TWI822173B - 運算裝置、控制裝置、培養系統以及培養系統的設計方法 - Google Patents
運算裝置、控制裝置、培養系統以及培養系統的設計方法 Download PDFInfo
- Publication number
- TWI822173B TWI822173B TW111125948A TW111125948A TWI822173B TW I822173 B TWI822173 B TW I822173B TW 111125948 A TW111125948 A TW 111125948A TW 111125948 A TW111125948 A TW 111125948A TW I822173 B TWI822173 B TW I822173B
- Authority
- TW
- Taiwan
- Prior art keywords
- culture
- control
- value
- culture tank
- oxygen
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 75
- 238000004364 calculation method Methods 0.000 title claims abstract description 44
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 142
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 139
- 239000001301 oxygen Substances 0.000 claims abstract description 139
- 238000004088 simulation Methods 0.000 claims abstract description 57
- 238000012258 culturing Methods 0.000 claims abstract description 12
- 230000036284 oxygen consumption Effects 0.000 claims description 8
- 238000013461 design Methods 0.000 claims description 6
- 230000004044 response Effects 0.000 claims description 6
- 239000001963 growth medium Substances 0.000 claims description 4
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 230000003111 delayed effect Effects 0.000 claims description 3
- 239000012531 culture fluid Substances 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims 8
- 239000013077 target material Substances 0.000 abstract 4
- 238000002474 experimental method Methods 0.000 description 23
- 238000001514 detection method Methods 0.000 description 14
- 239000006199 nebulizer Substances 0.000 description 7
- 238000005187 foaming Methods 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 210000004102 animal cell Anatomy 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 238000004891 communication Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 238000012549 training Methods 0.000 description 5
- 230000010355 oscillation Effects 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 239000002518 antifoaming agent Substances 0.000 description 3
- 230000005587 bubbling Effects 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004886 process control Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 238000004422 calculation algorithm Methods 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 230000010365 information processing Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000010801 machine learning Methods 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000005288 shirasu porous glass Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000006706 cellular oxygen consumption Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000011173 large scale experimental method Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Computer Hardware Design (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2021/029994 WO2023021571A1 (ja) | 2021-08-17 | 2021-08-17 | 演算装置、制御装置、培養システム、及び培養システムの設計方法 |
| WOPCT/JP2021/029994 | 2021-08-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202308949A TW202308949A (zh) | 2023-03-01 |
| TWI822173B true TWI822173B (zh) | 2023-11-11 |
Family
ID=85240159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW111125948A TWI822173B (zh) | 2021-08-17 | 2022-07-11 | 運算裝置、控制裝置、培養系統以及培養系統的設計方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11859166B2 (https=) |
| EP (1) | EP4389868A1 (https=) |
| JP (1) | JP7328465B2 (https=) |
| TW (1) | TWI822173B (https=) |
| WO (1) | WO2023021571A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025042031A1 (ko) * | 2023-08-23 | 2025-02-27 | 임성혁 | 미생물의 균일생장을 제어할 수 있는 스마트 팜 시스템 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006296423A (ja) * | 2005-03-24 | 2006-11-02 | Hitachi Ltd | 培養槽の制御装置及び培養装置 |
| JP2019129726A (ja) * | 2018-01-29 | 2019-08-08 | 長瀬産業株式会社 | Ｏｔｒシミュレータ |
| CN111699240A (zh) * | 2018-01-17 | 2020-09-22 | 生命技术公司 | 用于细胞培养缩放的系统和方法 |
| CN113046312A (zh) * | 2014-04-23 | 2021-06-29 | 朱诺治疗学股份有限公司 | 分离、培养和遗传工程改造用于过继治疗的免疫细胞群的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07203945A (ja) * | 1994-01-12 | 1995-08-08 | Hitachi Ltd | 生体の細胞の培養装置 |
| US7771988B2 (en) * | 2005-03-24 | 2010-08-10 | Hitachi, Ltd. | Control device for fermenter |
| JP5001659B2 (ja) | 2007-01-04 | 2012-08-15 | 住重関西施設管理株式会社 | 溶存酸素量制御装置 |
-
2021
- 2021-08-17 US US18/026,125 patent/US11859166B2/en active Active
- 2021-08-17 WO PCT/JP2021/029994 patent/WO2023021571A1/ja not_active Ceased
- 2021-08-17 EP EP21953620.8A patent/EP4389868A1/en active Pending
- 2021-08-17 JP JP2022575344A patent/JP7328465B2/ja active Active
-
2022
- 2022-07-11 TW TW111125948A patent/TWI822173B/zh active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006296423A (ja) * | 2005-03-24 | 2006-11-02 | Hitachi Ltd | 培養槽の制御装置及び培養装置 |
| CN113046312A (zh) * | 2014-04-23 | 2021-06-29 | 朱诺治疗学股份有限公司 | 分离、培养和遗传工程改造用于过继治疗的免疫细胞群的方法 |
| CN111699240A (zh) * | 2018-01-17 | 2020-09-22 | 生命技术公司 | 用于细胞培养缩放的系统和方法 |
| JP2019129726A (ja) * | 2018-01-29 | 2019-08-08 | 長瀬産業株式会社 | Ｏｔｒシミュレータ |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7328465B2 (ja) | 2023-08-16 |
| US20230348837A1 (en) | 2023-11-02 |
| WO2023021571A1 (ja) | 2023-02-23 |
| TW202308949A (zh) | 2023-03-01 |
| US11859166B2 (en) | 2024-01-02 |
| JPWO2023021571A1 (https=) | 2023-02-23 |
| EP4389868A1 (en) | 2024-06-26 |
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