TWI751998B - 結晶型化合物 - Google Patents

結晶型化合物 Download PDF

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Publication number
TWI751998B
TWI751998B TW105142467A TW105142467A TWI751998B TW I751998 B TWI751998 B TW I751998B TW 105142467 A TW105142467 A TW 105142467A TW 105142467 A TW105142467 A TW 105142467A TW I751998 B TWI751998 B TW I751998B
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TW
Taiwan
Prior art keywords
radiation
xrpd
crystal form
crystalline form
crystal
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TW105142467A
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English (en)
Chinese (zh)
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TW201800392A (zh
Inventor
安多尼 亞力山大 麥金尼
弗蘭克林 拜瑪士達
渥爾達 比士柯斯基
弗勒J 弗雷茲
楊永來
戴威A 恩蓋斯
華拉利亞 史目連卡亞
維卡特 古桑達
Original Assignee
美商大塚美國製藥股份有限公司
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Publication of TW201800392A publication Critical patent/TW201800392A/zh
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Publication of TWI751998B publication Critical patent/TWI751998B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/16—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings
    • C07C211/17—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
TW105142467A 2015-06-17 2016-12-21 結晶型化合物 TWI751998B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562181174P 2015-06-17 2015-06-17
PCT/US2016/038256 WO2016205762A1 (en) 2015-06-17 2016-06-17 Crystalline compounds
??PCT/US16/38256 2016-06-17
WOPCT/US16/38256 2016-06-17
US15/186,415 2016-06-17
US15/186,415 US9708261B2 (en) 2015-06-17 2016-06-17 Crystalline compounds

Publications (2)

Publication Number Publication Date
TW201800392A TW201800392A (zh) 2018-01-01
TWI751998B true TWI751998B (zh) 2022-01-11

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TW105142467A TWI751998B (zh) 2015-06-17 2016-12-21 結晶型化合物

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KR (1) KR102593783B1 (enExample)
CN (3) CN117466800A (enExample)
AU (2) AU2016279075C1 (enExample)
CA (2) CA3200692A1 (enExample)
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NZ (2) NZ739044A (enExample)
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SA (1) SA517390552B1 (enExample)
SG (1) SG10201911417PA (enExample)
SI (1) SI3597189T1 (enExample)
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WO (1) WO2016205762A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200801825B (en) 2005-07-27 2009-12-30 Dov Pharmaceutical Inc Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: Preparation and use to treat neuropsychiatric disorders
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
EP3080080A4 (en) * 2013-12-09 2017-08-16 Neurovance, Inc. Novel compositions
ES2922158T3 (es) 2015-06-17 2022-09-09 Otsuka America Pharmaceutical Inc Compuestos cristalinos
US11149004B2 (en) 2017-12-11 2021-10-19 Crystal Pharmaceutical (Suzhou) Co., Ltd. Crystalline form of EB-1020, processes for preparation and use thereof
CN114555557A (zh) * 2019-10-16 2022-05-27 大塚制药株式会社 森塔纳法啶的制备方法
US12698260B2 (en) * 2021-05-31 2026-08-04 Assia Chemical Industries Ltd. Solid state form of centanafadine HCL and process for preparation thereof
US12502358B1 (en) 2024-08-13 2025-12-23 Innovate Therapeutics Llc Centanafadine multiphasic controlled-release pharmaceutical formulation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013019271A1 (en) * 2011-07-30 2013-02-07 Neurovance, Inc. Use of (1r,5s)-(+)-1-(naphthalen-2-yl)-3-azabicyclo{3.1.0}hexane in the treatment of conditions affected by monoamine neurotransmitters
CN103476770A (zh) * 2010-11-25 2013-12-25 拉蒂欧制药有限责任公司 新的阿法替尼盐和多晶型物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2005117630A (ru) 2002-11-08 2006-01-20 Дов Фармасьютикал, Инк. (Us) Полиморфы гидрохлорида бицифадина
EP1740593B1 (en) 2004-04-19 2016-04-06 KRKA, tovarna zdravil, d.d., Novo mesto Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form i
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
CA2619817A1 (en) 2004-08-18 2006-03-02 Dov Pharmaceutical, Inc. Thermodynamically stable polymorph of an azabicyclohexane
US20070082939A1 (en) 2005-07-26 2007-04-12 Lippa Arnold S Methods and compositions for the treatment of neuropathies and related disorders
ZA200801825B (en) 2005-07-27 2009-12-30 Dov Pharmaceutical Inc Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: Preparation and use to treat neuropsychiatric disorders
US7919598B2 (en) 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
US20080058535A1 (en) * 2006-07-25 2008-03-06 Zhengming Chen Methods and compositions for production, formulation and use of 1 aryl-3-azabicyclo[3.1.0]hexanes
US8576985B2 (en) 2009-09-01 2013-11-05 Aptuit (West Lafayette) Llc Methods for indexing solid forms of compounds
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
US20140228421A1 (en) 2011-09-07 2014-08-14 Anthony McKinney Methods For Inhibiting Native And Promiscuous Uptake Of Monoamine Neurotransmitters
EP3080080A4 (en) 2013-12-09 2017-08-16 Neurovance, Inc. Novel compositions
ES2922158T3 (es) 2015-06-17 2022-09-09 Otsuka America Pharmaceutical Inc Compuestos cristalinos

