TWI806822B - 製備治療癌症之醫藥組成物之用途 - Google Patents

製備治療癌症之醫藥組成物之用途 Download PDF

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Publication number
TWI806822B
TWI806822B TW105134053A TW105134053A TWI806822B TW I806822 B TWI806822 B TW I806822B TW 105134053 A TW105134053 A TW 105134053A TW 105134053 A TW105134053 A TW 105134053A TW I806822 B TWI806822 B TW I806822B
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Taiwan
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compound
salt
days
monohydrate
daily dose
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TW105134053A
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Chinese (zh)
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TW201722427A (zh
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奈奇亞契 席
蔡勝力
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日商第一三共股份有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW105134053A 2015-10-23 2016-10-21 製備治療癌症之醫藥組成物之用途 TWI806822B (zh)

Applications Claiming Priority (2)

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US201562245632P 2015-10-23 2015-10-23
US62/245,632 2015-10-23

Publications (2)

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TW201722427A TW201722427A (zh) 2017-07-01
TWI806822B true TWI806822B (zh) 2023-07-01

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TW113124518A TW202515561A (zh) 2015-10-23 2016-10-21 用於治療癌症之醫藥組成物
TW105134053A TWI806822B (zh) 2015-10-23 2016-10-21 製備治療癌症之醫藥組成物之用途
TW112100559A TW202332444A (zh) 2015-10-23 2016-10-21 用於治療癌症之醫藥組成物

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TW113124518A TW202515561A (zh) 2015-10-23 2016-10-21 用於治療癌症之醫藥組成物

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US (3) US20180296547A1 (enExample)
EP (1) EP3364972A1 (enExample)
JP (4) JP6855472B2 (enExample)
KR (1) KR20180064540A (enExample)
CN (2) CN108135892A (enExample)
HK (1) HK1253098A1 (enExample)
TW (3) TW202515561A (enExample)
WO (1) WO2017069289A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3284466A4 (en) * 2015-04-13 2018-12-05 Daiichi Sankyo Company, Limited Treatment method combining mdm2 inhibitor and btk inhibitor
JP6855472B2 (ja) * 2015-10-23 2021-04-07 第一三共株式会社 がんを治療するためのmdm2阻害剤の投与計画
US10409015B1 (en) 2015-12-15 2019-09-10 Optomind Inc. Optical receiving device including focusing lens and reflector mounted to housing body and collimating lens mounted to housing cover
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
WO2023016977A1 (en) * 2021-08-09 2023-02-16 Boehringer Ingelheim International Gmbh Oral composition comprising a mdm2-antagonist for cancer therapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104812757A (zh) * 2012-09-06 2015-07-29 第一三共株式会社 二螺吡咯烷衍生物的晶体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
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DE602007007065D1 (de) * 2006-03-22 2010-07-22 Janssen Pharmaceutica Nv Cycloalkylaminderivate als inhibitoren der wechselwirkung zwischen mdm2 und p53
US20100068174A1 (en) * 2006-08-21 2010-03-18 Synta Pharmaceuticals Corp. Combination with bis (thiohydrazide amides) for treating cancer
EP2203447B1 (en) * 2007-09-21 2012-02-29 Janssen Pharmaceutica, N.V. Inhibitors of the interaction between mdm2 and p53
SI2684880T1 (en) * 2011-03-10 2018-08-31 Daiichi Sankyo Company, Limited DERIVAT DISPIROPYROLIDINE
US9937178B2 (en) * 2011-12-07 2018-04-10 Duke University Methods of identifying and using MDM2 inhibitors
JP5958208B2 (ja) * 2012-09-10 2016-07-27 凸版印刷株式会社 包装袋
WO2015033974A1 (ja) * 2013-09-04 2015-03-12 第一三共株式会社 スピロオキシインドール誘導体の製造方法
EP3094746A1 (en) * 2014-01-14 2016-11-23 Daiichi Sankyo Company, Limited Gene signatures associated with sensitivity to mdm2 inhibitors
KR102595395B1 (ko) 2015-02-20 2023-10-27 다이이찌 산쿄 가부시키가이샤 암의 병용 치료법
EP3284466A4 (en) 2015-04-13 2018-12-05 Daiichi Sankyo Company, Limited Treatment method combining mdm2 inhibitor and btk inhibitor
JP6855472B2 (ja) * 2015-10-23 2021-04-07 第一三共株式会社 がんを治療するためのmdm2阻害剤の投与計画

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104812757A (zh) * 2012-09-06 2015-07-29 第一三共株式会社 二螺吡咯烷衍生物的晶体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 Isabelle RC,et al. "Eff ect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplifi ed, well-diff erentiated or dediff erentiated liposarcoma: an exploratory proof-of-mechanism study", Lancet Oncol, 2012, 13, 1133-1140. *

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Publication number Publication date
EP3364972A1 (en) 2018-08-29
WO2017069289A1 (en) 2017-04-27
US20190201386A1 (en) 2019-07-04
JP2018531273A (ja) 2018-10-25
HK1253098A1 (zh) 2019-06-06
CN108135892A (zh) 2018-06-08
CN113521069A (zh) 2021-10-22
JP2023025214A (ja) 2023-02-21
JP6855472B2 (ja) 2021-04-07
US20220071975A1 (en) 2022-03-10
US20180296547A1 (en) 2018-10-18
TW202332444A (zh) 2023-08-16
US11058673B2 (en) 2021-07-13
JP2024164122A (ja) 2024-11-26
KR20180064540A (ko) 2018-06-14
TW201722427A (zh) 2017-07-01
TW202515561A (zh) 2025-04-16
JP7192011B2 (ja) 2022-12-19
JP2021098750A (ja) 2021-07-01

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