PL3652176T3 - Podstawione pochodne ksantyny - Google Patents

Podstawione pochodne ksantyny

Info

Publication number
PL3652176T3
PL3652176T3 PL18735588T PL18735588T PL3652176T3 PL 3652176 T3 PL3652176 T3 PL 3652176T3 PL 18735588 T PL18735588 T PL 18735588T PL 18735588 T PL18735588 T PL 18735588T PL 3652176 T3 PL3652176 T3 PL 3652176T3
Authority
PL
Poland
Prior art keywords
xanthine derivatives
substituted xanthine
substituted
derivatives
xanthine
Prior art date
Application number
PL18735588T
Other languages
English (en)
Inventor
Kai Gerlach
Christian Eickmeier
Achim Sauer
Stefan Just
Bertrand L. Chenard
Original Assignee
Boehringer Ingelheim International Gmbh
Hydra Biosciences, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh, Hydra Biosciences, Llc filed Critical Boehringer Ingelheim International Gmbh
Publication of PL3652176T3 publication Critical patent/PL3652176T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL18735588T 2017-07-11 2018-07-06 Podstawione pochodne ksantyny PL3652176T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17180721 2017-07-11
EP18735588.8A EP3652176B1 (en) 2017-07-11 2018-07-06 Substituted xanthine derivatives
PCT/EP2018/068366 WO2019011802A1 (en) 2017-07-11 2018-07-06 NEW SUBSTITUTED XANTHINE DERIVATIVES

Publications (1)

Publication Number Publication Date
PL3652176T3 true PL3652176T3 (pl) 2022-04-04

Family

ID=59325162

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18735588T PL3652176T3 (pl) 2017-07-11 2018-07-06 Podstawione pochodne ksantyny

Country Status (32)

Country Link
US (1) US10329292B2 (pl)
EP (1) EP3652176B1 (pl)
JP (1) JP7114702B2 (pl)
KR (1) KR102714554B1 (pl)
CN (1) CN110997675B (pl)
AR (1) AR112448A1 (pl)
AU (1) AU2018299824B2 (pl)
CA (1) CA3066922A1 (pl)
CL (1) CL2020000056A1 (pl)
CO (1) CO2019015102A2 (pl)
CY (1) CY1125014T1 (pl)
DK (1) DK3652176T3 (pl)
EA (1) EA039526B1 (pl)
ES (1) ES2903268T3 (pl)
HR (1) HRP20220029T1 (pl)
HU (1) HUE057600T2 (pl)
IL (1) IL271799B (pl)
LT (1) LT3652176T (pl)
MX (1) MX394089B (pl)
MY (1) MY200797A (pl)
PE (1) PE20200861A1 (pl)
PH (1) PH12020500079A1 (pl)
PL (1) PL3652176T3 (pl)
PT (1) PT3652176T (pl)
RS (1) RS62826B1 (pl)
SA (1) SA519410851B1 (pl)
SG (1) SG11201912168TA (pl)
SI (1) SI3652176T1 (pl)
SM (1) SMT202200013T1 (pl)
TW (1) TWI801398B (pl)
UA (1) UA124793C2 (pl)
WO (1) WO2019011802A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019231208B2 (en) 2018-03-05 2025-01-23 Gfb (Abc), Llc Imidazodiazepinediones and methods of use thereof
ES2964630T3 (es) * 2018-12-12 2024-04-08 Boehringer Ingelheim Int Derivados de xantina sustituidos
CN113166150B (zh) * 2018-12-12 2023-12-01 勃林格殷格翰国际有限公司 经取代的黄嘌呤衍生物
AU2020357178A1 (en) * 2019-10-04 2022-05-12 Gfb (Abc), Llc Biomarker-based treatment of focal segmental glomerulosclerosis and diabetic kidney disease
CN118373832B (zh) * 2023-01-20 2025-01-28 深圳晶蛋生物医药科技有限公司 大环类化合物、其药物组合物及其应用
AU2024219251A1 (en) * 2023-02-08 2025-09-11 China Pharmaceutical University Xanthine compound and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03007349A (es) * 2001-02-24 2003-12-04 Boehringer Ingelheim Pharma Derivados de xantina, su preparacion y su empleo como medicamentos.
US6869947B2 (en) * 2001-07-03 2005-03-22 Novo Nordisk A/S Heterocyclic compounds that are inhibitors of the enzyme DPP-IV
CA2657640A1 (en) * 2006-07-14 2008-01-24 Pfizer Products Inc. Tartrate salt of (7s)-7-[(5-fluoro-2-methyl-benzyl)oxy]-2-[(2r)-2-methylpiperazin-1-yl]-6,7-dihydro-5h-cyclopenta[b]pyridine
WO2014143799A2 (en) * 2013-03-15 2014-09-18 Hydra Biosciences, Inc. Substituted xanthines and methods of use thereof
TWI676626B (zh) * 2014-04-23 2019-11-11 美商美國禮來大藥廠 抑制瞬時受體電位a1離子通道
JP6667093B2 (ja) * 2014-08-11 2020-03-18 ハイドラ・バイオサイエンシーズ・リミテッド・ライアビリティ・カンパニーHydra Biosciences, LLC ピリド[2,3−d]ピリミジン−2,4(1H,3H)−ジオン誘導体
JP6667092B2 (ja) * 2014-08-11 2020-03-18 ハイドラ・バイオサイエンシーズ・リミテッド・ライアビリティ・カンパニーHydra Biosciences, LLC ピロロ[3,2−d]ピリミジン−2,4(3H,5H)−ジオン誘導体
JP6559228B2 (ja) 2014-09-17 2019-08-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 肥満症及び糖尿病の治療に有用なテトラヒドロイソキノリン誘導体及び医薬組成物

