CA3195063A1 - Solid forms of a cdk4 inhibitor - Google Patents
Solid forms of a cdk4 inhibitorInfo
- Publication number
- CA3195063A1 CA3195063A1 CA3195063A CA3195063A CA3195063A1 CA 3195063 A1 CA3195063 A1 CA 3195063A1 CA 3195063 A CA3195063 A CA 3195063A CA 3195063 A CA3195063 A CA 3195063A CA 3195063 A1 CA3195063 A1 CA 3195063A1
- Authority
- CA
- Canada
- Prior art keywords
- ppm
- cancer
- values
- crystalline form
- solid state
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fats And Perfumes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
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| US202063078636P | 2020-09-15 | 2020-09-15 | |
| US63/078,636 | 2020-09-15 | ||
| US202163240268P | 2021-09-02 | 2021-09-02 | |
| US63/240,268 | 2021-09-02 | ||
| PCT/IB2021/058320 WO2022058871A1 (en) | 2020-09-15 | 2021-09-13 | Solid forms of a cdk4 inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3195063A1 true CA3195063A1 (en) | 2022-03-24 |
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| CA3195063A Pending CA3195063A1 (en) | 2020-09-15 | 2021-09-13 | Solid forms of a cdk4 inhibitor |
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| EP (2) | EP4214202B1 (OSRAM) |
| JP (2) | JP7260606B2 (OSRAM) |
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| FI (1) | FI4214202T3 (OSRAM) |
| HU (1) | HUE070846T2 (OSRAM) |
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| TW (2) | TW202334125A (OSRAM) |
| WO (1) | WO2022058871A1 (OSRAM) |
| ZA (1) | ZA202303655B (OSRAM) |
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| KR20220054347A (ko) | 2019-08-26 | 2022-05-02 | 아비나스 오퍼레이션스, 인코포레이티드 | 에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 유도체로 유방암을 치료하는 방법 |
| CA3240993A1 (en) * | 2021-12-02 | 2023-06-08 | Pfizer Inc | Cdk4 inhibitor for the treatment of cancer |
| CN119604288A (zh) | 2022-07-29 | 2025-03-11 | 辉瑞大药厂 | 用于治疗癌症的包含kat6抑制剂的给药方案 |
| WO2024201340A1 (en) | 2023-03-30 | 2024-10-03 | Pfizer Inc. | Kat6a as a predictive biomarker for treatment of breast cancer with a cdk4 inhibitor and an antiestrogen and methods of treatment thereof |
| KR20250164842A (ko) | 2023-03-30 | 2025-11-25 | 화이자 인코포레이티드 | Kat6a 억제제에 의한 치료를 위한 예측 바이오마커로서의 kat6a 및 이의 치료 방법 |
| WO2024246824A1 (en) | 2023-06-02 | 2024-12-05 | Pfizer Inc. | Methods and modified dosing regimens comprising a cdk4 inhibitor for the treatment of cancer |
| WO2024246825A1 (en) | 2023-06-02 | 2024-12-05 | Pfizer Inc. | Combinations of estrogen receptor degraders and cdk4 inhibitors |
| WO2025024388A1 (en) | 2023-07-21 | 2025-01-30 | Accutar Biotechnology Inc. | Aminopyrimidine derivatives as cyclin-dependent kinase inhibitors |
| WO2025104624A1 (en) | 2023-11-14 | 2025-05-22 | Pfizer Inc. | Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol |
| WO2025202871A1 (en) | 2024-03-27 | 2025-10-02 | Pfizer Inc. | Methods for identifying biomarkers of treatment response and use thereof with a cdk4 inhibitor |
| WO2025202854A1 (en) | 2024-03-27 | 2025-10-02 | Pfizer Inc. | Cdk4 inhibitors and combinations with cdk2 inhibitors or further agents for use in the treatment of cancer |
| WO2025202900A1 (en) | 2024-03-27 | 2025-10-02 | Pfizer Inc. | Cdk4 inhibitors for use in the treatment of mantle cell lymphoma |
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| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| SG10202012466PA (en) * | 2016-07-13 | 2021-01-28 | Syros Pharmaceuticals Inc | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| UA124804C2 (uk) | 2016-08-15 | 2021-11-24 | Пфайзер Інк. | Піридопіримідинонові інгібітори cdk2/4/6 |
| CN118286225A (zh) * | 2018-04-26 | 2024-07-05 | 辉瑞公司 | 作为细胞周期蛋白依赖性激酶抑制剂的2-氨基-吡啶或2-氨基-嘧啶衍生物 |
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2021
- 2021-09-13 JP JP2021148619A patent/JP7260606B2/ja active Active
- 2021-09-13 EP EP21783049.6A patent/EP4214202B1/en active Active
- 2021-09-13 FI FIEP21783049.6T patent/FI4214202T3/fi active
- 2021-09-13 PT PT217830496T patent/PT4214202T/pt unknown
- 2021-09-13 DK DK21783049.6T patent/DK4214202T3/da active
- 2021-09-13 CN CN202180071477.7A patent/CN116507620B/zh active Active
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- 2021-09-13 MX MX2023003054A patent/MX2023003054A/es unknown
- 2021-09-13 EP EP25153633.0A patent/EP4578450A3/en active Pending
- 2021-09-13 SI SI202130288T patent/SI4214202T1/sl unknown
- 2021-09-13 CA CA3195063A patent/CA3195063A1/en active Pending
- 2021-09-13 HU HUE21783049A patent/HUE070846T2/hu unknown
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- 2021-09-13 WO PCT/IB2021/058320 patent/WO2022058871A1/en not_active Ceased
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- 2021-09-13 US US18/245,039 patent/US20230357211A1/en active Pending
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2022
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2023
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| EP4214202B1 (en) | 2025-02-26 |
| SI4214202T1 (sl) | 2025-05-30 |
| JP7260606B2 (ja) | 2023-04-18 |
| ES3022913T3 (en) | 2025-05-29 |
| PL4214202T3 (pl) | 2025-05-19 |
| AU2021345531A1 (en) | 2023-04-20 |
| EP4578450A2 (en) | 2025-07-02 |
| HUE070846T2 (hu) | 2025-07-28 |
| MX2023003054A (es) | 2023-04-05 |
| TW202334125A (zh) | 2023-09-01 |
| JP2022049005A (ja) | 2022-03-28 |
| JP7291839B2 (ja) | 2023-06-15 |
| AU2021345531B2 (en) | 2024-02-29 |
| EP4578450A3 (en) | 2025-07-16 |
| CN116507620B (zh) | 2025-11-18 |
| DK4214202T3 (da) | 2025-03-31 |
| PT4214202T (pt) | 2025-04-11 |
| ZA202303655B (en) | 2024-09-25 |
| FI4214202T3 (fi) | 2025-04-25 |
| US20230357211A1 (en) | 2023-11-09 |
| TW202216698A (zh) | 2022-05-01 |
| TWI809503B (zh) | 2023-07-21 |
| CN116507620A (zh) | 2023-07-28 |
| EP4214202A1 (en) | 2023-07-26 |
| JP2022186995A (ja) | 2022-12-15 |
| KR20230069983A (ko) | 2023-05-19 |
| BR112023004713A2 (pt) | 2023-04-18 |
| WO2022058871A1 (en) | 2022-03-24 |
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