SG11202012594RA - Spirochromane derivatives - Google Patents
Spirochromane derivativesInfo
- Publication number
- SG11202012594RA SG11202012594RA SG11202012594RA SG11202012594RA SG11202012594RA SG 11202012594R A SG11202012594R A SG 11202012594RA SG 11202012594R A SG11202012594R A SG 11202012594RA SG 11202012594R A SG11202012594R A SG 11202012594RA SG 11202012594R A SG11202012594R A SG 11202012594RA
- Authority
- SG
- Singapore
- Prior art keywords
- spirochromane
- derivatives
- spirochromane derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUP1800248A HU231333B1 (en) | 2018-07-13 | 2018-07-13 | Spirochromane derivatives |
PCT/IB2019/055948 WO2020012422A1 (en) | 2018-07-13 | 2019-07-12 | Spirochromane derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202012594RA true SG11202012594RA (en) | 2021-02-25 |
Family
ID=89992725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202012594RA SG11202012594RA (en) | 2018-07-13 | 2019-07-12 | Spirochromane derivatives |
Country Status (23)
Country | Link |
---|---|
US (1) | US20210330650A1 (en) |
EP (1) | EP3820869B1 (en) |
JP (1) | JP2021531260A (en) |
KR (1) | KR20210033002A (en) |
CN (1) | CN112823157A (en) |
AR (1) | AR115782A1 (en) |
AU (1) | AU2019300514B2 (en) |
BR (1) | BR112020026996A2 (en) |
CA (1) | CA3104258A1 (en) |
CL (1) | CL2021000080A1 (en) |
CO (1) | CO2021001216A2 (en) |
CU (1) | CU24680B1 (en) |
EA (1) | EA202190245A1 (en) |
ES (1) | ES2964617T3 (en) |
GE (1) | GEP20237534B (en) |
HU (2) | HU231333B1 (en) |
IL (1) | IL279938A (en) |
MX (1) | MX2021000460A (en) |
PE (1) | PE20211809A1 (en) |
PH (1) | PH12020552183A1 (en) |
SG (1) | SG11202012594RA (en) |
TW (1) | TWI821321B (en) |
WO (1) | WO2020012422A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW202202495A (en) | 2020-03-26 | 2022-01-16 | 匈牙利商羅特格登公司 | Naphthyridine and pyrido〔3,4-c〕pyridazine derivatives as gamma-aminobutyric acid a receptor subunit alpha 5 receptor modulators |
CN115403579A (en) * | 2021-05-27 | 2022-11-29 | 上海拓界生物医药科技有限公司 | Novel spiro derivative and application thereof |
HUP2100338A1 (en) | 2021-09-29 | 2023-04-28 | Richter Gedeon Nyrt | Bicyclic amine derivatives as gabaa alfa5 receptor modulators |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1782811A4 (en) | 2004-08-09 | 2010-09-01 | Eisai R&D Man Co Ltd | Novel antimalaria agent containing heterocyclic compound |
CA2617394C (en) | 2005-09-13 | 2014-06-03 | Janssen Pharmaceutica N.V. | 2-aniline-4-aryl substituted thiazole derivatives |
TW200813067A (en) * | 2006-05-17 | 2008-03-16 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
CN101490056A (en) * | 2006-05-17 | 2009-07-22 | 阿斯利康(瑞典)有限公司 | Nicotinic acetylcholine receptor ligands 101 |
EP2134713A2 (en) | 2006-12-20 | 2009-12-23 | Schering Corporation | Novel jnk inhibitors |
ES2460897T3 (en) | 2007-10-04 | 2014-05-14 | F. Hoffmann-La Roche Ag | Cyclopropyl aryl amide derivatives and uses thereof |
MX2010003156A (en) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Tetrazole-substituted aryl amide derivatives and uses thereof. |
EP2250162B1 (en) | 2008-02-07 | 2014-03-19 | AbbVie Inc. | Amide derivatives as positive allosteric modulators and methods of use thereof |
CL2009000662A1 (en) | 2008-03-19 | 2010-02-05 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4-triazole derivative compounds, modulators of the nicotinic acetylcholine receptor; pharmaceutical composition; its preparation process; and use for the prevention or treatment of psychotic disorders, intellectual impairment disorders or diseases, or inflammatory diseases or disorders. |
EP2110377A1 (en) * | 2008-04-15 | 2009-10-21 | DAC S.r.l. | Spirocyclic derivatives as histone deacetylase inhibitors |