Also Published As

Publication number Publication date
HRP20220029T1 (hr) 2022-04-15
JP7114702B2 (ja) 2022-08-08
MY200797A (en) 2024-01-16
SA519410851B1 (ar) 2023-02-26
EP3652176B1 (en) 2021-12-15
AR112448A1 (es) 2019-10-30
PE20200861A1 (es) 2020-08-25
CY1125014T1 (el) 2023-03-24
UA124793C2 (uk) 2021-11-17
KR102714554B1 (ko) 2024-10-10
DK3652176T3 (da) 2022-01-17
SMT202200013T1 (it) 2022-03-21
US20190016722A1 (en) 2019-01-17
CN110997675A (zh) 2020-04-10
IL271799B (en) 2022-08-01
PT3652176T (pt) 2022-01-13
PH12020500079A1 (en) 2020-10-05
WO2019011802A1 (en) 2019-01-17
SI3652176T1 (sl) 2022-04-29
TWI801398B (zh) 2023-05-11
CN110997675B (zh) 2022-06-07
ES2903268T3 (es) 2022-03-31
JP2020526591A (ja) 2020-08-31
TW201908318A (zh) 2019-03-01
MX394089B (es) 2025-03-24
LT3652176T (lt) 2022-02-25
EA039526B1 (ru) 2022-02-07
EA202090270A1 (ru) 2020-04-24
EP3652176A1 (en) 2020-05-20
KR20200030048A (ko) 2020-03-19
CA3066922A1 (en) 2019-01-17
BR112019025611A2 (pt) 2020-06-16
AU2018299824A1 (en) 2019-12-19
CO2019015102A2 (es) 2020-05-15
US10329292B2 (en) 2019-06-25
CL2020000056A1 (es) 2020-06-12
NZ759728A (en) 2024-11-29
RS62826B1 (sr) 2022-02-28
AU2018299824B2 (en) 2022-06-16
MX2020000402A (es) 2020-08-17
SG11201912168TA (en) 2020-01-30
IL271799A (en) 2020-02-27
HUE057600T2 (hu) 2022-05-28

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