TWI764786B - 沿著試樣之期望的x’方向成像該試樣的方法及顯微鏡系統 - Google Patents
沿著試樣之期望的x’方向成像該試樣的方法及顯微鏡系統Info
- Publication number
- TWI764786B TWI764786B TW110126589A TW110126589A TWI764786B TW I764786 B TWI764786 B TW I764786B TW 110126589 A TW110126589 A TW 110126589A TW 110126589 A TW110126589 A TW 110126589A TW I764786 B TWI764786 B TW I764786B
- Authority
- TW
- Taiwan
- Prior art keywords
- image sensor
- translation stage
- sample
- pixel
- specimen
- Prior art date
Links
Images
Classifications
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
- G02B21/26—Stages; Adjusting means therefor
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/362—Mechanical details, e.g. mountings for the camera or image sensor, housings
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
- G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
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- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V10/00—Arrangements for image or video recognition or understanding
- G06V10/10—Image acquisition
- G06V10/16—Image acquisition using multiple overlapping images; Image stitching
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
- G06V20/693—Acquisition
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N1/00—Scanning, transmission or reproduction of documents or the like, e.g. facsimile transmission; Details thereof
- H04N1/387—Composing, repositioning or otherwise geometrically modifying originals
- H04N1/3876—Recombination of partial images to recreate the original image
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Multimedia (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Optics & Photonics (AREA)
- Theoretical Computer Science (AREA)
- Signal Processing (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microscoopes, Condenser (AREA)
- Length Measuring Devices By Optical Means (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762457470P | 2017-02-10 | 2017-02-10 | |
| US62/457,470 | 2017-02-10 | ||
| US15/596,352 US10048477B1 (en) | 2017-02-10 | 2017-05-16 | Camera and specimen alignment to facilitate large area imaging in microscopy |
| US15/596,352 | 2017-05-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202140991A TW202140991A (zh) | 2021-11-01 |
| TWI764786B true TWI764786B (zh) | 2022-05-11 |
Family
ID=58779353
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110126589A TWI764786B (zh) | 2017-02-10 | 2018-01-30 | 沿著試樣之期望的x’方向成像該試樣的方法及顯微鏡系統 |
| TW111117109A TWI849418B (zh) | 2017-02-10 | 2018-01-30 | 沿著試樣之期望的x’方向成像該試樣的方法及顯微鏡系統 |
| TW107103241A TWI734891B (zh) | 2017-02-10 | 2018-01-30 | 沿著試樣之期望的x'方向成像該試樣的方法及顯微鏡系統 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW111117109A TWI849418B (zh) | 2017-02-10 | 2018-01-30 | 沿著試樣之期望的x’方向成像該試樣的方法及顯微鏡系統 |
| TW107103241A TWI734891B (zh) | 2017-02-10 | 2018-01-30 | 沿著試樣之期望的x'方向成像該試樣的方法及顯微鏡系統 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US10048477B1 (enExample) |
| EP (1) | EP3580599B1 (enExample) |
| JP (2) | JP7029821B2 (enExample) |
| KR (2) | KR102414312B1 (enExample) |
| CN (1) | CN110291438A (enExample) |
| TW (3) | TWI764786B (enExample) |
| WO (1) | WO2018147888A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017170698A1 (ja) * | 2016-03-31 | 2017-10-05 | キヤノン株式会社 | アダプタ、顕微鏡調節方法、顕微鏡システム及びプログラム。 |
| KR102414312B1 (ko) | 2017-02-10 | 2022-06-28 | 나노트로닉스 이미징, 인코포레이티드 | 현미경 검사에서 대 영역 이미징을 용이하게 하는 카메라 및 표본 정렬 |
| US10545096B1 (en) * | 2018-10-11 | 2020-01-28 | Nanotronics Imaging, Inc. | Marco inspection systems, apparatus and methods |
