CO2019015102A2 - Nuevos derivados de xantina sustituidos - Google Patents

Nuevos derivados de xantina sustituidos

Info

Publication number
CO2019015102A2
CO2019015102A2 CONC2019/0015102A CO2019015102A CO2019015102A2 CO 2019015102 A2 CO2019015102 A2 CO 2019015102A2 CO 2019015102 A CO2019015102 A CO 2019015102A CO 2019015102 A2 CO2019015102 A2 CO 2019015102A2
Authority
CO
Colombia
Prior art keywords
xanthine derivatives
substituted xanthine
new substituted
derivatives
new
Prior art date
Application number
CONC2019/0015102A
Other languages
English (en)
Inventor
Kai Gerlach
Christian Eickmeier
Achim Sauer
Stefan Just
Bertrand L Chenard
Original Assignee
Boehringer Ingelheim Int
Hydra Biosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Hydra Biosciences Llc filed Critical Boehringer Ingelheim Int
Publication of CO2019015102A2 publication Critical patent/CO2019015102A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a derivados de xantina sustituidos, a composiciones farmacéuticas que los contienen y a su uso en terapia, particularmente en el tratamiento de estados que tienen una asociación con canales iónicos que contienen TRPC5.
CONC2019/0015102A 2017-07-11 2019-12-30 Nuevos derivados de xantina sustituidos CO2019015102A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17180721 2017-07-11
PCT/EP2018/068366 WO2019011802A1 (en) 2017-07-11 2018-07-06 NEW SUBSTITUTED XANTHINE DERIVATIVES

Publications (1)

Publication Number Publication Date
CO2019015102A2 true CO2019015102A2 (es) 2020-05-15

Family

ID=59325162

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0015102A CO2019015102A2 (es) 2017-07-11 2019-12-30 Nuevos derivados de xantina sustituidos

Country Status (30)

Country Link
US (1) US10329292B2 (es)
EP (1) EP3652176B1 (es)
JP (1) JP7114702B2 (es)
KR (1) KR20200030048A (es)
CN (1) CN110997675B (es)
AR (1) AR112448A1 (es)
AU (1) AU2018299824B2 (es)
BR (1) BR112019025611A2 (es)
CA (1) CA3066922A1 (es)
CL (1) CL2020000056A1 (es)
CO (1) CO2019015102A2 (es)
CY (1) CY1125014T1 (es)
DK (1) DK3652176T3 (es)
EA (1) EA039526B1 (es)
ES (1) ES2903268T3 (es)
HR (1) HRP20220029T1 (es)
HU (1) HUE057600T2 (es)
IL (1) IL271799B (es)
LT (1) LT3652176T (es)
MX (1) MX2020000402A (es)
PH (1) PH12020500079A1 (es)
PL (1) PL3652176T3 (es)
PT (1) PT3652176T (es)
RS (1) RS62826B1 (es)
SA (1) SA519410851B1 (es)
SG (1) SG11201912168TA (es)
SI (1) SI3652176T1 (es)
TW (1) TWI801398B (es)
UA (1) UA124793C2 (es)
WO (1) WO2019011802A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3119229A1 (en) * 2018-12-12 2020-06-18 Boehringer Ingelheim International Gmbh Substituted xanthine derivatives
EP3894409B1 (en) * 2018-12-12 2023-08-23 Boehringer Ingelheim International GmbH Substituted xanthine derivatives
WO2021067946A1 (en) * 2019-10-04 2021-04-08 Goldfinch Bio, Inc. Biomarker-based treatment of focal segmental glomerulosclerosis and diabetic kidney disease
CN118373832A (zh) * 2023-01-20 2024-07-23 深圳晶蛋生物医药科技有限公司 大环类化合物、其药物组合物及其应用
WO2024164818A1 (zh) * 2023-02-08 2024-08-15 中国科学院上海药物研究所 黄嘌呤类化合物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2444772T3 (es) * 2001-02-24 2014-02-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Derivados de xantina, su preparación y uso como medicamentos
US6869947B2 (en) * 2001-07-03 2005-03-22 Novo Nordisk A/S Heterocyclic compounds that are inhibitors of the enzyme DPP-IV
KR20090029299A (ko) * 2006-07-14 2009-03-20 화이자 프로덕츠 인코포레이티드 (7ｓ)-7-[(5-플루오로-2-메틸-벤질)옥시]-2-[(2ｒ)-2-메틸피페라진-1-일]-6,7-다이하이드로-5ｈ-사이클로펜타[ｂ]피리딘의 타르트레이트 염
LT2970303T (lt) * 2013-03-15 2017-07-25 Hydra Biosciences, Inc. Pakeistieji ksantinai ir jų panaudojimo metodai
TWI676626B (zh) * 2014-04-23 2019-11-11 美商美國禮來大藥廠 抑制瞬時受體電位ａ１離子通道
WO2016023831A1 (en) 2014-08-11 2016-02-18 Hydra Biosciences, Inc. Pyrrolo[3,2-d]pyrimidine-2,4(3h,5h)-dione derivatives
EP3180340B1 (en) 2014-08-11 2018-10-10 Hydra Biosciences, Inc. Pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione derivatives
WO2016041845A1 (en) 2014-09-17 2016-03-24 Boehringer Ingelheim International Gmbh Tetrahydroisoquinoline derivatives and pharmaceutical compositions useful for the treatment of obesity and diabetes

Also Published As

Publication number Publication date
LT3652176T (lt) 2022-02-25
EP3652176A1 (en) 2020-05-20
CA3066922A1 (en) 2019-01-17
AU2018299824A1 (en) 2019-12-19
KR20200030048A (ko) 2020-03-19
PT3652176T (pt) 2022-01-13
EA202090270A1 (ru) 2020-04-24
JP7114702B2 (ja) 2022-08-08
IL271799A (en) 2020-02-27
RS62826B1 (sr) 2022-02-28
SA519410851B1 (ar) 2023-02-26
HRP20220029T1 (hr) 2022-04-15
CL2020000056A1 (es) 2020-06-12
AR112448A1 (es) 2019-10-30
CN110997675A (zh) 2020-04-10
WO2019011802A1 (en) 2019-01-17
PL3652176T3 (pl) 2022-04-04
SG11201912168TA (en) 2020-01-30
US20190016722A1 (en) 2019-01-17
CY1125014T1 (el) 2023-03-24
UA124793C2 (uk) 2021-11-17
CN110997675B (zh) 2022-06-07
TW201908318A (zh) 2019-03-01
MX2020000402A (es) 2020-08-17
PH12020500079A1 (en) 2020-10-05
DK3652176T3 (da) 2022-01-17
BR112019025611A2 (pt) 2020-06-16
SI3652176T1 (sl) 2022-04-29
JP2020526591A (ja) 2020-08-31
EP3652176B1 (en) 2021-12-15
US10329292B2 (en) 2019-06-25
HUE057600T2 (hu) 2022-05-28
IL271799B (en) 2022-08-01
AU2018299824B2 (en) 2022-06-16
EA039526B1 (ru) 2022-02-07
TWI801398B (zh) 2023-05-11
ES2903268T3 (es) 2022-03-31

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