MX2010011358A (en) | 2008-04-17 | 2010-11-10 | Glaxo Group Ltd | Indoles as modulators of nicotinic acetylcholin receptor subtype alpha-71. |
JP5486591B2 (en) | 2008-05-09 | 2014-05-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Trisubstituted pyrazoles as acetylcholine receptor modulators |
US8530483B2 (en) | 2008-05-30 | 2013-09-10 | Merck Sharp & Dohme Corp. | Substituted azabenzoxazoles |
JP5337313B2 (en) | 2009-12-31 | 2013-11-06 | ハッチソン・メディファーマ・リミテッド | Specific triazolopyridines and triazolopyrazines, compositions thereof and methods of their use |
WO2012042915A1 (en) | 2010-10-01 | 2012-04-05 | Raqualia Pharma Inc. | Sulfamoyl benzoic acid heterobicyclic derivatives as trpm8 antagonists |
EP2970180A1 (en) * | 2013-03-13 | 2016-01-20 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
PL3433234T3 (en) * | 2016-03-22 | 2022-01-24 | Merck Sharp & Dohme Corp. | Allosteric modulators of nicotinic acetylcholine receptors |
WO2018085171A1 (en) | 2016-11-01 | 2018-05-11 | Merck Sharp & Dohme Corp. | Substituted bicyclic heteroaryl allosteric modulators of nicotinic acetylcholine receptors |
US11046707B2 (en) * | 2016-12-14 | 2021-06-29 | 89Bio Ltd | Spiropiperidine derivatives |
-
2018
- 2018-07-13 HU HUP1800248A patent/HU231333B1/en unknown
-
2019
- 2019-06-27 TW TW108122548A patent/TWI821321B/en active
- 2019-07-12 PE PE2021000053A patent/PE20211809A1/en unknown
- 2019-07-12 SG SG11202012594RA patent/SG11202012594RA/en unknown
- 2019-07-12 CU CU2020000108A patent/CU24680B1/en unknown
- 2019-07-12 HU HUE19744868A patent/HUE064417T2/en unknown
- 2019-07-12 GE GEAP201915557A patent/GEP20237534B/en unknown
- 2019-07-12 MX MX2021000460A patent/MX2021000460A/en unknown
- 2019-07-12 EP EP19744868.1A patent/EP3820869B1/en active Active
- 2019-07-12 US US17/259,972 patent/US20210330650A1/en active Pending
- 2019-07-12 AU AU2019300514A patent/AU2019300514B2/en active Active
- 2019-07-12 AR ARP190101991A patent/AR115782A1/en unknown
- 2019-07-12 ES ES19744868T patent/ES2964617T3/en active Active
- 2019-07-12 CN CN201980046665.7A patent/CN112823157A/en active Pending
- 2019-07-12 JP JP2021500532A patent/JP2021531260A/en active Pending
- 2019-07-12 KR KR1020217004264A patent/KR20210033002A/en active Search and Examination
- 2019-07-12 EA EA202190245A patent/EA202190245A1/en unknown
- 2019-07-12 WO PCT/IB2019/055948 patent/WO2020012422A1/en unknown
- 2019-07-12 BR BR112020026996-4A patent/BR112020026996A2/en unknown
- 2019-07-12 CA CA3104258A patent/CA3104258A1/en active Pending
-
2020
- 2020-12-16 PH PH12020552183A patent/PH12020552183A1/en unknown
-
2021
- 2021-01-04 IL IL279938A patent/IL279938A/en unknown
- 2021-01-12 CL CL2021000080A patent/CL2021000080A1/en unknown
- 2021-02-03 CO CONC2021/0001216A patent/CO2021001216A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA3104258A1 (en) | 2020-01-16 |
TWI821321B (en) | 2023-11-11 |
HUP1800248A2 (en) | 2020-01-28 |
AU2019300514A1 (en) | 2021-02-11 |
MX2021000460A (en) | 2021-06-23 |
BR112020026996A2 (en) | 2021-04-06 |
ES2964617T3 (en) | 2024-04-08 |
IL279938A (en) | 2021-03-01 |
AR115782A1 (en) | 2021-02-24 |
EA202190245A1 (en) | 2021-04-20 |
EP3820869B1 (en) | 2023-08-30 |
CL2021000080A1 (en) | 2021-10-29 |
GEP20237534B (en) | 2023-09-11 |
PH12020552183A1 (en) | 2021-06-21 |
HU231333B1 (en) | 2023-01-28 |
KR20210033002A (en) | 2021-03-25 |
CU24680B1 (en) | 2023-10-06 |
TW202035399A (en) | 2020-10-01 |
PE20211809A1 (en) | 2021-09-14 |
JP2021531260A (en) | 2021-11-18 |
CO2021001216A2 (en) | 2021-02-26 |
EP3820869A1 (en) | 2021-05-19 |
CU20200108A7 (en) | 2021-07-02 |
AU2019300514B2 (en) | 2023-02-02 |
CN112823157A (en) | 2021-05-18 |
WO2020012422A1 (en) | 2020-01-16 |
US20210330650A1 (en) | 2021-10-28 |
HUE064417T2 (en) | 2024-03-28 |
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