| US10481379B1 (en) | 2018-10-19 | 2019-11-19 | Nanotronics Imaging, Inc. | Method and system for automatically mapping fluid objects on a substrate |
| US11294162B2 (en) | 2019-02-07 | 2022-04-05 | Nanotronics Imaging, Inc. | Fluorescence microscopy inspection systems, apparatus and methods with darkfield channel |
| CN109752832B (zh) * | 2019-03-25 | 2024-10-22 | 南京泰立瑞信息科技有限公司 | 一种显微镜镜筒在z轴上的运动控制方法及自动显微镜 |
| US11593919B2 (en) | 2019-08-07 | 2023-02-28 | Nanotronics Imaging, Inc. | System, method and apparatus for macroscopic inspection of reflective specimens |
| US10915992B1 (en) | 2019-08-07 | 2021-02-09 | Nanotronics Imaging, Inc. | System, method and apparatus for macroscopic inspection of reflective specimens |
| CN110996002B (zh) * | 2019-12-16 | 2021-08-24 | 深圳市瑞图生物技术有限公司 | 显微镜聚焦方法、装置、计算机设备和存储介质 |
| CN112469984B (zh) * | 2019-12-31 | 2024-04-09 | 深圳迈瑞生物医疗电子股份有限公司 | 一种图像分析装置及其成像方法 |
| DE102020113454A1 (de) | 2020-05-19 | 2021-11-25 | Carl Zeiss Microscopy Gmbh | Mikroskop und Verfahren zum Erzeugen eines aus mehreren mikroskopischen Einzelbildern zusammengesetzten Bildes |
| US11748871B2 (en) * | 2020-09-28 | 2023-09-05 | KLA Corp. | Alignment of a specimen for inspection and other processes |
| DE102021101439A1 (de) * | 2021-01-22 | 2022-07-28 | Carl Zeiss Microscopy Gmbh | Mikroskopiesystem und verfahren zur rotationsüberprüfung einer mikroskopkamera |
| EP4063709A1 (en) * | 2021-03-22 | 2022-09-28 | Roche Diagnostics GmbH | Laboratory system and corresponding method of operation |
| CN115020270B (zh) * | 2021-07-06 | 2025-05-16 | 深圳市森美协尔科技有限公司 | 晶圆测试设备及测试方法 |
| EP4177662A1 (en) * | 2021-11-09 | 2023-05-10 | Roche Diagnostics GmbH | Instrument for automatically dissecting a biological specimen on a slide |
| CN116263539A (zh) * | 2022-08-11 | 2023-06-16 | 上海睿钰生物科技有限公司 | 一种显微成像系统 |
| DE102023114945B3 (de) | 2023-06-07 | 2024-11-21 | Carl Zeiss Meditec Ag | Computerimplementiertes Bildgebungsverfahren und optisches Beobachtungsgerät |
| KR102852898B1 (ko) * | 2023-12-15 | 2025-09-02 | (주)코셈 | 다중창 박막을 이용한 대기압 전자현미경 |
| CN119846827B (zh) * | 2025-03-21 | 2025-06-13 | 浙江荷湖科技有限公司 | 一种针对电缸驱动的超大视野显微镜的视野调平方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004085833A (ja) * | 2002-08-26 | 2004-03-18 | Japan Science & Technology Corp | 一細胞長期観察装置 |
| US20060198558A1 (en) * | 2001-04-25 | 2006-09-07 | Amnis Corporation | Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging |
| US20110169936A1 (en) * | 2010-01-14 | 2011-07-14 | Olympus Corporation | Microscope |
| WO2011093939A1 (en) * | 2010-02-01 | 2011-08-04 | Illumina, Inc. | Focusing methods and optical systems and assemblies using the same |
| US20130088586A1 (en) * | 2011-10-07 | 2013-04-11 | Keyence Corporation | Magnification Observation Device |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2681722B2 (ja) * | 1990-11-29 | 1997-11-26 | ハウス食品株式会社 | 方向性のある物品の充填装置 |
| JP3620884B2 (ja) | 1995-03-01 | 2005-02-16 | 富士機械製造株式会社 | 画像処理装置 |
| JPH1048527A (ja) * | 1996-08-01 | 1998-02-20 | Olympus Optical Co Ltd | イメージローテータ装置及び走査型光学顕微鏡 |
| JPH10103924A (ja) * | 1996-09-27 | 1998-04-24 | Olympus Optical Co Ltd | 微少寸法測定装置 |
| US6107637A (en) * | 1997-08-11 | 2000-08-22 | Hitachi, Ltd. | Electron beam exposure or system inspection or measurement apparatus and its method and height detection apparatus |
| JP2006349762A (ja) | 2005-06-13 | 2006-12-28 | Olympus Corp | 測定顕微鏡装置 |
| JP2007114547A (ja) | 2005-10-21 | 2007-05-10 | Nikon Corp | 顕微鏡装置 |
| JP2011145470A (ja) | 2010-01-14 | 2011-07-28 | Olympus Corp | 顕微鏡 |
