diagnosticar y tratar trastornos eosinofílicos |
| SG11201700901SA (en) * | 2014-08-08 | 2017-03-30 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
| AU2016231122A1 (en) | 2015-03-11 | 2017-09-07 | Glaxosmithkline Intellectual Property Development Limited | TSLP binding proteins |
| MY186352A (en) | 2015-09-09 | 2021-07-15 | Novartis Ag | Thymic stromal lymphopoietin (tslp)-binding antibodies and methods of using the antibodies |
| JOP20190243A1 (ar) * | 2017-04-12 | 2019-10-13 | Medimmune Llc | علاج الربو بجسم مضاد لـ tslp |
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2017
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2018
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- 2018-04-12 EP EP18721605.6A patent/EP3609917A1/en active Pending
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- 2018-04-12 AU AU2018253118A patent/AU2018253118B2/en active Active
- 2018-04-12 SG SG11201909322V patent/SG11201909322VA/en unknown
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- 2018-04-12 UY UY0001037676A patent/UY37676A/es not_active Application Discontinuation
- 2018-04-12 TN TNP/2019/000289A patent/TN2019000289A1/en unknown
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2019
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2020
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2023
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2024
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Non-Patent Citations (1)
| Title |
|---|
| 網路文獻 NCT02512900. A Phase 1, Open-label Study to Evaluate the Pharmacokinetics of MEDI9929 (AMG 157) in Adolescents With Mild to Moderate Asthma. Results First Posted：2017-02-23 |
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