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103476770A (zh) * 2010-11-25 2013-12-25 拉蒂欧制药有限责任公司 新的阿法替尼盐和多晶型物
WO2013019271A1 (en) * 2011-07-30 2013-02-07 Neurovance, Inc. Use of (1r,5s)-(+)-1-(naphthalen-2-yl)-3-azabicyclo{3.1.0}hexane in the treatment of conditions affected by monoamine neurotransmitters

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
2007年5月,梁峻銘之研究論文「以一般化結晶技術篩選藥物多晶型的研究」 *

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WO2016205762A1 (en) 2016-12-22
JP2026083082A (ja) 2026-05-19
TW201800392A (zh) 2018-01-01
EP3597189B1 (en) 2022-06-01
AU2021200314B2 (en) 2022-08-04
HUE059348T2 (hu) 2022-11-28
EP3310352A4 (en) 2019-03-13
JP2018517742A (ja) 2018-07-05
JP2021138747A (ja) 2021-09-16
US11299458B2 (en) 2022-04-12
PL3597189T3 (pl) 2022-07-25
EP3310352A1 (en) 2018-04-25
LT3597189T (lt) 2022-07-11
KR20180014830A (ko) 2018-02-09
US9708261B2 (en) 2017-07-18
CN117088802A (zh) 2023-11-21
SG10201911417PA (en) 2020-01-30
US9856217B2 (en) 2018-01-02
AU2016279075B2 (en) 2020-10-22
CN117466800A (zh) 2024-01-30
SI3597189T1 (sl) 2022-08-31
DK3597189T3 (da) 2022-06-27
ES2922158T3 (es) 2022-09-09
CA3200692A1 (en) 2016-12-22
JP7583851B2 (ja) 2024-11-14
NZ739044A (en) 2022-08-26
US20210198198A1 (en) 2021-07-01
US20170334850A1 (en) 2017-11-23
AU2021200314A1 (en) 2021-03-18
HRP20220829T1 (hr) 2022-12-23
HK1247125A1 (zh) 2018-09-21
RU2018101244A (ru) 2019-07-22
JP6896651B2 (ja) 2021-06-30
US20260138950A1 (en) 2026-05-21
US20180194726A1 (en) 2018-07-12
CA2989431A1 (en) 2016-12-22
CN107921021A (zh) 2018-04-17
MY194868A (en) 2022-12-21
EP4049997A1 (en) 2022-08-31
US10280141B2 (en) 2019-05-07
MX2017016430A (es) 2018-11-09
MX387591B (es) 2025-03-18
US20160368871A1 (en) 2016-12-22
CA2989431C (en) 2023-08-29
JP2023071978A (ja) 2023-05-23
EP3597189A1 (en) 2020-01-22
US20200039934A1 (en) 2020-02-06
KR102593783B1 (ko) 2023-10-25
MX2020009949A (es) 2020-10-16
PT3597189T (pt) 2022-07-05
AU2016279075C1 (en) 2021-04-01
JP2025022896A (ja) 2025-02-14
CY1125352T1 (el) 2025-05-09
NZ776973A (en) 2022-11-25
PH12017502324A1 (en) 2018-06-25
SA517390552B1 (ar) 2022-04-13
JP7244575B2 (ja) 2023-03-22
RU2018101244A3 (enExample) 2019-12-23
AU2016279075A1 (en) 2018-02-01
US10800740B2 (en) 2020-10-13

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