| FR2963093B1 (fr) * | 2010-07-26 | 2012-08-03 | Vit | Installation d'inspection optique 3d de circuits electroniques |
| US8175452B1 (en) * | 2010-10-26 | 2012-05-08 | Complete Genomics, Inc. | Method and system for imaging high density biochemical arrays with sub-pixel alignment |
| JP5700797B2 (ja) | 2011-01-24 | 2015-04-15 | 株式会社キーエンス | 共焦点顕微鏡システム、画像処理方法および画像処理プログラム |
| JP5963453B2 (ja) * | 2011-03-15 | 2016-08-03 | 株式会社荏原製作所 | 検査装置 |
| US20130077892A1 (en) * | 2011-09-27 | 2013-03-28 | Yasunori Ikeno | Scan Order Optimization and Virtual Slide Stitching |
| JP5896725B2 (ja) * | 2011-12-20 | 2016-03-30 | オリンパス株式会社 | 撮像装置 |
| JP2014130221A (ja) * | 2012-12-28 | 2014-07-10 | Canon Inc | 画像処理装置、その制御方法、画像処理システム、及びプログラム |
| JP6562627B2 (ja) | 2014-12-10 | 2019-08-21 | キヤノン株式会社 | 顕微鏡システム |
| JP6560490B2 (ja) | 2014-12-10 | 2019-08-14 | キヤノン株式会社 | 顕微鏡システム |
| KR102414312B1 (ko) | 2017-02-10 | 2022-06-28 | 나노트로닉스 이미징, 인코포레이티드 | 현미경 검사에서 대 영역 이미징을 용이하게 하는 카메라 및 표본 정렬 |
-
2017
- 2017-05-16 KR KR1020197025718A patent/KR102414312B1/ko active Active
- 2017-05-16 EP EP17726165.8A patent/EP3580599B1/en active Active
- 2017-05-16 WO PCT/US2017/032826 patent/WO2018147888A1/en not_active Ceased
- 2017-05-16 KR KR1020227021558A patent/KR102668955B1/ko active Active
- 2017-05-16 JP JP2019543248A patent/JP7029821B2/ja active Active
- 2017-05-16 US US15/596,352 patent/US10048477B1/en active Active
- 2017-05-16 CN CN201780086206.2A patent/CN110291438A/zh active Pending
-
2018
- 2018-01-30 TW TW110126589A patent/TWI764786B/zh active
- 2018-01-30 TW TW111117109A patent/TWI849418B/zh active
- 2018-01-30 TW TW107103241A patent/TWI734891B/zh active
- 2018-06-29 US US16/023,308 patent/US10416426B2/en active Active
- 2018-06-29 US US16/023,219 patent/US10698191B2/en active Active
-
2020
- 2020-06-29 US US16/915,057 patent/US11099368B2/en active Active
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2022
- 2022-02-14 JP JP2022020249A patent/JP7428406B2/ja active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060198558A1 (en) * | 2001-04-25 | 2006-09-07 | Amnis Corporation | Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging |
| JP2004085833A (ja) * | 2002-08-26 | 2004-03-18 | Japan Science & Technology Corp | 一細胞長期観察装置 |
| US20110169936A1 (en) * | 2010-01-14 | 2011-07-14 | Olympus Corporation | Microscope |
| WO2011093939A1 (en) * | 2010-02-01 | 2011-08-04 | Illumina, Inc. | Focusing methods and optical systems and assemblies using the same |
| US20130088586A1 (en) * | 2011-10-07 | 2013-04-11 | Keyence Corporation | Magnification Observation Device |
Also Published As
| Publication number | Publication date |
|---|---|
| TW202234120A (zh) | 2022-09-01 |
| US20180231752A1 (en) | 2018-08-16 |
| TW201831858A (zh) | 2018-09-01 |
| US20180307016A1 (en) | 2018-10-25 |
| JP2022062236A (ja) | 2022-04-19 |
| EP3580599B1 (en) | 2024-12-25 |
| US10698191B2 (en) | 2020-06-30 |
| WO2018147888A1 (en) | 2018-08-16 |
| TW202140991A (zh) | 2021-11-01 |
| TWI734891B (zh) | 2021-08-01 |
| JP7428406B2 (ja) | 2024-02-06 |
| US20180335614A1 (en) | 2018-11-22 |
| KR20220093274A (ko) | 2022-07-05 |
| KR102414312B1 (ko) | 2022-06-28 |
| EP3580599A1 (en) | 2019-12-18 |
| KR102668955B1 (ko) | 2024-05-23 |
| US10416426B2 (en) | 2019-09-17 |
| JP2020507813A (ja) | 2020-03-12 |
| JP7029821B2 (ja) | 2022-03-04 |
| US20200326519A1 (en) | 2020-10-15 |
| CN110291438A (zh) | 2019-09-27 |
| US10048477B1 (en) | 2018-08-14 |
| KR20190112108A (ko) | 2019-10-02 |
| TWI849418B (zh) | 2024-07-21 |
| US11099368B2 (en) | 2021-08-24 |
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