TWI801398B - 新穎之經取代黃嘌呤素衍生物 - Google Patents

新穎之經取代黃嘌呤素衍生物 Download PDF

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Publication number
TWI801398B
TWI801398B TW107123858A TW107123858A TWI801398B TW I801398 B TWI801398 B TW I801398B TW 107123858 A TW107123858 A TW 107123858A TW 107123858 A TW107123858 A TW 107123858A TW I801398 B TWI801398 B TW I801398B
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Taiwan
Prior art keywords
compound
disorder
trpc5
disease
mmol
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TW107123858A
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English (en)
Chinese (zh)
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TW201908318A (zh
Inventor
凱 傑拉齊
克里斯丁 艾克梅爾
艾金 索爾
史蒂芬 賈斯特
柏特蘭德 謝納爾
Original Assignee
德商百靈佳殷格翰國際股份有限公司
美商海卓勒生物科學有限責任公司
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Publication of TW201908318A publication Critical patent/TW201908318A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW107123858A 2017-07-11 2018-07-10 新穎之經取代黃嘌呤素衍生物 TWI801398B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
??17180721.7 2017-07-11
EP17180721 2017-07-11
EP17180721.7 2017-07-11

Publications (2)

Publication Number Publication Date
TW201908318A TW201908318A (zh) 2019-03-01
TWI801398B true TWI801398B (zh) 2023-05-11

Family

ID=59325162

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107123858A TWI801398B (zh) 2017-07-11 2018-07-10 新穎之經取代黃嘌呤素衍生物

Country Status (30)

Country Link
US (1) US10329292B2 (uk)
EP (1) EP3652176B1 (uk)
JP (1) JP7114702B2 (uk)
KR (1) KR102714554B1 (uk)
CN (1) CN110997675B (uk)
AR (1) AR112448A1 (uk)
AU (1) AU2018299824B2 (uk)
BR (1) BR112019025611A2 (uk)
CA (1) CA3066922A1 (uk)
CL (1) CL2020000056A1 (uk)
CO (1) CO2019015102A2 (uk)
CY (1) CY1125014T1 (uk)
DK (1) DK3652176T3 (uk)
EA (1) EA039526B1 (uk)
ES (1) ES2903268T3 (uk)
HR (1) HRP20220029T1 (uk)
HU (1) HUE057600T2 (uk)
IL (1) IL271799B (uk)
LT (1) LT3652176T (uk)
MX (1) MX2020000402A (uk)
PH (1) PH12020500079A1 (uk)
PL (1) PL3652176T3 (uk)
PT (1) PT3652176T (uk)
RS (1) RS62826B1 (uk)
SA (1) SA519410851B1 (uk)
SG (1) SG11201912168TA (uk)
SI (1) SI3652176T1 (uk)
TW (1) TWI801398B (uk)
UA (1) UA124793C2 (uk)
WO (1) WO2019011802A1 (uk)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113166150B (zh) * 2018-12-12 2023-12-01 勃林格殷格翰国际有限公司 经取代的黄嘌呤衍生物
CA3119229A1 (en) * 2018-12-12 2020-06-18 Boehringer Ingelheim International Gmbh Substituted xanthine derivatives
US20240091303A1 (en) * 2019-10-04 2024-03-21 Goldfinch Bio, Inc. Biomarker-based treatment of focal segmental glomerulosclerosis and diabetic kidney disease
CN118373832A (zh) * 2023-01-20 2024-07-23 深圳晶蛋生物医药科技有限公司 大环类化合物、其药物组合物及其应用
CN118459461A (zh) * 2023-02-08 2024-08-09 中国科学院上海药物研究所 黄嘌呤类化合物及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201533044A (zh) * 2013-03-15 2015-09-01 海卓勒生物科學公司 經取代之黃嘌呤及其使用方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE353900T1 (de) * 2001-02-24 2007-03-15 Boehringer Ingelheim Pharma Xanthinderivate, deren herstellung und deren verwendung als arzneimittel
US6869947B2 (en) * 2001-07-03 2005-03-22 Novo Nordisk A/S Heterocyclic compounds that are inhibitors of the enzyme DPP-IV
CA2657640A1 (en) * 2006-07-14 2008-01-24 Pfizer Products Inc. Tartrate salt of (7s)-7-[(5-fluoro-2-methyl-benzyl)oxy]-2-[(2r)-2-methylpiperazin-1-yl]-6,7-dihydro-5h-cyclopenta[b]pyridine
TWI676626B (zh) * 2014-04-23 2019-11-11 美商美國禮來大藥廠 抑制瞬時受體電位ａ１離子通道
EP3180340B1 (en) 2014-08-11 2018-10-10 Hydra Biosciences, Inc. Pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione derivatives
WO2016023831A1 (en) 2014-08-11 2016-02-18 Hydra Biosciences, Inc. Pyrrolo[3,2-d]pyrimidine-2,4(3h,5h)-dione derivatives
JP6559228B2 (ja) 2014-09-17 2019-08-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 肥満症及び糖尿病の治療に有用なテトラヒドロイソキノリン誘導体及び医薬組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201533044A (zh) * 2013-03-15 2015-09-01 海卓勒生物科學公司 經取代之黃嘌呤及其使用方法

Also Published As

Publication number Publication date
US20190016722A1 (en) 2019-01-17
KR20200030048A (ko) 2020-03-19
PL3652176T3 (pl) 2022-04-04
CO2019015102A2 (es) 2020-05-15
EP3652176A1 (en) 2020-05-20
HRP20220029T1 (hr) 2022-04-15
CN110997675A (zh) 2020-04-10
IL271799B (en) 2022-08-01
AU2018299824B2 (en) 2022-06-16
RS62826B1 (sr) 2022-02-28
AU2018299824A1 (en) 2019-12-19
EA202090270A1 (ru) 2020-04-24
TW201908318A (zh) 2019-03-01
PH12020500079A1 (en) 2020-10-05
CY1125014T1 (el) 2023-03-24
AR112448A1 (es) 2019-10-30
CA3066922A1 (en) 2019-01-17
SA519410851B1 (ar) 2023-02-26
JP7114702B2 (ja) 2022-08-08
HUE057600T2 (hu) 2022-05-28
UA124793C2 (uk) 2021-11-17
JP2020526591A (ja) 2020-08-31
KR102714554B1 (ko) 2024-10-10
BR112019025611A2 (pt) 2020-06-16
LT3652176T (lt) 2022-02-25
CN110997675B (zh) 2022-06-07
IL271799A (en) 2020-02-27
US10329292B2 (en) 2019-06-25
DK3652176T3 (da) 2022-01-17
EP3652176B1 (en) 2021-12-15
SI3652176T1 (sl) 2022-04-29
MX2020000402A (es) 2020-08-17
WO2019011802A1 (en) 2019-01-17
EA039526B1 (ru) 2022-02-07
PT3652176T (pt) 2022-01-13
CL2020000056A1 (es) 2020-06-12
ES2903268T3 (es) 2022-03-31
SG11201912168TA (en) 2020-01-30

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