TWI809503B - Cdk4抑制劑之固體形式 - Google Patents

Cdk4抑制劑之固體形式 Download PDF

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Publication number
TWI809503B
TWI809503B TW110134168A TW110134168A TWI809503B TW I809503 B TWI809503 B TW I809503B TW 110134168 A TW110134168 A TW 110134168A TW 110134168 A TW110134168 A TW 110134168A TW I809503 B TWI809503 B TW I809503B
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TW
Taiwan
Prior art keywords
ppm
cancer
values
solid
crystalline form
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TW110134168A
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English (en)
Chinese (zh)
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TW202216698A (zh
Inventor
衛斯理 德韋特 克拉克
茱蒂絲 蓋兒 迪奧
布萊恩 馬修 薩瑪斯
Original Assignee
美商輝瑞大藥廠
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Publication of TW202216698A publication Critical patent/TW202216698A/zh
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Publication of TWI809503B publication Critical patent/TWI809503B/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fats And Perfumes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW110134168A 2020-09-15 2021-09-14 Cdk4抑制劑之固體形式 TWI809503B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063078636P 2020-09-15 2020-09-15
US63/078,636 2020-09-15
US202163240268P 2021-09-02 2021-09-02
US63/240,268 2021-09-02

Publications (2)

Publication Number Publication Date
TW202216698A TW202216698A (zh) 2022-05-01
TWI809503B true TWI809503B (zh) 2023-07-21

Family

ID=78000744

Family Applications (2)

Application Number Title Priority Date Filing Date
TW112102545A TW202334125A (zh) 2020-09-15 2021-09-14 Cdk4抑制劑之固體形式
TW110134168A TWI809503B (zh) 2020-09-15 2021-09-14 Cdk4抑制劑之固體形式

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TW112102545A TW202334125A (zh) 2020-09-15 2021-09-14 Cdk4抑制劑之固體形式

Country Status (18)

Country Link
US (1) US20230357211A1 (OSRAM)
EP (2) EP4214202B1 (OSRAM)
JP (2) JP7260606B2 (OSRAM)
KR (1) KR20230069983A (OSRAM)
CN (1) CN116507620B (OSRAM)
AU (1) AU2021345531B2 (OSRAM)
CA (1) CA3195063A1 (OSRAM)
DK (1) DK4214202T3 (OSRAM)
ES (1) ES3022913T3 (OSRAM)
FI (1) FI4214202T3 (OSRAM)
HU (1) HUE070846T2 (OSRAM)
MX (1) MX2023003054A (OSRAM)
PL (1) PL4214202T3 (OSRAM)
PT (1) PT4214202T (OSRAM)
SI (1) SI4214202T1 (OSRAM)
TW (2) TW202334125A (OSRAM)
WO (1) WO2022058871A1 (OSRAM)
ZA (1) ZA202303655B (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114667147B (zh) 2019-08-26 2024-09-06 阿尔维纳斯运营股份有限公司 用四氢萘衍生物作为雌激素受体降解剂的治疗乳腺癌的方法
US20250041298A1 (en) * 2021-12-02 2025-02-06 Pfizer Inc. Cdk4 inhibitor for the treatment of cancer
EP4561571A1 (en) 2022-07-29 2025-06-04 Pfizer Inc. Dosing regimens comprising a kat6 inhibitor for the treatment of cancer
WO2024201340A1 (en) 2023-03-30 2024-10-03 Pfizer Inc. Kat6a as a predictive biomarker for treatment of breast cancer with a cdk4 inhibitor and an antiestrogen and methods of treatment thereof
CN120981721A (zh) 2023-03-30 2025-11-18 辉瑞大药厂 Kat6a作为用kat6a抑制剂治疗的预测性生物标志物和相关治疗方法
WO2024246825A1 (en) 2023-06-02 2024-12-05 Pfizer Inc. Combinations of estrogen receptor degraders and cdk4 inhibitors
WO2024246824A1 (en) 2023-06-02 2024-12-05 Pfizer Inc. Methods and modified dosing regimens comprising a cdk4 inhibitor for the treatment of cancer
US12338248B2 (en) 2023-07-21 2025-06-24 Accutar Biotechnology Inc. Aminopyrimidine derivatives as cyclin-dependent kinase inhibitors
WO2025104624A1 (en) 2023-11-14 2025-05-22 Pfizer Inc. Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol
WO2025202900A1 (en) 2024-03-27 2025-10-02 Pfizer Inc. Cdk4 inhibitors for use in the treatment of mantle cell lymphoma
WO2025202854A1 (en) 2024-03-27 2025-10-02 Pfizer Inc. Cdk4 inhibitors and combinations with cdk2 inhibitors or further agents for use in the treatment of cancer
WO2025202871A1 (en) 2024-03-27 2025-10-02 Pfizer Inc. Methods for identifying biomarkers of treatment response and use thereof with a cdk4 inhibitor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019207463A1 (en) * 2018-04-26 2019-10-31 Pfizer Inc. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
KR102587758B1 (ko) * 2016-07-13 2023-10-12 사이로스 파마수티컬스, 인크. 시클린-의존성 키나제 7 (cdk7)의 억제제
RS61934B1 (sr) 2016-08-15 2021-07-30 Pfizer Inhibitori piridopirimdinona cdk2/ 4/6

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019207463A1 (en) * 2018-04-26 2019-10-31 Pfizer Inc. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors

Also Published As

Publication number Publication date
CN116507620A (zh) 2023-07-28
SI4214202T1 (sl) 2025-05-30
EP4214202A1 (en) 2023-07-26
HUE070846T2 (hu) 2025-07-28
PL4214202T3 (pl) 2025-05-19
TW202216698A (zh) 2022-05-01
MX2023003054A (es) 2023-04-05
CA3195063A1 (en) 2022-03-24
JP7291839B2 (ja) 2023-06-15
DK4214202T3 (da) 2025-03-31
JP7260606B2 (ja) 2023-04-18
TW202334125A (zh) 2023-09-01
EP4214202B1 (en) 2025-02-26
AU2021345531A1 (en) 2023-04-20
JP2022186995A (ja) 2022-12-15
US20230357211A1 (en) 2023-11-09
EP4578450A2 (en) 2025-07-02
BR112023004713A2 (pt) 2023-04-18
JP2022049005A (ja) 2022-03-28
KR20230069983A (ko) 2023-05-19
PT4214202T (pt) 2025-04-11
ES3022913T3 (en) 2025-05-29
CN116507620B (zh) 2025-11-18
AU2021345531B2 (en) 2024-02-29
ZA202303655B (en) 2024-09-25
WO2022058871A1 (en) 2022-03-24
FI4214202T3 (fi) 2025-04-25
EP4578450A3 (en) 2025-07-16

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