TWI781912B - 有效於治療肝毒性及脂肪肝疾病的化合物及其用途 - Google Patents

有效於治療肝毒性及脂肪肝疾病的化合物及其用途 Download PDF

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TWI781912B
TWI781912B TW105131118A TW105131118A TWI781912B TW I781912 B TWI781912 B TW I781912B TW 105131118 A TW105131118 A TW 105131118A TW 105131118 A TW105131118 A TW 105131118A TW I781912 B TWI781912 B TW I781912B
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liver
combination
mannitol
pharmaceutically acceptable
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TW105131118A
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TW201722897A (zh
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胡幼圃
石東原
熊正輝
何欣恬
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欣耀生醫股份有限公司
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/425—Thiazoles
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
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  • Biotechnology (AREA)
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  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
TW105131118A 2015-09-24 2016-09-26 有效於治療肝毒性及脂肪肝疾病的化合物及其用途 TWI781912B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562222959P 2015-09-24 2015-09-24
US62/222,959 2015-09-24
US201562257697P 2015-11-19 2015-11-19
US62/257,697 2015-11-19
WOPCT/CN2016/078039 2016-03-31
PCT/CN2016/078039 WO2017084234A1 (zh) 2015-11-19 2016-03-31 预防或治疗脂肪肝的药物组合物

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TW201722897A TW201722897A (zh) 2017-07-01
TWI781912B true TWI781912B (zh) 2022-11-01

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EP4609911A3 (en) 2015-09-24 2025-11-19 Sinew Pharma Inc. Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof
CN107613968A (zh) * 2015-11-19 2018-01-19 欣耀生医股份有限公司 预防或治疗脂肪肝的药物组合物
JP2021513548A (ja) * 2018-02-14 2021-05-27 シニュー・ファーマ・インコーポレイテッドＳｉＮｅｗ Ｐｈａｒｍａ Ｉｎｃ． アセトアミノフェン（ａｐａｐ）によって引き起こされる毒性を予防、低減または根絶するための方法および組成物
CN110538187A (zh) * 2018-05-28 2019-12-06 北京大学 Cpt1激活剂
KR102136326B1 (ko) * 2018-09-06 2020-07-22 서울대학교산학협력단 가시박으로부터 분리한 플라보노이드 유도체를 유효성분으로 포함하는 간 질환 예방 또는 치료용 조성물
TWI691719B (zh) * 2018-10-19 2020-04-21 香港商阿瓦隆 海帕波有限公司 半乳糖快速定量檢測系統及其應用
CN109920550A (zh) * 2018-12-25 2019-06-21 天津大学 一种基于dMRI研究青少年肌阵挛性癫痫的方法
WO2020152122A1 (en) * 2019-01-21 2020-07-30 Singapore Health Services Pte. Ltd. Treatment of hepatotoxicity
CN110269855A (zh) * 2019-07-19 2019-09-24 辽宁大学 黄酮类小分子化合物在制备抑制胰脂肪酶活性药物中的应用
US12383191B1 (en) * 2020-05-04 2025-08-12 PathAI, Inc. Systems and methods for assessing liver pathology
CN113999272A (zh) * 2021-10-29 2022-02-01 广西医科大学 香蜂草苷的制备方法及其应用
CN113875982A (zh) * 2021-11-19 2022-01-04 武汉森澜生物科技有限公司 一种含二氢杨梅素的抗衰组合物及其应用
CN117482082A (zh) * 2023-11-27 2024-02-02 西北大学 金松双黄酮在制备抗慢性肾损伤药物中的应用

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US20200009097A1 (en) 2020-01-09
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US20240335404A1 (en) 2024-10-10
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MX395231B (es) 2025-03-25
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HUE072982T2 (hu) 2025-12-28
CA2999368C (en) 2026-07-21
US11285123B2 (en) 2022-03-29
JP7261850B2 (ja) 2023-04-20
BR112018005905A2 (pt) 2018-10-16
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AU2021205040B2 (en) 2023-11-16
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HRP20250899T1 (hr) 2025-11-07
ZA201802373B (en) 2019-04-24
CN120349362A (zh) 2025-07-22
US10456371B2 (en) 2019-10-29
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AU2016327930B2 (en) 2021-04-15
US20180256526A1 (en) 2018-09-13
EP3353144A4 (en) 2019-06-05
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KR20180058795A (ko) 2018-06-01
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HK1244266A1 (zh) 2018-08-03
CA3232521A1 (en) 2017-03-30
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